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| 1 | Poxue Huayu and Tianjing Busui Decoction for cerebral hemorrhage Upregulation of neurotrophic factor expression显示文摘This study established a rat model of cerebral hemorrhage by injecting autologous anticoagulated blood.Rat models were intragastrically administered 5,10,20 g/kg Poxue Huayu and Tianjing Busui Decoction,supplemented with Hirudo,raw rhubarb,raw Pollen Typhae,gadfly,Fructrs Trichosanthis,Radix Notoginseng,Rhizoma Acori Talarinowii,and glue of tortoise plastron,once a day,for 14 consecutive days.Results demonstrated that brain water content significantly reduced in rats with cerebral hemorrhage,and intracerebral hematoma volume markedly reduced after treatment.Immunohistochemical staining revealed that brain-derived neurotrophic factor,tyrosine kinase B and vascular endothelial growth factor expression noticeably increased around the surrounding hematoma.Reverse transcription-PCR revealed that brain-derived neurotrophic factor and tyrosine kinase B mRNA expression significantly increased around the surrounding hematoma.Neurologic impairment obviously reduced.These results indicated that Poxue Huayu and Tianjing Busui Decoction exert therapeutic effects on cerebral hemorrhage by upregulating the expression of brain-derived neurotrophic factor. | Jixiang Ren Xiangyu Zhou Jian Wang Jianjun Zhao Pengguo Zhang | 2013 | Neural Regeneration Research2013，8，22： | 19 |
| 2 | Porous graphene:Properties,preparation,and potential applications显示文摘Graphene has recently emerged as an important and exciting material.Inspired by its outstanding properties,many researchers have extensively studied graphene-related materials both experimentally and theoretically.Porous graphene is a collection of graphene-related materials with nanopores in the plane.Porous graphene exhibits properties distinct from those of graphene,and it has widespread potential applications in various fields such as gas separation,hydrogen storage,DNA sequencing,and supercapacitors.In this review,we summarize recent progress in studies of the properties,preparation,and potential applications of porous graphene,and show that porous graphene is a promising material with great potential for future development. | XU PengTao YANG JiXiang WANG KeSai ZHOU Zhen SHEN PanWen | 2012 | Chinese Science Bulletin2012，57，23： | 18 |
| 3 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 4 | Influence and mechanism of N-(3-oxooxtanoyl)-L-homoserine lactone(C_8-oxo-HSL) on biofilm behaviors at early stage显示文摘N-acyl-homoserines quenching,enzymatic quenching of bacterial quorum sensing,has recently applied to mitigate biofilm in membrane bioreactor.However,the effect of AHLs on the behavior of biofilm formation is still sparse.In this study,Pseudomonas aeruginosa biofilm was formed on ultra-filtration membrane under a series of N-(3-oxooxtanoyl)-L-homoserine lactone(C8-oxo-HSL)concentrations.Diffusing C8-oxo-HSL increased the growth rate of cells on biofilm where the concentration of C8-oxo-HSL was over 10-7g/L.The C8-oxo-HSL gradient had no observable influence on cell density and extracellular polymeric substances of biofilm with over 10-7g/L C8-oxo-HSL.Surprisingly,10-11-10-8g/L of C8-oxo-HSL had no effect on cell growth in liquid culture.The cell analysis demonstrated that the quorum sensing system might enhance the growth of neighboring cells in contact with surfaces into biofilm and may influence the structure and organization of biofilm. | Siqing Xia Lijie Zhou Zhiqiang Zhang Jixiang Li | 2012 | Journal of Environmental Sciences2012，24，12： | 4 |
