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| 1 | m^6A Regulates Neurogenesis and Neuronal Development by Modulating Histone Methyltransferase Ezh2显示文摘N6-methyladenosine (m6A),catalyzed by the methyltransferase complex consisting of Mettl3 and Mettl14,is the most abundant RNA modification in mRNAs and participates in diverse biological processes. However,the roles and precise mechanisms of m6A modification in regulating neuronal development and adult neurogenesis remain unclear. Here,we examined the function of Mettl3,the key component of the complex,in neuronal development and adult neurogenesis of mice. We found that the depletion of Mettl3 significantly reduced m6A levels in adult neural stem cells (aNSCs) and inhibited the proliferation of aNSCs. Mettl3 depletion not only inhibited neu-ronal development and skewed the differentiation of aNSCs more toward glial lineage,but also affected the morphological maturation of newborn neurons in the adult brain. m6A immunoprecip-itation combined with deep sequencing (MeRIP-seq) revealed that m6A was predominantly enriched in transcripts related to neurogenesis and neuronal development. Mechanistically,m6A was present on the transcripts of histone methyltransferase Ezh2,and its reduction upon Mettl3 knockdown decreased both Ezh2 protein expression and consequent H3K27me3 levels. The defects of neurogenesis and neuronal development induced by Mettl3 depletion could be rescued by Ezh2 overexpression. Collectively,our results uncover a crosstalk between RNA and histone modifica-tions and indicate that Mettl3-mediated m6A modification plays an important role in regulating neurogenesis and neuronal development through modulating Ezh2. | Junchen Chen Yi-Chang Zhang Chunmin Huang Hui Shen Baofa Sun Xuejun Cheng Yu-Jie Zhang Yun-Gui Yang Qiang Shu Ying Yang Xuekun Li | 2019 | Genomics, Proteomics & Bioinformatics2019，17，2： | 12 |
| 2 | Linkage between permafrost distribution and river runoff changes across the Arctic and the Tibetan Plateau显示文摘River runoff in the Arctic and the Tibetan Plateau(TP) change significantly in recent decades. However, the mechanisms of the physical processes of permafrost river runoff change remain uncertain across large scale. This study investigated the mainstreams and tributaries of main Arctic and TP rivers dominated by permafrost and assessed the linkage between hydrological regime change and permafrost. The results show that the effects of permafrost on river runoff are highly dependent on the permafrost coverage of a watershed. For the past decades, the majority of the Arctic and TP basins showed increased discharge, while all of the studied basins showed increased baseflow, with faster increasing speed than total discharge.Both total discharge and baseflow annual change rate(ΔQ and ΔBF) increased with permafrost coverage, indicating the increments of streamflow are enhanced with high permafrost coverage. Meanwhile, the annual change of precipitation showed weak connection with total discharge and baseflow change. The high permafrost coverage basins showed high annual maximum/minimum discharge ratio(Qmax/Qmin), while the Qmax/Qminchanged slightly in low permafrost cover basins. Our results highlight the importance of permafrost coverage on streamflow regime change for permafrost basins across the northern hemisphere. Due to these linkage between permafrost extent and runoff regime change and the increasing changes of permafrost, more attention should be paid to the change of hydrological processes in permafrost-underlain basins. | Chunlin SONG Genxu WANG Tianxu MAO Junchen DAI Daqing YANG | 2020 | Science China Earth Sciences2020，63，2： | 10 |
| 3 | Transparently curved metamaterial with broadband millimeter wave absorption显示文摘We present a conformal metamaterial with simultaneous optical transparency and broadband millimeter-wave absorption for a curved surface. By tailoring the reflection response of meta-atoms at oblique angles, it is possible to achieve excellent absorption performance from 26.5 to 40.0 GHz within a wide angular range from 0° to 60°for transverse-electric and transverse-magnetic waves. In the meantime, by employing transparent substrates,including polyvinyl chloride and polyethylene terephthalate, good optical transmittance(80.1%) and flexibility are obtained simultaneously. The reflectivity of a curved metallic surface coated with the proposed curved metamaterial is simulated and measured experimentally. Both results demonstrate excellent absorption performance of the metamaterial, which is highly favored for practical applications. | CHENG ZHANG JIN YANG WENKANG CAO WEI YUAN JUNCHEN KE LIUXI YANG QIANG CHENG TIEJUN CUI | 2019 | Photonics Research2019，7，4： | 7 |
