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| 1 | Bidirectional regulation of angiogenesis by phytoestrogens through estrogen receptor-mediated signaling networks显示文摘Sex hormone estrogen is one of the most active intrinsic angiogenesis regulators; its therapeutic use has been limited due to its carcinogenic potential. Plant-derived phytoestrogens are attractive alternatives, but reports on their angiogenic activities often lack in-depth analysis and sometimes are controversial. Herein, we report a data-mining study with the existing literature, using IPA system to classify and characterize phytoestrogens based on their angiogenic properties and pharmacological consequences. We found that pro-angiogenic phytoestrogens functioned predominantly as cardiovascular protectors whereas anti-angiogenic phytoestrogens played a role in cancer prevention and therapy. This bidirectional regulation were shown to be target-selective and, for the most part, estrogen-receptor-dependent. The transactivation properties of ERα and ERβ by phytoestrogens were examined in the context of angiogenesis-related gene transcription. ERα and ERβ were shown to signal in opposite ways when complexed with the phytoestrogen for bidirectional regulation of angiogenesis. With ERα, phytoestrogen activated or inhibited transcription of some angiogenesis-related genes, resulting in the promotion of angiogenesis, whereas, with ERβ, phytoestrogen regulated transcription of angiogenesis-related genes, resulting in inhibition of angiogenesis. Therefore, the selectivity of phytoestrogen to ERα and ERβ may be critical in the balance of pro- or anti-angiogenesis process. | LIU Hai-Xin WANG Yu LU Qing YANG Ming-Zhu FAN Guan-Wei KARAS Richard H GAO Xiu-Mei ZHU Yan | 2016 | Chinese Journal of Natural Medicines2016，14，4： | 4 |
| 2 | The protective effects of estrogen on the cardiovascularsystem显示文摘 | Mendelsohn M E Karas R H | 1999 | NEnglJ Med1999，340，23： | 1 |
| 3 | A selective disassembly methodology for end-of-life products显示文摘 | KARA S POMPRASITPOL P KEBEMICK H | 2005 | Assembly Automation2005，25，2： | 1 |
| 4 | Sleep disturbances and suicidal behavior in patients with major depression显示文摘 | Agargun MY Kara H Solmaz M | 1997 | Journal of Clinical Psychiatry1997，58，： | 1 |
| 5 | Alterations of plasma magne- sium, copper, zinc, iron and selenium concentrations and some related erythrocyte antioxidant enzyme activities i patients with Alzheimer's disease 显示文摘 | Vural H Demirin H Kara Y | 2010 | Journal of Trace Elements in Medicine and Biology2010，24，3： | 1 |
| 6 | The effect of recombinant human growth hormone(rhGH)on trinitrobenzene sulfonic acid-induced colitis in rats an experimental study显示文摘 | Kara E Sungurtekin H Sungurtekin U | | 0，，02： | 1 |
| 7 | Molecular and cellular basis of cardiovascular gender differences显示文摘 | Mendelsohn M E Karas R H | 2005 | Science2005，308，5728： | 1 |
| 8 | Closure or nonclosure of the visceral peritoneum at eesare-an delivery显示文摘 | NageleF Karas H spiteer D etal | 1996 | Am J obstet Gynecol1996，174，10： | 1 |
| 9 | Automatic transformations between geoscience standards using XML显示文摘 | Kara LN Brain H | 2005 | Comput Geosci2005，31，9： | 1 |
| 10 | Sequences and factors: a guide to MHC class Ⅱ transcription显示文摘 | Glimcher L H Kara C J | 1992 | Annual Review of Immunology1992，10，： | 1 |
| 11 | Lycopene and 1,25-dihydroxyvitamin D3 cooperate in the inhibition of cell cycle progression and induction of differventiation in HL-60 leukemic cells 显示文摘 | Amir H Karas M Giat J | 1993 | Nutr Cancer1993，33，1： | 1 |
| 12 | Immobilization of a-amylase on Cu^2+ chelated poly ( ethylene glycol dimethacrylate-n-vinyl imidazole) matrix via adsorption 显示文摘 | Kara A Osman B Yavuz H | 2005 | React Funct Polym2005，62，： | 1 |
| 13 | Predisposing factors fordelirium in the surgical intensive care unit 显示文摘 | ALDEMIR M OZEN S KARA I H | 2001 | Crit Care2001，5，： | 1 |
| 14 | Image assessment for a destination with limited comparativeadvantages显示文摘 | Cathy H C Hsua Kara Wolfeb Soo K Kang | 2004 | Tourism Management2004，25，： | 1 |
| 15 | Magnesium infusion:re-duces perioperative pain显示文摘 | Kara H Sahin N Ulusan V | 2002 | Eur-J-Anaesthesiol2002，19，1： | 1 |
| 16 | Boron removal by ion exchange membranes 显示文摘 | AYYILDIZ H KARA H | 2005 | Desalination2005，180，123： | 1 |
| 17 | Repetitive and frightening dreams and suicidal behavior in patients with major depression显示文摘 | Agargun MY Cilli AS Kara H | 1998 | Comprehensive Psychiatry1998，39，： | 1 |
| 18 | Gallbladder perforation: clinical presentation, predisposing factors, and surgical out- comes of 46 patients显示文摘 | Derici H Karner E Kara C | 2011 | Turk J Gastroenterol2011，22，5： | 1 |
| 19 | Isolated cortical venous thrombo-sis associated with intracranial hypotension Headache syndrome显示文摘 | Albayram S Kara B Ipek H | 2009 | J Clin Neurosci2009，49，： | 1 |
| 20 | Closum or nonclosure visceral peritoneum at cesarean delivery显示文摘 | NAGELE F KARAS H SPITZER D | 1996 | Am J Obstet Gynecol1996，174，： | 1 |
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