| 5 | Loss of ARID1A Promotes Hepatocellular Carcinoma Progression via Up-regulation of MYC Transcription显示文摘Background and Aims:AT-rich interactive domain-containing protein 1A(ARID1A)is frequently mutated or deficient in hepatocellular carcinoma(HCC).However,the role of ARID1A in HCC remains unclear.Therefore,the biological role of ARID1A in HCC was evaluated and a potential mechanism was investigated.Methods:Arid1a was knocked out in the livers of mice using the CRISPR/Cas9 system delivered by hydrodynamic tail vein injection.The development of HCC was observed in different mouse models.The correlation of ARID1A and prognosis in patients with HCC was analyzed using cBioPortal.The effect of ARID1A on cell proliferation was assessed by MTT assay following the manipulation of candidate genes.Results:ARID1A deficiency alone did not cause HCC in mice,but knockout of ARID1A accelerated liver tumorigenesis in response to diethylnitrosamine(DEN)or when a combination knockout of phosphatase and tensin homolog(Pten)plus tumor protein P53(p53)was introduced.ARID1A mutations were associated with a poorer prognosis in HCC patients.The mRNA level of MYC was significantly higher in patients with an ARID1A mutation compared to those without a mutation.Ectopic expression of ARID1A inhibited HCC cell proliferation.ARID1A knockout increased HCC cell growth and resulted in disruptions to DNA damage repair and apoptosis following radiation stress.Furthermore,mechanistic studies revealed that ARID1A inhibited the proliferation of HCC cells via transcriptional down-regulation of MYC.Conclusions:These results describe ARID1A as a tumor suppressor in the liver.A deficiency in ARID1A predicts worse survival in HCC patients and promotes HCC progression via up-regulation of MYC transcription. | Yao Xiao Guodong Liu Xiwu Ouyang Denggao Zai Jixiang Zhou Xiaoli Li Qi Zhang Jie Zhao | 2021 | Journal of Clinical and Translational Hepatology2021，9，4： | 2 |
| 6 | The feasibility of using soil seed bank for natural regeneration of degraded sandy grasslands显示文摘Desertification in degraded grasslands is manifested through the development of bare sandy patches,which eventually lead to habitat fragmentation.The ability of these bare sandy patches to regenerate naturally through in-situ soil seed banks is not well understood.To fill this knowledge gap,we randomly selected 24 bare sandy patches with areas ranging from 19 to 898 m^(2) in a desertified grassland of the Horqin sandy land,Northern China to determine whether soil seed bank can be used for natural regeneration of bare sandy patches.Species composition and density of soil seed bank as well as aboveground vegetation composition,abundance and coverage were investigated.We then determined their relationships with in-situ habitat characteristics.Our observations showed that the studied area had low soil seed bank density and species richness,as well as depauperate soil seed bank communities.Consequently,local soil seed bank was not able to provide sufficient seed source for natural regeneration.This was indicated by the relationships between aboveground vegetation,soil seed bank and the in-situ habitat characteristics.For bare patches with an area between 300 m^(2) and 900 m^(2),increase the soil seed bank density and species richness should be the main restoration measures.For bare patches with a small area of less than 50 m^(2),restoration of vegetation density should be the main measure.Our data highlighted that different extents of desertification,indicated by different bare patches,are requiring distinct restoration measures. | Yongcui Wang Lei Chu Zhimin Liu MuSa Ala Jixiang Lin Jianqiang Qian Quanlai Zhou Lixin Wang | 2022 | International Soil and Water Conservation Research2022，10，3： | 1 |
| 7 | Field Efficacy Trial and Optimum Control Period of Rice False Smut(Ustilaginoidea virens) in Single Cropping Middle-late Rice显示文摘[Objective]The paper was to study optimum chemical agents and control periods against rice false smut( Ustilaginoidea virens) in single cropping middle-late rice. [Method]Taking chemical agents( triadimefon,armure,Jinggangmycin) as main treatments and spraying periods( within 7 d before initial heading stage,within 7 d before initial heading stage + initial heading stage,initial heading stage) as assisted treatments,the field efficacy trial and optimum control period of U. virens in single cropping middle-late rice were studied using Huanghuazhan and Jinnongsimiao as experimental materials in 2013. [Result] Three chemical agents,triadimefon,armure,Jinggangmycin,extremely reduced diseased panicle rate and disease index of U. virens,but there was no significant difference among three chemical agents. Spraying period did not have significant impact on diseased panicle rate and disease index of