| 4 | Large-scale blow spinning of heat-resistant nanofibrous air filters显示文摘Particulate matter(PM)pollution has become a serious problem worldwide and various kinds of nanofibrous filters aiming to solve the problem have been developed.It is urgent to remove PM from high-temperature pollution sources,such as industrial emissions,coal furnaces,and automobile exhaust gases.However,filtration at pollution sources remains challenging because most existing air filters are not resistant to high temperature.Herein,heat-resistant polyimide(PI)nanofibrous air filters are fabricated via a simple and scalable solution blow-spinning method.These air filters show excellent thermal stability at high temperature up to 420℃.They exhibit a filtration efficiency as high as 99.73%at ambient temperature and over 97%at 300℃.In addition,a field test shows that the filters remove>97%of PM from the car exhaust fumes.Hence,the blow-spun PI nanofibrous membranes combined with the facile preparation strategy have great potential in high temperature air filtration fields and other similar applications such as water purification and protein separation. | Ziwei Li Jianan Song Yuanzheng Long Chao Jia Zhenglian Liu Lei Li Cheng Yang Junchen Liu Sen Lin Haiyang Wang Yibo Liu Minghao Fang Hui Wu | 2020 | Nano Research2020，13，3： | 6 |
| 5 | Comparison of dimension reduction-based logistic regression models for case-control genome-wide association study:principal components analysis vs.partial least squares显示文摘With recent advances in biotechnology, genome-wide association study(GWAS) has been widely used to identify genetic variants that underlie human complex diseases and traits. In case-control GWAS, typical statistical strategy is traditional logistical regression(LR) based on single-locus analysis. However, such a single-locus analysis leads to the well-known multiplicity problem, with a risk of inflating type I error and reducing power. Dimension reduction-based techniques, such as principal component-based logistic regression(PC-LR), partial least squares-based logistic regression(PLS-LR), have recently gained much attention in the analysis of high dimensional genomic data. However, the perfor?mance of these methods is still not clear, especially in GWAS. We conducted simulations and real data application to compare the type I error and power of PC-LR, PLS-LR and LR applicable to GWAS within a defined single nucleotide polymorphism(SNP) set region. We found that PC-LR and PLS can reasonably control type I error under null hypothesis.On contrast, LR, which is corrected by Bonferroni method, was more conserved in all simulation settings. In particular, we found that PC-LR and PLS-LR had comparable power and they both outperformed LR, especially when the causal SNP was in high linkage disequilibrium with genotyped ones and with a small effective size in simulation. Based on SNP set analysis, we applied all three methods to analyze non-small cell lung cancer GWAS data. | Honggang Yi Hongmei Wo Yang Zhao Ruyang Zhang Junchen Dai Guangfu Jin Hongxia Ma Tangchun Wu Zhibin Hu Dongxin Lin Hongbing Shen Feng Chen | 2015 | The Journal of Biomedical Research2015，29，4： | 2 |
| 6 | OSMRβmutants enhance basal keratinocyte differentiation via inactivation of the STAT5/KLF7 axis in PLCA patients显示文摘Dear Editor,Primary localized cutaneous amyloidosis(PLCA)is a skinlimited disorder characterized by deposition of amyloid material in the superficial dermis.According to clinical characteristics,PLCA is divided into lichen,macular,and nodular amyloidosis.PLCA is found worldwide but has a higher incidence in South America and Southeast Asia,such as in Brazil and China(Chang et al.,2014;Tey et al.,2016). | Jun Liu Junchen ChenYadan Zhong Xiaoling Yu Ping Lu Jianqi Feng Xin Zhang Shufeng Ma Chao Yang Bin Yang Zhili Rong | 2021 | Protein & Cell2021，12，8： | 1 |
