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| 1 | Role of bacteria in carcinogenesis, with special reference to carcinoma of the gallbladder显示文摘Carcinoma of the gallbladder (CaGB) is the fifth commonest gastrointestinal tract cancer and is endemic in several countries. The interplay of genetic susceptibility, infections, and life style factors has been proposed to be responsible for carcinogenesis of gallbladder. Persistence of infection leading to chronic inflammation, and production of certain toxins and metabolites with carcinogenic potentials, by certain bacteria has been speculated to be involved in the transformation of the gallbladder epithelium. Therefore, any bacteria that have evolved to acquire both of the above carcinogenic mechanisms can cause cancer. Salmonella typhi has been found to be prominently associated with CaGB. Chronic typhoid carriage (persistence) and production of mediators of chronic infl ammation and a genotoxic toxin (cytotoxic distending toxin, CdtB) are also known for this bacterium. Furthermore, the natural concentrating function of the gallbladder might amplify the carcinogenic effect of the mediators of carcinogenesis. In addition to S. typhi, certain species of Helicobacter (H. bilis and H. hepaticus) and Escherichia coli have also been implicated in carcinogenesis. As the isolation rate is verypoor with the presently available culture techniques, the existence of bacteria in a viable but non-cultivable state is quite likely; therefore, sensitive and specif ic molecular techniques might reveal the etiological role of bacterial infection in gallbladder carcinogenesis. If bacteria are found to be causing cancers, then eradication of such infections might help in reducing the incidence of some cancers. | Gopal Nath Anil K Gulati Vijay K Shukla | 2010 | World Journal of Gastroenterology2010，16，43： | 12 |
| 2 | In-vitro scolicidal activity of Mallotus philippinensis (Lam.) Muell Arg. fruit glandular hair extract against hydatid cyst Echinococcus granulosus显示文摘Objective: To investigate new scolicidal agent from natural resources to cope with the side effects associated with synthetic drugs in Echinococcosis. Methods: The scolicidal potential of methanolic fruit powder extract (10 and 20 mg/mL) of Mallotus philippinensis ( M. philippinensis ) was investigated. Viability of protoscoleces was confirmed by trypan blue exclusion method, where mortality was observed at concentration of 10 and 20 mg/mL in 60 min treatment against Echinococcus granulosus ( E. granulosus ), under in-vitro conditions with reference to the known standard drug Praziquantel . Results: At concentration 10 and 20 mg/mL, the mortality rate was observed 97% and 99% respectively for 60 min treatment; while up to 93% mortality was observed with 20 mg/mL for only 10 min treatment. The concentration above 20 mg/mL for above 2 h showed 100% mortality, irrespective of further incubation. Conclusions: As compared with the standard anti-parasitic drug Praziquantel our extract has significant scolicidal activity with almost no associated side effects. | Mayank Gangwar Vijay C Verma Tryambak D Singh Sushil K Singh RK Goel Gopal Nath | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，8： | 3 |
| 3 | Automatic extraction of tank outlets in a sub-watershed using digital elevation models显示文摘 | Nisar A hamed T R Gopal Rao K Murthy J S R | 2002 | Agricultural Water Management2002，57，3： | 1 |
| 4 | Amylolytic bacteria producing lactic acid显示文摘 | VISHNU C SUDHA R K GOPAL R | 1998 | J Sci Ind Res1998，57，： | 1 |
| 5 | Comparison of atherosclerotic plaque burden and composition between diabetic and non diabetic patients by non invasive CT angiography显示文摘 | Ibebuogu UN Nasir K Gopal A | 2009 | Int J Cardiovasc Imaging2009，25，7： | 1 |
| 6 | High efficiency double heterojunction polymer photovoltaic cells using highly ordered TiO2 nanotube arrays 显示文摘 | Gopal K M Karthik S Maggie P | 2007 | Appl Phys Lett2007，91，15： | 1 |
| 7 | Removal of fluoride from drinking water by adsorption onto alum- impregnated activated alumina 显示文摘 | TRIPATHY S S BERSILLONn J L GOPAL K | 2006 | Separation and Purification Technology2006，50，3： | 1 |
| 8 | Oligosacchrides and glycoconjugates in bo- vine milk and colostrum显示文摘 | GOPAL P K GILL H S | 2000 | Br J Nutr2000，84，： | 1 |
| 9 | Chlorination byproducts,their toxicodynamics and removal from drinking water显示文摘 | Gopal K Tripath S S Bersillon J L | | 0，，1： | 1 |
| 10 | A review on biodiesel produc tion, combustion, emissions and performance显示文摘 | Basha S A Gopal K R Jebaraj S | 2009 | Renewable and Sustainable Energy Reviews2009，13，6： | 1 |
| 11 | Antibiotic susceptibility profiles of new probiotic Lactobacillus and Bifidobacterium strains显示文摘 | ZHOU J S PILLIDGE C J GOPAL P K | 2005 | International Journal of Food Microbiology2005，98，2： | 1 |
| 12 | comparison of two- and three-dimensional echocardiography with cineventriculography for measurement of left ventricular volume in patients 显示文摘 | SAPIN P M SCHRODER K M GOPAL A S | 1994 | J Am Coll Cardiol1994，24，5： | 1 |
| 13 | Chemical struc tures of amphidionols 5 and 6 isolated from marine dinoflagellate Amphidinium klebsii and their cholesterol-dependent membrane disruption 显示文摘 | Gopal K P Matsumori N Konoki K | 1997 | J Mar Biotechnol1997，5，23： | 1 |
| 14 | Production of polyclonal antibodyies against ochratoxin A and its detection in chilies by ELISA显示文摘 | Thirumala-Devi K Mayo M A Gopal Reddy | 2000 | J Agric Food Chem2000，48，： | 1 |
| 15 | Effects of sodium acetate dip treatment and vacuum-packaging on chemical, microbiological, textural and sensory changes of Pearlspot (Etroplus suratensis) during chill storage显示文摘 | MANJU S JOSE L SRIN1VASA GOPAL T K | 2007 | Food Chemistry2007，102，： | 1 |
| 16 | Effect of pyrethroids on carbohydrate metabolic pathways in common carp,Cyprinus carpio显示文摘 | KAMALAVENE K GOPAL V SAMPSON U | 2001 | Pest Manag Sci2001，57，： | 1 |
| 17 | An investigation on glycerol biosynthesis by an osmophilie yeast in a bioreaetor 显示文摘 | Sahoo D K Gopal P Agarwal G P | 2001 | Process Biochemistry2001，，36： | 1 |
| 18 | GIS-basedfuzzy membership model for crop -land suitability analysis 显示文摘 | NISAR A T R GOPAL R K MURTHY J S R | 2000 | Agricultural Systems2000，63，2： | 1 |
| 19 | In vitro adherence properties of Lactobacillus rhamnosus DR20 and Bifido-bacterium lactis DR10 strains and their antagonistic activity against an enterotoxigenic Escherichia coli 显示文摘 | Gopal P K Prasad J Smart J | 2001 | International Journal of food Microbiology2001，67，： | 1 |
| 20 | Comparison of atherosclerotic plaque burden and composition between diabetic and non diabetic patients by non invasive CT angiography显示文摘 | Ibebuogu UN Nasir K Gopal A | | 0，，： | 1 |
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