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| 1 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 2 | Potentiality of Pr3+- and Pr3++Ce3+- doped crystals for tunable UV upconversion lasers 显示文摘 | Nicolas S Descroix E Joubert M F | 2003 | Opt Mater2003，22，： | 2 |
| 3 | Linear β-1,3-glucans are elicitors of defense responses in tobacco显示文摘 | KLARZYNASKI O PLESSE B JOUBERT J M | 2000 | Plant Physiology2000，124，： | 1 |
| 4 | Analysis of factors influencing post-natal growth and development of the muscle fibre 显示文摘 | Joubert D M | 1956 | Animal Science1956，47，： | 1 |
| 5 | Linear β-1,3-glucanase are elicitors of defense responses in tobacco显示文摘 | Klarzynaski O Plesse B Joubert J M | 2000 | Plant Physiol2000，124，： | 1 |
| 6 | The form drag of two-dimen- sional bluff-plates immersed in turbulent boundary layers 显示文摘 | Good M C Joubert P N | 1968 | Journal of Fluid Mechanics1968，31，3： | 1 |
| 7 | Recent trends and patterns in breast cancer incidence among Eastern and Southeastern Asian women显示文摘 | Shin HR Joubert C Boniol M | 2010 | Cancer Causes Control2010，21，11： | 1 |
| 8 | Neutron diffraction study of the ferrimagnetic ilmenite(nickel manganese oxide (NiMnO3)显示文摘 | Pernet M Joubert J C Ferrand B | 1975 | Solid State Communications1975，16，5： | 1 |
| 9 | Protein chemical modification on endogenous amino acids显示文摘 | Basl6 E Joubert N Pucheault M | 2010 | Chem Biol2010，17，3： | 1 |
| 10 | Ring-opening polymerization of caprolactone and L-lactide from silica nanoparticles surface 显示文摘 | JOUBERT M | 2004 | J Polym Sci Part A: Polym Chem2004，42，8： | 1 |
| 11 | Application of gemini surfactants as diesel fuel wax dispersants显示文摘 | Maithufi M N Joubert D J Klumperman B | 2010 | Energy Fuels2010，25，6： | 1 |
| 12 | Surface patterning of micron-sized aluminum flakes by seeded dispersion polymerization: Towards waterborne colored pigments by gold nanoparticles adsorption显示文摘 | JOUBERT M SAVE M MORNET S | 2014 | Polymer2014，55，3： | 1 |
| 13 | Linear β-1,3-glucanase are elicitors of defense responses in tobacco显示文摘 | Klarzynaski O Plesse B Joubert J M | 2000 | Plant Physiol2000，124，： | 1 |
| 14 | Job demands,job resources,burnout and work engagement of managers at a platinum mine in the North West Province显示文摘 | S ROTHMANN JOUBERT J H M | 2007 | South African Journal Of Business Management2007，38，3： | 1 |
| 15 | Linear β-1,3-glucans are elicitors of defense responses in tobacco 显示文摘 | KLARZYNASKI O PLESSE B JOUBERT J M | 2000 | Plant Physiology2000，124，： | 1 |
| 16 | Influence of phenolic compounds on Agrobacterium vir gene induction and onion gene transfer显示文摘 | Joubert P Sangwan RS Elarabiaouad M | 1995 | Phytochemistry1995，40，6： | 1 |
| 17 | Prognostic and immunohistochemical validation of the capella classification of pancreatic neumendocrine tumours:an analysis of 82 sporadic cases显示文摘 | Heymann MF Joubert M Nemeth J | 2000 | Histopathology2000，36，5： | 1 |
| 18 | Analysis of factors influencing postnatal growth and development of the muscle fiber显示文摘 | JOUBERT D M | | 0，，： | 1 |
| 19 | Use of NIRS for quantification of mangiferin and hesperidin contents of dried green honeybush ( Cyclopia genistoides ) plant material 显示文摘 | Joubert E Manley M Botha M | 2006 | J Agr Food Chem2006，54，15： | 1 |
| 20 | Identification bymass spectrometry of two-dimensional gel electrophoresis-separated proteins extracted from lager brewing yeast显示文摘 | Joubert R Strub J M Zugmeyer S | 2001 | Electrophoresis2001，22，14： | 1 |
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