| 7 | StriFA:stride finite automata for high-speed regular expression matching in network intrusion detection systems显示文摘 | Wang Xiaofei Xu Yang Jiang Junchen | 2013 | IEEE Systems Journal2013，7，3： | 1 |
| 8 | Phase engineering two-dimensional nanostructures for electrocatalytic hydrogen evolution reaction显示文摘Hydrogen(H2)is considered to be a promising substitute for fossil fuels.Two-dimensional(2D)nanomaterials have exhibited an efficient electrocatalytic capacity to catalyze hydrogen evolution reaction(HER).Particularly,phase engineering of 2D nanomaterials is opening a novel research direction to endow 2D nanostructures with fascinating properties for deep applications in catalyzing HER.In this review,we briefly summarize the research progress and present the current challenges on phase engineering of 2D nanomaterials for their applications in electrocatalytic HER.Our summary will be of significance to provide fundamental understanding for designing novel 2D nanomaterials with unconventional phases to electrochemically catalyze HER. | Zhongshui Li Yang Yue Junchen Peng Zhimin Luo | 2023 | Chinese Chemical Letters2023，34，1： | 1 |
| 9 | Computational prediction and functional analysis of arsenic-binding proteins in human cells显示文摘Background:Arsenic has a broad anti-cancer ability against hematologic malignancies and solid tumors.To systematically understand the biological functions of arsenic,we need to identify arsenic-binding proteins in human cells.However,due to lack of effective theoretical tools and experimental methods,only a few arsenic-binding proteins have been identified.Methods:Based on the crystal structure of ArsM,we generated a single mutation free energy profile for arsenic binding using free energy perturbation methods.Multiple validations provide an indication that our computational model has the ability to predict arsenic-binding proteins with desirable accuracy.We subsequently apply this computational model to scan the entire human genome to identify all the potential arsenic-binding proteins.Results:The computationally predicted arsenic-binding proteins show a wide range of biological functions,especially in the signaling transduction pathways.In the signaling transduction pathways,arsenic directly binds to the key factors(e.g.,Notch receptors,Notch ligands,Wnt family proteins,TGF-beta,and their interacting proteins)and results in significant inhibitions on their enzymatic activities,further having a crucial impact on the related signaling pathways.Conclusions:Arsenic has a significant impact on signaling transduction in cells.Arsenic binding to proteins can lead to dysfunctions of the target proteins,having crucial impacts on both signaling pathway and gene transcription.We hope that the computationally predicted arsenic-binding proteins and the functional analysis can provide a novel insight into the biological functions of arsenic,revealing a mechanism for the broad anti-cancer of arsenic. | Shichao Pang Junchen Yang Yilei Zhao Yixue Li Jingfang Wang | 2019 | Quantitative Biology2019，7，3： | 0 |
| 10 | Themis suppresses the effector function of CD8^(+)T cells in acute viral infection显示文摘CD8^(+)T cells play a central role in antiviral immune responses.Upon infection,naive CD8^(+)T cells differentiate into effector cells to eliminate virus-infected cells,and some of these effector cells further differentiate into memory cells to provide long-term protection after infection is resolved.Although extensively investigated,the underlying mechanisms of CD+T-cell differentiation remain incompletely understood.Themis is a T-cell-specific protein that plays critical roles in T-cell development.Recent studies using Themis T-cell conditional knockout mice also demonstrated that Themis is required to promote mature CD8^(+)T-cell homeostasis,cytokine responsiveness,and antibacterial responses.In this study,we used LCMV Armstrong infection as a probe to explore the role of Themis in viral infection.We found that preexisting CD8^(+)T-cell homeostasis defects and cytokine hyporesponsiveness do not impair viral clearance in Themis T-cell conditional knockout mice.Further analyses showed that in the primary immune response,Themis deficiency promoted the differentiation of CD8^(+)effector cells and increased their TNF and IFNy production.Moreover,Themis deficiency impaired memory precursor cell(MPEC)differentiation but promoted short-lived effector