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| 1 | 法国的生态博物馆显示文摘 | 阿兰·茹贝尔(Alain Joubert) 张晋平(译) | 2005 | 中国博物馆2005，，3： | 16 |
| 2 | Endoscopy-based management decreases the risk of postoperative recurrences in Crohn's disease显示文摘AIM: To investigate whether an endoscopy-based management could prevent the long-term risk of postoperative recurrence.METHODS: From the pathology department database, we retrospectively retrieved the data of all the patients operated on for Crohn's disease(CD) in our center(1986-2015). Endoscopy-based management was defined as systematic postoperative colonoscopy(median time after surgery = 9.5 mo) in patients with no clinical postoperative recurrence at the time of endoscopy. RESULTS: From 205 patients who underwent surgery, 161 patients(follow-up > 6 mo) were included. Endoscopic postoperative recurrence occurred in 67.6%, 79.7%, and 95.5% of the patients, respectively 5, 10 and 20 years after surgery. The rate of clinical postoperative recurrence was 61.4%, 75.9%, and 92.5% at 5, 10 and 20 years, respectively. The rate of surgical postoperative recurrence was 19.0%, 38.9% and 64.7%, respectively, 5, 10 and 20 years after surgery. In multivariate analysis, previous intestinal resection, prior exposure to anti-TNF therapy before surgery, and fistulizing phenotype(B3) were postoperative risk factors. Previous perianal abscess/fistula(other perianal lesions excluded), were predictive of only symptomatic recurrence. In multivariate analysis, an endoscopy-based management(n = 49/161) prevented clinical(HR = 0.4, 95%CI: 0.25-0.66, P < 0.001) and surgical postoperative recurrence(HR = 0.30, 95%CI: 0.13-0.70, P = 0.006).CONCLUSION: Endoscopy-based management should be recommended in all CD patients within the first year after surgery as it highly decreases the long-term risk of clinical recurrence and reoperation. | Anne-Laure Boucher Bruno Pereira Stéphanie Decousus Marion Goutte Felix Goutorbe Anne Dubois Johan Gagniere Corinne Borderon Juliette Joubert Denis Pezet Michel Dapoigny Pierre J Déchelotte Gilles Bommelaer Anthony Buisson | 2016 | World Journal of Gastroenterology2016，22，21： | 3 |
| 3 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 4 | Autophagy Induction by the Pathogen Receptor CD46显示文摘 | Pierre-Emmanuel Joubert Grégory Meiffren Isabel Pombo Grégoire Guillemette Pontini Clémence Richetta Monique Flacher Olga Azocar Pierre-Olivier Vidalain Marc Vidal Vincent Lotteau Patrice Codogno Chantal Rabourdin-Combe Mathias Faure | 2009 | Cell Host & Microbe2009，，4： | 2 |
| 5 | Risk factor management and depression post-stroke: The value of an integrated model of care显示文摘 | Jacques Joubert Chris Reid Lynette Joubert David Barton Denise Ruth David Jackson John O’. Sullivan Stephen M. Davis | 2005 | Journal of Clinical Neuroscience2005，，1： | 2 |
| 6 | Potentiality of Pr3+- and Pr3++Ce3+- doped crystals for tunable UV upconversion lasers 显示文摘 | Nicolas S Descroix E Joubert M F | 2003 | Opt Mater2003，22，： | 2 |
| 7 | Photon avalanche upconversion in rare earth laser materials显示文摘 | Marie-France Joubert | 1999 | Optical Materials1999，，2： | 2 |
| 8 | From ultrasoft pseudopotential to the projector augmented wave method 显示文摘 | Kress G Joubert D | 1999 | Phys Rev B1999，59，： | 1 |
| 9 | Linear β-1,3-glucans are elicitors of defense responses in tobacco显示文摘 | KLARZYNASKI O PLESSE B JOUBERT J M | 2000 | Plant Physiology2000，124，： | 1 |
| 10 | Influence of 2-methoxyestradiol on cell mor- phology and Cdc2 Kinase activity in WHC03 esophageal carcino- ma cells显示文摘 | Joubert A Marais S | 2007 | Biomed Res2007，28，1： | 1 |
| 11 | Analysis of factors influencing post-natal growth and development of the muscle fibre 显示文摘 | Joubert D M | 1956 | Animal Science1956，47，： | 1 |
| 12 | From Ultrasoft Pseudopotentials to the Projector Augmented-wave Method显示文摘 | Kresse G Joubert D | 1999 | Phys Rev B1999，59，： | 1 |
| 13 | Influence of prostagland in A2 on Bax,Bcl-2 and PCNA expression in MCF-7 cells显示文摘 | Joubert A Bianchi P Maritz C | 2006 | Biomed Res2006，27，4： | 1 |
| 14 | Cure of Fisher rats bearing :adioresistant F98 glioma treated with cis-platinum and irradiated with monochromatic synchrotron X-rays显示文摘 | Biston MC Joubert A Adam JF | 2004 | Cancer Res2004，64，7： | 1 |
| 15 | Linear β-1,3-glucanase are elicitors of defense responses in tobacco显示文摘 | Klarzynaski O Plesse B Joubert J M | 2000 | Plant Physiol2000，124，： | 1 |
| 16 | From ultrasoft pseudopotentials to the projector augmented-wave method 显示文摘 | Kresse G Joubert D | 1999 | Phys Rev1999，59，： | 1 |
| 17 | From ultrasoft pseudopotentials to the projector augmented-wave method显示文摘 | Kresse G Joubert D | 1999 | Phys Rev B1999，59，3： | 1 |
| 18 | From ultrasoft pseudopotentials to the projector augmented-wave method 显示文摘 | KRESSE G JOUBERT D | 1999 | Phys RevB1999，59，3： | 1 |
| 19 | The form drag of two-dimen- sional bluff-plates immersed in turbulent boundary layers 显示文摘 | Good M C Joubert P N | 1968 | Journal of Fluid Mechanics1968，31，3： | 1 |
| 20 | Chikungnnya virus- induced autophagy delays caspase-dependent cell death 显示文摘 | Joubert PE Wemeke SW de la Calle C | 2012 | J Exp Med2012，209，5： | 1 |
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