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| 1 | Oxidative stress and lipid peroxidation products:effect of pinealectomy or exogenous melatonin injections on biomarkers of tissue damage during acute pancreatitis显示文摘BACKGROUND:Melatonin (N-acetyl-5-methoxytripta-mine) is a free radical scavenger and a strong antioxidant,secreted by the pineal gland.In this study,we evaluated the effects of decreasing and increasing serum melatonin levels on malonyldialdehyde (MDA),superoxide dismutase (SOD),and reduced glutathione (GSH) levels in pancreatic tissue from rats with experimental acute pancreatitis.METHODS:Experimental acute pancreatitis was induced in three groups of Wistar albino rats (10 animals per group) by pancreatic ductal ligation.The first group had only acute pancreatitis and served as the control.Surgical pinealectomy was added to acute pancreatitis in the second group,removing the source of endogenous melatonin (low melatonin levels group).The third group was given 0.1 ml daily intraperitoneal injections of 20 mg/ml melatonin solution for one week (high melatonin levels group).The effects of melatonin levels were evaluated by comparison of the levels of MDA,SOD,and GS in pancreatic tissue.RESULT:We found that intraperitoneal melatonin injections decreased the levels of MDA and increased the levels of SOD and GSH in pancreatic tissue.CONCLUSION:Exogenous melatonin has a preventive effect on lipid peroxidation and oxidative damage in acute pancreatitis. | Cavit l Kahraman Dinler O■uz Hasdemir Oktay Büyüka■ik Güler Bu■dayci | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，1： | 7 |
| 2 | Risk stratification in symptomatic intracranial atherosclerotic disease with conventional vascular risk factors and cerebral haemodynamics显示文摘Background and purpose Symptomatic intracranial atherosclerotic stenosis(sICAS)is associated with a considerable risk of recurrent stroke despite contemporarily optimal medical treatment.Severity of luminal stenosis in sICAS and its haemodynamic significance quantified with computational fluid dynamics(CFD)models were associated with the risk of stroke recurrence.We aimed to develop and compare stroke risk prediction nomograms in sICAS,based on vascular risk factors and these metrics.Methods Patients with 50%-99%sICAS confirmed in CT angiography(CTA)were enrolled.Conventional vascular risk factors were collected.Severity of luminal stenosis in sICAS was dichotomised as moderate(50%-69%)and severe(70%-99%).Translesional pressure ratio(PR)and wall shear stress ratio(WSSR)were quantified via CTA-based CFD modelling;the haemodynamic status of sICAS was classified as normal(normal PR&WSSR),intermediate(otherwise)and abnormal(abnormal PR&WSSR).All patients received guideline-recommended medical treatment.We developed and compared performance of nomograms composed of these variables and independent predictors identified in multivariate logistic regression,in predicting the primary outcome,recurrent ischaemic stroke in the same territory(SIT)within 1 year.Results Among 245 sICAS patients,20(8.2%)had SIT.The D2H2A nomogram,incorporating diabetes,dyslipidaemia,haemodynamic status of sICAS,hypertension and age≥50 years,showed good calibration(P for Hosmer-Lemeshow test=0.560)and discrimination(C-statistic 0.73,95%CI 0.60 to 0.85).It also had better performance in risk reclassification and provided larger net benefits in decision curve analysis,compared with nomograms composed of conventional vascular risk factors only,and plus the severity of luminal stenosis in sICAS.Sensitivity analysis in patients with anterior-circulation sICAS showed similar results.Conclusions The D2H2A nomogram,incorporating conventional vascular risk factors and the haemodynamic significance of sICAS as assessed in CFD models,could be a useful tool to stratify sICAS patients for the risk of recurrent stroke under contemporarily optimal medical treatment. | Xuan Tian Hui Fang Linfang Lan Hing Lung Ip Jill Abrigo Haipeng Liu Lina Zheng Florence S Y Fan Sze Ho Ma Bonaventure Ip Bo Song Yuming Xu Jingwei Li Bing Zhang Yun Xu Yannie O Y Soo Vincent Mok Ka Sing Wong Thomas W Leung Xinyi Leng | 2023 | Stroke & Vascular Neurology2023，8，1： | 2 |
