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| 1 | Targeting PI3K/AKT signaling for treatment of idiopathic pulmonary fibrosis显示文摘Idiopathic pulmonary fibrosis(IPF) is a chronic progressive fibrotic interstitial pneumonia with unknown causes. The incidence rate increases year by year and the prognosis is poor without cure.Recently, phosphatidylinositol 3-kinase(PI3 K)/protein kinase B(PKB/AKT) signaling pathway can be considered as a master regulator for IPF. The contribution of the PI3 K/AKT in fibrotic processes is increasingly prominent, with PI3 K/AKT inhibitors currently under clinical evaluation in IPF. Therefore,PI3 K/AKT represents a critical signaling node during fibrogenesis with potential implications for the development of novel anti-fibrotic strategies. This review epitomizes the progress that is being made in understanding the complex interpretation of the cause of IPF, and demonstrates that PI3 K/AKT can directly participate to the greatest extent in the formation of IPF or cooperate with other pathways to promote the development of fibrosis. We further summarize promising PI3 K/AKT inhibitors with IPF treatment benefits, including inhibitors in clinical trials and pre-clinical studies and natural products, and discuss how these inhibitors mitigate fibrotic progression to explore possible potential agents, which will help to develop effective treatment strategies for IPF in the near future. | Jincheng Wang Kaili Hu Xuanyan Cai Bo Yang Qiaojun He Jiajia Wang Qinjie Weng | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 31 |
| 2 | First identification of kdr allele F1534S in VGSC gene and its association with resistance to pyrethroid insecticides in Aedes albopictus populations from Haikou City,Hainan Island,China显示文摘Background:Aedes albopictus is distributed widely in China,as a primary vector of Dengue fever and Chikungunya fever in south of China.Chemical insecticide control is one of the integrated programmes to prevent mosquito-borne diseases.Long-term applications of pyrethroids have resulted in the development of resistance in Ae.albopictus populations in China.However,the susceptibility of Ae.albopictus to pyrethroids in Hainan Island was unclear.Knockdown resistance(kdr),caused by point mutations in the VGSC gene,is one of the mechanisms that confer resistance to DDT and pyrethroids.This study was to investigate the resistance level of Ae.albopictus populations in Haikou City to three pyrethroid insecticides,and elucidate the relationship between the resistant phenotype and kdr mutations.Methods:The Aedes albopictus samples were collected in Xinbu Island(XI),Longtang Town(LT),Shishan Town(ST),Baishamen Park(BP),and Flower Market(FM)from Haikou City,Hainan Island,China.The larval susceptibility to deltamethrin,permethrin and beta-cypermethrin was tested by larval bioassays,and adult susceptibility to deltamethrin and DDT was determined by adult bioassays.The degree of resistance was determined by resistance ratio value(RR50>3)for larvae and by mortality for adult.The kdr alleles at codon 1534 of the VGSC gene were genotyped.The relationship between kdr genotypes and resistant phenotypes was analyzed by Chi-square test.Results:Out of five populations,assessed by larval bioassays,XI was susceptible to deltamethrin and permethrin;LT was susceptible to permethrin and beta-cypermethrin;and ST was susceptible to permithrin.FM and BP both were resistant to all of the three pyrethroids,and FM showed the highest degree of resistance,with RR50 values from 65.17 to 436.36.A total of 493 individuals from the larval bioassays were genotyped for kdr alleles.Five alleles were detected,including two wildtype alleles,TTC(F)(67.04%)and TTT(F)(0.41%),and three mutant alleles,TGC(C)(0.30%),TCC(S)(31.54%)and TTG(L)(0.71%).There was a clear correlation between mutant alleles(or F1534S)and resistant phenotypes(P<0.01).Conclusion:Two novel kdr mutant alleles F1534S and F1534L were detected in the pyrethroid resistant populations of Ae.albopictus in Haikou Hainan,China.For the first time,the mutant F1534S was associated with pyrethroid resistance in Ae.albopictus. | Huiying Chen Kaili Li Xiaohua Wang Xinyan Yang Yi Lin Fang Cai Wenbin Zhong Chunyan Lin Zhongling Lin Yajun Ma | 2016 | Infectious Diseases of Poverty2016，5，1： | 19 |
