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| 1 | 溶栓时间(入院到用药时间)的延迟及其对脑卒中治疗时间与预后的影响显示文摘尽管美国心脏协会/美国脑卒中协会关于脑卒中的治疗均提出了倡议,大量急性缺血性脑卒中患者仍然在到达就诊60min后才开始启动组织型纤溶酶原激活剂(阿替普酶)溶栓治疗。该研究旨在描述延迟的原因及其与患者预后之间的关系。 | 刘莉 叶鹏 Kamal N Sheng S Xian Y Matsouaka R Hill MD Bhatt DL Saver JL Reeves MJ Fonarow GC Schwamm LH Smith EE | 2017 | 中华高血压杂志2017，25，4： | 15 |
| 2 | Is there a relationship between vitamin D with insulin resistance and diabetes mellitus?显示文摘Available data suggest a possible link between abnormalvitamin D level and abnormal glucose homeostasis,two of the most common chronic medical conditions.Both conditions are associated with inflammation,and the exact mechanism for role of either on the other is not well clear.Literature investigating the link between vitamin D and either pre-diabetic states or diabetes is reviewed.Vitamin D deficiency is detrimental to insulin synthesis and secretion in animal and human studies.In humans,it has been shown by majority of observational studies,that vitamin D is positively correlated with insulin sensitivity and its role is mediated both by direct mechanism through the availability of vitamin D receptors in several tissues and indirectly through the changes in calcium levels.Large number of,but not all,variable samples cross sectional human trials have demonstrated an inverse relation between vitamin D status and impaired glucose tolerance,insulin resistance or diabetes.To compliment this conclusively,evidence from intervention studies is critically warranted before we can frankly state that vitamin D plays a role in diabetes prevention or treatment.Absence of both sizable prospective observational trials utilizing 25(OH)D as the main variable and the non-availability of randomized studies specifically designed to assess the effects of vitamin D on pre-diabetes and diabetes states,are the main obstacles to draw solid and conclusive relationships. | Kamal AS Al-Shoumer Thamer M Al-Essa | 2015 | World Journal of Diabetes2015，6，8： | 13 |
| 3 | Effect of preoperative biliary drainage on outcome of classical pancreaticoduodenectomy显示文摘AIM: To investigate the role of preoperative biliary drainage (PBD) in the outcome of classical pancreaticodu odenectomy. METHODS: A 10-year retrospective data analysis was performed on patients (n = 48) undergoing pancreaticoduodenectomy from March 1994 to March 2004 in department of surgery at SMS medical college, Jaipur, India. Demographic variables, details of preoperative stenting, operative procedure and post operative complications were noted. RESULTS: Preoperative biliary drainage was performed in 21 patients (43.5%). The incidence of septic complications was significantly higher in patients with biliary stent placement (P < 0.05, 0 vs 4). This group of patients also had a significantly higher minor biliary leak rate. Mortality and hospital stay in each group was comparable. CONCLUSION: Within this study population the use of PBD by endoscopic stenting was associated with a high incidence of infective complications. These findings do not support the routine use of biliary stenting in patients prior to pancreatico-duodenectomy. | Chandra Shekhar Bhati Chandrashekhar Kubal Pankaj Kumar Sihag Ankur Atal Gupta Raj Kamal Jenav Nicholas G Inston Jagdish M Mehta | 2007 | World Journal of Gastroenterology2007，13，8： | 12 |
| 4 | 高粱-小麦粉复合面包面团发酵流变学与烘焙特性(英文)显示文摘研究高粱粉(过100目筛)对高粱-小麦粉复合面团特性及其面包品质的影响。以小麦粉为参照样,将高粱粉与小麦粉分别按照10/90,20/80,30/70,40/60,50/50(m/m)的比例进行混合,然后采用Mixolab和F3发酵流变仪分析测定面团搅拌和发酵流变特性,并对面包的品质进行评定。结果表明:用高粱粉取代部分小麦粉,随着取代率的增加会降低面团吸水率、面团形成时间及其稳定性。当取代率为10%时,面包芯和面包皮色泽(除b值外)与参照样无显著差别。除弹性和回复性外,当高粱粉对小麦粉的取代率不高于20%时,面包的其它质构参数都没有显著差异。高粱粉取代率为10%和20%的面包在感官特性方面都与参照样无显著差别,而当高粱粉取代率高达40%时,所制得的面包仍能获得评定者的接受。 | Kamal M. ADAM 王凤 贾春利 黄卫宁 RAYAS-DUARTE Patricia | 2013 | 食品与机械2013，29，1： | 12 |
