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| 1 | Early palliative care for patients with metastatic non-small-cell lung cancer显示文摘Comments This landmark article demonstrates that integration of early palliative care with standard oncologic practice shortly after diagnosis may improve quality of life,mood,and overall survival for adults with advanced non-small-cell lung cancer(NSCLC).If validated,these findings could support a paradigm shift in the care of adults with metastatic NSCLC and possibly patients with other tumor types characterized by short survival and high symptom burden. | Temel JS Greer JA Muzikansky A Gallagher ER Admane S Jackson VA Dahlin CM Blinderman CD Jacobsen J Pirl WF Billings JA Lynch TJ | 2010 | 中国肺癌杂志2010，13，9： | 165 |
| 2 | The role of whole brain radiation therapy in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline显示文摘 | Gaspar LE Mehta MP Patchell RA Burri SH Robinson PD Morris RE Ammirati M Andrews DW Asher AL Cobbs CS Kondziolka D Linskey ME Loeffler JS McDermott M Mikkelsen T Olson JJ Paleologos NA Ryken TC Kalkanis SN. | 2010 | 中国神经肿瘤杂志2010，8，1： | 98 |
| 3 | 国际疼痛研究协会疼痛定义修订版:概念、挑战和折中显示文摘现行国际疼痛研究协会(IASP)将疼痛定义为'与实际或潜在组织损伤,或描述的类似损伤相关的一种不愉快的感觉和情感体验',该定义是由一个分类小组委员会推荐,并于1979年被IASP理事会所采纳。这一定义已被疼痛领域的卫生保健专业人士和研究人员广泛接受,并被一些行业、政府及非政府组织(包括世界卫生组织)所采用。近年来,一些业内人士认为,随着对疼痛更深入的了解,有必要对这个定义重新审定,并提出了修改建议。因此,2018年,IASP成立了一个主席特别工作小组,该小组是由14名来自多个国家的在疼痛相关的临床和基础科学方面拥有广泛专业知识的人员组成,其任务是评估现行定义及其附带注释,并对其保留还是修改提出建议。本文提供了关键概念的摘要、对IASP会员和公众评论的分析以及两年内委员会对疼痛定义和注释的最终修订意见。特别工作小组最后建议将疼痛定义修改为'与组织损伤或潜在组织损伤相关或类似相关的一种不愉快的感觉和情感体验',并将原来的附带注释更新为一系列简要说明并提供相关词源。今年年初,IASP理事会一致接受了修订后的定义和注释。 | Raja SN.Carr DB Cohen M.Finnerup NB Flor H.Gibson S Keefe FJ.Mogil JS Ringkamp M.Sluka KA Song XJ.Stevens B Sullivan MD.Tutelman PR Ushida T.Vader K 程志祥(译) 许继军(译) 程建国(审校) 刘先国(审校) 刘延青(审校) | 2020 | 中华疼痛学杂志2020，16，5： | 137 |
| 4 | 北京友谊医院1998~2001年轮状病毒哨点监测分析显示文摘目的 了解 5岁以下儿童中以医院为基础的轮状病毒流行情况。方法 按WHO轮状病毒监测的通用方法 (CID 98)进行 ,轮状病毒检测采用聚丙烯酰胺凝胶电泳 /酶联免疫吸附试验(ELISA)。毒株分型用ELISA/逆转录聚合酶链反应。结果 从 1998年 4月至 2 0 0 1年 3月收集的4 84份腹泻患儿粪便标本中 ,检出阳性标本 12 3份 ,总的轮状病毒感染检出率为 2 5 .4 % ,住院和门诊患儿检出率分别是 31.6 %和 2 7.3% ,而在轮状病毒流行季节 ,则可以引起高达 4 6 .2 %急性腹泻住院率。腹泻患儿发病呈现两个明显的季节高峰 :一个由细菌性痢疾引起的夏季 (6~ 9月 )发病高峰 ,另一个是轮状病毒感染腹泻造成的秋冬季 (10~ 12月 )发病高峰。轮状病毒感染 96 .8%发生于 3岁以下幼儿 ,主要在 6~ 11月龄 (38.2 % )和 1~ 2岁 (2 8.5 % )年龄组 ,轮状病毒感染率在 6~ 35月龄年龄段最高。流行的轮状病毒G血清型依次为G1(5 5 .3% )、G2 (2 6 .8% )、G3(9.8% )和G4 (0 .8% ) ,没有发现G9型 ,10份 (8.1% )标本未能分型 ,混合感染 (0 .8% )罕见。结论 轮状病毒腹泻是北京市儿童的重要传染病 ,开发应用安全有效的轮状病毒疫苗将对减轻轮状病毒疾病负担有重要作用。 | 童志礼 马莉 章菁 侯安存 郑丽舒 金宗平 谢华萍 马兰 张丽杰 Ivanoff B Glass RI Bresee JS JIANG Xi Kilgore PE 方肇寅 | 2003 | 中华流行病学杂志2003，24，12： | 27 |
| 5 | 猪舍内气流变化的模拟研究显示文摘圈养动物舍内的气流变化对于室内的污染物扩散起到非常关键的作用,采用基于有限容积方法的计算流体动力学(CFD)软件对建于奥胡斯大学农业工程研究所空气物理实验室中的1:12.5猪舍模型内的气流进行了稳态和三维模拟。将模拟的气流速度与室内一个参考点的实际测试速度进行了对比,同时分析了气流入口不同紊流动能及扩散率取值对室内测试参考点气流速度模拟值的影响。结果表明,模拟值与测试值的相对误差在0.4%~11.4%之间。 | 佟国红 张国强 MORSING S STROM JS RAVN P | 2007 | 沈阳农业大学学报2007，38，3： | 25 |