U. virens,whereas spraying within7 d before initial heading stage and during initial heading stage had relatively good control effect. Yield increased significantly after application of three chemical agents,and armure led to greater increase. The reason for yield increase was that seed setting rate was significantly increased,and the number of filled grains per panicle was significantly increased. Although spraying period influenced yield,the difference was not significant. [Conclusion] Triadimefon,armure and Jinggangmycin had good control effects against U. virens in single cropping middle-late rice,of which armure had better control effects. Spraying chemical agents increased seed setting rate,and further increased the number of filled grains per panicle and yield. Spraying within 7 d before initial heading stage and during initial heading stage had relatively better control effect against U. virens. | Liu Huaizhen Li Kanghuo Huang Qing Lu Xiuming Zhang Bin Li Huifeng Zou Jixiang Zhou Shaochuan | 2014 | Plant Diseases and Pests2014，5，2： | 1 |
| 8 | Optical Fiber Magnetic Field Sensors with TbDyFe Magnetostrictive Thin Films as Sensing Materials显示文摘 | Yang Minghong Dai Jixiang Zhou Ciming | 2009 | Opt Express2009，17，20： | 1 |
| 9 | The application of artificial intelligence and radiomics in lung cancer显示文摘Lung cancer is one of the most leading causes of death throughout the world,and there is an urgent requirement for the precision medical management of it.Artificial intelligence(AI)consisting of numerous advanced techniques has been widely applied in the field of medical care.Meanwhile,radiomics based on traditional machine learning also does a great job in mining information through medical images.With the integration of AI and radiomics,great progress has been made in the early diagnosis,specific characterization,and prognosis of lung cancer,which has aroused attention all over the world.In this study,we give a brief review of the current application of AI and radiomics for precision medical management in lung cancer. | Yaojie Zhou Xiuyuan Xu Lujia Song Chengdi Wang Jixiang Guo Zhang Yi Weimin Li | 2020 | Precision Clinical Medicine2020，3，3： | 1 |
| 10 | Sulforaphane inhibits mammary adipogenesis by targeting adipose mesenchymal stem cells显示文摘 | Qinglin Li Jixiang Xia Yuan Yao Da-wei Gong Hongfei Shi Qun Zhou | 2013 | Breast Cancer Research and Treatment2013，，2： | 1 |
| 11 | Isolation of an antifungal Paenibacillus strain HT16 from locusts and purification of its medium-dependent antagonistic component显示文摘 | ZHOU Wenwen HUANG Jixiang NIU Tiangui | 2008 | Journal of Applied Microbiology2008，105，： | 1 |
| 12 | Study on Transparent Glass-ceramic显示文摘 | Han Jianjun Liu Jixiang MaoYulan Zhou Xuedong | 1997 | Journal of Wuhan University of Technology1997，19，4： | 1 |
| 13 | KLF4 facilitates chromatin accessibility remodeling in porcine early embryos显示文摘Chromatin accessibility remodeling driven by pioneer factors is critical for the development of early embryos.Current studies have illustrated several pioneer factors as being important for agricultural animals,but what are the pioneer factors and how the pioneer factors remodel the chromatin accessibility in porcine early embryos is not clear.By employing low-input DNase-seq(liDNase-seq),we profiled the landscapes of chromatin accessibility in porcine early embryos and uncovered a unique chromatin accessibility reprogramming pattern during porcine preimplantation development.Our data revealed that KLF4 played critical roles in remodeling chromatin accessibility in porcine early embryos.Knocking down of KLF4 led to the reduction of chromatin accessibility in early embryos,whereas KLF4 overexpression promoted the chromatin openness in porcine blastocysts.Furthermore,KLF4 deficiency resulted in mitochondrial dysfunction and developmental failure of porcine embryos.In addition,we found that overexpression of KLF4 in blastocysts promoted lipid droplet accumulation,whereas knockdown of KLF4 disrupted this process.Taken together,our study revealed the chromatin accessibility dynamics and identified KLF4 as a key regulator in chromatin accessibility and cellular metabolism during porcine preimplantation embryo development. | Wei Zhu Guowei Bu Ruifeng Hu Jixiang Zhang Lianyong Qiao Kai Zhou Tingting Wang Qiao Li Jingjing Zhang Linhui Wu Yali Xie Taotao Hu Shichun Yang Jiaqi Guan Xiaoyu Chu Juanjuan Shi Xia Zhang Falong Lu Xin Liu Yi-Liang Miao | 2024 | Science China(Life Sciences)2024，67，1： | 0 |
