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| 1 | 激光干涉仪引力波探测器显示文摘引力波的存在是爱因斯坦在广义相对论中提出的一个重要预言,引力波探测是当代物理学最重要的前沿领域之一。经过近半个世纪的艰苦努力,随着几个大型激光干涉仪引力波探测器在21世纪初的出现并于近几年达到前所未有的灵敏度,引力波探测进入了一个崭新的时代。人类有望在第二代地基激光干涉仪引力波探测器开始科学运行(约2015年)之后的几年内,不仅可以直接探测到引力波,更将打开一扇观测宇宙的新窗口。引力波探测也将成为继电磁辐射、宇宙线和中微子之后,人类探索宇宙奥秘的又一重要手段。介绍了激光干涉仪引力波探测器的性能和工作原理,详细分析了其关键部件,如:迈克尔孙干涉仪、法布里–珀罗腔、功率循环系统、激光器、清模器、倒摆、单体几何反弹簧过滤器、真空系统等的结构、性能和工艺特点,展望了其广阔的发展前景。 | 王运永 朱兴江 刘见 马宇波 朱宗宏 曹军威 都志辉 王小鸽 钱进 殷聪 刘忠有 BLAIR D JU Li ZHAO Chun-nong | 2014 | 天文学进展2014，32，3： | 15 |
| 2 | Metformin does not improve survival in patients with hepatocellular carcinoma显示文摘AIM:To assess whether metformin,which has a chemopreventive effect in chronic liver disease,has any chemotherapeutic effect in hepatocellular carcinoma.METHODS:This was a retrospective study of 701 patients with newly diagnosed hepatocellular carcinoma(HCC)seen between January 2005 and June 2011 at Mayo Clinic,Rochester,Minnesota.This patient cohort was a part of the global HCC BRIDGE study,which is a large longitudinal study of HCC determining the realworld experience of HCC characteristics,management and patient outcomes.We defined significant metformin exposure as continuation of this agent at least 90d beyond diagnosis of HCC,and compared survival of diabetic patients on metformin to diabetic patients not on metformin and non-diabetics.RESULTS:Our cohort was 72.9%male,with a mean±SD age of 62.6±12.3 years.The most common etiologies of liver disease were hepatitis C(34%),alcoholic liver disease(29%),fatty liver disease(15%)and hepatitis B(9%).By univariate analysis,using diabetics not on metformin as the reference group,diabetic patients with HCC on metformin had no survival advantage,with a HR(95%CI)of 1.0(0.8-1.3).Non-diabetic HCC patients also did not appear to have a survival advantage as compared to diabetic HCC patients not on metformin,as demonstrated by a HR(95%CI)of1.1(0.7-1.7).Diabetics on metformin beyond 90 d after HCC diagnosis had a longer median survival at 34.2 mo,as compared to 25.5 mo among diabetic patients who were not on metformin or had discontinued metformin within 90 d after HCC diagnosis.This finding was likely due to potential survival bias among those who lived long enough to receive metformin.CONCLUSION:Although the literature suggests a chemotherapeutic effect in other malignancies,our study demonstrates no survival benefit to the use of metformin in diabetic patients with HCC. | Mamatha Bhat Roongruedee Chaiteerakij William S Harmsen Cathy D Schleck Ju Dong Yang Nasra H Giama Terry M Therneau Gregory J Gores Lewis R Roberts | 2014 | World Journal of Gastroenterology2014，20，42： | 11 |
| 3 | 血清netrin-1增加与缺血性脑卒中预后改善相关显示文摘先前的实验研究表明,血清netrin-1与缺血性脑卒中进展相关。进一步了解缺血性脑卒中患者中netrin-1的变化可能为缺血性脑卒中的预后评估提供新的思路。该研究旨在探讨血清netrin-1与缺血性脑卒中预后的关系。研究人员测定3346例中国急性缺血性脑卒中抗高血压试验(China antihypertensive trial in acute ischemic stroke,CATIS)中缺血性脑卒中患者基线血清netrin-1水平,所有患者均在脑卒中发病后3个月进行随访。主要观察指标是脑卒中发病后3个月内死亡和严重残疾(改良Rankin 量表评分≥3)。 | 刘莉 叶鹏 Guo D Zhu Z Zhong C Peng H Wang A Xu T Peng Y Xu T Chen CS Li Q Ju Z Geng D Chen J Zhang Y He J | 2019 | 中华高血压杂志2019，27，5： | 6 |
| 4 | <ce:link locator='fx1'/> Adalimumab for Maintenance of Clinical Response and Remission in Patients With Crohn’s Disease: The CHARM Trial显示文摘 | Jean–Frédéric Colombel William J. Sandborn Paul Rutgeerts Robert Enns Stephen B. Hanauer Remo Panaccione Stefan Schreiber Dan Byczkowski Ju Li Jeffrey D. Kent Paul F. Pollack | 2007 | Gastroenterology2007，，1： | 4 |
