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| 1 | Metastatic type 1 gastric carcinoid:A real threat or just a myth?显示文摘AIM:To describe disease characteristics and treatment modalities in a group of rare patients with metastatic gastric carcinoid type 1(GCA1).METHODS:Information on clinical,biochemical,radiological,histopathological findings,the extent of the disease,as well as the use of different therapeutic modalities and the long-term outcome were recorded.Patients’data were assessed at presentation,and thereafter at 6 to 12 monthly intervals both clinically and biochemically,but also endoscopically and histopathologically.Patients were evaluated for the presence of specific symptoms;the presence of autoimmune disorders and the presence of other gastrointestinal malignancies in other family members were also recorded.The evaluation of response to treatment was defined using established WHO criteria.RESULTS:We studied twenty consecutive patients with a mean age of 55.1 years.The mean follow-up period was 83 mo.Twelve patients had regional lymph node metastases and 8 patients had liver metastases.The primary tumor mean diameter was 20.13±10.83mm(mean±SD).The mean Ki-67 index was 6.8%±11.2%.All but one patient underwent endoscopic or surgical excision of the tumor.The disease was stable in all but 3 patients who had progressive liver disease.All patients remained alive during the follow-up period.CONCLUSION:Metastatic GCA1 carries a good overall prognosis,being related to a tumor size of≥1 cm,an elevated Ki-67 index and high serum gastrin levels. | Simona Grozinsky-Glasberg Dimitrios Thomas Jonathan R Strosberg Ulrich-Frank Pape Stephan Felder Apostolos V Tsolakis Krystallenia I Alexandraki Merav Fraenkel Leonard Saiegh Petachia Reissman Gregory Kaltsas David J Gross | 2013 | World Journal of Gastroenterology2013，19，46： | 11 |
| 2 | Sessile serrated adenomas:Demographic,endoscopic and pathological characteristics显示文摘AIM:To study the demographic and endoscopic characteristics of patients with sessile serrated adenoma(SSA) in a single center.METHODS:Patients with SSA were identified by review of the pathology database of Mayo Clinic Arizona from 2005 to 2007.A retrospective chart review was performed to extract data on demographics,polyp characteristics,presence of synchronous adenomatous polyps or cancer,polypectomy methods,and related complications.RESULTS:One hundred and seventy-one(2.9%) of all patients undergoing colonoscopy had a total of 226 SSAs.The mean(SE) size of the SSAs was 8.1(0.4) mm;42% of SSAs were ≤ 5 mm,and 69% were ≤ 9 mm.Fifty-one per cent of SSAs were located in the cecum or ascending colon.Approximately half of the patients had synchronous polyps of other histological types,including hyperplastic and adenomatous polyps.Synchronous adenocarcinoma was present in seven(4%) cases.Ninety-seven percent of polyps were removed by colonoscopy.CONCLUSION:Among patients with colon polyps,2.9% were found to have SSAs.Most of the SSAs were located in the right side and were safely managed by colonoscopy. | Suryakanth R Gurudu Russell I Heigh Giovanni De Petris Evelyn G Heigh Jonathan A Leighton Shabana F Pasha Isaac B Malagon Ananya Das | 2010 | World Journal of Gastroenterology2010，16，27： | 7 |
| 3 | Increased presence of effector lymphocytes during Helicobacter hepaticus-induced colitis显示文摘AIM:To identify and characterize drosophila mothers against decapentaplegic(SMAD)3-dependent changes in immune cell populations following infection with Helicobacter hepaticus(H.hepaticus).METHODS:SMAD3 -/-(n=19)and colitis-resistant SMAD3+/-(n=24)mice(8-10 wk of age)were in-fected with H.hepaticus and changes in immune cell populations[T lymphocytes,natural killer(NK)cells,T regulatory cells]were measured in the spleen and mesenteric lymph nodes(MsLNs)at 0 d,3 d,7 d and 28 d post-infection using flow cytometry.Genotypedependent changes in T lymphocytes and granzyme B+ cells were also assessed after 28 d in proximal colon tissue using immunohistochemistry.RESULTS:As previously observed,SMAD3 -/-,but not SMAD3+/-mice,developed colitis,peaking at 4 wk post-infection.No significant changes in T cell subsets were observed in the spleen or in the MsLNs between genotypes at any time point.However,CD4+and CD8+/ CD62Llo cells,an effector T lymphocyte population,as well as NK cells(NKp46/DX5+)were significantly higher in the MsLNs of SMAD3-/-mice at 7 d and 28 d post-infection.In the colon,a higher number of CD3+cells were present in SMAD3-/-compared to SMAD3+/-mice at baseline,which did not significantly change during infection.However,the number of granzyme B+cells,a marker of cytolytic lymphocytes,significantly increased in SMAD3-/-mice 28 d post-infection compared to both SMAD3+/-mice and to baseline values.This was consistent with more severe colitis development in these animals.CONCLUSION:Data suggest that defects in SMAD3 signaling increase susceptibility to H.hepaticus-induced colitis through aberrant activation and/or dysregulation of effector lymphocytes. | Sarah J McCaskey Elizabeth A Rondini Jonathan F Clinthorne Ingeborg M Langohr Elizabeth M Gardner Jenifer I Fenton | 2012 | World Journal of Gastroenterology2012，18，13： | 2 |
