|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Segmentation of Hematoxylin-Eosin stained breast cancer histopathological images based on pixel-wise SVM classifier显示文摘Hematoxylin-Eosin(HE) staining is the routine diagnostic method for breast cancer(BC), and large amounts of HE stained histopathological images are available for analysis. It is emergent to develop computational methods to efficiently and objectively analyze these images, with the aim of providing potentially better diagnostic and prognostic information for BC. This work focuses on analyzing our in-house HE stained histopathological images of breast cancer tissues. Since tumor nests(TNs) and stroma morphological characteristics can reflect the biological behaviors of breast invasive ductal carcinoma(IDC), accurate segmentation of TNs and the stroma is the first step towards the subsequent quantitative analysis. We first propose a method based on the pixel-wise support vector machine(SVM) classifier for segmenting TNs and the stroma, then extract four morphological characters related to the TNs from the images and investigate their relationships with the patients' 8-year disease free survival(8-DFS). The evaluation result shows that the classification based segmentation method is able to distinguish between TNs and stroma with 87.1% accuracy and 80.2% precision,suggesting that the proposed method is promising in segmenting HE stained IDC histopathological images. The Kaplan-Meier survival curves show that three morphological characters(number of TNs, total perimeter, and average area of TNs) in the images have statistical correlations with 8-DFS of the patients, illustrating that the segmented images can help to identify new morphological factors in IDC TNs for the prediction of BC prognosis. | QU AiPing CHEN JiaMei WANG LinWei YUAN JingPing YANG Fang XIANG QingMing MASKEY Ninu YANG GuiFang LIU Juan LI Yan | 2015 | Science China(Information Sciences)2015，58，9： | 12 |
| 2 | Magnetostriction of Pseudobinary Compounds Pr_(0.15)Tb_xDy_(0.85-x)Fe_2(x=0 to 0.85)显示文摘The compound ingots of Pr0.15TbxDy0.85-xFe2 (x=0 to 0.85) were prepared by arc melting in a water Cu boat using arc furnace under a purified Ar atmosphere. Appropriate annealing (850℃, 100 h) can obtain single Laves phase compound. The magnetostriction for these systems will rise obviously when partially substituted Tb or Dy by Pr. | Yangxian LI and Jingping QU (Hebei University of Technology, Tianjin 300130, China) Chengchun TANG, Guangheng WU and Wenshan ZHAN (State Key Laboratory for Magnetism, Institute of Physics, CAS, BeiJing 100080, China) | 2000 | Journal of Materials Science & Technology2000，16，6： | 2 |
| 3 | A convenient method to reduce hydroxyl-substituted aromatic carboxylic acid with NaBH 4 /Me 2 SO 4 /B(OMe) 3显示文摘 | Yuhan Zhou Guchao Gao Hui Li Jingping Qu | 2008 | Tetrahedron Letters2008，，20： | 1 |
| 4 | Palladium-catalyzed stereoselective trifluoromethylated allylic alkylation of 3-substituted oxindoles显示文摘An efficient catalytic methodology for trifluoromethylated allylic alkylation of 3-substituted oxindoles usingα-(trifluoromethyl)alkenyl acetates as the trifluoromethyl-containing allylic alkylation partner is described.The reaction proceeds smoothly with the incorporation of Pd(OAc)_(2) and(R)-BINAP,affording various functionalized trifluoromethyl-containing 3,3’-disubstituted oxindoles with high yields and good enantioselectivities. | Dong Li Shuaibo Zhang Bangzhong Wang Wuding Sun Jinfeng Zhao Jingping Qu Yuhan Zhou | 2022 | Organic Chemistry Frontiers2022，9，3： | 0 |
