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| 1 | Enteral stents for the management of malignant colorectal obstruction显示文摘Colorectal cancer(CRC) is the 3rd most common cancer in the United States with more than 10000 new cases diagnosed annually. Approximately 20% of patients with CRC will have distant metastasis at time of diagnosis, making them poor candidates for primary surgical resection. Similarly, 8%-25% of patients with CRC will present with bowel obstruction and will require palliative therapy. Emergent surgical decompression has a high mortality and morbidity, and often leads to a colostomy which impairs the patient's quality of life. In the last decade, there has been an increasing use of colonic stents for palliative therapy to relieve malignant colonic obstruction. Colonic stents have been shown to be effective and safe to treat obstruction from CRC, and are now the therapy of choice in this scenario. In the setting of an acute bowel obstruction in patients with potentially resectable colon cancer, stents may beused to delay surgery and thus allow for decompression, adequate bowel preparation, and optimization of the patient's condition for curative surgical intervention. An overall complication rate(major and minor) of up to 25% has been associated with the procedure. Long term failure of stents may result from stent migration and tumor ingrowth. In the majority of cases, repeat stenting or surgical intervention can successfully overcome these adverse effects. | Jeremy Kaplan Anna Strongin Douglas G Adler Ali A Siddiqui | 2014 | World Journal of Gastroenterology2014，20，37： | 13 |
| 2 | 睾酮和良性前列腺增生症显示文摘由于医患双方对于男性迟发性腺功能减退症状的警觉,使得近期针对此类患者的睾酮治疗增多。但是考虑到睾酮治疗对前列腺的影响,尤其可能增加前列腺癌发病风险,促进了该方面的研究进展。出乎意料的是大量的回顾性或小样本随机研究提示睾酮治疗或可改善男性下尿路症状。虽然此改善的确切机理仍在争论中,但或许和代谢综合征密切相关。对于临床医生,这些研究的结果虽然让人期待,但是缺乏高等级证据支持。因此在诊断迟发性腺功能减退症或考虑睾酮治疗前,仍需对患者进行包括病史、体检和睾酮测量在内的全面临床检查。睾酮补充治疗可能导致尿潴留和加重下尿路症状,这些产品说明上标注的风险依然存在,应该在用药前向患者解释说明。 | Thomas R Jarvis Bilal Chughtai Steven A Kaplan | 2015 | Asian Journal of Andrology2015，17，2： | 7 |
| 3 | Do statins reduce hepatitis C RNA titers during routine clinical use?显示文摘AIM: To compare hepatitis C virus (HCV) titers in patients with chronic hepatitis C with and without exposure to 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins).METHODS: Medical records were reviewed for 6463 patients with documented HCV infection at a single center between March 2004 and September 2006. Patients with confi rmed viremia and meeting inclusion criteria were assigned to one of three groups: Group A (n = 50), dyslipidemic patients with statin usage during HCV RNA polymerase chain reaction (PCR) determination; Group B (n = 49), dyslipidemic patients with prior or future statin usage but not at the time of HCV RNA PCR determination; and Group C (n = 102), patients without statin usage during the study period. The primary analysis explored the effect of statin therapy on HCV viremia. Secondary analyses assessed class effect, dose response, and effect of other lipid-lowering therapies on HCV viral titers.RESULTS: Median HCV RNA titers did not signif icantly differ among the three groups (Group A: 4 550 000 IU/mL, Group B: 2 850 000 IU/mL, Group C: 3 055 000 IU/mL).For those subjects with longitudinal assessment of HCV viremia prior to and while on statins, there were no signif icant differences between pre- and post-HCV viral titers. Additionally, no differences in HCV titers were observed at any dose level of the most prescribed statin, simvastatin. However, hypertriglyceridemia independently correlated with HCV titers, and niacin exposure was associated with signif icantly lower viral titers (P < 0.05).CONCLUSION: There was no apparent effect of statins on HCV viral replication in this analysis. Further investigation is warranted to explore the possible antiviral properties of triglyceride-lowering agents and their potential role as adjuncts to standard HCV therapy. | Kimberly A Forde Connie Law Rose O’Flynn David E Kaplan | 2009 | World Journal of Gastroenterology2009，15，40： | 2 |