| 3 | A Novel 3D Non-Stationary UAV-MIMO Channel Model and Its Statistical Properties显示文摘The wireless communication systems based on Unmanned Aerial Vehicles(UAVs) have found a wide range of applications recently. In this paper, we propose a new three-dimensional(3 D) non-stationary multiple-input multiple-output(MIMO) channel model for the communication links between the UAV and mobile terminal(MT). The new model originates the traditional geometry-based stochastic models(GBSMs) but considers the non-stationary propagation environment due to the rapid movements of the UAV, MT, and clusters. Meanwhile, the upgrade time evolving algorithms of time-variant channel parameters, i.e., the path number based on birth-death processes of clusters, path delays, path powers, and angles of arrival and departure, are developed and optimized. In addition, the statistical properties of proposed GBSM including autocorrelation function(ACF), cross-correlation function(CCF), and Doppler power spectrum density(DPSD) are investigated and analyzed. Simulation results demonstrate that our proposed model provides a good agreement on the statistical properties with the corresponding derived theoretical ones, which indicates its usefulness for the performance evaluation and validation of the UAV based communication systems. | Qiuming Zhu Kaili Jiang Xiaomin Chen Weizhi Zhong Ying Yang | 2018 | China Communications2018，15，12： | 18 |
| 4 | Pterygium in Aged Population in Doumen County, China显示文摘Purpose:To estimate the prevalence of pterygium and its influence on visual acuity in aged population of Doumen County,southern China.Methods:A population-based survey was conducted in Doumen County,the rural area of southern China,twenty-seven sample units were selected by random sampling.The prevalence and severity of pterygium and it-related low visual acuity were analyzed.Results:Of the total 4762 individuals aged 50 years or over,4214 were examined.The prevalence of pterygium was 33.01% in subjects aged 50 years or above.There was a significantly higher prevalence in female(35.70%)than in male(29.70%,P=0.025).The prevalence of pterygium in age groups of 50s,60s,70s and 80s years old is 33.98%,36.40%,30.73% and 25.40%,respectively.Most of the pterygia were located in the nasal side(93.31%)of cornea,and only 6.69% in the temporal side.0.92% of the eyes had visual acuity less than 0.32,which were directly caused by pterygia.Conclusion:The current survey suggests that the pterygium is one of the most common diseases of external eye in th population ged 50 years and above.It is still leading to the impairment of visual acuity in the rural area. | Kaili Wu, Mingguang He, Jingjing Xu, Shaozhen LiZhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China | 2002 | 眼科学报2002，18，3： | 18 |
| 5 | The development of collagen based composite scaffolds for bone regeneration显示文摘Bone is consisted of bone matrix,cells and bioactive factors,and bone matrix is the combination of inorganic minerals and organic polymers.Type I collagen fibril made of five triple-helical collagen chains is the main organic polymer in bone matrix.It plays an important role in the bone formation and remodeling process.Moreover,collagen is one of the most commonly used scaffold materials for bone tissue engineering due to its excellent biocompatibility and biodegradability.However,the low mechanical strength and osteoinductivity of collagen limit its wider applications in bone regeneration field.By incorporating different biomaterials,the properties such as porosity,structural stability,osteoinductivity,osteogenicity of collagen matrixes can be largely improved.This review summarizes and categorizes different kinds of biomaterials including bioceramic,carbon and polymer materials used as components to fabricate collagen based composite scaffolds for bone regeneration.Moreover,the possible directions of future research and development in this field are also proposed. | Dawei Zhang Xiaowei Wu Jingdi Chen Kaili Lin | 2018 | Bioactive Materials2018，3，1： | 16 |
| 6 | Nanoparticles modified by polydopamine: Working as “drug” carriers显示文摘Inspired by the mechanism of mussel adhesion,polydopamine(PDA),a versatile polymer for surface modification has been discovered.Owing to its unique properties like extraordinary adhesiveness,excellent biocompatibility,mild synthesis requirements,as well as distinctive drug loading approach,strong photothermal conversion capacity and reactive oxygen species(ROS)scavenging facility,various PDA-modified nanoparticles have been desired as drug carriers.These nanoparticles with diverse nanostructures are exploited in multifunctions,consisting of targeting,imaging,chemical treatment(CT),photodynamic therapy(PDT),photothermal