|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Treatment responses in Asians and Caucasians with chronic hepatitis C infection显示文摘AIM:To conduct a multicentre retrospective review of virological response rates in Asians infected with genotype 1 chronic hepatitis C(CHC) treated with combination interferon and ribavirin and then to compare their responses to that among Caucasians.METHODS:Asian patients infected with genotype 1 CHC treated at 4 Australian centres between 2001 to 2005 were identified through hospital databases.Baseline demographic characteristics,biochemical,virological and histological data and details of treatment were collected.Sustained virological responses(SVR) in this cohort were then compared to that in Caucasian subjects,matched by genotype,age,gender and the stage of hepatic fibrosis.RESULTS:A total of 108 Asians with genotype 1 CHC were identified.The end of treatment response(ETR) for the cohort was 79% while the SVR was 67%.Due to the relatively advanced age of the Asian cohort,only sixty-four subjects could be matched with Caucasians.The ETR among matched Asians and Caucasians was 81% and 56% respectively(P=0.003),while the SVR rates were 73% and 36%(P <0.001) respectively.This difference remained significant after adjusting for other predictive variables. | Kenneth K Yan Marianne Guirgis Amany Zekry Thuy Dinh Anouk Dev Jacob George Alice Lee | 2008 | World Journal of Gastroenterology2008，14，21： | 12 |
| 2 | Effects of resveratrol in experimental and clinical non-alcoholic fatty liver disease显示文摘The prevalence of obesity and related conditions like non-alcoholic fatty liver disease(NAFLD) is increasing worldwide and therapeutic options are limited.Alternative treatment options are therefore intensively sought after.An interesting candidate is the natural polyphenol resveratrol(RSV) that activates adenosinmonophosphate-activated protein kinase(AMPK) and silent information regulation-2 homolog 1(SIRT1).In addition,RSV has known anti-oxidant and anti-inflammatory effects.Here,we review the current evidence for RSVmediated effects on NAFLD and address the different aspects of NAFLD and non-alcoholic steatohepatitis(NASH) pathogenesis with respect to free fatty acid(FFA) flux from adipose tissue,hepatic de novo lipogenesis,inadequate FFA β-oxidation and additional intra- and extrahepatic inflammatory and oxidant hits.We review the in vivo evidence from animal studies and clinical trials.The abundance of animal studies reports a decrease in hepatic triglyceride accumulation,liver weight and a general improvement in histological fatty liver changes,along with a reduction in circulating insulin,glucose and lipid levels.Some studies document AMPK or SIRT1 activation,and modulation of relevant markers of hepatic lipogenesis,inflammation and oxidation status.However,AMPK/SIRT1-independent actions are also likely.Clinical trials are scarce and have primarily been performed with a focus on overweight/obese participants without a focus on NAFLD/NASH and histological liver changes.Future clinical studies with appropriate design are needed to clarify the true impact of RSV treatment in NAFLD/NASH patients. | Sara Heebll Karen Louise Thomsen Steen B Pedersen Hendrik Vilstrup Jacob George Henning Grnbk | 2014 | World Journal of Hepatology2014，6，4： | 11 |