| 5 | 桉树叶凋落物对树林和农作物的他感作用(英文)显示文摘调查了土壤中配以不同量的桉树叶凋落物对温室条件生长的常见作物和树木的他感作用。用于生物鉴定物种包括三种常见农作物(Falen(Vigna unguiculata),Chickpea(Cicer arietinum),Arhor(Cajanus cajan))和两种广泛栽植树种(Sadakoroi(Albizia procera)and Ipil ipil(Leucaena leucocephala))。实验材料在室温(27°C)条件下用托盘培养,混以不同剂量的凋落物的土壤培养材料的各项指标与对照比较。结果表明,桉树凋落叶诱导抑制作用,且该作用依赖于萃取物和凋落物浓度,受作用物种类型。实验用材料的剂量越高,抑制作用则越高,反之,亦然。尽管生物鉴定种均受到抑制,其中仍有表现较好的种。基于本实验结果,推荐Vigna unguiculata,Cicer arietinum种于复合农林系统中。在混交林中,Leucaena leucochephala和Albizia procera比较,优先选择Leucaena leucochephala。图4表7参39。 | Romel Ahmed A. T. M. Rafiqul Hoque Mohammed Kamal Hossain | 2008 | Journal of Forestry Research2008，19，1： | 11 |
| 6 | 重症患者获得性肌无力17例临床分析显示文摘目的:探讨重症患者获得性肌无力(ICUAW)的肌电图和肌肉病理学特点,及其对预后的影响。方法回顾性分析山东大学齐鲁医院重症医学科2011年10月至2014年10月入住重症加强治疗病房(ICU)患者ICUAW的发生情况,选择20例肌肉活检患者的临床资料,收集肌电图及肱二头肌肌肉病理活检与电镜超微结构观察结果,记录机械通气时间、 ICU住院时间、总住院时间及预后。结果10例肌电图检查患者中1例符合吉兰-巴雷综合征肌电图改变,1例确诊为危重病性肌病(CIM)患者肌电图无异常,4例CIM患者表现为肌源性损害,4例CIM患者合并神经源性损害〔即危重病性多神经肌病(CIPMN)〕。17例ICUAW患者肌肉活检均显示为选择性Ⅱ型肌纤维萎缩,其中9例存在肌细胞坏死;2例患者肌肉活检证实为常染色体隐性遗传性肌病导致的肌无力与呼吸衰竭,1例吉兰-巴雷综合征患者肌肉活检无异常。5例患者电镜超微结构显示肌小节结构严重损伤与破坏、线粒体几乎消失。17例ICUAW患者机械通气时间(38.3 d±31.7),ICU住院时间(60.5±36.4) d,总住院时间(70.5±38.8) d;4例患者死亡。结论肌电图有助于鉴别CIM与神经系统疾病;而肌肉活检有助于发现少见病因导致的肌无力,重症患者以坏死性肌病为主,多合并肌源性与神经源性损伤,对患者预后产生不利影响。 | Kamal Aktar 韩辉 丁士芳 吴大玮 | 2015 | 中华危重病急救医学2015，27，4： | 10 |
| 7 | Solving the electronic structure problem with machine learning显示文摘Simulations based on solving the Kohn-Sham(KS)equation of density functional theory(DFT)have become a vital component of modern materials and chemical sciences research and development portfolios.Despite its versatility,routine DFT calculations are usually limited to a few hundred atoms due to the computational bottleneck posed by the KS equation.Here we introduce a machine-learning-based scheme to efficiently assimilate the function of the KS equation,and by-pass it to directly,rapidly,and accurately predict the electronic structure of a material or a molecule,given just its atomic configuration.A new rotationally invariant representation is utilized to map the atomic environment around a grid-point to the electron density and local density of states at that grid-point.This mapping is learned using a neural network trained on previously generated reference DFT results at millions of grid-points.The proposed paradigm allows for the high-fidelity emulation of KS DFT,but orders of magnitude faster than the direct solution.Moreover,the machine learning prediction scheme is strictly linear-scaling with system size. | Anand Chandrasekaran Deepak Kamal Rohit Batra Chiho Kim Lihua Chen Rampi Ramprasad | 2019 | npj Computational Materials2019，，1： | 10 |
| 8 | Mismatch repair genes (hMLH1, hPMS1, hPMS2, GTBP/hMSH6,HMSH2) in the pathogenesis of hepatocellular carcinoma显示文摘AIM: DNA misrnatch repair (MMR) is an impotent mechanism for maintaining fidelity of genomic DNA. Abnormalities in one or more MMR genes are implicated in the development of many cancers. We investigated the role of expression of MMR genes (hMLH1, hPMS1, hPMS2, GTBP/hMSH6, hMSH2) in hepatocellular carcinogenesis. METHODS: We evaluated the expression level of MMR genes in 33 hepatocellular carcinoma (HCC) cases using the multiplex reverse transcription (RT) PCR assays, as well as in 16 cases of normal adjacent hepatic tissues. Β-actin gene was used as an internal control and calibrator for quantification of gene expression. RESULTS: Out of the 33 studied cases, 25 were HCV positiveand 30 (90.9%) showed reduced expression in one or more of the studied MMR genes. Reduced expression was found in hMSH2 (71.9%), hMLH1 (53.3%), GTBP (51.1%), hPMS2 (33.3%) and hPMS1 (6%). A significant correlation was found between reduced expression of hPMS2(P= 0.0069) and GTBP(P= 0.0034), hPMS2and non-cirrhosis (P= 0.0197),hMLH1 and high grade. On the other hand, 57.1%, 50%, 