therapy(PTT),tissue regeneration ability,therefore have attracted great attentions in plenty biomedical applications.Herein,recent progress of PDA-modified nanoparticle drug carriers in cancer therapy,antibiosis,prevention of inflammation,theranostics,vaccine delivery and adjuvant,tissue repair and implant materials are reviewed,including preparation of PDA-modified nanoparticle drug carriers with various nanostructures and their drug loading strategies,basic roles of PDA surface modification,etc.The advantages of PDA modification in overcoming the existing limitations of cancer therapy,antibiosis,tissue repair and the developing trends in the future of PDA-modified nanoparticle drug carriers are also discussed. | Anting Jin Yitong Wang Kaili Lin Lingyong Jiang | 2020 | Bioactive Materials2020，5，3： | 13 |
| 7 | Genome-Wide Expression Pattern Analyses of the Arabidopsis Leucine-Rich Repeat Receptor-Like Kinases显示文摘像受体的蛋白质 kinases (RLK ) 是在房间房间和房间环境通讯起关键作用的 transmembrane 蛋白质的一个大组。基于细胞外的领域结构, RLK 被分类进超过 21 个亚科,充满白氨酸的重复 RLK (LRR-RLKs ) 在象 Arabidopsis 和米饭那样的植物在之中属于最大的亚科。在 Arabidopsis,有近似 223LRR-RLKs,但是哪个中的仅仅大约 60 个机能上地迄今为止被描述了。为了系统地在调整调查 LRR-RLKs 的 theroles,种生长,开发,和压力改编,我们产生了 promoter::GUS 为在 Arabidopsis 的所有 223 LRR-RLK 基因的转基因的植物并且在各种各样的发展舞台分析了他们的详细表达式模式。Theresults 提供 forfunctionally 阐明的珍贵资源这个大、必要的发信号的蛋白质亚科。 | Yunzhe Wu Qingqing Xun Yi Guo Jinghua Zhang Kaili Cheng Tao Shi Kai He Suiwen Hou Xiaoping Gou Jia Li | 2016 | Molecular Plant2016，9，2： | 13 |
| 8 | A Facile Method to Improve the High Rate Capability of Co_(3)O_(4)Nanowire Array Electrodes显示文摘The capability of fast charge and fast discharge is highly desirable for the electrode materials used in supercapacitors and lithium ion batteries.In this article,we report a simple strategy to considerably improve the high rate capability of Co_(3)O_(4)nanowire array electrodes by uniformly loading Ag nanoparticles onto the surfaces of the Co_(3)O_(4)nanowires via the silver-mirror reaction.The highly electrically conductive silver nanoparticles function as a network for the facile transport of electrons between the current collectors(Ti substrates)and the Co_(3)O_(4)active materials.High capacity as well as remarkable rate capability has been achieved through this simple approach.Such novel Co_(3)O_(4)-Ag composite nanowire array electrodes have great potential for practical applications in pseudo-type supercapacitors as well as in lithium ion batteries. | Hua Cheng Zhou Guang Lu Jian Qiu Deng C.Y.Chung Kaili Zhang Yang Yang Li | 2010 | Nano Research2010，3，12： | 12 |
| 9 | Multiplexed Five-Color Molecular Imaging of Cancer Cells and Tumor Tissues with Carbon Nanotube Raman Tags in the Near-Infrared显示文摘Single-walled carbon nanotubes(SWNTs)with five different C13/C12 isotope compositions and well-separated Raman peaks have been synthesized and conjugated to five targeting ligands in order to impart molecular specificity.Multiplexed Raman imaging of live cells has been carried out by highly specific staining of cells with a five-color mixture of SWNTs.Ex vivo multiplexed Raman imaging of tumor samples uncovers a surprising up-regulation of epidermal growth factor receptor(EGFR)on LS174T colon cancer cells from cell culture to in vivo tumor growth.This is the first time five-color multiplexed molecular imaging has been performed in the near-infrared(NIR)region under a single laser excitation.Near zero interfering background of imaging is achieved due to the sharp Raman peaks unique to nanotubes over the low,smooth autofluorescence background of biological species. | Zhuang Liu Scott Tabakman Sarah Sherlock Xiaolin Li Zhuo Chen Kaili Jiang Shoushan Fan Hongjie Dai | 2010 | Nano Research2010，3，3： | 11 |
| 10 | Opioid receptor antagonists modulate Ca^2+-activated K^+ channels in mesenteric arterial smooth muscle cells of rats in hemorrhagic shock显示文摘 | KAILi WANGZhong-Feng 等 | 2003 | Acta Pharmacologica Sinica2003，24，4： | 11 |