| 5 | Synthesis,characterization and reactivity of thiolate-bridged cobalt-iron and ruthenium-iron complexes显示文摘Thiolate-bridged hetero-bimetallic complexes[Cp^(*)M(MeCN)N_(2)S_(2)FeCl][PF_(6)](2,M=Ru;3,M=Co,Cp^(*)=η^(5)-C_(5)Me_(5),N_(2)S_(2)=N,N'-dimethyl-3,6-diazanonane-1,8-dithiolate)were prepared by self-assembly of dimer[N_(2)S_(2)Fe]2 with mononuclear precursor[Cp^(*)Ru(MeCN)_(3)][PF_(6)]or[Cp^(*)Co(MeCN)_(3)][PF_(6)]_(2)in the presence of CHCl_(3)as a chloride donor.Complexes 2 and 3 exhibit obviously different redox behaviors investigated by cyclic voltammetry and spin density distributions supported by DFT calculations.Notably,iron-cobalt complex 3 possesses versatile reactivities that cannot be achieved for complex 2.In the presence of CoCp_(2),complex 3 can undergo one-electron reduction to generate a stable formally Co^(II)Fe^(II)complex[Cp^(*)CoN_(2)S_(2)FeCl](4).Besides,the terminal chloride on the iron center in 3 can be removed by dehalogenation agent AgPF_(6)or exchanged with azide to afford the corresponding complexes[Cp^(*)Co(MeCN)N_(2)S_(2)Fe(MeCN)][PF_(6)]_(2)(5)and[Cp^(*)Co(MeCN)N_(2)S_(2)Fe(N_(3))][PF_(6)](6).In addition,complexes 2,3 and 4 show distinct catalytic reactivity toward the disproportionation of hydrazine into ammonia.These results may be helpful to understand the vital role of the heterometal in some catalytic transformations promoted by heteromultinuclear complexes. | Chao Guo Linan Su Dawei Yang Baomin Wang Jingping Qu | 2022 | Chinese Chemical Letters2022，33，1： | 0 |
| 6 | Enantioselective Synthesis ofα-Alkenylatedγ-Lactam Enabled by Ni-Catalyzed 1,4-Arylcarbamoylation of 1,3-Dienes显示文摘The facile construction of chiral quaternaryα-alkenylated pyrrolidinones is a long-term challenge in organic synthesis.The asymmetric difunctionalization of 1,3-dienes represents the most compelling tool for assembling alkenylated compounds by regioselective 1,2-or 1,4-difunctionalization.Nevertheless,the manipulation of unactivated 1,3-dienes to forge the quarternary stereogenic center still remains largely underdeveloped.Herein,we disclose a nickelcatalyzed asymmetric 1,4-arylcarbamoylation of unactivated 1,3-dienes tethered on carbamoyl fluoride with readily available arylboronic acids,providing rapid access to the enantioenrichedα-alkenylated pyrrolidinones bearing the quaternary stereogenic center in high yields with broad functional group tolerance.Moreover,this chiral ligand-controlled asymmetric transformation overcomes the intrinsic substrate control with a preexisting chiral center. | Feng He Liting Hou Xianqing Wu Haojie Ding Jingping Qu Yifeng Chen | 2023 | CCS Chemistry2023，5，2： | 0 |
| 7 | Pd-catalyzed diastereoselective 1,1-diarylation of 1,1-disubstituted alkenes enabling the modular synthesis of 1,1,2,2-tetraarylethanes显示文摘The highly diastereoselective dicarbofunctionalization of substituted olefins still remains a daunting challenge in synthetic chemistry.Herein,we report a Pd-catalyzed diastereoselective 1,1-diarylation of 1,1-diarylethylene with chelation group free to enable the modular synthesis of smart material candidates,1,1,2,2-tetraarylethanes(TAEs),which represent the first protocol by assembling four different aryl groups into ethane motif.Preliminary mechanistic experiments suggest that the crucial Pd–H species generated in situ do not disengage from the alkene intermediate during the reaction. | Chengxi Zhang Yang Xi Jingping Qu Yifeng Chen | 2023 | Science China Chemistry2023，66，12： | 0 |