| 4 | Endoscopic ultrasound-fine needle injection for oncological therapy显示文摘The minimal invasiveness and precision of endoscopicultrasound(EUS) has lead to both its widespread use as a diagnostic and staging modality for gastrointestinal and pancreaticobiliary malignancies, and to its expand-ing role as a therapeutic modality. EUS-guided celiac plexus neurolysis is now a well-accepted modality for palliation of pain in patients with pancreatic cancer. EUS-guided ablation, brachytherapy, fiducial marker placement, and antitumor agent injection have been described as methods of performing minimally invasive oncological therapy. EUS-fine needle injection may be performed as adjunctive, alternative, or palliative treatment. This review summarizes the studies to date that have described these methods. A literature search using the Pub Med/MEDLINE databases was performed. While most published studies to date are limited with disappointing outcomes, the concept of a role of EUS in oncological therapy seems promising. | Jeremy Kaplan Amaara Khalid Natalie Cosgrove Ayesha Soomro Syed Mohsin Mazhar Ali A Siddiqui | 2015 | World Journal of Gastrointestinal Oncology2015，7，12： | 2 |
| 5 | Clinicopathologic characteristics and therapeutic outcomes of primary gastrointestinal non - Hodgkin's lymphomas in centralAnatolia 显示文摘 | Eser B Kaplan B Unal A | 2006 | Leuk Lymphoma2006，47，1： | 1 |
| 6 | Castration induces acute vasoconstriction of blood vessels in the prostate concomitant with a reduction of prostaticnitricoxide synthase activity显示文摘 | Hayek OR Shabsigh A Kaplan SA | 1999 | Jurol1999，162，4： | 1 |
| 7 | Cell Migration and Prolix-Feration During the in Vitro Wound Repair of the Respiratory Epithelium显示文摘 | ZAHM J M KAPLAN H Herard A L | 1995 | Eur Respir J1995，19，8： | 1 |
| 8 | In Search of Insight显示文摘 | Kaplan C A Simon H A | 1990 | Cognitive Psychology1990，32，： | 1 |
| 9 | Enzyme-based molecular imprinting with metals显示文摘 | Cui A Singh A Kaplan DE | 2002 | Biomacromolecules2002，3，： | 1 |
| 10 | Mutagenicity of 2,4,6-trinitrotoluene surfactant complexes显示文摘 | Kaplan D L Kaplan A M | 1982 | Bulletin of Environmental Contamination and Toxicology1982，28，： | 1 |
| 11 | Primary bipolar hemiprosthesis for unstable intertrochanteric fractures显示文摘 | Rodop O Kira A Kaplan H | 2002 | Int Orthop2002，26，4： | 1 |
| 12 | Capacity building:Shifting the paradigms of practice显示文摘 | Kaplan A | 2000 | Development in Practice2000，10，34： | 1 |
| 13 | Primary bipolar hemiprosthesis for unstable intertro chanteric fractures 显示文摘 | Rodop O Kiral A Kaplan H | 2002 | Int Ortho p2002，26，4： | 1 |
| 14 | The correlation between epithelial cell proliferation and inflammation in odontogenic keratocyst 显示文摘 | Kaplan I Hirshberg A | 2004 | Oral On- col2004，40，10： | 1 |
| 15 | Demethylation of promoter regulatory elements contributes to perforin overexpression in CD4+ lupus T cells显示文摘 | Kaplan MJ Lu Q Wu A | | 0，，06： | 1 |
| 16 | Predictability of El Nifio over the past 148 years显示文摘 | Chen D Cane M A Kaplan A | 2004 | Nature2004，428，6984： | 1 |
| 17 | Comparative studies of functional and binding assays for IgG anti-Fcε R1 (α-subunit) in chronic urticaria 显示文摘 | Frrer M Kinet JP Kaplan A | 1998 | J Allergy Clin lmmunol1998，101，5： | 1 |
| 18 | Seeing is believing: the importance of video laryngoscopy in teaching and in managing the difficult airway显示文摘 | Kaplan M B Ward D Hagberg C A Berci G Hagiike M | 2006 | Surg Endosc2006，202，： | 1 |
| 19 | The psychopathology of nostalgia显示文摘 | KAPLAN H A | 1987 | Psychoanal Review1987，74，： | 1 |
| 20 | ACE2 of the heart: From angiotensin I to angiotensin(1-7)显示文摘 | Keidar S Kaplan M Gamliel-Lazarovich A | 2007 | Cardiovasc Res2007，73，3： | 1 |
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