| 4 | Strategies to tackle the challenges of external beam radiotherapy for liver tumors显示文摘Primary and metastatic liver cancer is an increasingly common and difficult to control disease entity.Radiation offers a non-invasive treatment alternative for these patients who often have few options and a poor prognosis.However,the anatomy and aggressiveness of liver cancer poses significant challenges such as accurate localization at simulation and treatment,management of motion and appropriate selection of dose regimen.This article aims to review the options available and provide information for the practical implementation and/or improvement of liver cancer radiation programs within the context of stereotactic body radiotherapy and image-guided radiotherapy guidelines.Specific patient inclusion and exclusion criteria are presented given the significant toxicity found in certain sub-populations treated with radiation.Indeed,certain sub-populations,such as those with tumor thrombosis or those with larger lesions treated with transarterial chemoembolization,have been shown to have significant improvements in outcome with the addition of radiation and merit special consideration.Implementing a liver radiation programrequires three primary challenges to be addressed:(1) immobilization and motion management;(2) localization;and(3) dose regimen and constraint selection.Strategies to deal with motion include simple internal target volume(ITV) expansions,non-gated ITV reduction strategies,breath hold methods,and surrogate marker methods to enable gating or tracking.Localization of the tumor and organs-at-risk are addressed using contrast infusion techniques to take advantage of different normal liver and cancer vascular anatomy,imaging modalities,and margin management.Finally,a dose response has been demonstrated and dose regimens appear to be converging.A more uniform approach to treatment in terms of technique,dose selection and patient selection will allow us to study liver radiation in larger and,hopefully,multicenter randomized studies. | Michael I Lock Jonathan Klein Hans T Chung Joseph M Herman Edward Y Kim William Small Nina A Mayr Simon S Lo | 2017 | World Journal of Hepatology2017，9，14： | 2 |
| 5 | Concordance between functional magnetic resonance imaging and introperative language mapping显示文摘 | MAXIMILIAN I R JONATHAN D V SYED H | 1999 | Stereotact Funct Neurosurg1999，72，4： | 1 |
| 6 | Using CALPUFF to evaluate the impacts of power plant emissions in illinois:model sensitivity and implications 显示文摘 | JONATHAN I L JOHN D S DENNIS H D | 2002 | Atmospheric Environment2002，36，： | 1 |
| 7 | Early versus late Gamma Knife radiosurgery following transsphenoidal resection for nonfunc- tioning pituitary macroadenomas:a matched cohort study 显示文摘 | Pomeraniec BS Jonathan I Robert F | 2015 | J Neu- rosurg2015，123，4： | 1 |
| 8 | Cumulus cells are required for the increased apoptotic potential in oocytes of aged mice显示文摘 | Gloria I Perez Jonathan L | 1997 | Human Reproduction1997，12，： | 1 |
| 9 | Technology Integration: Turning Great Research into Great Products 显示文摘 | MARCO I Jonathan W | 1997 | Harvard Business Review1997，75，36： | 1 |
| 10 | Changes in pore size distribution upon thermal cycling of TATB-based explosives measured by ultra-small angle X-Ray scattering显示文摘 | Trevor M W Tony van B Jonathan R I L | 2006 | Propellants Explosives Pyrotechnics2006，31，6： | 1 |
| 11 | Stress treatments and ficoll for improving green plant regeneration in triticale anther culture 显示文摘 | Sirkka I Jonathan R | 2000 | Plant Science2000，150，： | 1 |
| 12 | Decimation of Triangle Meshes 显示文摘 | William J Schroeder Jonathan A Zarge William E I orens- en | 1992 | ACM SIGGRAPH Computer Graphics1992，26，2： | 1 |
| 13 | Stress treatments and ficoll for improving green plant regeneration in triticale anther culture 显示文摘 | Sirkka I Jonathan R | 2000 | Crop Science2000，40，： | 1 |
| 14 | A common genetic basis in sweet corn inbred cr1 for cross sensitivi- ty to multiple cytochrome P450-metabolized herbicides 显示文摘 | Jonathan N N Martin M Williams I I | 2008 | Weed Science2008，56，： | 1 |
| 15 | Syn-thesis and characterization of Sr2MgMo06_s : an anodematerial for the solid oxide fuel cell 显示文摘 | Huang Yunhui Ronald I Dass Jonathan C Denyszyn | 2006 | ElectrochemSoc2006，153，7： | 1 |
| 16 | Early warning of rainfall-induced shallow landslides and debris flows in the USA 显示文摘 | REX I B JONATHAN W G | 2010 | Landslides2010，7，： | 1 |
| 17 | Reactive navigation and opportunistic localization for autonomous underground mining vehicles 显示文摘 | Jonathan M R Elliot S D Peter I C | 2002 | Information Sciences2002，145，： | 1 |
| 18 | The prognostic value of endogenous hypoxia - related markers for head and neck squamous cell carcinomas treated with ARCON 显示文摘 | JONATHAN R A WIJFFELS K I PEETERS W | 2006 | Radiother Oncol2006，79，3： | 1 |
| 19 | Management of helicotylenchus multicinctus in sugarcane with intercrops and organic amendments nematol显示文摘 | Jonathan E I Gajendran G Manuel W W | 1999 | Medit1999，27，： | 1 |
| 20 | Immunohistochemical analysis of bcl-2, bax, bcl-x and mcl-1 expression in prostate cancers显示文摘 | Krajewska M Krajewski S Jonathan I | 1996 | Am J Pathol1996，148，： | 1 |
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