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| 1 | Antimicrobial peptides and the gut microbiome in inflammatory bowel disease显示文摘Antimicrobial peptides(AMP)are highly diverse and dynamic molecules that are expressed by specific intestinal epithelial cells,Paneth cells,as well as immune cells in the gastrointestinal(GI)tract.They play critical roles in maintaining tolerance to gut microbiota and protecting against enteric infections.Given that disruptions in tolerance to commensal microbiota and loss of barrier function play major roles in the pathogenesis of inflammatory bowel disease(IBD)and converge on the function of AMP,the significance of AMP as potential biomarkers and novel therapeutic targets in IBD have been increasingly recognized in recent years.In this frontier article,we discuss the function and mechanisms of AMP in the GI tract,examine the interaction of AMP with the gut microbiome,explore the role of AMP in the pathogenesis of IBD,and review translational applications of AMP in patients with IBD. | John Gubatan Derek R Holman Christopher J Puntasecca Danielle Polevoi Samuel JS Rubin Stephan Rogalla | 2021 | World Journal of Gastroenterology2021，27，43： | 3 |
| 2 | 接受最佳治疗的高危血管病患者中C反应蛋白对脂蛋白(a)相关心血管病风险的影响显示文摘脂蛋白(a)是动脉粥样硬化性心血管病的遗传致病危险因素,但目前还不清楚哪些动脉粥样硬化性心血管病患者从脂蛋白(a)降低中受益最大。在二级预防中炎症是否会调节与脂蛋白(a)相关的心血管病风险也未知。该文旨在确定在接受最佳治疗的高危心血管病患者中,脂蛋白(a)相关的心血管病风险是否受到全身炎症的调节。 | 周卫(译) 刘莉(摘/审校) Puri R Nissen SE Arsenault BJ St John J Riesmeyer JS Ruotolo G McErlean E Menon V Cho L Wolski K Lincoff AM Nicholls SJ | 2020 | 中华高血压杂志2020，28，11： | 1 |
| 3 | Baseline characteristics of patients in the treatment of preserved eardiac function heart failure with an aldosterone antagonist trial显示文摘 | Sanjiv JS John FH Nancy KS | 2013 | Circulation Heart Failure2013，6，： | 1 |
| 4 | Modulation of interleukin-1beta and tumor necrosis factor alpha signaling by P2 purinergic receptors in human fetal astrocytes显示文摘 | John GR | 2000 | J Neurosci2000，20，14： | 1 |
| 5 | Biomechanical analysisof facet and graft loading in a Smith-Robinson type cervical spinemodel显示文摘 | John MO Timothy AG Michael JS | 1994 | Spine1994，19，16： | 1 |
| 6 | H5 avian and H9 swine influenza virus haemagglutinin structures:possible origin of influenza subtypes 显示文摘 | David JS John JS | 2002 | EMBO J2002，21，5： | 1 |
| 7 | Mitochondrial permeability transition:a common pathway to necrosis and apoptosis显示文摘 | Kim JS He L John J | 2003 | Biochem Biophys Res Commun2003，304，3： | 1 |
| 8 | Treatment of non-small ceil Lung cancer stage I and stage II ACCP evidence-based clin- ical practice guidelines (2nd Edition) 显示文摘 | Walter JS John H Steven F | 2007 | Chest2007，132，3： | 1 |
| 9 | IFITM3 inhibits influenza A virus infection by preventing cytosolic entry显示文摘 | Feeley EM Sims JS John SP | 2011 | PLoS Pathog2011，7，10： | 1 |
| 10 | Survey of vaginal floracandida species isolates from women of different age group byuse of species-specific PCR detection显示文摘 | John PV Matthew JS Sean GC | 2008 | Journa of Clini-cal Microbiology2008，46，4： | 1 |
| 11 | Imbalance between xanthine oxidase and nitric oxide synthase signaling pathways underlies mechanoenergetic uncoupling in the failing heart显示文摘 | Saavedra WF Paolocci N St John ME Skaf MW Stewart GC Xie JS | 2002 | Circ Res2002，90，： | 1 |
| 12 | IFITM3 inhibits influenza A virus infection by preventing cytosolic entry 显示文摘 | Feeley EM Sims JS John SP | 2011 | PLoS Pathog2011，7，10： | 1 |
| 13 | H5 avian and H9 swine influenza virus haemagglutinin structures:possible origin of influenza subtypes显示文摘 | HA Y STEVEN DJ JOHN JS | 2002 | EMBO J2002，21，： | 1 |
| 14 | The amyloid hypothesis of alzhemier's disease progress and problems on the road to therapeutics显示文摘 | Dennis JS | 2002 | Science2002，297，： | 1 |
| 15 | Breast and ovarian cancer in relatives of cancer patients,with and without BRCA niutations显示文摘 | Lee JS John EM Mc Guire V | 2006 | Cancer Epidemiol Biomarkers Prev2006，15，2： | 1 |
| 16 | Baseline characteristics of patients in the treatment of preserved cardiac function heart failure with an aldosterone antagonist trial显示文摘 | Sanjiv JS John FH Nancy KS | 2013 | Circulation Heart Failure2013，6，： | 1 |
| 17 | Modular architecture and novel protein protein interactions regulating the RGS-eontaining rho guanine nucleotide exchange factors 显示文摘 | Jose VP John B Gutkind JS | 2004 | Methods in Enzymology2004，390，： | 1 |
| 18 | The pharmacodynamics of cisatracurium in healthy adults显示文摘 | John JS Hugh D Hermann M | 1996 | Curr Opinion Anesthesiol1996，9，1： | 1 |
| 19 | Structural Snapshots of Human HDAC8 ProvideInsights into the Class I His- tone Deacetylases显示文摘 | John RS Robert JS Bradley AK Clifford M Joseph DH Andy JJ Christine L Andrew A Joseph JB Ellen C Jie T Bi CS Erik V Robert W Ellen ML Douglas RD Gyorgy S Marc N Mark WK Ronald VS Duncan EM and Leslie WT | 2004 | Structure2004，12，： | 1 |
| 20 | Size-specific dose estimates (SSDE) in pediatric and adult body CT examinations显示文摘 | John MB Keith JS Dianna DC | 2011 | Report of AAPM TG2011，204，： | 1 |
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