| 1 | Risk prediction models for biochemical recurrence after radical prostatectomy using prostate-specific antigen and Gleason score显示文摘为预言前列腺癌症的风险的许多计算机模型被开发了为生物化学的复发(BCR ) 的预言包括。然而,在一个 BCR 免费时期是稀罕的以后,在单个时间点为单个 BCR 免费概率当模特儿。从经历了 laparoscopic 激进分子前列腺切除术( LRP )的 1656 个病人的后续数据被用来模型使用开发一个人工的神经网络( ANN )预言 BCR 并且把它与逻辑回归( LR )作比较临床、病理学的参数,前列腺特定的抗原( PSA ),边缘地位( R0/1 ),病理学的阶段(磅),和格利森分数( GS )。为在在操作,另外的 ANN,和 LR 以后的任何给定的时间的单个 BCR 预言,模型每 6 个月被计算多达 7.5 年后续。在为 ANN (0.754 ) 和 LR 的操作特征(巨鸟) 曲线(AUC ) 建模的接收装置(0.755 ) 下面的区域计算了立即后面的 LRP,为 GS 比那大(AUC:0.715;P = 0.0015 和 0.001 ) ,磅或 PSA (AUC:0.619;P 总是 < 0.0001 ) 独自一个。GS 比 PSA 更好预言了 BCR (P = 0.0001 ) ,但是 ANN 和 LR 模型之间没有差别(P = 0.39 ) 。我们的 ANN 和 LR 模型从激进的前列腺切除术预言了单个 BCR 风险多达 10 年手术后。ANN 和 LR 模型同等地并且显著地独自与 PSA 和 GS 相比改进了 BCR 的预言。当 GS 和 ANN 产量价值被联合时,更精确的 BCR 预言是可能的,特别在有 GS ≥ 的高风险的病人; 7。 | Xin-Hai Hu Henning Cammann Hellmuth-A Meyer Klaus Jung Hong-Biao Lu Natalia Levas Ahmed Magheli Carsten Stephan Jonas Busch | 2014 | Asian Journal of Andrology2014，16，6： | 2 |
| 2 | Sports activity patterns and cardio-metabolic health over time among adults in Germany: Results of a nationwide 12-year follow-up study显示文摘Background:Physical activity is favorable for health,and vigorous sports activity is particularly beneficial.This study investigates the association between changes in sports participation patterns over time and cardio-metabolic and self-perceived health outcomes.Methods:Data from 3752 adults(18-79 years of age)who participated in 2 national health interview and examination surveys in 1997-1999 and 2008-2011 were included,with a mean follow-up time of about 12 years.A change in self-reported sports activity was analyzed with respect to the incidence of type 2 diabetes,coronary heart disease(CHD),hypertension,obesity,dyslipidemia,metabolic syndrome,and poor self-perceived health.Participants with pre-existing disease or risk factor of interest at baseline were excluded from the analysis.Being sufficiently active in sports was specified as doing sports for at least 1-2 h per week,and 4 activity categories were defined:1)inactive at both time points(inactive-inactive),2)inactive at baseline and active at follow-up(inactive-active),3)active at baseline and inactive at follow-up(active-inactive),and 4)active at both time points(active-active).Associations between sports activity engagement and health outcomes were estimated by logistic regression models with different stages of adjustments.Results:Not engaging in any regular sports activity at both time points(inactive-inactive)was associated with higher rates of type 2 diabetes(odds ratio(OR)=1.82,95%confidence interval(95%CI):1.08-3.08),CHD(OR=1.82,95%CI:1.16-2.84),hypertension(OR=1.36,95%CI:1.03-1.81),metabolic syndrome(OR=1.58,95%CI:1.08-2.32),and poor self-perceived health(OR=2.54,95%CI:1.83-3.53)compared to doing regular sports for a minimum of 1-2 h per week over time(active-active).In case of change from inactivity to any regular sports activity(inactive-active),the rate of risk factor occurrence was not statistically different from the active-active reference group except for poor self-perceived health,but it was higher for type 2 diabetes(OR=2.15,95%CI:1.12-4.14)and CHD(OR=1.77,95%CI:1.03-3.03).Being active at baseline but inactive at follow-up(active-inactive)was not associated with higher disease incidence of type 2 diabetes(OR=0.70,95%CI:0.25-1.97)or CHD(OR=1.20,95%CI:0.49-2.99),but was associated with higher rates of hypertension(OR=1.61,95%CI:1.11-2.34),obesity(OR=2.34,95%CI:1.53-3.57),metabolic syndrome(OR=1.70,95%CI:1.11-2.63),and poor self-perceived health(OR=2.16,95%CI:1.53-3.07)at follow-up.Conclusion:Even a low weekly quantity(1-2 h)of regular sports activity is partly associated with health benefits.Being formerly but not currently active was not associated with an increased disease incidence,but was associated with a higher risk-factor development compared to the reference group(active-active).Becoming active was preventive for risk-factor development but was not preventive for disease incidence,which probably means that the health benefits from sports activity are not sustainable and disease incidence is only shifted to a later period in life.For this reason,the promotion of and commitment to regular sports activity should be addressed as early as possible over the lifespan to achieve the best health benefits. | Lars Gabrys Jens Baumert Christin Heidemann Markus Busch Jonas David Finger | 2021 | Journal of Sport and Health Science2021，10，4： | 1 |
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