| 6 | ISUOG实用指南(更新版):胎儿心脏超声筛查指南解读显示文摘本文是对以往国际妇产科超声学会(The International Society of Ultrasound in Obstetrics and Gynecology,ISUOG)发表的关于孕中期胎儿心脏超声筛查常规[1]的修订和更新版本,为产前超声筛查先天性心脏病的最新观点。新的ISUOG指南与其他指南相一致,推荐将超声筛查胎儿心脏的左右心室流出道观和四腔观列入常规筛查。 | 孙夫丽 吴青青 王莉 Carvalho JS Allan LD | 2014 | 中华医学超声杂志(电子版)2014，11，4： | 25 |
| 7 | 长春市儿童医院1998~2001年轮状病毒哨点监测分析显示文摘目的 为在中国开发和应用轮状病毒疫苗提供流行病学背景资料。方法 以医院为基础的哨点监测 ,在长春市儿童医院 5岁以下腹泻患儿中进行 ,收集患儿临床资料和粪便标本 ,轮状病毒检测用聚丙烯酰胺凝胶电泳 (PAGE)和 或酶联免疫吸附试验 (ELISA) ,毒株分型用ELISA和 或逆转录 聚合酶链反应 (RT PCR)。所有资料录入计算机进行数据分析。结果 3年监测中共调查 2 3 4 3例腹泻患儿 ,收集便样 12 11份 ,轮状病毒检出率门诊患儿和住院患儿分别为 3 1.0 %和 52 .9%。轮状病毒感染 95.0 %发生于 2岁以下儿童。每年寒冷季节流行 (11月到次年 3月 )。流行的轮状病毒G血清型依次为G1(82 .4% )、G2 (5.0 % )、G3 (3 .3 % )和G 4(0 .9% ) ,P基因型以P[8]和P[4]为常见。共检出 9种P~G结合的毒株 ,其中世界常见的 4种流行株占 75.6%。结论 轮状病毒流行毒株呈现超常多样性 。 | 孙利炜 童志礼 李丽红 章菁 陈琦 郑丽舒 刘静 谢华萍 王承训 张丽杰 Ivanoff B Glass RI Bresee JS Jiang XI Kilgore PE 方肇寅 | 2003 | 中华流行病学杂志2003，24，11： | 25 |
| 8 | Preoperative functional MR imaging localization of language and motor areas: effect on therapeutic decision making in patients with potentially resectable brain tumors显示文摘 | Petrella JR Shah LM Harris KM Friedman AH George TM Sampson JH Pekala JS Voyvodic JT | 2006 | 中国神经肿瘤杂志2006，4，2： | 14 |
| 9 | 术前肌电图和脑干听觉诱发电位与面肌痉挛微血管减压术后迟发性面瘫发生的关系(英文)显示文摘Background Delayed facial palsy ( DFP) after microvascular decompression ( MVD) in patients with hemifacial spasm ( HFS) is not uncommon,but the cause remains unknown. Objectives To assess whether intraoperative electromyography ( EMG) and brainstem auditory evoked potential ( BAEP) can predict DFP after MVD. Methods Between September 2009 and February 2011 we examined 86 patients,9 of whom ( 10. 4% ) developed DFP after MVD on the same side. All patients underwent MVD and were followed - up for a median period of 13 months ( range 6-22) . We retrospectively examined intraoperative facial EMG and BAEP findings using our MVD patients' registry. We excluded secondary HFS and immediate postoperative facial palsy after MVD in this study. We assessed the prevalence and clinical characteristics of DFP and compared EMG and BAEP findings between DFP and non-DFP groups. Results: All pa- tients recovered completely,with a mean time to recovery of 37. 8 days ( range 22-57) . There were no significant differences between DFP and non - DFP patients in terms of the amplitude and latency of intraoperative EMG and BAEP. Conclusion The usefulness of intraoperative facial EMG and BAEP is limited and cannot predict DFP after MVD for HFS. We speculate that DFP after MVD is not associated with permanent nerve damage according to the EMG findings. | Kim HJ Park YS Ryu JS Huh R Han I Shin DA Kim TG Cho KG Chung SS | 2012 | 中华神经外科疾病研究杂志2012，11，4： | 13 |
| 10 | 心肌梗死第三次全球统一定义显示文摘心肌梗死的定义
急性心肌梗死的诊断标准
临床存在心肌缺血并有心肌坏死的证据时,应当使用“心肌梗死”这一术语。此时出现下列任一项均可诊断心肌梗死: | Thygesen K Alpert JS Jaffe AS 陈阳(节译) 徐兆龙(节译) 刘仁光(节译) | 2013 | 辽宁医学院学报2013，34，1： | 13 |
| 11 | Mechanisms of angiogenesis in gliomas显示文摘 | Kargiotis O Rao JS Kyritsis AP | 2006 | 中国神经肿瘤杂志2006，4，1： | 12 |