| 11 | Remodeling the blood–brain barrier microenvironment by natural products for brain tumor therapy显示文摘Brain tumor incidence shows an upward trend in recent years; brain tumors account for 5% of adult tumors, while in children, this figure has increased to 70%. Moreover, 20%–30% of malignant tumors will eventually metastasize into the brain. Both benign and malignant tumors can cause an increase in intracranial pressure and brain tissue compression, leading to central nervous system(CNS) damage which endangers the patients' lives. Despite the many approaches to treating brain tumors and the progress that has been made, only modest gains in survival time of brain tumor patients have been achieved. At present, chemotherapy is the treatment of choice for many cancers, but the special structure of the blood–brain barrier(BBB) limits most chemotherapeutic agents from passing through the BBB and penetrating into tumors in the brain. The BBB microenvironment contains numerous cell types, including endothelial cells, astrocytes, peripheral cells and microglia, and extracellular matrix(ECM). Many chemical components of natural products are reported to regulate the BBB microenvironment near brain tumors and assist in their treatment. This review focuses on the composition and function of the BBB microenvironment under both physiological and pathological conditions, and the current research progress in regulating the BBB microenvironment by natural products to promote the treatment of brain tumors. | Xiao Zhao Rujing Chen Mei Liu Jianfang Feng Jun Chen Kaili Hu | 2017 | Acta Pharmaceutica Sinica B2017，7，5： | 9 |
| 12 | A comparative study of the osteogenic performance between the hierarchical micro/submicro-textured 3D-printed Ti6Al4V surface and the SLA surface显示文摘Three-dimensional(3D)printed titanium and its alloys have broad application prospect in the field of biomedical implant materials,although the biological performance of the original surface should be improved.Learning from the development experience of conventional titanium implants,to construct a hierarchical hybrid topological surface is the future direction of efforts.Since the original 3D-printed(3D hereafter)Ti6Al4V surface inherently has micron-scale features,in the present study,we introduced submicron-scale pits on the original surface by acid etching to obtain a hierarchical micro/submicro-textured surface.The characteristic and biological performance of the 3D-printed and acid-etched(3DA hereafter)surface were evaluated in vitro and in vivo,compared with the conventional sandblasted,large-grit,acid-etched(SLA hereafter)surface.Our results suggested the adhesion,proliferation and osteogenic differentiation of bone marrow derived mesenchymal stromal cells(BMSCs),as well as the in vivo osseointegration on 3DA surfaces were significantly improved.However,the overall osteogenic performance of the 3DA surface was not as good as the conventional SLA surface. | Jinkai Zhanga Jiaqiang Liu Chengtao Wang Fengshan Chen Xudong Wang Kaili Lin | 2020 | Bioactive Materials2020，5，1： | 8 |
| 13 | Studies on Production of Biodiesel by Esterification of Fatty Acids by a Lipase Preparation from Candida sp. 99-125显示文摘A self-made lipase preparation from Candida sp. 99-125 was used for the production of biodiesel through enzymatic esterification of fatty acids. The crude lipase powder and fermentation broth were immobilized on a cheap fiber cloth carrier. The conditions of lipase-catalyzed esterification between long-chain fatty acids and methanol in a solvent system were investigated in detail, including the temperature, pH value, substrate concentration, solvent, absorbent agent, enzyme dosage and purity, immobilization method, the mode of addition of substrate. The results show that reaction temperature, pH of lipase micro-environment, substrate concentration, enzyme dosage and purity affect the esterification strongly. Several new methods and enzymatic procedures for improving the enzymatic reaction involving the process cost are also discussed, such as fossil diesel fuel as reaction solvent, immobilization method, multi-step gradient addition of methanol. The esterification degree of 92.8% was obtained with oleic acid and methanol under the optimal reaction condition after 12.5 h reaction time. The half-life of the immobilized lipase preparation from crude free lipase powder for esterification was 15 days. | DENG Li(邓利) NIE Kaili(聂开立) WANG Fang(王芳) TAN Tianwei(谭天伟) | 2005 | Chinese Journal of Chemical Engineering2005，13，4： | 8 |