| 3 | Influence of lanthanum level and interactions with nitrogen source on early development of Juglans nigra显示文摘稀土元素元素在中国农业被用于 30 年改进生长和产量。众多的科学研究在生理学,矿物质营养,和生长显示出改进,尽管有害效果可以也发生。很少的研究在木质的种类上被执行了。我们指数地使肥沃一个年旧黑核桃(Juglans nigra L.) 有 0, 0.1, 1, 10,或 100 mg 镧(La ) 和 800 mg 氮(N) 的幼苗作为 NaNO3,(NH4 ) 2SO4, NH4NO3,或没有 N。一月追随者期末考试授精,生长,矿物质营养,光合作用,叶绿素,和硝酸盐 reductase 活动被估计。植物与 La 的高水平使肥沃减少了好根生长,镁的集中,钙,镍,和磷,光合作用层次,和叶绿素一个内容。叶的 La 集中显示出相互作用效果,与乘在在到给 10 mg La 为的那些的 100 mg La 喂的植物的更大的集中的三~四(NH4 ) 2SO4 和 NH4NO3 处理。在层次的 La 增加的建议不有益的效果在在 N 之间的这研究和相互作用使用了的结果采购原料, La 层次没在黑核桃幼苗的生长,矿物质营养,或生理学上有重要影响。 | Nicodemus Michael A Salifu K Francis Jacobs Douglass F | 2009 | Journal of Rare Earths2009，27，2： | 4 |
| 4 | Distribution and effects of polymorphic RANTES gene alleles in HIV/HCV coinfection - A prospective cross-sectional study显示文摘AIM: Chemokines and their receptors are crucial for immune responses in HCV and HIV infection. RANTES gene polymorphisms lead to altered gene expression and influence the natural course of HIV infection. Therefore,these mutations may also affect the course of HIV/HCV coinfection.METHODS: We determined allele frequencies of RANTES-403 (G→A), RANTES-28 (C→G) and RANTESIN1.1 (T→C) polymorphisms using real-time PCR and hybridization probes in patients with HIV (n = 85), HCV (n= 112), HIV/HCV coinfection (n = 121), and 109 healthy controls. Furthermore, HIV and HCV loads as well as CD4+ and CD8+ cell counts were compared between different RANTES genotypes.RESULTS: Frequencies of RANTES-403 A, RANTES-28 G and RANTES-IN1.1 C alleles were higher in HIV infected patients than in healthy controls (-403: 28.2% vs 15.1%,P = 0.002; -28: 5.4% vs 2.8%, not significant; IN1.1:19.0% vs 11.0%, P = 0.038). In HIV/HCV coinfected patients, these RANTES alleles were less frequent than in patients with HIV infection alone (15.4% P = 0.002;1.7%; P = 0.048; 12.0%; not significant). Frequencies of these alleles were not significantly different between HIV/HCV positive patients, HCV positive patients and healthy controls.CONCLUSION: All three RANTES polymorphisms showed increased frequencies of the variant allele exclusively in patients with HIV monoinfection. The finding that the frequencies of these alleles remained unaltered in HIV/HCV coinfected patients suggests that HCV coinfection interferes with selection processes associated with these alleles in HIV infection. | Golo Ahlenstiel Agathe Iwan Jacob Nattermann Karin Bueren Jürgen K Rockstroh Hans H Brackmann Bernd Kupfer Olfert Landt Amnon Peled Tilman Sauerbruch Ulrich Spengler Rainer P Woitas | 2005 | World Journal of Gastroenterology2005，11，48： | 3 |
| 5 | 环境铅暴露与血压的关系:2003-2010美国健康和营养调查显示文摘在铅暴露逐渐降低的环境下,该文通过分析2003-2010美国健康和营养调查资料,旨在研究血铅与血压、高血压的关系。纳入研究对象12 725人,其中非洲裔21.1%,西语裔20.5%,白人58.4%,女性48.7%。与非非洲裔比较,非洲裔的血压[126.5/71.9比123.9/69.6mm Hg(1mm Hg=0. | Hara A Thijs L Asayama K Gu YM Jacobs L Zhang ZY Liu YP Nawrot TS Staessen JA 刘莉 叶鹏 | 2014 | 中华高血压杂志2014，22，10： | 3 |