| 5 | Low-stiffness silicon cantilevers with integrated heaters and piezoresistive sensors for high-density AFM thermomechanical data storage 显示文摘 | CHUI B W STOWE T D JU Y S | 1998 | Journal of Microclecromechanical Systems1998，7，1： | 1 |
| 6 | Thermomechanical cracking due to moving frictional loads显示文摘 | HUANG J H JU F D | 1985 | Wear1985，102，12： | 1 |
| 7 | Gaussian Mixture Discriminant Analysis and Sub-pixel Land Cover Characterization in Remote Sensing 显示文摘 | JU J C KOLACZYK E D GOPAL S | 2003 | Remote Sensing Environment2003，84，： | 1 |
| 8 | Sturcture damage diagnosis using neural network and feature fusion 显示文摘 | Liu Y Y Ju Y F Duan C D | 2011 | Engineering Applications of Artificial Intelli- gence2011，24，1： | 1 |
| 9 | Modeling and simulation of quenching and tempering process in steels显示文摘 | DENG X H JU D Y | 2013 | Physics Procedia2013，50，： | 1 |
| 10 | Evaluation of fracture toughness by small-punch testing techniques using sharp notched specimens显示文摘 | Ju J B Jang J Kwon D | 2003 | International Journal of Pressure Vessels & Piping2003，80，4： | 1 |
| 11 | Effect of additives on the microstructure of ferrite sintered body and its characteristic evaluation 显示文摘 | SUZUKI Y BI/(N P JU D Y MITAMURA T KOBAYASHI H | 2001 | J Jpn Soc Powder Powder Metallurgy2001，48，： | 1 |
| 12 | Thermal flow simulation on twin rollcasting process for thin strip production of magnesium alloy 显示文摘 | Ju D Y ZHAO H Y HU X D | 2005 | Materials Science Forum2005，，： | 1 |
| 13 | Multi temporal MODIS Landsat Data Fusion for Relative Radiometric Normalization,Gap Filling,and Prediction of Landsat Data显示文摘 | Roy D P Ju J Lewis P | 2008 | Remote Sensing of Environment2008，112，： | 1 |
| 14 | A cysteine-rich domain of the “mannose” receptor mediates GalNAc-4-SO4 binding显示文摘 | Fiete D J Beranek M C Baenziger JU | 1998 | Proc Natl Acad Sci U S A1998，95，5： | 1 |
| 15 | Adalimumab for Maintenance of Clinical Response and Remission in Patients With Crohn’s Disease: The CHARM Trial显示文摘 | Jean–Frédéric Colombel William J. Sandborn Paul Rutgeerts Robert Enns Stephen B. Hanauer Remo Panaccione Stefan Schreiber Dan Byczkowski Ju Li Jeffrey D. Kent Paul F. Pollack | 2007 | Gastroenterology2007，，： | 1 |
| 16 | Celastrol ameliorates HIV-1 Tat-induced inflammatory responses via NF-kappaB and AP-1 inhibition and heme oxygenase-I induction in astrocytes 显示文摘 | Youn G S Kwon D J Ju S M | 2014 | Toxicol Appl Pharmacol2014，280，1： | 1 |
| 17 | Hypoxia increase persistent sodium current in rat ventricular myocytes显示文摘 | Ju Y K Saint D A Gage P W | 1996 | J Physiol1996，497，2： | 1 |
| 18 | Casuarinin suppresses TARC/CCLI7 and MDC/CCL22 production via blockade of NF - KB and STATI activation in HaCaT cells 显示文摘 | Kwon D J Bae YS Ju SM | 2012 | Biochem Biophys Res Commun2012，417，4： | 1 |
| 19 | Assessment of adrenal reserve in pregnancy: defining the normal response to the adrenocorticotropin stimulation test 显示文摘 | Suri D Moran J Hibbard JU | 2006 | J Clin Endoerinol Metab2006，91，10： | 1 |
| 20 | Structure damage diagnosis using neural network and feature fusion显示文摘 | Liu Y Y Ju Y F Duan C D | | 0，，01： | 1 |
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