20%, 18.8%, and 6% of the normal tissues distant to tumors showed reduced expression of hMSH2, hMLH1, GTBP, hPMS2, and hPMS1 respectively. Multivariate analysis revealed a significant correlation between the expression level of hMSH2(P= 0.008), hMLH1 (P= 0.001) and GTBP (P = 0.032)and HCC, between hPMS2, GTBP and HCVassociated HCC (P<0.001, 0.002).CONCLUSION: Reduced expression of MMR genes seemsto play an important role in HCV-associated HCC. hPMS2 islikely involved at an early stage of hepatocarcinogenesis since it was detected in normal adjacent tissues. Reduced expression of hPMS2 provides a growth advantage and stimulates proliferation which encourages malignant transformation in non-cirrhotic HCV-infected patients via acquisition of more genetic damages. | Abdel-Rahman N. Zekri Gelane M. Sabry Abeer A. Bahnassy Kamal A. Shalaby Sabrin A.Abdel-Wahabh Serag Zakaria | 2005 | World Journal of Gastroenterology2005，11，20： | 10 |
| 9 | The joint automated repository for various integrated simulations (JARVIS) for data-driven materials design显示文摘The Joint Automated Repository for Various Integrated Simulations(JARVIS)is an integrated infrastructure to accelerate materials discovery and design using density functional theory(DFT),classical force-fields(FF),and machine learning(ML)techniques.JARVIS is motivated by the Materials Genome Initiative(MGI)principles of developing open-access databases and tools to reduce the cost and development time of materials discovery,optimization,and deployment. | Kamal Choudhary Kevin F.Garrity Andrew C.E.Reid Brian DeCost Adam J.Biacchi Angela R.Hight Walker Zachary Trautt Jason Hattrick-Simpers A.Gilad Kusne Andrea Centrone Albert Davydov Jie Jiang Ruth Pachter Gowoon Cheon Evan Reed Ankit Agrawal Xiaofeng Qian Vinit Sharma Houlong Zhuang Sergei V.Kalinin Bobby G.Sumpter Ghanshyam Pilania Pinar Acar Subhasish Mandal Kristjan Haule David Vanderbilt Karin Rabe Francesca Tavazza | 2020 | npj Computational Materials2020，，1： | 10 |
| 10 | Anti-wear properties evaluation of frictional sliding interfaces in automobile engines lubricated by copper/graphene nanolubricants显示文摘Owing to the significance of improving fuel economy, reducing emissions, and extending the durability of engine components, this study focused on the tribological performance of nano-additives. In this study, copper (Cu) and graphene (Gr) nanomaterials were dispersed in a fully formulated engine oil (5W-30) with different concentrations. The tribological trials were investigated under various speeds and loads, utilizing a reciprocating tribometer to mimic the ring/liner interfaces in the engine. The frictional surface morphologies were com-prehensively analyzed using electron probe X-ray microanalysis (EPMA), field emission scanning electron microscopy (FESEM), energy dispersive spectrometer (EDS), and three dimensional (3D) surface profilometry to explore the mechanisms responsible for improving the tribological performance of the frictional sliding parts in the engine. The tribological test results illustrated that lubrication by nano-additives reduced the wear rate (WR) and friction coefficient (COF) by 25%–30% and 26.5%–32.6%, respectively, as compared with 5W-30. The results showed that this is a promising approach for increasing the durability and lifespan of frictional sliding components and fuel economy in automobile engines. | Mohamed Kamal Ahmed ALI Xianjun HOU Mohamed AAABDELKAREEM | 2020 | Friction2020，8，5： | 9 |
