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| 1 | Oct 4+/Tenascin C+ neuroblastoma cells serve as progenitors of tumor-derived endothelial cells显示文摘Neuroblastoma (NB ) 联系了 endothelial microvessels (他们) 可以被导出肿瘤的 endothelial 房间(侦探) 衬里,那是遗传上不稳定的并且 chemoresistant。这里,我们由集中于 Octamer 有约束力的抄写因素 4 在 NB 探讨了侦探祖先的鉴定(Oct-4 ) 作为一个通常认为的标记。Oct-4 + 房间在主要 NB 样品被检测(n = 23 ) ,变形骨头髓把发成送气音(n = 10 ) , NB 房间线(n = 4 ) ,并且 orthotopic 肿瘤(n = 10 ) 在 immunodeficient 老鼠由 HTLA-230 NB 房间线形成了。大多数 Oct-4 + 房间显示出 perivascular 分布,与他们中的 5% 个一起在 perinecrotic 区域的 homing。自从他们与恶意的房间分享了 MYCN oncogene 的扩大,所有 Oct-4 + 房间是导出肿瘤的。表示的 Perivascular Oct-4 + 细胞起源房间相关的、神经祖先相关、 NB 相关的标记包括表面 Tenascin C (TNC ) ,那不在 perinecrotic Oct-4 + 细胞和体积肿瘤细胞。在 vitro 区分进在包含脉管的 endothelial 生长因素(VEGF ) 的媒介在文化之上表示 vascular-endothelial-cadherin,前列腺特定的膜抗原和 CD31 的象 endothelial 一样房间的 TNC + 然而并非 TNC − HTLA-230 房间。TNC + 然而并非 TNC − HTLA-230 房间形成了 neurospheres 什么时候在没有浆液的媒介有教养。房间部分是 tumorigenic,但是仅仅肿瘤由包含的他们由侦探衬里的 TNC + 房间形成了。在结论,我们在 NB 肿瘤识别了包含 Oct-4 + 肿瘤房间的二个通常认为的壁龛。Oct-4 +/TNC+ perivascular NB 房间显示了粘性的高度并且用作侦探的祖先。Oct4 +/TNC+ 祖先的治疗学的指向可以抵抗导出 NB 的 EC 的贡献到肿瘤恶化和 chemoresistance。 | Annalisa Pezzolo Federica Parodi Danilo MarimPietri Lizzia Raffaghello Claudia Cocco Angela Pistorio Manuela Mosconi Claudio Gambini Michele Cilli Silvia Deaglio Fabio Malavasi Vito Pistoia | 2011 | Cell Research2011，21，10： | 2 |
| 2 | Synthesis and immunological activity of a branched peptide carrying the T-cell epitope of gp43, the major exocellular antigen of Paracoccidioides brasiliensis 显示文摘 | Taborda C P Nakaie C R Cilli E M | 2004 | Scand J Immunol2004，59，1： | 1 |
| 3 | Acute hyperglycemia and acute hyperinsulinemia decrease plasma fibrinolytic activity and increase plasminogen activator inhibitor type 1 in the rat显示文摘 | Giaccari A Cilli C | 2001 | Acta Diabetol2001，38，： | 1 |
| 4 | Early prenatal management of a fetal ventricular tachycardia treated in utero by amiodarone with long term follow-up显示文摘 | Sehleieh JM Bernard Du Haut Cilly F Laurent MC | 2000 | Prenat Diagn2000，20，6： | 1 |
| 5 | Endovascular treat- ment of thoracic aortic disease : four years of experience 显示文摘 | Bortone A S De Cillis E D'Agostino D | 2004 | Circu- lation2004，110，11： | 1 |
| 6 | Acute hyperglycemia and a- cute hyperinsulinemia decrease plasma fibrinolytic activity and in- crease plasminogen activator inhibitor type 1 in the rat 显示文摘 | Pandolfi A Giaccari A Cilli C | 2001 | Acta Diabetol2001，38，： | 1 |
| 7 | Repetitive and frightening dreams and suicidal behavior in patients with major depression显示文摘 | Agargun MY Cilli AS Kara H | 1998 | Comprehensive Psychiatry1998，39，： | 1 |
| 8 | Reconstruction of intercalary gap after wide surgicalresection of adamantinoma of the tibia显示文摘 | Kiral A Pehlivan O Cilli F | | 0，，11： | 1 |
| 9 | Rec- ommended dielectric tests and test procedures for converter trans- formers and smoothing reactors 显示文摘 | KENNEDY W N CRICHTON C C CILLIES D A | 1986 | IEEE Transactions on Pow-erDelivery1986，1，3： | 1 |
| 10 | Further evaluation of intensified and increased total dose of cyclophosphamide for the treatment of primary breast cancer: Findings from National Surgical Adjuvant Breast and Bowel Project B-25显示文摘 | Fisher B Anderson S De Cillis A | 1999 | J Clin Onco11999，17，11： | 1 |
| 11 | Radiographic correlation of symptomatic and asymptomatic flexible flatfoot in young male adults 显示文摘 | Pehlivan O Cilli F Mahirogullari M | 2009 | Int Orthop2009，33，2： | 1 |
| 12 | Oxcarbazepine-induced syndrome of inappropriate secretion of antidiuretic hormone显示文摘 | Cilli AS Algun E | 2002 | J Clin Psychiatry2002，63，8： | 1 |
| 13 | Detection of the emerging rotavirus G12Pgenotype at high frequency in brazil in 2014:Successive replacement of predominant strains after vaccine introduction显示文摘 | Luchs A Cilli A Morillo SG | 2016 | Acta Trop2016，156，： | 1 |
| 14 | Human NK cell infusions prolong survival of metastatic human neuroblastoma-bearing NOD/scid mice显示文摘 | Castriconi R Dondero A Cilli M | 2007 | Cancer Immunol Immun2007，56，11： | 1 |
| 15 | Evaluation of enterovirus 71 immune status in Sao Paulo state显示文摘 | Luchs A Cilli A Russo DH | 2011 | Brazil Virol J2011，8，： | 1 |
| 16 | Platelet antiag gregating activity of Taraxacum off ic inale Weber显示文摘 | Neef H Cilli F Declerck P J | 1996 | Phytother Res1996，10，4： | 1 |
| 17 | Clinical evaluation of proximal contacts of ClassⅡesthetic direct restorations显示文摘 | Prakki A Cilli R Chalup Saad JO | 2004 | Quintessence Int2004，35，10： | 1 |
| 18 | Limitation in subtalar motion in a patient nine years after treatment for medial subtalar dislocation显示文摘 | Cilli F | 2006 | Acta Orthop Traumatol Turc2006，40，2： | 1 |
| 19 | Human NK cell infusions prolong survival of metastatic human neuroblastoma-bearing NOD/scid mice 显示文摘 | Castriconi R Dondero A Cilli M | 2007 | Cancer Immunol Immunother2007，56，11： | 1 |
| 20 | Radiographic correlation of symptomatic and asymptomatic flexible flatfoot in young male adults显示文摘 | Pehlivan O Cilli F Mahirogullari M | 2009 | Int Orthop2009，33，2： | 1 |
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