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| 1 | The effects of land consolidation on the ecological connectivity based on ecosystem service value: A case study of Da'an land consolidation project in Jilin province显示文摘Land consolidation has a profound impact on landscape patterns and ecological functions at various scales through engineering and biological measures. In recent years, China invests more than 100 billion RMB yuan on land consolidation each year. To understand how land consolidation affects landscape patterns and ecosystems, we investigated the ecosystem service value and the ecological connectivity in a consolidated area of Da'an city from 2008 to 2014 using a revised ecological connectivity index. The results indicated that land consolidation has certain negative influences on the ecosystem services in this area. The total ecosystem service value will decrease by nearly 30% in the late stage of consolidation. This decrease is caused by the loss of ecosystem service of the wetland and grassland, despite a sensible increase of cultivated land. In addition, land consolidation could change the ecological connectivity as well as the land use structure. Up to 85% of the entire area will be in low connectivity in the late stage of consolidation, representing a 6.23% increase in the total coverage compared to pre-consolidation. Finally, the different connectivity landscape and their key areas can be identified by the revised ecological connectivity index effectively. This study is helpful to trace out the relationships between landscape pattern and ecological process, and provides insights for ecological planning and designing of land consolidation in this area. We suggest that more attentions should be paid to improve the quality and ecosystem service value per unit area of the landscape, to establish ecological compensation mechanism of wetland losses, and to create the ecological corridors along the least accumulated impendence surface in the key areas during land consolidation. | WANG Jun YAN Shenchun GUO Yiqiang LI Junran SUN Guoqing | 2015 | Journal of Geographical Sciences2015，25，5： | 26 |
| 2 | Regional homogeneity abnormalities in patients with tensiontype headache:a resting-state fMRI study显示文摘Tension-type headache(TTH) is the most prevalent type of primary headache. Many studies have shown that the pathogenesis of primary headache is associated with fine structural or functional changes. However, these studies were mainly based on migraine. The present study aimed to investigate whether TTH patients show functional disturbances compared with healthy subjects. We used restingstate functional magnetic resonance imaging(f MRI) and regional homogeneity(Re Ho) analysis to identify changes in the local synchronization of spontaneous activity in patients with TTH. Ten patients with TTH and 10 age-, gender-, and education-matched healthy controls participated in the study. After demographic and clinical characteristics were acquired, a 3.0-T MRI system was used to obtain restingstate f MRIs. Compared with healthy controls, the TTH group exhibited significantly lower Re Ho values in the bilateral caudate nucleus, the precuneus, the putamen, the left middle frontal gyrus, and the superior frontal gyrus. There was no correlation between mean Re Ho values in TTH patients and duration of TTH, number of attacks, duration of daily attacks, Visual Analogue Scale score, or Headache Impact Test-6 score. These results suggest that TTHpatients exhibit reduced synchronization of neuronal activity in multiple regions involved in the integration and processing of pain signals. | Pian Wang Handan Du Ning Chen Jian Guo Qiyong Gong Junran Zhang Li He | 2014 | Neuroscience Bulletin2014，30，6： | 6 |
| 3 | Roles of Hydroxyl Groups during Side-Chain Alkylation of Toluene with Methanol over Zeolite Na-Y: A Density Functional Theory Study显示文摘 | Xu Li Junran Lu Yi Li Jihong Yu | 2017 | Chinese Journal of Chemistry2017，35，5： | 3 |
| 4 | Landscape Network Approach to Assess Ecological Impacts of Road Projects on Biological Conservation显示文摘Awareness of the adverse ecological effects of road and other large construction projects has resulted in a rapidly growing demand to quantitatively predict and evaluate the effects on gene flow among plants and animals in natural habitats.In this study,we evaluated the effects of different road construction scenarios on animal species movement by using the methods of ecological landscape connectivity in the typical regions of Yunnan Province,China.The results showed landscape connectivity levels(Probability of Connectivity(PC))decreased after road construction and species with lower dispersal abilities were more affected to the subsequent habitat fragmentation.First level roads affected landscape connectivity most significantly.At a distance of 100 m,the PC index decreased more than 50%.Further analysis suggested that the use of landscape connectivity to assess landscape processes revealed the adverse effects on the species movement more effectively compared with the traditional landscape pattern analysis.In addition,we conducted a graph theory and a least-cost modeling discussion,it is obvious that they are powerful tools to represent and analyze landscape networks with respect to related species movement.Network analysis offers a quantitative and simple but effective tool for ecological process assessment and biological conservation on large scales. | LIU Shiliang DENG Li CHEN Liding LI Junran DONG Shikui ZHAO Haidi | 2014 | Chinese Geographical Science2014，24，1： | 3 |
