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| 1 | Liver resection versus liver transplantation for hepatocellular carcinoma within the Milan criteria based on estimated microvascular invasion risks显示文摘Background:Preoperative prediction of microvascular invasion(MVI)in hepatocellular carcinoma(HCC)may optimize individualized treatment decision-making.This study aimed to investigate the prognostic differences between HCC patients undergoing liver resection(LR)and liver transplantation(LT)based on predicted MVI risks.Methods:We analysed 905 patients who underwent LR,including 524 who underwent anatomical resection(AR)and 117 who underwent LT for HCC within the Milan criteria using propensity score matching.A nomogram model was used to predict preoperative MVI risk.Results:The concordance indices of the nomogram for predicting MVI were 0.809 and 0.838 in patients undergoing LR and LT,respectively.Based on an optimal cut-off value of 200 points,the nomogram defined patients as high-or low-risk MVI groups.LT resulted in a lower 5-year recurrence rate and higher 5-year overall survival(OS)rate than LR among the high-risk patients(23.6%vs 73.2%,P<0.001;87.8%vs 48.1%,P<0.001)and low-risk patients(19.0%vs 45.7%,P<0.001;86.5%vs 70.0%,P=0.002).The hazard ratios(HRs)of LT vs LR for recurrence and OS were 0.18(95%confidence interval[CI],0.09–0.37)and 0.12(95%CI,0.04–0.37)among the high-risk patients and 0.37(95%CI,0.21–0.66)and 0.36(95%CI,0.17–0.78)among the low-risk patients.LT also provided a lower 5-year recurrence rate and higher 5-year OS rate than AR among the high-risk patients(24.8%vs 63.5%,P=0.001;86.7%vs 65.7%,P=0.004),with HRs of LT vs AR for recurrence and OS being 0.24(95%CI,0.11–0.53)and 0.17(95%CI,0.06–0.52),respectively.The 5-year recurrence and OS rates between patients undergoing LT and AR were not significantly different in the low-risk patients(19.4%vs 28.3%,P=0.129;85.7%vs 77.8%,P=0.161).Conclusions:LT was superior to LR for patients with HCC within the Milan criteria with a predicted high or low risk of MVI.No significant differences in prognosis were found between LT and AR in patients with a low risk of MVI. | Pinghua Yang Fei Teng Shilei Bai Yong Xia Zhihao Xie Zhangjun Cheng Jun Li Zhengqing Lei Kui Wang Baohua Zhang Tian Yang Xuying Wan Hao Yin Hao Shen Timothy M Pawlik Wan Yee Lau Zhiren Fu Feng Shen | 2023 | Gastroenterology Report2023，11，1： | 1 |
| 2 | Synergetic roadmap of carbon neutrality and clean air for China显示文摘It is well recognized that carbon dioxide and air pollutants share similar emission sources so that synergetic policies on climate change mitigation and air pollution control can lead to remarkable co-benefits on greenhouse gas reduction,air quality improvement,and improved health.In the context of carbon peak,carbon neutrality,and clean air policies,this perspective tracks and analyzes the process of the synergetic governance of air pollution and climate change in China by developing and monitoring 18 indicators.The 18 indicators cover the following five aspects:air pollution and associated weather-climate conditions,progress in structural transition,sources,inks,and mitigation pathway of atmospheric composition,health impacts and benefits of coordinated control,and synergetic governance system and practices.By tracking the progress in each indicator,this perspective presents the major accomplishment of coordinated control,identifies the emerging challenges toward the synergetic governance,and provides policy recommendations for designing a synergetic roadmap of Carbon Neutrality and Clean Air for China. | Qiang Zhang Zhicong Yin Xi Lu Jicheng Gong Yu Lei Bofeng Cai Cilan Cai Qimin Chai Huopo Chen Hancheng Dai Zhanfeng Dong Guannan Geng Dabo Guan Jianlin Hu Cunrui Huang Jianing Kang Tiantian Li Wei Li Yongsheng Lin Jun Liu Xin Liu Zhu Liu Jinghui Ma Guofeng Shen Dan Tong Xuhui Wang Xuying Wang Zhili Wang Yang Xie Honglei Xu Tao Xue Bing Zhang Da Zhang Shaohui Zhang Shaojun Zhang Xian Zhang Bo Zheng Yixuan Zheng Tong Zhu Jinnan Wang Kebin He | 2023 | Environmental Science and Ecotechnology2023，，4： | 0 |