| 12 | 吸入糖皮质激素可增加慢性阻塞性肺疾病患者感染肺结核的风险显示文摘背景和目的:口服糖皮质激素和应用抗肿瘤坏死因子-α制剂均可增加肺结核感染的风险。然而,目前尚没有关于吸入糖皮质激素(ICS)是否增加肺结核感染风险的相关资料。本研究拟通过评价患者的影像学资料来了解ICS可否增加慢阻肺患者感染肺结核的风险。 | Kim JH Park JS Kim KH 黄慧 徐作军 | 2013 | 中华结核和呼吸杂志2013，36，6： | 12 |
| 13 | Immune responses against SARS-coronavirus nucleocapsid protein induced by DNA vaccine显示文摘 | Zhao P Cao J Zhao LJ Ke JS Pan W Ren H Yu JG Qi ZT | 2005 | 第二军医大学学报2005，26，10： | 12 |
| 14 | 2017 ISHNE/HRS动态心电图和体外心电监测/远程监测专家共识(2):诊断适应证及临床预测显示文摘动态心电图(ambulatory ECG,AECG)在临床中被广泛用于检测心律失常和识别常规心电图不易捕捉的心律失常特征性表现。AECG记录系统可采集到大量的心律信息,为临床提供可靠的诊断依据。本文介绍了动态监测技术在心血管疾病诊断及管理中的适应证,评价了该技术在特定临床环境中用于危险分层的预测价值。 | Steinberg JS Varma N Cygankiewicz I 高洁(译) 肖美凤(译) 王新康(译) 卢喜烈(译) 薛求真(译) | 2019 | 实用心电学杂志2019，28，4： | 10 |
| 15 | Multivariate statistical analysis of clinicopathologic factors influencing survival of patients with bile duct carcinoma显示文摘AIM: To evaluate the influence of various clinicopathologicfactors on survival of patients with bile duct carcinoma aftercurative resection.METHODS: A retrospective analysis was made for 86 casesof bile duct carcinoma treated from January 1981 toSeptember 1995. Fifteen clinicopathologic factors possiblyinfluencing survival were selected. Independent variableswere first analyzed by univariate methods. Survival forvariable was estimated by the method of Kaplan and Meier.The variables that were statistically significant by univarlateanalysis were included in a multivariate analysis, which wereconfirmed using the Cox stepwise proportion hazard modelwith the help of SPSS 10.0 for Windows software.RESULTS: The overall cumulative survival rate was 72.6 %at 1 year, 32.4 % at 3 years, and 18.7 % at 5 years. Theresults of univariate analysis showed that the majorsignificant prognostic factors influencing survival of thesepatients were histological type of lesion, lymph nodemetastasis, pancreatic invasion, duodenal invasion, pedneuralinvasion, macroscopic vessel involvement, resected surgicalmargin and depth of cancer invasion (P=0.02, 0.02, 0.004,0.005, 0.01, 0.43, 0.03 and 0.04). Age, sex, location of tumor,size of tumor, macroscopic type of lesions, hepaticmetastasis, and hepatic invasion were not significantlyassociated with prognosis (P>0.05). Pancreatic invasion,perineural invasion and lymph node metastases were thethree most important prognostic factors by multivariateanalysis using the Cox proportional hazards model.CONCLUSION: Pancreatic invasion, pedneural invasion andlymph node metastases are the most important prognosticfactors for bile duct carcinoma after curative resection. | He, P Shi, JS Chen, WK Wang, ZR Ren, H Li, H | 2002 | World Journal of Gastroenterology2002，8，5： | 10 |
| 16 | 围术期大剂量阿托伐他汀疗法能够减少心脏手术后的急性肾损伤吗?显示文摘他汀类药物能够影响急性肾损伤(AKI)的几个环节。为了验证假说:围术期短期大剂量阿托伐他汀能够减少心脏手术后发生AKI,美国学者从2009年11月到2014年10月在范德比尔特大学医学中心进行了成人心脏手术患者的双盲、安慰剂对照的随机临床试验。 | Billings FT 4th Hendricks PA Schildcrout JS 王建中 | 2016 | 中华肾病研究电子杂志2016，5，1： | 9 |