| 11 | Telbivudine vs tenofovir in hepatitis B e antigen-negative chronic hepatitis B patients: OPTIMA roadmap study显示文摘AIM To make efficacy and safety comparison of telbivudineraodmap and tenofovir-roadmap in hepatitis B e antigen(HBe Ag)-negative chronic hepatitis B(CHB) patients.METHODS This was the first prospective, randomised, two-arm, open-label, non-inferiority study in HBe Ag-negative CHB patients that compared telbivudine and tenofovir administered as per roadmap concept. Patients were treated up to 24 wk and, depending on virologic response, continued the same therapy or received addon therapy up to 104 wk. Eligible patients received an additional 52 wk of treatment in the extension period(i.e., up to 156 wk). Patients who developed virologic breakthrough(VB) while on monotherapy also received add-on therapy. The primary efficacy endpoint was the rate of patients achieving hepatitis B virus(HBV) DNA < 300 copies/m L at week 52. Secondary efficacy endpoints included the rates of HBV DNA < 300 and < 169 copies/m L, HBV DNA change from baseline, alanine aminotransferase normalisation, hepatitis B surface antigen(HBs Ag) loss, HBs Ag seroconversion, VB, and emergence of resistance at various timepoints throughout the study. Safety and estimated glomerular filtration rate(e GFR) were also analysed.RESULTS A total of 241 patients were randomised. Non-inferiority of telbivudine arm to tenofovir arm was demonstrated at week 52(± 7 d window), with over 91% of patients in each treatment arm achieving HBV DNA level < 300 copies/m L. Both arms were similar in terms of key secondary efficacy variables at weeks 104 and 156. The percentage of patients achieving HBV DNA < 300 copies/m L remained high and was similar in the telbivudine and tenofovir arms at both weeks 104 and 156. Over 82% of patients in both arms achieved alanine aminotransferase normalisation at week 52, and this percentage remained high at weeks 104 and 156. Telbivudine treatment progressively reduced serum HBs Ag levels from baseline while no change was reported in quantitative HBs Ag during therapy with tenofovir. Both treaments showed acceptable safety profiles. The telbivudine arm showed e GFR improvement unlike the tenofovir arm.CONCLUSION Efficacy was shown for both telbivudine-roadmap and tenofovir-roadmap regimens in HBe Ag-negative CHB patients over 156 wk. Telbivudine arm was associated with renal improvement. | Zahari Krastev Diana Petrova Iskren Kotzev Mustafa Kemal Celen Meryl Mendelson Richa Chandra Priti Pandey Kamal Hamed | 2016 | World Journal of Hepatology2016，8，32： | 9 |
| 12 | Burden of pediatric hepatitis C显示文摘Hepatitis C virus(HCV)is a major health burden infecting 170-210 million people worldwide.Additional 3-4millions are newly-infected annually.Prevalence of pediatric infection varies from 0.05%-0.36%in the United States and Europe;up to 1.8%-5.8%in some developing countries.The highest prevalence occurs in Egypt,sub-Saharan Africa,Amazon basin and Mongolia.HCV has been present in some populations for several centuries,notably genotypes 1 and 2 in West Africa.Parenteral anti-schistosomal therapy practiced in the 1960s until the early 1980s had spread HCV infection throughout Egypt.Parenteral acquisition of HCV remains a major route for infection among Egyptian children.Insufficient screening of transfusions,unsterilized injection equipment and re-used needles and syringes continue to be major routes of HCV transmission in developing countries,whereas vertical transmission and adolescent high-risk behaviors(e.g.,injection drug abuse)are the major routes in developed countries.The risk of vertical transmission from an infected mother to her unborn/newborn infant is approximately 5%.Early stages of HCV infection in children do not lead to marked impairment in the quality of life nor to cognitive,behavioral or emotional dysfunction;however,caregiver stress and family system strain may occur.HCV slowly progresses to serious complications as cirrhosis(1%-2%)and hepatocellular carcinoma(HCC)especially in the presence of risk factors as hemolytic anemias,obesity,treated