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| 1 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 2 | An investigation of preharvest browning of Litchi peel显示文摘 | Joubert A J Van Lelyveld L J | 1975 | Phytophylactica1975，，7： | 1 |
| 3 | Narcissism and hostility显示文摘 | Hart P L Joubert C E | 1996 | Psychological Reports1996，79，1： | 1 |
| 4 | MR elastography: Spleen stiffness measurements in healthy volunteers-preliminary experi- ence显示文摘 | Mannelli L Godfrey E Joubert I | 2010 | AJR Am J Roentgenol2010，195，2： | 1 |
| 5 | Hemagglutination by canine parvovirus: serologic studies and diagnostic application 显示文摘 | Carmichael L E Joubert J C Pollock R H | 1980 | Am J Vet Res1980，4，5： | 1 |
| 6 | Anisotropic diffraction peak broadening and dislocation substructure in hydrogen-cycled LaNi5 and substitutional derivatives显示文摘 | CERNY L JOUBERT J M LATROCHE M | 2000 | J Appl Cryst2000，33，： | 1 |
| 7 | MR elastography: spleen stiffness ts in healthy volunteers-preliminary experience显示文摘 | Mannelli L Godfrey E Joubert I | 2010 | AJR Am J Roentgenol2010，195，2： | 1 |
| 8 | Wall Thickness Evaluation of Single Crystal Hollow Turbine Blades by Eddy Current Sensor显示文摘 | Bihan Y L Joubert P Y Placko D | 2001 | NDT&E International2001，34，： | 1 |
| 9 | Continuous production of ethanol from starch using glucoamylase and yeast co-immobilized in pectin gel显示文摘 | Raquel L C Giordano Joubert Trovati Willibaldo Schmidell | 2008 | Applied Biochemistry and Biotechnology2008，147，1： | 1 |
| 10 | Hemag-glutination by canine parvovirus:serologic studies and diagnos-tic applications显示文摘 | CAMICHAEL L E JOUBERT J C POLLOCK R V | 1980 | Am J Vet Res1980，41，5： | 1 |
| 11 | Hemagglutination by canine parvovirus: serologic studies and diagnostic applications显示文摘 | Carmichael L E Joubert J C Pollock R V | 1980 | AmJ VetRes1980，41，5： | 1 |
| 12 | Improving the performance of a continuous process for the production of ethanol from starch 显示文摘 | Joubert Trovati Roberto C Giordano Raquel L C Giordano | 2009 | Applied Biochemistry and Biotechnology2009，156，1： | 1 |
| 13 | Risk factor management and depression post-stroke: the value of an integrated model of care 显示文摘 | Joubert J Reid C Joubert L | 2006 | J Clin Neurosci2006，13，1： | 1 |
| 14 | Hemagglutination by canine parvovirus: Serologic studies and diagnostic applications显示文摘 | Carmichael L E Joubert J C Pollock R V H | 1980 | American Journal of Veterinary Research1980，41，5： | 1 |
| 15 | Risk factpr management and depression post-stroke : The value of an integrated model of care显示文摘 | Joubert J Reid C Joubert L | 2006 | J Clin Nearosci2006，13，1： | 1 |
| 16 | Risk iaetor management and depression post-stroke: The value of an integrated model of care显示文摘 | Joubert J Reid C Joubert L | 2006 | J Clin Nearosci2006，13，1： | 1 |
| 17 | Dynamic stall control using deployable leading-edge vortex gene- rators显示文摘 | PAPE A L COSTES M JOUBERT G | 2012 | AIAA Journal2012，50，10： | 1 |
| 18 | The distribution and invasive potential of fountain grass Pennisetum setaceum in Namibia显示文摘 | Joubert D F Cunningham P L | 2002 | Dinteria2002，27，： | 1 |
| 19 | Planning empty container relocations under uncertainty显示文摘 | Bean W L Joubert J W | 2010 | South African Journal of Industrial Engineering2010，21，1： | 1 |
| 20 | Near Infrared Re- flectance Analysis of the Fermentation Characteris- tics of Silage Prepared by Chamical Treatment to Prevent Volatilisation of Fermentation End Prod- ucts 显示文摘 | Snyman L D Joubert H W | 1992 | Animal Feed Science and Technology1992，37，1： | 1 |
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