| 17 | 小胶质细胞对星形胶质细胞的免疫和神经保护功能的调节作用(英文)显示文摘在中枢神经系统中,小胶质细胞和星形胶质细胞对神经元的发育、功能维持及细胞存活具有重要的作用。但在炎症反应过程中,星形胶质细胞增生的作用及其对神经元的影响目前并不十分清楚。因此,本研究对不同种类的细胞进行培养,给予细菌脂多糖(lipopolysaccharide,LPS)刺激,观察各种细胞的反应。结果显示,星形胶质细胞可以减轻炎症反应的神经元毒性,提示星形胶质细胞增生主要具有神经保护作用。如果去掉上清液中由星形胶质细胞分泌的胶质细胞源性神经营养因子(glial cell line-derived neurotrophic factor,GDNF),这种神经保护作用显著降低。为了研究星形胶质细胞的免疫功能,本研究培养了高浓度的星形胶质细胞,并发现LPS不能诱导肿瘤坏死因子(tumor necrosis factor,TNF)-α及诱导型一氧化氮合酶(inducible nitric oxide synthase,iN OS)/一氧化氮(nitric oxide,NO)(iN OS/NO)释放。但如果在培养的高浓度星形胶质细胞中增加0.5%~1%的小胶质细胞,则可以诱导TNF-α及iN OS/NO的释放。这提示小胶质细胞和星形胶质细胞间的相互作用对于LPS诱导星形胶质细胞释放前炎症因子及GDNF是必须的。我们还发现,小胶质细胞释放的TNF-α可以通过旁分泌作用调节星形胶质细胞的神经保护功能。综上所述,本研究结果提示星形胶质细胞可能不会直接被LPS激活,而是通过与小胶质细胞相互作用被激活,释放神经营养因子,减少因炎症反应激活的小胶质细胞释放的毒性物质对神经元的损害作用。 | Chen SH Oyarzabal EA Sung YF Chu CH Wang Q Chen SL Lu RB Hong JS 唐颖馨 | 2015 | 神经损伤与功能重建2015，10，1： | 9 |
| 18 | Improved technique of vascular anastomosis for small intestinal transplantation in rats显示文摘AIM To establish a new improved vascularanastomotic technique to simplify the surgicaltechnique and increase the survival rate of smallintestinal transplantation in rats.METHODS The graft removed en blocconsisted of entire small intestine,portal veinand aortic segment with superior mesentericartery.The graft was perfused in situ and thegut lumen was irrigated during the operation.Heterotopic small bowel transplantation wasperformed by microvascular end-to-sideanastomosis between the donor aortic segmentwith superior mesenteric artery and the recipientabdominal aorta,and by the formation of a'Cuff'anastomosis between the donor portalvein and the recipient left renal vein.Both endsof the grafts were exteriorized as stomas.RESULTS A total of 189 intestinaltransplantations were performed in rats,33 ofwhich were involved in the formal experimentalgroup,with a survival rate of 84.8%.Theaverage time for the donor surgery was 80min±10min;for graft repair 10min±3min;and forrecipient surgery 95min±15min.The averagetime for the arterial anastomosis and the veinanastomosis was 18min±5min and 1min,respectively.The warm ischemic time and coldischemic time were 22min±5min and less than60min,respectively.The whole operation wascompleted by a single surgeon,the operativetime being about 3 hours.CONCLUSION The vascular anastomosis used in this study could simplify surgical technique,reduce the operative time and elevate thesurvival rate of small intestinal transplantationin rats. | Li YX Li JS Li N | 2000 | World Journal of Gastroenterology2000，6，2： | 8 |