malignancy,and concomitant human immune deficiency and/or hepatitis B virus co-infection.HCV vaccine remains elusive to date.Understanding the immune mechanisms in patients who successfully cleared the infection is essential for vaccine development.The pediatric standard of care treatment consists of pegylated interferon-α2a or b plus ribavirin for 24-48 wk.The new oral direct acting antivirals,approved for adults,need further evaluation in children.Sustained virologic response varies depending on the viral load,genotype,duration of infection,degree of aminotransferase elevation,adiposity and single nucleotide polymorphisms of interleukin(IL)-28B locus.The goals of treatment in individual patients are virus eradication,prevention of cirrhosis and HCC,and removing stigmatization;meanwhile the overall goal is decreasing the global burden of HCV.IL-28B polymorphisms have been also associated with spontaneous clearance of vertically acquired HCV infection.The worldwide economic burden of HCV for children,families and countries is estimated to be hundreds of millions of US dollars per year.The United States,alone,is estimated to spend 199-336 million dollars in screening,monitoring and treatment during one decade.The emotional burden of having an HCV infected child in a family is more difficult to estimate. | Mortada Hassan El-Shabrawi Naglaa Mohamed Kamal Alanani | 2013 | World Journal of Gastroenterology2013，19，44： | 9 |
| 13 | DMD光栅的衍射特性及其在可调谐激光中的应用显示文摘相比较于液晶空间光调制器,数字微镜晶片(DMD)具有开关速度快、显示精度高、偏振不相关、衍射效率高和宽带调制等优势。研究利用DMD的衍射效应作为波长选择器,将其应用于可调谐光纤激光器中,理论推导这种二维DMD光栅的衍射效率与入射光角度,像素间距等物理量之间的定量关系,重点讨论了两种不同像素间距的0.7″和0.55″DMD在单像素因子和多像素干涉共同作用下的衍射级数和强度分布。研究结果表明:0.7″DMD在光强不显著为零且满足实验约束条件下,允许出现4个干涉极大值,但由于极大值位置均远离闪耀条件,因此光强相对较弱。0.55″DMD仅出现1个干涉极大值,且接近闪耀条件,因此光强和效率均明显高于0.7″DMD的情况。由此可见,在可调谐光纤激光器中,利用0.55″DMD光栅作为波长选择器更有利于减小衍射损耗,提高系统稳定性。 | 陈笑 颜玢玢 宋菲君 王义全 肖峰 Kamal Alameh | 2012 | 光学学报2012，32，7： | 9 |
| 14 | Cephalomedullary fixation for femoral neck/intertrochanteric and ipsilateral shaft fractures: surgical tips and pitfalls显示文摘为大腿骨的柄骨折和 ipsilateral 的 ObjectiveSurgical 管理选择近似腿节骨折从单个植入变化到双 implant 固定。特别因为不太软的织物解剖和容忍加速的康复的立即的手术后的重量,在如此的破裂的 Cephalomedullary 固定比另外的技术有相对优点。然而,外科是技术上费力的,有为这固定描述外科的技术的文学的少量。学习的目的是为大腿骨的柄骨折和 ipsilateral 描述 cephalomedullary 固定的外科的技术近似的腿节 fractureMethodsSixteen 盒子(有一个平均数的 10 男性和 6 女性 41.8 变老;年) ipsilateral ,近似腿节和柄破裂被单个阶段的 cephalomedullary 固定在第三级的水平对待在北印度的损伤中心。破裂根据 AO 分类被分类。象对每个骨折模式唯一的技术挑战一样的外科的持续时间的一个 intraoperative 记录最为所有 patientsResultsThe 被保存普通近似大腿骨的模式是在 9 个我们的病人观察的 AO B2.1。当 AO A1.2 在 3 个病人断裂时, AO B2.3 破裂在 4 个病人被看见。四 AO B2.1 和 2 AO B2.3 破裂与 Watson-Jones 途径要求了开的减小。吝啬的起作用的时间在 78 附近;当外科的经验增加了,纪录,它趋于减少。仅仅有 malreduction 的一个盒子,它要求大腿骨的柄骨折和 neck/intertrochanteric 折断的 ipsilateral 的修订 surgery.ConclusionCombination 是为损伤外科医生的一个困难的破裂模式。Cephalomedullary 钉子是一优秀植入因为这断裂,但是避免复杂并发症要求小心的插入。外科与一条明确的学习曲线是技术上费力的。不过,这些破裂的一个多数能被在这篇文章被总结了的后面的基本外科的原则被 singleimplant cephalomedullary 固定通过手术管理。 | Kamal Bali Nitesh Gahlot Sameer Aggarwal Vijay Goni | 2013 | Chinese Journal of Traumatology2013，16，1： | 9 |
| 15 | Bulk and bubble-scale experimental studies of influence of nanoparticles on foam stability显示文摘Influence of silicon oxide(SiO_2) and aluminum oxide(Al_2O_3) nanoparticles on the stability of nanoparticles and sodium dodecyl sulfate(SDS) mixed solution foams was studied at bulk and bubble-scale. Foam apparent viscosity was also determined in Hele-Shaw cell In order to investigate the foam performance at static and dynamic conditions. Results show that the maximum adsorption of surfactant on the nanoparticles occurs at 3 wt% surfactant concentration. Foam stability increases while the foamability decreases with the increasing nanoparticle concentration. However, optimum nanoparticle concentration corresponding to maximum foam stability was obtained at 1.0 wt% nanoparticle