| 3 | MEASUREMENT AND ANALYSIS OF THREE- DIMENSIONAL KINEMATICS OF CERVICAL SPINE WITH THE USE OF COMPUTER VIDEO-IMAGE PROCESSING显示文摘Having a wide range of motion,the cervical spine is rather predisposed to trau-ma and other disorders with serious consequences.The motion of cervical spine is acomplex one composed of micromotions,including horizontal displacements along allthree axes and rotations around them with six freedom degrees of movement.Reporton precise measurement of the three-dimensional motion of the cervical section | Jun Wang Chunli Zhang Xinzhi Xui Institute of Orthopaedics and Traumatology,Fourth Military Medical University,Xi’an 710032,China | 1993 | Chinese Journal of Biomedical Engineering(English Edition)1993，2，4： | 0 |
| 4 | Convergence analysis of the adaptive finite element method with the red-green refinement显示文摘In this paper, we analyze the convergence of the adaptive conforming P 1 element method with the red-green refinement. Since the mesh after refining is not nested into the one before, the Galerkin-orthogonality does not hold for this case. To overcome such a difficulty, we prove some quasi-orthogonality instead under some mild condition on the initial mesh (Condition A). Consequently, we show convergence of the adaptive method by establishing the reduction of some total error. To weaken the condition on the initial mesh, we propose a modified red-green refinement and prove the convergence of the associated adaptive method under a much weaker condition on the initial mesh (Condition B). | ZHAO XuYing 1, 3 , HU Jun 2,? & SHI ZhongCi 1 1 State Key Laboratory of Scientific and Engineering Computing, Institute of Computational Mathematics and Scientific/Engineering Computing, Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing 100190, China 2 Key Laboratory of Mathematics and Applied Mathematics (Peking University), Ministry of Education and School of Mathematical Sciences, Peking University, Beijing 100871, China 3 Graduate University of Chinese Academy of Sciences, Beijing 100190, China | 2010 | Science China Mathematics2010，53，2： | 0 |
| 5 | Establishment of highly efficient transgenic system for black soldier fly(Hermetia illucens)显示文摘The black soldier fly(BSF),Hermetia illucens,is a promising insect for miti-gating solid waste problems as its larvae are able to bioconvert organic waste into valuable biomass.We recently reported a high-quality genome assembly of the BSF;analysis of this genome sequence will further the understanding of insect biology and identify genes that can be manipulated to improve efficiency of bioconversion.To enable genetic manip-ulation of the BSF,we have established the first transgenic methods for this economically important insect.We cloned and identified the ubiquitous actin5C promoter(Hiactin5C-p3k)and 3 endogenous U6 promoters(HiU6:1,HiU6:2,and HiU6:3).The Hiactin5C pro-moter was used to drive expression of a hyperactive variant of the piggyBac transposase,which exhibited up to 6-fold improvement in transformation rate when compared to the wild-type transposase.Furthermore,we evaluated the 3 HiU6 promoters using this trans-genic system.HiU6:1 and HiU6:2 promoters provided the highest knockdown efficiency with RNAi and are thus promising candidates for future Clustered Regularly Interspaced Short Palindromic Repeats(CRISPR)development.Overall,our findings provide valuable genetic engineering toolkits for basic research and genetic manipulation of the BSF. | Zongqing Kou Xingyu Luo Yuguo Jiang Bihui Chen Yu Song Yaohui Wang Jun Xui Jeffery K.Tomberlin Yongping Huang | 2023 | Insect Science2023，30，4： | 0 |
| 6 | NEW TRITERPENOIDAL SAPONINS FROM MUSSAENDA PUBESECUS显示文摘A cyclolanostene-type triterpene and two saponins derived thereform,namely MP-C,D and F,were isolated from the acid-hydrolyzate of the mixture ofsaponins of Mussaenda pubesecus.Their structures were elucidated on the basisof chemical and UV,IR,1H,13C NMR and MS spectral evidence.The two newsaponins MP-D and F were named Mussaendoside A and C,respectively. | Jun Ping XUI~(1)*)Zi LUO~(2))Jie Ying DONG~(2))and Ren Sheng XU~(1))Shanghai Institute of Materia Medica,Academia Sinica,Shanghai 200031~(1))East China University of Chemical Technology,Shanghai 200237~(2)) | 1990 | Chinese Chemical Letters1990，1，1： | 0 |
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