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| 1 | Stages at presentation,prognostic factors,and outcome of breast cancer in males显示文摘 | John MD Jun SY | 1999 | The American J Surg1999，177，5： | 1 |
| 2 | Practice variability in manament of transient ischemic attacks 显示文摘 | John ston SC Smith WS | 1999 | Eur Neurol1999，42，： | 1 |
| 3 | PCR Detection and serological evidence of Granulocytic Ehrlichial infection in Roe deer and chamois 显示文摘 | Jorge SL John WS Kurt P | 2002 | J Clin Microbiol2002，40，： | 1 |
| 4 | PCR detection of Granulocytic Ehrlichiae in Izodes riclnus ticks and wild small mammals in western Switzerlan 显示文摘 | Jorge SL Laurence A John WS | 2000 | J Clin Microbiol2000，38，： | 1 |
| 5 | Risk factors for severe respiratory syncytial virus disease in Children with cancer: the importance of lymphopenia and young age 显示文摘 | Chadi ME Grant WS John PD | 2008 | Pediatrics2008，121，2： | 1 |
| 6 | Vertebral fractufts andmortality in olderwomen:a prospective study显示文摘 | John Steinmann Browner WS Palermo L | 2005 | Arch Intern Med2005，159，6： | 1 |
| 7 | Diagnosis of human Ehrlichia by PCR assay of acute-phase serum显示文摘 | James AC William LN John WS | 1999 | J Clin Microbiol1999，37，： | 1 |
| 8 | Prevalence and patterns oftooth agenesis among Malay children 显示文摘 | Mani SA Mohsin WS John J | 2014 | Southeast Asian J Trop Med Public Health2014，45，2： | 1 |
| 9 | A soft-Tissue approach to midfacial hypoplasia associated with treacher collins syndrome显示文摘 | Pierre S Patrick LR John WS | 2006 | Ann Plast Surg2006，56，5： | 1 |
| 10 | Corneal toxicity of propamidine显示文摘 | Johns KJ Head WS O’Day DM | 1988 | Arch Ophthalmol1988，106，1： | 1 |
| 11 | Acute and reversible cardiomyopathy provoked by stress in women from the united States显示文摘 | Scott WS John RL Andrey GZ | 2005 | Circulation2005，111，： | 1 |
| 12 | Acute and reversible cardiomyopathy provoked by stress in women from the United States显示文摘 | Scott WS John RL Andrey GZ | 2005 | Circulation2005，111，： | 1 |
| 13 | Identification, cloning, and exoression of a functional phenylalanyl-tRNA Synthetase (pheRS) from Staphylococcus aureus显示文摘 | John WS Martin H Emma JJ | 2001 | Protein Expression and Purification2001，21，3： | 1 |
| 14 | Early diagnosis of retiopentoneal necrotizing fasciitis 显示文摘 | John PP Edward P Charles WS | 2001 | Crit Care Med2001，29，5： | 1 |
| 15 | Genetics and phenotyping in chron-ic sinusitis显示文摘 | Spencer CP Larry B John WS | 2011 | J Aller Clin Immunol2011，128，4： | 1 |
| 16 | 14-Isoestrone methyl ether and its identity with totally synthetic material显示文摘 | Johnson WS Johns WF | 1957 | J Org Chem1957，79，4： | 1 |
| 17 | Chronic leptin infusion increases arterial pressure显示文摘 | Eugene WS Michael WB John EH | 1998 | Hypertension1998，31，2： | 1 |
| 18 | Mandibular arch perimeter changes with lip bumper threatment显示文摘 | OSBORN WS ANDERSON JU JOHN STONE | 1991 | Am J Orthod Dentofacial Orthop1991，999，5： | 1 |
| 19 | Stages at presentation,prognostic factors,and outcome of breast cancer in males显示文摘 | Vetto WS John MD Jun SY | 1999 | The American J Surg1999，177，5： | 1 |
| 20 | Chemokine receptor 8 expression may be linked to disease severity and elevated interleukin 6 secretion in acute pancreatitis显示文摘BACKGROUND Acute pancreatitis(AP)is an inflammatory disease,which presents with epigastric pain and is clinically diagnosed by amylase and lipase three times the upper limit of normal.The 2012 Atlanta classification stratifies the severity of AP as one of three risk categories namely,mild AP(MAP),moderately severe AP(MSAP),and severe AP(SAP).Challenges in stratifying AP upon diagnosis suggest that a better understanding of the underlying complex pathophysiology may be beneficial.AIM To identify the role of the chemokine receptor 8(CCR8),expressed by T-helper type-2 Lymphocytes and peritoneal macrophages,and its possible association to Interleukin(IL)-6 and AP stratification.METHODS This study was a prospective case-control study.A total of 40 patients were recruited from the Chris Hani Baragwanath Academic Hospital and the Charlotte Maxeke Johannesburg Academic Hospital.Bioassays were performed on 29 patients(14 MAP,11 MSAP,and 4 SAP)and 6 healthy controls as part of a preliminary study.A total of 12 mL of blood samples were collected at Day(D)1,3,5,and 7 post epigastric pain.Using multiplex immunoassay panels,real-time polymerase chain reaction(qRT-PCR)arrays,and multicolour flow cytometry analysis,immune response-related proteins,genes,and cells were profiled respectively.GraphPad Prism^(TM) software and fold change(FC)analysis was used to determine differences between the groups.P<0.05 was considered significant.RESULTS The concentration of IL-6 was significantly different at D3 post epigastric pain in both the MAP group and MSAP group with P=0.001 and P=0.013 respectively,in a multiplex assay.When a FC of 2 was applied to identify differentially expressed genes using RT2 Profiler,CCR8 was shown to increase steadily with disease severity from MAP(1.33),MSAP(38.28)to SAP(1172.45)median FC.Further verification studies using RT-PCR showed fold change increases of CCR8 in MSAP and SAP ranging from 1000 to 1000000 times when represented as Log10,compared to healthy control respectively at D3.The findings also showed differing lymphocyte and monocyte cell frequency between the groups.With monocyte population frequency as high as 70%in MSAP at D3.CONCLUSION The higher levels of CCR8 and IL-6 in the severe patients and immune cell differences compared to MAP and controls provide an avenue for exploring AP stratification to improve management. | Mwangala Nalisa Ekene Emmanuel Nweke Martin D Smith Jones Omoshoro-Jones John WS Devar Rebecca Metzger Tanya N Augustine Pascaline N Fru | 2021 | World Journal of Gastrointestinal Pathophysiology2021，12，6： | 1 |
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