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3篇 您的检索式：作者名="Juan Gambini"

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		题名	作者	年代	出处	被引量
	1	Oestradiol or genistein rescues neurons from amyloidbeta-induced cell death by inhibiting activation of p38 显示文摘	Soraya L Vallés Consuelo Borrás Juan Gambini etal	2008	AgingCell2008，7，1：	1
	2	Development of 99m Tc(CO) 3 -dendrimer-FITC for cancer imaging显示文摘	Marcos R. Tassano Paola F. Audicio Juan P. Gambini Marcelo Fernandez Juan P. Damian Maria Moreno Jose A. Chabalgoity Omar Alonso Juan C. Benech Pablo Cabral	2011	Bioorganic & Medicinal Chemistry Letters2011，，18：	1
	3	99mTc Radiolabeled Archaeosomes as a Potential Melanoma Imaging Agent显示文摘Melanoma incidence is growing worldwide.Although recent advances in imaging,there is not still available a specific melanoma agent that can be used for melanoma staging.Archaeosomes may be defined as liposomes composed of one or more polar lipids extracted from the Archaea domain(Archaebacterium).As liposomes have been used as vehicles for drugs and isotopes,the aim of this work is to evaluate radiolabelled 99mTc-archaeosomes as a potential melanoma imaging agent.and evaluate its potential role as a melanoma imaging agent.Archaeosomes were prepared by handshaken method and were radiolabeled with 99mTc;radiolabelling efficiency and purity were evaluated through different chromatographic systems.In vitro stability of 99mTc-diethylene-triamine-pentaacetate(DTPA)-archaeosomes was performed through L-cysteine challenge.Archaeosome size distribution was determined by laser light scattering,having nanometer size between 90 and 120 nm.Radiolabelling efficiency was>90%;99mTc-DTPAarchaeosomes presented a radiochemical purity superior to 80%evaluated 24 h post-radiolabelling.For the highest concentration of L-cysteine(30 mM)and 1 h incubation,radiochemical purity was 92.90%,6.41%was bound to cysteine,and 0.69%remained as 99mTcO4-.Biodistribution and scintigraphic imaging studies in healthy C57 black mice showed high liver,spleen uptake,and renal elimination.Melanoma bearing mice had similar biodistribution as healthy mice but increased melanoma uptake,with T/M ratio of 46±3.7.Our results show the feasibility of 99mTc radiolabelling archaeosomes and their potential role as a melanoma imaging agent.	Mirel Cabrera Marcos Tassano Marcelo Fernandez Juan Pablo Gambini Pablo Cabral	2018	Proceedings of Anticancer Research2018，2，3：	0

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