cell(SLEC)differentiation.Themis deficiency also enhanced effector cytokine production in memory CD8^(+)T cells while impairing central memory CD8^(+)T-cell formation.Mechanistically,we found that Themis mediates PD-1 expression and its signaling in effector CD8^(+)T cells,which explains the elevated cytokine production in these cells when Themis is disrupted. | Jian Tang Xian Jia Jian Li Junchen Dong Jiayu Wang Wanyun Li Yuzhen Zhu Yanyan Hu Bowen Hou Chunjie Lin Yu Cong Tong Ren Changsheng Yan Hongying Yang Qian Lai Haiping Zheng Yuzhou Bao Namrata Gautam Hong-Rui Wang Bing Xu Xiao Lei Chen Qing Li Nicholas R.J.Gascoigne Guo Fu | 2023 | Cellular & Molecular Immunology2023，20，5： | 0 |
| 11 | Yellow-Fluorescence Carbon Dots Employed for pH Sensing and Detection of Tigecycline显示文摘Long-wavelength fluorescence carbon dots (CDs) show great importance in multiple fields,especially for the biochemical sensing.Here,we proposed one type of CDs doped with nitrogen and sulfur through the hydrothermal method,which exhibited obvious yellow-fluorescence in aqueous solution.Importantly,the fluorescence intensity of CDs decreased with pH decreasing in the acidic range,thus a linear relationship between pH and fluorescence intensity was established,exhibiting the potential of pH sensing.Additionally,introducing tigecycline into CDs resulted in their decreased fluorescence,thus,we further established a strategy of detecting tigecycline with the concentration range of 200 μM to 7 nM.Meanwhile,we elucidated the static quenching as the major mechanism for CDs responding tigecycline,which was induced by the formed new complex between CDs and tigecycline.Furthermore,the practicality of the method was verified by examining the recovery of tigecycline in the actual lake-water samples. | Jingwen Zhao Junchen Wang Linggao Zeng Sen Zhou Xiaoming Yang | 2023 | Chinese Journal of Chemistry2023，41，24： | 0 |
| 12 | Concentrated ternary ether electrolyte allows for stable cycling of a lithium metal battery with commercial mass loading high-nickel NMC and thin anodes显示文摘A new concentrated ternary salt ether-based electrolyte enables stable cycling of lithium metal battery(LMB)cells with high-mass-loading(13.8 mg cm^(−2),2.5 mAh cm^(−2))NMC622(LiNi_(0.6)Co_(0.2)Mn_(0.2)O_(2))cathodes and 50μm Li anodes.Termed“CETHER-3,”this electrolyte is based on LiTFSI,LiDFOB,and LiBF4 with 5 vol%fluorinated ethylene carbonate in 1,2-dimethoxyethane.Commer-cial carbonate and state-of-the-art binary salt ether electrolytes were also tested as baselines.With CETHER-3,the electrochemical performance of the full-cell battery is among the most favorably reported in terms of high-voltage cycling stability.For example,LiNi_(x)Mn_(y)Co_(1-x-y)O_(2)(NMC)-Li metal cells retain 80%capacity at 430 cycles with a 4.4 V cut-off and 83%capacity at 100 cycles with a 4.5 V cut-off(charge at C/5,discharge at C/2).According to simulation by density functional theory and molecular dynamics,this favorable performance is an outcome of enhanced coordination between Li^(+)and the solvent/salt molecules.Combining advanced microscopy(high-resolution transmission electron microscopy,scanning electron microscopy)and surface science(X-ray photoelectron spectroscopy,time-of-fight secondary ion mass spectroscopy,Fourier-transform infrared spectroscopy,Raman spectroscopy),it is demonstrated that a thinner and more stable cathode electrolyte interphase(CEI)and solid electrolyte interphase(SEI)are formed.The CEI is rich in lithium sulfide(Li_(2)SO_(3)),while the SEI is rich in Li_(3)N and LiF.During cycling,the CEI/SEI suppresses both the deleterious transformation of the cathode R-3m layered near-surface structure into disordered rock salt and the growth of lithium metal dendrites. | Jun Yang Xing Li Ke Qu Yixian Wang Kangqi Shen Changhuan Jiang Bo Yu Pan Luo Zhuangzhi Li Mingyang Chen Bingshu Guo Mingshan Wang Junchen Chen Zhiyuan Ma Yun Huang Zhenzhong Yang Pengcheng Liu Rong Huang Xiaodi Ren David Mitlin | 2023 | Carbon Energy2023，5，3： | 0 |
