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| 1 | Molecular detection of Helicobacter pylori antibiotic resistance in stool vs biopsy samples显示文摘AIM To compare(1) demographics in urea breath test(UBT) vs endoscopy patients; and(2) the molecular detection of antibiotic resistance in stool vs biopsy samples.METHODS Six hundred and sixteen adult patients undergoing endoscopy or a UBT were prospectively recruited to the study. The Geno Type Helico DR assay was used to detect Helicobacter pylori(H. pylori) and antibiotic resistance using biopsy and/or stool samples from CLOpositive endoscopy patients and stool samples from UBT-positive patients. RESULTS Infection rates were significantly higher in patients referred for a UBT than endoscopy(overall rates: 33% vs 19%; treatment-na?ve patients: 33% vs 14.7%, respectively). H. pylori-infected UBT patients were younger than H. pylori-infected endoscopy patients(41.4 vs 48.4 years, respectively, P < 0.005), with a higher percentage of H. pylori-infected males in the endoscopy-compared to the UBT-cohort(52.6% vs 33.3%, P = 0.03). The Geno Type Helico DR assay was more accurate at detecting H. pylori infection using biopsy samples than stool samples [98.2%(n = 54/55) vs 80.3%(n =53/66), P < 0.005]. Subset analysis using stool and biopsy samples from CLO-positive endoscopy patients revealed a higher detection rate ofresistance-associated mutations using stool samples compared to biopsies. The concordance rates between stool and biopsy samples for the detection of H. pylori DNA, clarithromycin and fluoroquinolone resistance were just 85%, 53% and 35%, respectively. CONCLUSION Differences between endoscopy and UBT patients provide a rationale for non-invasive detection of H. pylori antibiotic resistance. However, the Geno Type Helico DR assay is an unsuitable approach. | Denise E Brennan Joseph Omorogbe Mary Hussey Donal Tighe Grainne Holleran Colm O'Morain Sinéad M Smith Deirdre McNamara | 2016 | World Journal of Gastroenterology2016，22，41： | 6 |
| 2 | Drug-drug interactions between antithrombotic medications and the risk of gastrointestinal bleeding显示文摘 | Joseph AD Lucie O James MB | 2007 | CMAJ2007，177，4： | 1 |
| 3 | Drug interactions between antithrombotic medications and the risk of gastrointestinal bleeding 显示文摘 | Joseph AD Lucie O James MB | 2007 | CMAJ2007，177，4： | 1 |
| 4 | Three -dimensionalobservations of swarms of Antarctic krill (Euphausia superba)made using a multi-beam echosounder显示文摘 | Martin JC Joseph DW David AD | 2010 | Deep Sea ResearchPart II:Topical Studies in Oceanography2010，57，78： | 1 |
| 5 | FDA drug approval summary: pegaspargase (Oncaspar) for the first-llne treatment of children with acute lymphoblastic leukemia (ALL) 显示文摘 | PATRICIA AD JOSEPH G MARTIN HC | 2007 | The Oncologist2007，12，8： | 1 |
| 6 | FDA drug approval summa- ry: pegaspargase (oneaspar) for the first-Line treatment of children with acute lymphob|astic leukemia (ALL) 显示文摘 | Patricia AD Joseph G Cohen MH | 2007 | The Oncologist2007，12，8： | 1 |
| 7 | Drug-drug interactions between anti thrombotic medications and the risk of gastrointestinal bleeding显示文摘 | Joseph AD Lucie 0 James MB | 2007 | CMAJ2007，177，4： | 1 |
| 8 | High phosphate diet-induced primary hyperparathyroidism:an animal model显示文摘 | Steven AD Raymond O | 1991 | Surgery1991，110，2： | 1 |
| 9 | Comparative distribution of neuropeptide Y Y1 and Y5 receptors in the rat brain by using immunohistochemistry 显示文摘 | Wolak ML De Joseph MR Cator AD | 2003 | J Comp Neurol2003，464，3： | 1 |
| 10 | Minimally invasive saphenous vein harvesting:endothelial integrity and early clinical results显示文摘 | David GC Joseph AD Eric AP | 1998 | Ann Thorac Surg1998，66，： | 1 |
| 11 | Leadership effects on organizational climate and financial performance: Local leadership effect in chain organizations 显示文摘 | Bas A S Koene Ad L W Vogelaarb Joseph L Soetersb | 2002 | The Leadership Quarterly2002，13，3： | 1 |
| 12 | Many class lintegrons omprise distinct stable structures occurring in different species of enterobacteriaceae isolated from widespread geographic region in Europe显示文摘 | Pedro Martinez Freijo AD C Fluit Franz Joseph Achmitz | 1999 | Antimirobial Agents and Chemotherapy1999，43，： | 1 |
| 13 | Blood transfusions in children:a multi-institutional analysis of practices and complications显示文摘 | Slonim AD Joseph JG Turenne WM | 2008 | Transfusion2008，48，1： | 1 |
| 14 | Tapestry: A resilient global - scale overlay for service deployment显示文摘 | Zhao BY Huang L Stribling J Rhea SC Joseph AD Kubiatowicz J | 2004 | IEEE Journal on Selected Areas in Communications2004，22，1： | 1 |
| 15 | FDA drug app- roval summary: pegaspargase (oncaspar) for the first- line treatment of children with acute lymphoblastic leuke- mia (ALL)显示文摘 | Patricia AD Joseph G Martin HC | 2007 | The Oncologist2007，12，8： | 1 |
| 16 | Doxorubicin-induced apoptosis:implication in cardiotoxicity显示文摘 | Kalyanaraman B Joseph J Kalvedis AD | 2002 | Mon Cell Biochem2002，234，2： | 1 |
| 17 | Comparative ropeptide YY1 and distribution of neu- Y5 receptors in the rat brain by using immunohistoehemis try显示文摘 | Wolak ML De Joseph MR Cator AD | 2003 | J Comp Neurol2003，464，： | 1 |
| 18 | Insect immunity:Isolation from the lepidopteran Heliothis virescens of a novel insect defensin with potent antifungal activity显示文摘 | Ades S Uttenweiler Joseph S | 1999 | J Biol Chem1999，274，14： | 1 |
| 19 | Hybrid Intraoperative Pulmo- nary Artery Stent Placement for Congenital Heart Disease 显示文摘 | Shaji CM Frank C Joseph AD | 2008 | Am J Cardio12008，102，12： | 1 |
| 20 | Experimental investigation of adhesive-based self-healing of cementitious materials显示文摘 | JOSEPH C JEFFERSON AD ISAACS B LARK R GARDNER D | 2010 | Mag Concrete Research2010，62，11： | 1 |
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