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| 1 | Predictive values of multidetector-row computed tomography combined with serum tumor biomarkers in preoperative lymph node metastasis of gastric cancer显示文摘Objective: Multidetector-row computed tomography(MDCT) and serum tumor biomarkers are commonly used to evaluate the preoperative lymph node metastasis and the clinical staging of gastric cancer(GC). This study intends to evaluate the clinical predictive value of MDCT and serum tumor biomarkers in lymph node metastasis of GC.Methods: The clinicopathologic data of 445 GC patients who underwent radical gastrectomy were retrospectively analyzed to evaluate the diagnostic value of MDCT and serum tumor biomarkers in lymph node metastatic staging of GC before surgery.Results: With the multinomial logistic regression analysis, the independent relative factors of lymph node metastasis of GC were identified as tumor size, depth of tumor invasion, vessel invasion, vascular embolus, and soft tissue invasion. The optimal critical value of the short diameter of lymph nodes detected by MDCT scanning for evaluation of preoperative lymph node metastasis was 6.0 mm, with 75.7% as predictive accuracy of lymph node metastasis compared to the postoperative pathological results of GC patients. In addition, the critical value of the short diameter of lymph nodes combined with serum tumor biomarkers [including carbohydrate antigen(CA)-724 and CA-199] could show an enhancement of predictive sensitivity of lymph node metastasis(up to 89.3%) before surgery.Conclusions: MDCT combined with serum tumor biomarkers should be adopted to improve preoperative sensitivity and accuracy of lymph node metastasis for GC patients. | Huihui Bai Jingyu Deng Nannan Zhang Huifang Liu Wenting He Jinyuan Liu Han Liang | 2019 | Chinese Journal of Cancer Research2019，31，3： | 11 |
| 2 | High Velocity Electric Arc Sprayed Fe-Al-Nb-B Composite Coating and Its Wear Behavior显示文摘A type of Fe-Al-Nb-B cored wire was designed and the coating was prepared using a robot-based electric wire arc spraying process. The Fe-Al binary cored wire and coating were also prepared as comparison. The phase composition and structure of the coatings were investigated using X-ray diffraction (XRD), scanning electron microscopy (SEM) coupled with energy dispersive X-ray spectroscopy (EDS) and transmission electron microscopy (TEM). The coating tribological properties were evaluated with the micromotion wear tester under different conditions. The results show that, although typical lamellar structure was performed for both the arc sprayed Fe-Al-Nb-B coating and Fe-Al coating, the structure composition, mechanical and wear properties of the former are quite different from those of latter. The Fe-Al-Nb-B coating is a typical composite coating, which is distributed inhomogeneously with α-Fe crystalline, FeAl and Fe 3 Al intermetallics, amorphous and nanocrystallines as well as locally existed oxide phases. As a result, the mircrohardness and wear resistance of the Fe-Al-Nb-B composite coating increased significantly. Finally the mechanism of the coating wear resistant behavior was discussed based on the experimental results such as friction coefficient, two dimensional and three dimensional worn surface profiles. | Yongxiong CHEN Xiubing LIANG Jinyuan BAI Binshi XU | 2013 | Acta Metallurgica Sinica(English Letters)2013，26，3： | 4 |
| 3 | Multiplex imaging reveals the architecture of the tumor immune microenvironment显示文摘The tumor immune microenvironment(TME)is composed of a variety of components,such as tumor cells,immune cells,and the extracellular matrix.The TME has been studied through transcriptomic,proteomic,metabolomic,and phosphoproteomic approaches,which have provided researchers with a wealth of TME-related molecular information. | Junlei Zhang Jinyuan Song Jianpeng Sheng Xueli Bai Tingbo Liang | 2021 | Cancer Biology & Medicine2021，18，4： | 2 |
| 4 | Quantitative estimation and spatial reconstruction of urban and rural construction land in Jiangsu Province, 1820-1985显示文摘Land cover is the most evident landscape signal to characterize the influence of human activities on terrestrial ecosystems.Since the industrial revolution,the expansion of construction land has profoundly changed the status of land use coverage and changes.This study is proposed to reconstruct the spatial pattern of construction land(urban construction land and rural settlement land)for five historical periods over the past 200 years in Jiangsu Province with 200 m′200 m grids on the basis of quantitative estimation.Urban construction land is estimated based on data about city walls,four gates along walls,and other socio-economic factors.Rural settlement land is calculated based on the rural population and per capita housing allowance.The spatial pattern of historical construction land is simulated based on the distribution of modern construction land in 1985 with a quantitative-boundarysuitability control method and thorough consideration over connectivity of different land use types.The study concludes that:(1)the amount of construction land in Jiangsu Province is estimated at 963.46 km^2 in 1820,1043.46 km^2 in 1911,1672.40 km^2 in 1936,1980.34 km^2 in1952 and 10,687.20 km^2 in 1985;and(2)the spatial distribution of construction land features the great proclivity to water bodies and main roads and the strong polarization of existent residence.The results are verified directly and indirectly by applying the trend verification of construction land changes and patterns,the correlation analysis between rural settlement land and local arable land,and quantitative accuracy test of the reconstructed construction land to actual historical survey maps covering four sample regions in 1936. | XIE Jinyuan JIN Xiaobin LIN Yinan CHENG Yinong YANG Xuhong BAI Qing ZHOU Yinkang | 2017 | Journal of Geographical Sciences2017，27，10： | 1 |
| 5 | Synergetic treatment of oxygen microcapsules and lenvatinib for enhanced therapy of HCC by alleviating hypoxia condition and activating anti-tumor immunity显示文摘Hypoxia is a typical characteristic of hepatocellular carcinoma(HCC), which causes tremendous obstacles to tumor treatments. Current first-line treatment may further deteriorate tumor hypoxia. For example,Lenvatinib, a receptor tyrosine kinase inhibitor(RTKI), suppresses tumor growth via blocking vascular endothelial growth factor(VEGF) signaling, and can also inhibit angiogenesis, thus limiting oxygen supply to tumor sites. Therefore, alleviating tumor microenvironment(TME) hypoxia holds great potential for enhancing the therapeutic effect of RTKI. Here, nanoparticle-stabilized oxygen microcapsules, a stable and biocompatible oxygen-loaded delivery system, are successfully prepared through interfacial polymerization of polydopamine nanoparticles. The microcapsules with a large loading capacity of oxygen in the core show excellent bioavailability and dispersity, which could effectively improve the hypoxic TME when they serve as oxygen delivery vehicles. Synergetic treatments of Lenvatinib and oxygen microcapsules could induce the transition of “cold tumor” in an immune-suppressed state to “hot tumor” in an immune-activated state by improving tumor hypoxic TME and reducing angiogenesis in HCC. It is revealed that combined treatments of oxygen microcapsules and Lenvatinib could polarize tumor-associated macrophages(TAMs) to anti-tumor M1 cells and activate T cell-mediated anti-tumor immune responses.The results suggest that synergetic therapy using oxygen microcapsules and Lenvatinib could alleviate the hypoxic TME and enhance the therapeutic performance of RTKI, demonstrating a promising anti-tumor strategy for enhanced therapy of HCC. | Jianpeng Sheng Jiangchao Wu Xianghong Yin Zhu Sun Xun Wang Junlei Zhang Jianghui Tang Yongtao Ji Jinyuan Song Xiaobao Wei Lin Wang Yaxing Zhao Hui Zhang Taohong Li Qi Zhang Xueli Bai Li Chen Dong Chen Tingbo Liang | 2023 | Chinese Chemical Letters2023，34，4： | 0 |
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