concentration for the hydrophilic SiO_2/SDS and Al_2O_3/SDS foams. Foam performance was enhanced with increasing nanoparticles hydrophobicity. Air-foams were generally more stable than CO_2 foams.Foam apparent viscosity increased in the presence of nanoparticles from 20.34 mPa·s to 84.84 mPa·s while the film thickness increased from 27.5 μm to 136 μm. This study suggests that the static and dynamic stability of conventional foams could be improved with addition of appropriate concentration of nanoparticles into the surfactant solution. The nanoparticles improve foam stability by their adsorption and aggregation at the foam lamellae to increase film thickness and dilational viscoelasticity. This prevents liquid drainage and film thinning and improves foam stability both at the bulk and bubble scale. | Nurudeen Yekeen Ahmad Kamal Idris Muhammad A.Manan Ali Mohamed Samin Abdul Rahim Risal Tan Xin Kun | 2017 | Chinese Journal of Chemical Engineering2017，25，3： | 9 |
| 16 | Recent advances and applications of deep learning methods in materials science显示文摘Deep learning(DL)is one of the fastest-growing topics in materials data science,with rapidly emerging applications spanning atomistic,image-based,spectral,and textual data modalities.DL allows analysis of unstructured data and automated identification of features.The recent development of large materials databases has fueled the application of DL methods in atomistic prediction in particular.In contrast,advances in image and spectral data have largely leveraged synthetic data enabled by high-quality forward models as well as by generative unsupervised DL methods.In this article,we present a high-level overview of deep learning methods followed by a detailed discussion of recent developments of deep learning in atomistic simulation,materials imaging,spectral analysis,and natural language processing.For each modality we discuss applications involving both theoretical and experimental data,typical modeling approaches with their strengths and limitations,and relevant publicly available software and datasets.We conclude the review with a discussion of recent cross-cutting work related to uncertainty quantification in this field and a brief perspective on limitations,challenges,and potential growth areas for DL methods in materials science. | Kamal Choudhary Brian DeCost Chi Chen Anubhav Jain Francesca Tavazza Ryan Cohn Cheol Woo Park Alok Choudhary Ankit Agrawal Simon J.L.Billinge Elizabeth Holm Shyue Ping Ong Chris Wolverton | 2022 | npj Computational Materials2022，，1： | 9 |
| 17 | Intraoperative blood loss in orthotopic liver transplantation:The predictive factors显示文摘Liver transplantation has been associated with massive blood loss and considerable transfusion requirements. Bleeding in orthotopic liver transplantation is multifactorial. Technical difficulties inherent to this complex surgical procedure and pre operative derangements of the primary and secondary coagulation system are thought to be the principal causes of perioperative hemorrhage. Intraoperative practices such as massive fluid resuscitation and resulting hypothermia and hypocalcemia secondary to citrate toxicity further aggravate the preexisting coagulopathy and worsen the perioperative bleeding. Excessive blood loss and transfusion during orthotopic liver transplant are correlated with diminished graft survival and increased septic episodes and prolonged ICU stay. With improvements in surgical skills, anesthetic technique, graft preservation, use of intraoperative cell savers and overall perioperative management, orthotopic liver transplant is now associated with decreased intra operative blood losses. The purpose of this review is to discuss the risk factors predictive of increased intra operative bleeding in patients undergoing orthotopic liver transplant. | Chandra Kant Pandey Anshuman Singh Kamal Kajal Mandeep Dhankhar Manish Tandon Vijay Kant Pandey Sunaina Tejpal Karna | 2015 | World Journal of Gastrointestinal Surgery2015，7，6： | 8 |
