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| 1 | 美国临床肿瘤学会IV期非小细胞肺癌化疗的临床实践指南更新显示文摘本文旨在为IV期非小细胞肺癌患者的治疗提供更新版推荐。本文资料检索源自2002年以来公布的相关随机试验文献。此指南范围限于化疗与生物治疗。更新委员会对这些文献进行了总结并提供了推荐更新。162篇文献符合标准被纳入参考。本推荐基于可改善总生存期的治疗方法。仅改善无进展生存期的治疗方法推动了对毒性及生存质量的监测。对于体力状态评分为0分或1分患者的一线治疗,可推荐以铂类为基础的细胞毒性药物的两药联用。对铂类治疗有禁忌的患者,可采用非铂类细胞毒性两药联合。对于体力状态评分为2分的患者,单一细胞毒性药物即可。对于疾病进展或经过4个周期的治疗仍对治疗无反应的患者,应停止一线细胞毒性化疗。即使在6个周期后患者对治疗仍有反应,亦应停止两药细胞毒性化疗。对于伴有明确的表皮生长因子受体(epidermal growth factor receptor,EGFR)突变的患者,可推荐一线采用吉非替尼治疗;对于EGFR突变为阴性或不明确的患者,细胞毒性化疗更佳。除具有特定临床特征的患者外,可推荐贝伐单抗与卡铂-紫杉醇联用。对于通过免疫组化证实EGFR阳性的肿瘤患者,可推荐西妥昔单抗与顺铂-长春瑞滨联用。多西紫杉醇、厄洛替尼、吉非替尼或培美曲塞被推荐作为二线治疗。对于未曾接受过厄洛替尼或吉非替尼治疗的患者,可推荐厄洛替尼作为三线治疗。现有数据不足以推荐常规三线采用细胞毒性药物。已有的证据也不足以推荐常规应用分子标记物选择化疗。 | Christopher G. AZZOLI Sherman Baker JR Sarah TEMIN William PAO Timothy ALIFF Julie BRAHMER David H. JOHNSON Janessa L. LASKIN Gregory MASTERS Daniel MILTON Luke NORDQUIST David G. PFISTER Steven PIANTADOSI Joan H. SCHILLER Reily SMITH Thomas J. SMITH John R. STRAWN David TRENT Giuseppe GIACCONE 丁燕(翻译) 南娟(翻译) 刘谦(翻译) 周清华(校对) 陈军(校对) | 2010 | 中国肺癌杂志2010，13，3： | 43 |
| 2 | Neuronal apoptosis: Current understanding of molecular mechanisms and potential role in ischemic brain injury显示文摘 | Johnson EM Jr Greenlund LJ Akins PT | 1995 | J Neurotrauma1995，12，84： | 2 |
| 3 | Spectral reflectance response to nitrogen fertilization in field grown corn显示文摘This study was carried out to analyze the spectral reflectance response of different nitrogen levels for corn crops.Four different nitrogen treatments of 0%,80%,100%and 120%BMP(best management practice)were studied.Principal component analysis-loading(PCA-loading)was used to identify the effective wavelengths.Partial least squares(PLS)and multiple linear regression(MLR)models were built to predict different nitrogen values.Vegetation indices(VIs)were calculated and then used to build more prediction models.Both full and selected wavelengths-based models showed similar prediction trends.The overall PLS model obtained the coefficient of determination(R^(2))of 0.6535 with a root mean square error(RMSE)of 0.2681 in the prediction set.The selected wavelengths for overall MLR model obtained the R^(2) of 0.6735 and RMSE of 0.3457 in the prediction set.The results showed that the wavelengths in visible and near infrared region(350-1000 nm)performed better than the two either spectral regions(1001-1350/1425-1800 nm and 2000-2400 nm).For each data set,the wavelengths around 555 nm and 730 nm were identified to be the most important to predict nitrogen rates.The vogelmann red edge index 2(VOG 2)performed the best among all VIs.It demonstrated that spectral reflectance has the potential to be used for analyzing nitrogen response in corn. | Chuanqi Xie Ce Yang Alexander Hummel Jr Gregg A Johnson Forrest T Izuno | 2018 | International Journal of Agricultural and Biological Engineering2018，11，4： | 2 |
| 4 | Status of caustic and emulsion methods 显示文摘 | Johnson Jr C E | 1976 | JPetTechnol1976，28，1： | 1 |