| 8 | Nickel/Quinim Enabled Asymmetric Carbamoyl-Acylation of Unactivated Alkenes显示文摘Transition metal-catalyzed difunctionalization of tethered alkene has emerged as a prevailing tool for the expedient construction of synthetically valuable cyclic compounds.However,most efforts have been devoted to the reaction of styrene-type substrates due to their rigid scaffold and high reactivity.With respect to the difunctionalization of nonaromatic tethered olefin,especially the mono-substituted alkene,still remains largely underdeveloped.Herein,we disclose a nickel/Quinim complex and TBADT-cocatalyzed asymmetric carbamoyl-acylation of unactivated alkene tethered on nonaromatic carbamoyl chlorides with diverse aldehydes.The reaction exhibits broad substrate scope with good functional group tolerance,as well as high reaction efficiency and enantioselectivity.Both monosubstituted and 1,1-substituted alkenes can work well with either aliphatic or aromatic aldehydes under the current protocol,providing convenient access to an array of medicinally useful chiralγ-lactams derivatives bearing a convertible acyl functionality.This reaction showcases more application possibilities of the chiral Quinim ligand in the future asymmetric catalytic transformations. | Xianqing Wu Haiyan Li Feng He Jingping Qu Yifeng Chen | 2023 | Chinese Journal of Chemistry2023，41，14： | 0 |
| 9 | Construction of a low-valent thiolate-bridged dicobalt platform and its reactivity toward hydrogen activation and evolution显示文摘Low-valence transition metallic complexes have drawn longstanding attention due to their high reactivity toward catalytic transformation of various small molecules.Among these known complexes,the low-valence metal centres are commonly stabilized by neutral bulky ligands with strong electron-donating capacity.However,low-valence bimetallic complexes supported by anionic sulfur and cyclopentadienyl ligands are still difficult to obtain in high isolated yield.Herein,we report the synthesis and characteri-zation of two scarce thiolate-bridged Co^(I)Co^(II)and Co^(I)Co^(I)complexes bearing sterically demanding ligands through two stepwise one-electron reduction processes.Interestingly,the Co^(I)Co^(II)complex can facilely promote the homolytic cleavage of dihydrogen across the short Co−Co metallic bond to give a Co^(II)Co III dihydride bridged complex,which is capable of serving as a competent hydrogen atom transfer agent.Moreover,the anionic Co^(I)Co^(I)complex can trigger a stepwise hydrogen generation cycle involving several isolated and structurally well-characterized intermediates. | Tao Mei Dawei Yang Linan Su Baomin Wang Jingping Qu | 2022 | Chinese Chemical Letters2022，33，5： | 0 |
| 10 | Influence of stresses on martensitic transformation in ferromagnetic shape memory Ni_(50)Mn_(19)Fe_6Ga_(25) ribbons显示文摘The influence of stresses on martensitic transformation in Ni50Mn19Fe6Ga25 melt-spun ribbons was studied. X-ray diffraction examination shows that the ribbon has a pure cubic L21 phase at room temperature and that the ribbom surface exhibits [100] preferentially oriented texture, while the [110] axis is about 45°tilted from the normal of the ribbon. By calculating the d spacing at different angles with the length direction of the ribbon, the tension was observed. It was found that the direction of the stress was along [010] direction of the oriented textured grains. During cooling, there is no obvious structural transition observed in as-spun ribbons. However, when the ribbons were annealed at 900 K for 24 h, the tension along [010] direction disappeared and the structural transition from cubic to tetragonal occurred obviously during cooling. It indicates that it is the tension along [010] direction to suppress the martensitic transformation in the as-spun ribbons. | MENG Fanbin LI Yangxian LIU Heyan QU Jingping LIU Zhuhong CHEN Jinglian WU Guangheng | 2004 | Science China(Technological Sciences)2004，47，6： | 0 |