| 14 | Diabetes inhibits corneal epithelial cell migration and tight junction formation in mice and human via increasing ROS and impairing Akt signaling显示文摘Corneal wounds usually heal quickly;but diabetic patients have more fragile corneas and experience delayed and painful healing. In the present study, we compared the healing capacity of corneal epithelial cells (CECs) between normal and diabetic conditions and the potential mechanisms. Primary murine CEC derived from wild-type and diabetic (db/db) mice, as well as primary human CEC were prepared. Human CEC were exposed to high glucose (30 mM) to mimic diabetic conditions. Cell migration and proliferation were assessed using Scratch test and MTT assays, respectively. Reactive oxygen species (ROS) production in the cells was measured using dichlorofluorescein reagent. Western blot was used to evaluate the expression levels of Akt. Transepithelial electrical resistance (TEER) and zonula occludens-1 (ZO-1) expression were used to determine tight junction integrity. We found that the diabetic CEC displayed significantly slower cell proliferation and migration compared with the normal CEC from both mice and humans. Furthermore, ROS production was markedly increased in CEC grown under diabetic conditions. Treatment with an antioxidant N-acetyl cysteine (NAC, 100 μM) significantly decreased ROS production and increased wound healing in diabetic CEC. Barrier function was significantly reduced in both diabetic mouse and human CEC, while NAC treatment mitigated these effects. We further showed that Akt signaling was impaired in diabetic CEC, which was partially improved by NAC treatment. These results show that diabetic conditions lead to delayed wound-healing capacity of CEC and impaired tight junction formation in both mice and human. Increased ROS production and inhibited Akt signaling may contribute to this outcome, implicating these as potential targets for treating corneal wounds in diabetic patients. | Qi-wei Jiang Denis Kaili Jonaye Freeman Chong-yang Lei Bing-chuan Geng Tao Tan Jian-feng He Zhi Shi Jian-jie Ma Yan-hong Luo Heather Chandler Hua Zhu | 2019 | Acta Pharmacologica Sinica2019，40，9： | 8 |
| 15 | Criteria for strong H-tensors显示文摘H 张肌是在张肌分析和计算起一个重要作用的一个新发达概念。在这份报纸,我们探索 H 张肌的性质并且为强壮的 H 张肌建立一些新标准。基于主要 subtensor,特别地,我们提供强壮的 H 张肌的一个新必要、足够的条件,并且基于概括斜产品优势的一种类型,我们为识别强壮的 H 张肌建立一些新标准。在这份报纸获得的结果为强壮的 H 矩阵扩大相应结论并且为强壮的 H 张肌改进存在结果。 | Yiju WANG Kaili ZHANG Hongchun SUN | 2016 | Frontiers of Mathematics in China2016，11，3： | 8 |
| 16 | Highly conductive dodecaborate/MXene composites for high performance supercapacitors显示文摘With the increasingly prominent energy and environmental issues,the supercapacitors,as a highly efficient and clean energy conversion and storage devices,meet the requirements well.However,it is still a challenge to enhance the capacitance and energy density of supercapacitors.A novel and highly conductive dodecaborate/MXene composites have been designed for high performance supercapacitors.The surface charge property of MXene was modified by a simple ultrasonic treatment with ammonium ion,and the dodecaborate ion can be inserted into the inner surface of MXene by electrostatic adsorption.Due to the unique icosahedral cage conjugate structure formed by the B-B bond and the highly delocalized three-dimensionalπbond structure of the electrons,the negative charge is delocalied on the whole dodecaborate ion,which reduces the ability to bind to cations.Therefore,the cations can move easily,and the dodecaborate can act as a“lubricant”for ion diffusion between the MXene layers,which significantly improves the ion transfer rate of supercapacitors.The dodecaborate/MXene composites can achieve an extremely high specific capacitance of 366 F.g^-1 at a scan rate of 2 mV.s^-1,which is more than eight times higher than that of MXene(43 F1-)at the same scan rate.Our finding provides a novel route on the fabrication of the high performance supercapacitors. | Zhenxing Li Chang Ma Yangyang Wen Zhiting Wei Xiaofei Xing Junmei Chu Chengcheng Yu Kaili Wang Zhao-Kui Wang | 2020 | Nano Research2020，13，1： | 7 |
| 17 | THE RECURSIVE SOLUTION OF QUEUE LENGTH FOR Geo/G/1 QUEUE WITH N-POLICY显示文摘This paper considers a discrete-time queue with N-policy and LAS-DA(late arrival system with delayed access) discipline.By using renewal process theory and probability decomposition techniques,the authors derive the recursive expressions of the queue-length distributions at epochs n^-,n^+,and n.Furthermore,the authors obtain the stochastic decomposition of the queue length and the relations between the equilibrium distributions of the queue length at different epochs(n^-,n^+,n and departure epoch D_n). | Chuanyi LUO Yinghui TANG Wei LI Kaili XIANG | 2012 | Journal of Systems Science & Complexity2012，25，2： | 7 |