| 5 | Single case evaluation of the effects of aromatherapy and mas- sage on disturbed behaviour in severe dementia 显示文摘 | Brooker D JR Snape M Johnson E | 1997 | BrJ Clin Psychol1997，36，2： | 1 |
| 6 | Common dihydrofolate reductase 19-base pair deletion allele:a novel risk factor for preterm delivery显示文摘 | Johnson WG Scholl TO Spychala JR | | 0，，03： | 1 |
| 7 | Expression and possible function of nerve growth factor receptors on Schwann cells显示文摘 | EM Johnson Jr Taniuchi M | 1988 | Trends Neurosci1988，11，7： | 1 |
| 8 | An open-label extension study to investigate the long-term safety and tolerability of THC/CBD oromucosal spray and oromucosal THC spray in patients with terminal cancer-related pain refractory to strong opioid analgesics显示文摘 | Johnson JR Lossignol D Burnell- Nugent M | | J Pain Symptom Manage0，46，2： | 1 |
| 9 | FDA drug ap- proval summaries:Pemetrexed(Alimta)显示文摘 | Hazarika M White RM Johnson JR | 2004 | Oncologist2004，9，5： | 1 |
| 10 | Reaction of o-phthalaldehyde and thiols with primary amines: formation of 1-alkyl(and aryl) thio-2-alkylisoindoles显示文摘 | Simons JR S Johnson D F | 1978 | J Org Chem1978，43，14： | 1 |
| 11 | Conflicts between Gibbsian thermodynamics and recent treatments of interfacial energies in solid liquid-vapor system显示文摘 | JOHNSON R E JR | 1959 | Journal of Physical Chemistry1959，，63： | 1 |
| 12 | An empirical analysis of the integration-responsiveness framework : US construction equipment industry firms in global competition 显示文摘 | Johnson J H Jr | 1995 | Journal of International Business Studies1995，26，3： | 1 |
| 13 | Analysis of the primary and compensatory curvatures following Zielk instrumentation for idiopathic scoliosis显示文摘 | Johnson JR Ostermann PA | 1989 | Spine1989，14，： | 1 |
| 14 | Conflicts between Gibbsian thermodynamics and recent lxeztmants of interfaclal energies in solid-liquid-vapor system显示文摘 | Johnson R E Jr | 1959 | Journal of Physical Chemistry1959，63，： | 1 |
| 15 | ACL tibial remnant, to save or not 显示文摘 | Junkin DM Jr Johnson DL | 2008 | Orthopedics2008，2，： | 1 |
| 16 | Neurturin and GDNF promote proliferation and survival of enteric neuro- nand glial progenitors in vitro 显示文摘 | Heuckeroth RO Lampe PA Johnson Jr EM | 1998 | Dev Biol1998，200，： | 1 |
| 17 | Antimicrobial drug-resistant Escherichia coli from humans and poultry products, Minnesota and Wisconsin, 2002- 2004显示文摘 | Johnson JR Sannes MR Croy C | 2007 | Emerg Infect Dis2007，13，6： | 1 |
| 18 | Information loss over time defines the memory defect of propofol:a comparative response with thiopental and dexmedetomidine显示文摘 | Veselis R A Reinsel R A Feshchenko V A Johnson R Jr | 2004 | Anesthesiology2004，101，4： | 1 |
| 19 | Estimation of the flow of microbial nitrogen to the duodenum using milk uric acid or allantoin 显示文摘 | TIMMERMANS S J Jr JOHNSON L M HARRISON J H | 2000 | Journal of Dairy Science2000，83，： | 1 |
| 20 | Information content in the circular dichroism of proteins显示文摘 | HENNESSEY J P JOHNSON W C Jr | 1981 | Biochemistry1981，20，5： | 1 |
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