| 5 | Disrupted Brain Connectivity Networks in Drug-Naive,First-Episode Major Depressive Disorder显示文摘 | Junran Zhang Jinhui Wang | 2011 | Biol Psychiatry2011，70，4： | 1 |
| 6 | Disrupted Brain Connectivity Networks in Drug-Naive, First-Episode Major Depressive Disorder显示文摘 | Junran Zhang Jinhui Wang Qizhu Wu Weihong Kuang Xiaoqi Huang Yong He Qiyong Gong | 2011 | Biological Psychiatry2011，，4： | 1 |
| 7 | Sediment deposition and soil nutrient heterogeneity in two desert grassland ecosystems, southern New Mexico显示文摘 | Junran Li Gregory S. Okin Lorelei J. Alvarez Howard E. Epstein | 2009 | Plant and Soil2009，，1： | 1 |
| 8 | Quantitative effects of vegetation cover on wind erosion and soil nutrient loss in a desert grassland of southern New Mexico, USA显示文摘 | Junran Li Gregory S. Okin Lorelei Alvarez Howard Epstein | 2007 | Biogeochemistry2007，，3： | 1 |
| 9 | Disrupted brain connectivity networks in drug-naive, first-episode maior depressive disorder 显示文摘 | Zhang Junran Wang Jinhui Wu Qizhu | 2011 | Biological Psychiatry2011，70，4： | 1 |
| 10 | The Role of the BRCAI Tumor Suppressor in DNA Double-Strand Break Repair 显示文摘 | Junran Zhang Simon N | 2005 | Mol Cancer Res2005，3，10： | 1 |
| 11 | Recent development of nano-materials used in DNA biosensors显示文摘 | XU Kai HUANG Junran YE Zunzhong | 2009 | Sensors2009，9，7： | 1 |
| 12 | Structures and magnetism of rwo novel heptanuclear lanthanide-centered trigonal prismatic lusters: (C104) 2· 25H2O (Ln=La, Tb; H2L=Iminodiacetic Acid) 显示文摘 | Liu Qinde Gao Song Li Junran | 2000 | Inorganic Chemistry2000，39，12： | 1 |
| 13 | Disrupted Brain Connectivity Networks in Drug-Naive, First-Episode Major Depressive Disorder 显示文摘 | Zhang Junran Wang Jinhui | 2011 | Biological Psychiatry2011，70，4： | 1 |
| 14 | Molecule-based Electrorheological Material, Electrorheological Performance and Molecule Structure 显示文摘 | HUO Li LIAO Fuhui LI Junran | 2011 | International Journal of Modern Physics B2011，25，25： | 1 |
| 15 | Molecule-based Electrorheological Material, Rare Earth Complex of 13-cyclodextrin Inclusion Compound 显示文摘 | LIAO Fuhui LI Junran | 2012 | Colloids and Surfaces A : Physicochemical and Engineering Aspects2012，394，： | 1 |
| 16 | High-Field Magnetic Resonance Imaging of Suicidality in Patients With Major Depressive Disorder显示文摘 | Jia Zhiyun Huang Xiaoqi Wu Qizhu Zhang Tijiang Lui Su Zhang Junran Amatya Nabin Kuang Weihong Chan Raymond C K Kemp Graham J Mechelli Andrea Gong Qiyong | 2010 | The American Journal of Psychiatry2010，，： | 1 |
| 17 | The role of the BRCA1 tumor suppressor in DNA double-strand break repair 显示文摘 | Junran Zhang Simon N | 2005 | Mol Cancer Res2005，3，： | 1 |
| 18 | Effects of wind erosion on the spatial heterogeneity of soil nutrients in two desert grassland communities显示文摘 | Junran Li Gregory S. Okin Lorelei Alvarez Howard Epstein | 2008 | Biogeochemistry2008，，1： | 1 |
| 19 | METTL3-mediated m^(6)A modification of HMGA2 mRNA promotes subretinal fibrosis and epithelial-mesenchymal transition显示文摘Subretinal fibrosis is a major cause of the poor visual prognosis for patients with neovascular age-related macular degeneration(nAMD).Myofibroblasts originated from retinal pigment epithelial(RPE)cells through epithelial-mesenchymal transition(EMT)contribute to the fibrosis formation.N^(6)-Methyladenosine(m^(6)A)modification has been implicated in the EMT process and multiple fibrotic diseases.The role of m^(6)A modification in EMT-related subretinal fibrosis has not yet been elucidated.In this study,we found that during subretinal fibrosis in the mouse model of laser-induced choroidal neovascularization,METTL3 was upregulated in RPE cells.Through m^(6)A epitranscriptomic microarray and further verification,high-mobility group AT-hook 2(HMGA2)was identified as thekey downstream target of METTL3,subsequently activating potent EMT-inducing transcription factor SNAIL.Finally,by subretinal injections of adeno-associated virus vectors,we confirmed that METTL3 deficiency in RPE cells could efficiently attenuate subretinal fibrosis in vivo.In conclusion,our present research identified an epigenetic mechanism of METTL3-m^(6)A-HMGA2 in subretinal fibrosis and EMT of RPE cells,providing a novel therapeutic target for subretinal fibrosis secondary to nAMD. | Yuwei Wang Yuhong Chen Jian Liang Mei Jiang Ting Zhang Xiaoling Wan Jiahui Wu Xiaomeng Li Jieqiong Chen Junran Sun Yifan Hu Peirong Huang Jingyang Feng Te Liu Xiaodong Sun | 2023 | Journal of Molecular Cell Biology2023，15，3： | 1 |
| 20 | The Role of the BRCA1Tumor Suppressor in DNA Double-Strand Break Repair显示文摘 | Junran Zhang Simon N | 2005 | Mol Cancer Res2005，3，10： | 1 |
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