| 18 | An improved random forest classifier for multi-class classification显示文摘The paper presents an improved-RFC(Random Forest Classifier)approach for multi-class disease classification problem.It consists of a combination of Random Forest machine learning algorithm,an attribute evaluator method and an instance filter method.It intends to improve the performance of Random Forest algorithm.The performance results confirm that the proposed improved-RFC approach performs better than Random Forest algorithm with increase in disease classification accuracy up to 97.80%for multi-class groundnut disease dataset.The performance of improved-RFC approach is tested for its efficiency on five benchmark datasets.It shows superior performance on all these datasets. | Archana Chaudhary Savita Kolhe Raj Kamal | 2016 | Information Processing in Agriculture2016，3，4： | 8 |
| 19 | Intensivist-based deep sedation using propofol for pediatric outpatient flexible bronchoscopy显示文摘AIM To evaluate the safety and efficacy of sedating pediatric patients for outpatient flexible bronchoscopy.METHODS A retrospective chart review was conducted for all children, age 17 years or under who underwent flexible bronchoscopy under deep sedation in an outpatient hospital-based setting. Two sedation regimens were used; propofol only or ketamine prior to propofol. Patients were divided into three age groups; infants(less than 12 mo), toddlers(1-3 years) and children(4-17 years). Demographics, indication for bronchoscopy, sedative dosing, sedation and recovery time and adverse events were reviewed.RESULTS Of the total 458 bronchoscopies performed, propofol only regimen was used in 337(74%) while propofol and ketamine was used in 121(26%). About 99% of the procedures were successfully completed. Children in the propofol + ketamine group tend to be youngerand have lower weight compared to the propofol only group. Adverse events including transient hypoxemia and hypotension occurred in 8% and 24% respectively. Median procedure time was 10 min while the median discharge time was 35 min. There were no differences in the indication of the procedure, propofol dose, procedure or recovery time in either sedative regimen. When compared to other age groups, infants had a higher incidence of hypoxemia.CONCLUSION Children can be effectively sedated for outpatient flexible bronchoscopy with high rate of success. This procedure should be performed under vigilance of highly trained providers. | Kamal Abulebda Samer Abu-Sultaneh Sheikh Sohail Ahmed Elizabeth A S Moser Renee C McKinney Riad Lutfi | 2017 | World Journal of Critical Care Medicine2017，6，4： | 8 |
| 20 | High-throughput density functional perturbation theory and machine learning predictions of infrared,piezoelectric,and dielectric responses显示文摘Many technological applications depend on the response of materials to electric fields,but available databases of such responses are limited.Here,we explore the infrared,piezoelectric,and dielectric properties of inorganic materials by combining highthroughput density functional perturbation theory and machine learning approaches.We computeΓ-point phonons,infrared intensities,Born-effective charges,piezoelectric,and dielectric tensors for 5015 non-metallic materials in the JARVIS-DFT database.We find 3230 and 1943 materials with at least one far and mid-infrared mode,respectively. | Kamal Choudhary Kevin F.Garrity Vinit Sharma Adam J.Biacchi Angela R.Hight Walker Francesca Tavazza | 2020 | npj Computational Materials2020，，1： | 7 |
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