| 11 | Synthesis and Magnetostriction of (Ce_xTb_(1-x))_(0.5)Pr_(0.5)Fe_2 Compounds显示文摘The structural and magnetostrictive properties of (CexTb1-x)0.5Pr0.5Fe2 were investigated. Ceconcentration must exceed x=0.6 in order to obtain the pure Laves phase. The magnetostriction and anisotropy constant increase with the Tb-content in this system. The anisotropy value of PrFe2 is lower than that of isostructural DyFe2. From the X-ray step-scanned data we found that λ111 of PrFe2 is 1310x10-6. A large increase of magnetostriction can be observed under a small prestress of 6 MPa for Ce0.5Pr0.5Fe2. | Yangxian LI, Guizhi XU and Jingping QU (School of Materials Science and Engineering, Hebei University of Technology, Tianjin 300130, China) Chengchun TANG, Guangheng WU and Wenshan ZHAN (State Key Laboratory for Magnetism, Institute of Physics, Chinese Academy of Sciences, Beijing 100080, China) | 2000 | Journal of Materials Science & Technology2000，16，2： | 0 |
| 12 | Heterogeneous transition dynamic equations and the self-organized origin of the nesting rhythmic beddings in Panzhihua lithosomes显示文摘Dynamic equations were developed for heterogeneous phase-transition in a system of coupled nucleation, growth and ripening. Based on these equations, a self-organized origin of small-scale nesting rhythmic beddings in Pahzhihua lithosomes was investigated and the results showed that the beddings could be formed by the cross supersaturated nucleation-crystallization of augite and feldspar successively. This process could be implemented by coupling with supersaturated nucleation, Ostwald ripening, component diffusion and the primary grain diffusion under a proper temperature gradient. The slightly intensive supersaturated nucleation and Ostwald ripening occurring in Panzhihua lithosomes may relate closely to the mineral components such as V-Ti-Magnetite. | WU Jingping, LI Caiwei, BAO Zhengyu, YANG Wenhua, ZHOU Chenggang, SANG Zunan, LI Fanglin & QU Songsheng College of Chemistry and Molecular, Wuhan University, Wuhan 430071, China Faculty of Material Science and Chemical Engineering, China University of Geosciences, Wuhan 430074, China Information Department, Zhongshan University, Guangzhou 510000, China Faculty of Earth Science, China University of Geosciences, Wuhan 430074, China | 2005 | Science China Earth Sciences2005，48，1： | 0 |
| 13 | Electronic Structure of Thiolate-bridged Diiron Complexes and a Single-electron Oxidation Reaction" A Combination of Experimental and Computational Studies显示文摘diiron 硫建筑群的单个电子的氧化[Cp *Fe (μ-bdt ) FeCp *](1, Cp *=η5-C5 我 5 ;bdt=benzene-1,2-dithiolate ) 到[Cp *Fe (μ-bdt ) FeCp *]+(2 ) 试验性地被进行了。与氧化还原作用活跃的特性一起的 bdt ligand 计算地被建议了是 dianion (bdt 2−) 而非以前建议的 monoanion (在 1 的 bdt ·−) 基尽管它有不等距离的芳香的 CC,结合长度。 1 的扎根的状态被预言是二个低纺纱的铁的离子( S Fe =0)并且 2 有一个中等纺纱的铁的离子( S Fe =1/2)和一个低纺纱的铁的中心( S Fe =0),和 1~2 的氧化被计算是 single-metal-based 过程。两建筑群没有重要 antiferromagnetic 联合特性。 | Si Chen Lun Luo Yang Li Dawei Yang Jingping Qu Yi Luo | 2016 | Chinese Journal of Chemistry2016，34，9： | 0 |
| 14 | Nickel-Catalyzed Regiodivergent Acylzincation of Styrenes with Organozincs and CO显示文摘Transition metal-catalyzed carbometallation of unsaturated hydrocarbons constitutes one of the most efficient synthetic methodologies for the construction of C—C bond.Recently,the incorporation of organometallic reagent with the CO gas as a nucleophilic acyl synthon could enable the acylmetallation reaction,which greatly increases the horizon of carbometallation chemistry.Herein,we report a nickel-catalyzed regiodivergent acylzincation of o-cyano cinnamate ester and o-cyano styrene,in which the cyano moiety intramolecularly captures zinc intermediates to trigger the tandem cyclization process.This protocol features mild conditions,broad substrate scope and excellent functional group tolerance,thus affording a diverse array of highly functionalized carbocyclic compounds. | Chenglong Wang Ning Liu Xianqing Wu Jingping Qu Yifeng Chen | 2024 | Chinese Journal of Chemistry2024，42，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员