| 13 | Manipulating micro-electric field and coordination-saturated site configuration boosted activity and safety of frustrated single-atom Cu/O Lewis pair for acetylene hydrochlorination显示文摘Simultaneously boosting acetylene hydrochlorination activity and avoiding formation of explosive copper acetylide over Cu-based catalyst,which represented a promising alternative to Hg-based and noble metal catalysts,remained challenging.Herein,we fabricated a frustrated single-atom Cu/O Lewis pair catalyst(Cu/O-FLP)by coupling epoxide group(C-O-C)with atomdispersed Cu-cis-N_(2)C_(2)Cl center to address this challenge.The basic epoxy site modulated the electron-deficient state of Lewisacidic Cu center and paired with the Cu-cis-N_(2)C_(2)Cl moiety to preferentially break HCl into different electronegative Cu-Clδ-and C-O-H^(δ+)intermediates,which further induced both an extra localized electric field to polarize acetylene and a upshift of the dband center of catalyst,thereby promoting adsorption and enrichment of acetylene by enhancing the dipolar interaction between acetylene and active intermediates.Moreover,the generated Cu-Clδ-and C-O-H^(δ+)drastically reduced the energy barrier of ratelimiting step and made vinyl chloride easier to desorb from the Lewis-basic oxygen-atom site rather than traditional Lewis-acidic Cu center.These superiorities ensured a higher activity of Cu/O-FLP compared with its counterparts.Meanwhile,preferential dissociation of HCl endowed single-atom Cu with the coordination-saturated configuration,which impeded formation of explosive copper acetylide by avoiding the direct interaction between Cu and acetylene,ensuring the intrinsic safety during catalysis. | Junchen Peng Dandan Dong Zongyuan Wang Hong Yang Dongyang Qiao Qinqin Wang Wei Sun Minmin Liu Jiajun Wang Mingyuan Zhu Bin Dai Fei He Chaofeng Huang | 2023 | Nano Research2023，16，7： | 0 |
| 14 | Green Fabrication of Freestanding Piezoceramic Films for Energy Harvesting and Virus Detection显示文摘Most electronics such as sensors,actuators and energy harvesters need piezoceramic films to interconvert mechanical and electrical energy.Transferring the ceramic films from their growth substrates for assembling electronic devices commonly requires chemical or physical etching,which comes at the sacrifice of the substrate materials,film cracks,and environmental contamination.Here,we introduce a van der Waals stripping method to fabricate large-area and freestanding piezoceramic thin films in a simple,green,and cost-effective manner.The introduction of the quasi van der Waals epitaxial platinum layer enables the capillary force of water to drive the separation process of the film and substrate interface.The fabricated lead-free film,Ba_(0.85)Ca_(0.15)Zr_(0.1)Ti_(0.9)O_(3)(BCZT),shows a high piezoelectric coefficient d_(33)=209±10 pm V−1 and outstanding flexibility of maximum strain 2%.The freestanding feature enables a wide application scenario,including micro energy harvesting,and covid-19 spike protein detection.We further conduct a life cycle analysis and quantify the low energy consumption and low pollution of the water-based stripping film method. | Shiyuan Liu Junchen Liao Xin Huang Zhuomin Zhang Weijun Wang Xuyang Wang Yao Shan Pengyu Li Ying Hong Zehua Peng Xuemu Li Bee Luan Khoo Johnny C.Ho Zhengbao Yang | 2023 | Nano-Micro Letters2023，15，9： | 0 |
| 15 | Converting rubber seed oil into hydrocarbon fuels via supported Pd-catalyst显示文摘The one-step hydrotreatment of rubber seed oil to produce hydrocarbon fuels has been carried out via supported Pd-catalyst,and analyzed emphatically some elements affected catalytic cracking process,for example,temperature,hydrogen partial pressure and dosage of catalyst,etc.Through experimental research,the author found out the appropriate catalytic cracking conditions as follows:310℃ of reaction temperature,2 MPa of hydrogen partial pressure,15 of the ratio of oil to catalyst(m(oil)/m(catalyst)),100 r/min of stirring speed.Under these conditions,effective component of hydrocarbon fuels in the converted oil accounts for 99.49%,and the proportion of C_(8)-C_(16) can reach as high as 79.61%.The converted oil was similar to petroleum-based oil in chemical composition,and can be used for future the aviation biofuels development as the source of raw material because it contains a large amount of hydrocarbon in the range of C_(8)-C_(16). | Chen Yubao Hao Yajie Zhao Yongyan Zhou Liming Yang Shunping Gao Yanni Ma Jiangli Du Junchen Dona Souliyathai Zhang Aimin | 2017 | International Journal of Agricultural and Biological Engineering2017，10，6： | 0 |
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