| 18 | Geochemistry and genesis of authigenic pyrite from gas hydrate accumulation system in the Qilian Mountain permafrost, Qinghai, northwest China显示文摘A type of authigenic pyrites that fully fill or semi-fill the rock fractures of drillholes with gas hydrate anomalies are found in the Qilian Mountain permafrost; this type of pyrite is known as 'fracture-filling' pyrite. The occurrence of 'fracture-filling' pyrite has a certain similarity with that of the hydrate found in this region, and the pyrite is generally concentrated in the lower part of the hydrate layer or the hydrate anomaly layer. The morphology, trace elements, rare earth elements, and sulfur isotope analyses of samples from drillhole DK-6 indicate that the 'fracture-filling' pyrites are dominated by cubic ones mainly aligned in a step-like fashion along the surfaces of rock fractures and are associated with a circular structure, lower Co/Ni and Sr/Ba, lower ?REE, higher LREE, significant Eu negative anomalies, and ? 34 SCDT positive bias. In terms of the pyrites' unique crystal morphology and geochemical characteristics and their relationship with the hydrate layers or abnormal layers, they are closely related with the accumulation system of the gas hydrate in the Qilian Mountain permafrost. As climate change is an important factor in affecting the stability of the gas hydrate, formation of fracture-filling pyrites is most likely closely related to the secondary change of the metastable gas hydrate under the regional climate warming. The distribution intensity of these pyrites indicates that when the gas hydrate stability zone(GHSZ) is narrowing, the hydrate decomposition at the bottom of the GHSZ is stronger than that at the top of the GHSZ, whereas the hydrate decomposition within the GHSZ is relatively weak. Thus, the zone between the shallowest and the deepest distribution of the fracture-filling pyrite recorded the largest possible original GHSZ. | WANG PingKang ZHU YouHai LU ZhenQuan HUANG Xia PANG ShouJi ZHANG Shuai JIANG ShaoQing LI QingHai YANG KaiLi LI Bing | 2014 | Science China Earth Sciences2014，57，9： | 6 |
| 19 | 3D-printed surface promoting osteogenic differentiation and angiogenetic factor expression of BMSCs on Ti6Al4V implants and early osseointegration in vivo显示文摘Three-dimensional-printed(3 D-P) titanium implants display many advantages, such as design flexibility,higher efficiency, the capability to easily construct complex or customized structures, etc., and is believed to potentially replace traditional implants. However, the biological performance of the 3 D-P titanium surface has not been investigated systematically. Herein, we analyzed the surface characteristics of 3 D-P Ti6 Al4 V implants and evaluated the biological responses of bone marrow derived mesenchymal stromal cells(BMSCs) to the 3 D-P surface in vitro. Moreover, after implantation into the rat femoral condyle for3 and 6 weeks, the osseointegration performance was evaluated. The results showed the 3 D-P Ti6 Al4 V implant presented distinct fluctuant macroscale rough surface and relatively better hydrophilicity which enhanced the adhesion, proliferation, osteogenic differentiation and angiogenetic factor expression of BMSCs. Moreover, the in vivo osseointegration performance was also better than that of the control group at the early stage. The present study suggested the 3 D-P titanium alloy is a promising candidate to be used as implant material. | Jinkai Zhang Wenhui Zhou Hui Wang Kaili Lin Fengshan Chen | 2019 | Journal of Materials Science & Technology2019，35，2： | 6 |
| 20 | Efficient catalytic conversion of carbohydrates into 5-ethoxymethylfurfural over MIL-101-based sulfated porous coordination polymers显示文摘In this work, a series of MIL-101-SO3H(x) polymeric materials were prepared and further used for the first time as efficient heterogeneous catalysts for the conversion of fructose-based carbohydrates into 5-ethoxymethylfurfural(EMF) in a renewable mixed solvent system consisting of ethanol and tetrahydrofuran(THF). The influence of –SO3H content on the acidity as well as on the catalytic activity of the porous coordination polymers in EMF production was also studied. High EMF yields of 67.7% and 54.2% could be successively obtained from fructose and inulin in the presence of MIL-101-SO_3H(100) at 130 °C for 15 h.The catalyst could be reused for five times without significant loss of its activity and the recovery process was facile and simple. This work provides a new platform by application of porous coordination polymers(PCPs) for the production of the potential liquid fuel molecule EMF from biomass in a sustainable solvent system. | Xiaofang Liu Hu Li Hu Pan Heng Zhang Shan Huang Kaili Yang Wei Xue Song Yang | 2016 | Journal of Energy Chemistry2016，25，3： | 6 |
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