| 19 | Intratumoral dendritic cell vaccin ation elicits potent tumoricidal im munity against malignant glioma in rats显示文摘Dendritic cells(DC)are attractive candidates for innovative cancer immunotherapy by virtu e of their ability to function as powe rful antigen presenting cells and elicit potent antitumor cytotoxic immune r esponses.With the aim of generating antitumor immunity,the authors sought to enhance in vivo tum or antigen presentation by using an i ntratumoral DC vaccination strateg y in the setting of partially irradiated intracranial brain tumo rs.Fisher rats,implanted with 9L gliomas in the right corpus striatum,w ere treated with freshly cultured,unpulsed syngeneic DC inoculated directly into the tumor bed.Intracranially inoculated DCs were found to drain to ipsilateral deep cervical lymph nodes.This was a ssociated with increased local and s ystemic antitumor cytoxicity,as evidenced by robust infiltration of treated tumors with CD4and CD8T ce lls as well as by increased IFN-gamma protein and message levels in in vitr o restimulated splenic lymphocytes.DC therapy resulted in prolonged survival and immunity to s ubsequent intracranial tumor re-ch allenge.These results demonstrate the viability of intratumoral DC vaccination as an effectiv e therapeutic strategy for intracra nial glioma. | Ehtesham M Kabos P Gutierrez MA Samoto K Black KL Yu JS | 2003 | 癌症2003，22，7： | 8 |
| 20 | 急性脊髓损伤患者治疗的临床操作指南:关于MRI基线在临床治疗决策与结果预测中作用的几点建议(英文)显示文摘The objective of this guideline is to outline the role of magnetic resonance imaging(MRI) in clinical decision making and outcome prediction in patients with traumatic spinal cord injury(SCI).Methods A systematic review of the literature was conducted to address key questions related to the use of MRI in patients with traumatic SCI.This review focused on longitudinal studies that controlled for baseline neurologic status.A multidisciplinary Guideline Development Group(GDG) used this information,their clinical expertise,and patient input to develop recommendations on the use of MRI for SCI patients.Based on GRADE(Grading of Recommendation,Assessment,Development and Evaluation),a strong recommendation is worded as ' we recommend,' whereas a weaker recommendation is indicated by 'we suggest.' Results Based on the limited available evidence and the clinical expertise of the GDG,our recommendations were:(1) 'We suggest that MRI be performed in adult patients with acute SCI prior to surgical intervention,when feasible,to facilitate improved clinical decision-making'(quality of evidence,very low) and(2) 'We suggest that MRI should be performed in adult patients in the acute period following SCI,before or after surgical intervention,to improve prediction of neurologic outcome '(quality of evidence,low).Conclusions These guidelines should be implemented into clinical practice to improve outcomes and prognostication for patients with SCI. | Fehlings MG Martin AR Tetreault LA Aarabi B Anderson P Arnold PM Brodke D Burns AS Chiba K Dettori JR Furlan JC Hawryluk G Holly LT Howley S Jeji T Kalsi-Ryan S Kotter M Kurpad S Kwon BK Marino RJ Massicotte E Merli G Middleton JW Nakashima H Nagoshi N Palmieri K Singh A Skelly AC Tsai EC Vaccaro A Wilson JR Yee A Harrop JS | 2017 | 中华神经外科疾病研究杂志2017，16，6： | 8 |
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