| 6 | Management of enterocutaneous fistulae:A 10 years experience显示文摘AIM:To compare the outcomes of conservative vs surgical treatment of enterocutaneous fistulae(ECF) in a community teaching hospital over a decade.METHODS:All cases of ECF between 1997 and 2007 were reviewed for management strategy.RESULTS:Of the 83 patients with ECF,60(72%) were postoperative.Sixty-six patients(79.5%) were treated initially with conservative measures.Eighteen patients failed to respond to conservative treatment and required later(secondary) exploration;this group consisted of an equal number of low vs high output fistulae.Seventeen(20.5%) patients underwent initial(primary) def initivesurgery secondary to anastomotic leak and peritonitis.Surgical procedures included resection of ECF with anastomosis(24),exclusion(6) and direct-drainage(4).No signif icant difference was seen in the recurrence rate for conservative(10%) vs operative-treatment(20%).role as an initial management in both low and high output fistulae.In selective cases only,early primary exploration is recommended. | Deepa Taggarshe Daniel Bakston Michael Jacobs Alasdair McKendrick Vijay K Mittal | 2010 | World Journal of Gastrointestinal Surgery2010，2，7： | 2 |
| 7 | Polycyclic aromatic hydrocarbons of environmental and importance显示文摘 | Jacob K W | 1986 | Fresenius J Anal Chem1986，323，： | 1 |
| 8 | Token+constraint systems for tangible interaction with digital information 显示文摘 | Ullmer B Ishii H Jacob R J K | 2005 | A CM Transactions on Computer Human Interaction2005，12，1： | 1 |
| 9 | An alternative molecular mechanism of action of5-fluorouracil, a potent anticancer drug 显示文摘 | Ghoshal K Jacob ST | 1997 | Biochmical Pharmacology1997，55，： | 1 |
| 10 | Evidence for the nature of true Lewis sites in faujasite - type zeolites显示文摘 | JACOBS P A H K BEYER | 1979 | J Phys Chem1979，83，9： | 1 |
| 11 | On the capacity of a cellular CDMA system显示文摘 | GILHOUSEN K S JACOBS I M PADOVANI R | 1991 | IEEE Transactions on Vehicular Technology1991，40，2： | 1 |
| 12 | Efficient hydrolytic hydrogenation of cellulose in the presence of Ru-loaded zeolites and trace amounts of mineral acid显示文摘 | GEBOERS J VAN DE VYVER S CARPENTIER K JACOBS P SELS B | 2011 | Catal Commun2011，47，19： | 1 |
| 13 | Circulating tumor cells:detection,molecular profiling and future prospects显示文摘 | Jacob K Sollier C Jabado N | 2007 | Expert Rev Proteomics2007，4，6： | 1 |
| 14 | Synthesis and electrochemical performance of reduced graphene oxide/maghemite composite anode for lithium ion batteries显示文摘 | KIM I T MAGASINSKI A JACOB K | 2013 | Carbon2013，52，： | 1 |
| 15 | Activation volumes for solid-solid transformations in nanocrystals显示文摘 | Jacobs K Zaziski D Scher E C | 2001 | Science2001，293，5536： | 1 |
| 16 | Local oppugnant color texture pattern for image retrieval system显示文摘 | JACOB I J SRINIVASAGAN K G JAYAPRIYA K | 2014 | Pattern Recognition Letters2014，42，6： | 1 |
| 17 | On the capacity of a cellular CDMA systems显示文摘 | Gilhousen K S Jacobs I M | 1991 | IEEE Transactions Vehicular Technology1991，40，2： | 1 |
| 18 | The uncut Roux-en-Y with jejunal pouch:a new reconstruction technique for total gastrectomy显示文摘 | Chaiyasate K Jacobs M Brooks SE | 2007 | Surgery2007，142，1： | 1 |
| 19 | TCP Vegas- A: Improving the performance of TCP Vegas 显示文摘 | SRIJITH K N LILLYKUTTY JACOB ANANDA A L | 2005 | Computer Communications2005，28，4： | 1 |
| 20 | Comparison of cultural and morphological characters and ITS sequences in anamorphs of Botryosphaeria and related taxa显示文摘 | Jacobs K A Rehner S A | 1998 | Mycologia1998，90，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员