| 3 | Food fight! Parenteral nutrition,enteral stimulation and gut-derived mucosal immunity显示文摘 | Hermsen JL Sano Y Kudsk KA | 2009 | Langenbecks Arch Surg2009，394，： | 1 |
| 4 | Glutamine-enriehed total parenteral nutrition maintains intestinal neterleukin-4 and mucosal immunoglobulin A levels 显示文摘 | Kudsk KA Wu Y Fukatsu K | 2000 | JPEN2000，24，10： | 1 |
| 5 | Injury induces localized airway increases in pro-inflammatory cytokines in humans and mice 显示文摘 | JONKER MA HERMSEN JL GOMEZ FE SANO Y KUDSK KA | 2011 | Surg Infect (Larchmt)2011，12，1： | 1 |
| 6 | Modulation of Nrf2-dependent antioxidant functions in the RPE by Zip2,a zinc transporter protein显示文摘 | Rezaei KA Chen Y Cai J | 2008 | Invest Ophthalmol Vis Sci2008，49，： | 1 |
| 7 | Reductions in C -reactive protein in older adults with type 2 diabetes are related to improvements in body composition follow-ing a randomized controlled trial of resistance training 显示文摘 | Mavros Y Kay S Simpson KA | 2014 | Cachexia Sarcopenia Muscle2014，5，2： | 1 |
| 8 | Properties of protease extracted from tea-field soil 显示文摘 | KA MIMURA Y HAYANO K | 2000 | Biology and Fertilily of Soils2000，30，： | 1 |
| 9 | Route and type of nutrition influence IgA-mediating intestinal cytokines 显示文摘 | Wu Y Kudsk KA DeWitt RC | 1999 | Ann Surg1999，229，： | 1 |
| 10 | Influ- ence of alcohointake, cigarette smoking and occupational status on idliopathic osteonecro- sis of Lhe femoral head显示文摘 | MaLsuo K Hirohata T Sugio ka Y | 1988 | Clin O rthop1988，，： | 1 |
| 11 | The effect of dexmedetnmidine on arterial-cardiac baroreflex function assessed by spectral and transfer function analysis显示文摘 | Ehara T Ogawa Y Ka|o J et at | 2012 | J Anesth2012，26，4： | 1 |
| 12 | Angiogenesis is induced in a rabbit model of hindlimb ischemia by naked DNA encoding an HIF-1alpha/VP16 hybrid transcription factor显示文摘 | Vincent KA Shyu KG Luo Y | 2000 | Circulation2000，102，18： | 1 |
| 13 | Interface modification of polymer stabilized cholesteric liquid crystal 显示文摘 | KA R S JU Y W YEONG H C | 2009 | Adv Technol2009，20，： | 1 |
| 14 | Fine structural localization of exudated protein tracers in the brain 显示文摘 | Olsson Y Hossmann KA | 1970 | Acta Neuropathol1970，16，2： | 1 |
| 15 | Serum total homocysteine concentrations and risk of morality from stroke and coroanry heart disease in Japanese:The JACC study显示文摘 | Cui R Moriyama Y Koike KA | | 0，，02： | 1 |
| 16 | Metaplastic breast carcinomas are enriched in markers of tumor-initiating cells and epithelial to mesenchymal transition显示文摘 | Zhang Y Toy KA Kleer CG | 2012 | Mod Pathol2012，25，2： | 1 |
| 17 | The glycine box:a determinant of specificity for fibroblast growth factor显示文摘 | Luo Y Lu W Mohamedali KA | 1998 | Biochemistry1998，37，： | 1 |
| 18 | Does a positive ankle stress test in- dicate the need for operative treatment after lateral malleolus fracture? A preliminary report 显示文摘 | Koval K J Ego1 KA Cheung Y | 2007 | J Orthop Trauma2007，21，7： | 1 |
| 19 | Effect of CYP3A5-k 3 genotype on the pharmacokinetics and pharmacodynamics of alprazolam in healthy subjects显示文摘 | Park J Y Kim KA Park PW | 2006 | Clin Pharmacol Ther2006，79，6： | 1 |
| 20 | ParaceUin-1, a renal tight junction protein required for paracellular Mg2+ resorption显示文摘 | Simon DB Lu Y Choate KA | 1999 | Science1999，285，： | 1 |
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