| 14 | Conceptual carbon-reduction process design and quantitative sustainable assessment for concentrating high purity ethylene from wasted refinery gas显示文摘The direct emission of waste refinery gas after combustion will cause a severe greenhouse effect.Recovering high-value-added ethylene from wasted refinery gas has fundamental economic and environmental significance. Due to the complexity of the composition of refinery waste gas, designing and optimizing the whole recovery process is still a challenging task. Herein, a novel process(SCOAS) was proposed to obtain polymer-grade ethylene from wasted refinery gas through a direct separation process,and heat pump-assisted thermal integration optimization(HPSCOAS) was carried out. The unique feature of the novel approach is that a new stripper and ethylene reabsorber follow the dry gas absorber to ensure ethylene recovery and methane content. An industrial model, shallow cooling oil absorption(SCOA), and concentration combined cold separation system of ethylene unit using wasted refinery gas was established to analyze the technology and environment. Based on the detailed process modeling and simulation results, the quantitative sustainability assessment of economy and environment based on product life cycle process is carried out. The results show that compared with the traditional process when the same product is obtained, the total annual cost of the HPSCOAS process is the lowest, which is 15.4% lower than that of the SCOA process and 6.1% lower than that of the SCOAS process. In addition,compared with the SCOA process and the HPSCOAS process, the SCOAS process has more environmental advantages. The non-renewable energy consumed by SCOAS is reduced by about 24.8% and 6.1%, respectively. The CO_(2) equivalent is reduced by about 38.6% and 23.7%. | Jixiang Liu Xin Zhou Gengfei Yang Hui Zhao Zhibo Zhang Xiang Feng Hao Yan Yibin Liu Xiaobo Chen Chaohe Yang | 2023 | Chinese Journal of Chemical Engineering2023，57，5： | 0 |
| 15 | Scalar curvatures in almost Hermitian geometry and some applications显示文摘On an almost Hermitian manifold, there are two Hermitian scalar curvatures associated with a canonical Hermitian connection. In this paper, two explicit formulas on these two scalar curvatures are obtained in terms of the Riemannian scalar curvature, norms of the components of the covariant derivative of the fundamental 2-form with respect to the Levi-Civita connection, and the codifferential of the Lee form. Then we use them to get characterization results of the K?hler metric, the balanced metric, the locally conformal K?hler metric or the k-Gauduchon metric. As corollaries, we show partial results related to a problem given by Lejmi and Upmeier(2020) and a conjecture by Angella et al.(2018). | Jixiang Fu Xianchao Zhou | 2022 | Science China Mathematics2022，65，12： | 0 |
| 16 | Chemical Weeding in Dry Direct Seeding Fields of Single Cropping Middlelate Rice显示文摘Chemical weeding in dry direct seeding fields of single cropping middle-late rice was studied in Huida vegetable farm of Huizhou City in 2012. The main treatment was herbicide( pretilachlor + bensulfuron-methyl,Yangguo and butachlor),and the sub-treatment was application method( soil treatments,seedling treatment and integrated treatment). The results showed that 80 g pretilachlor + bensulfuron-methyl( 36% pretilachlor + 4% bensulfuron-methyl) diluted with 50 kg water could be sprayed or 200 g Yangguo( 23. 9% butachlor + 1. 1% bensulfuron-methyl) mixed with 15 kg sandy soil could be broadcasted per 667 m2 on the sowing day or the second day under moist condition of soil,which could effectively control weeds in dry direct seeding fields of single cropping middle-late rice. | Liu Huaizhen Li Kanghuo Huang Qing Lu Xiuming Zhang Bin Li Huifen Zou Jixiang Zhou Shaochuan | 2014 | Plant Diseases and Pests2014，5，3： | 0 |
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