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| 1 | Numerical simulation and experimental verification of bubble size distribution in an air dense medium fluidized bed显示文摘Bubble size distribution is the basic apparent performance and obvious characteristics in the air dense medium fluidized bed (ADMFB). The approaches of numerical simulation and experimental verification were combined to conduct the further research on the bubble generation and movement behavior. The results show that ADMFB could display favorable expanded characteristics after steady fluidization. With different particle size distributions of magnetite powder as medium solids, we selected an appropriate prediction model for the mean bubble diameter in ADMFB. The comparison results indicate that the mean bubble diameters along the bed heights are 35 mm < D b < 66 mm and 40 mm < D b < 69 mm with the magnetite powder of 0.3 mm+0.15mm and 0.15mm+0.074mm, respectively. The prediction model provides good agreements with the experimental and simulation data. Based on the optimal operating gas velocity distribution, the mixture of magnetite powder and <1mm fine coal as medium solids were utilized to carry out the separation experiment on 6-50mm raw coal. The results show that an optimal separation density d P of 1.73g/cm 3 with a probable error E of 0.07g/cm 3 and a recovery efficiency of 99.97% is achieved, which indicates good separation performance by applying ADMFB. | He Jingfeng Zhao Yuemin Luo Zhenfu He Yaqun Duan Chenlong | 2013 | International Journal of Mining Science and Technology2013，23，3： | 11 |
| 2 | Kinetics of the hydrogen absorption and desorption processes of hydrogen storage alloys: A review显示文摘High hydrogen absorption and desorption rates are two significant index parameters for the applications of hydrogen storage tanks.The analysis of the hydrogen absorption and desorption behavior using the isothermal kinetic models is an efficient way to investigate the kinetic mechanism.Multitudinous kinetic models have been developed to describe the kinetic process.However,these kinetic models were de-duced based on some assumptions and only appropriate for specific kinetic measurement methods and rate-controlling steps(RCSs),which sometimes lead to confusion during application.The kinetic analysis procedures using these kinetic models,as well as the key kinetic parameters,are unclear for many researchers who are unfamiliar with this field.These problems will prevent the kinetic models and their analysis methods from revealing the kinetic mechanism of hydrogen storage alloys.Thus,this review mainly focuses on the summarization of kinetic models based on different kinetic measurement methods and RCSs for the chemisorption,surface penetration,diffusion of hydrogen,nucleation and growth,and chemical reaction processes.The analysis procedures of kinetic experimental data are expounded,as well as the effects of temperature,hydrogen pressure,and particle radius.The applications of the kinetic models for different hydrogen storage alloys are also introduced. | Qian Li Xi Lin Qun Luo Yuʼan Chen Jingfeng Wang Bin Jiang Fusheng Pan | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，1： | 9 |
| 3 | Processes of coastal ecosystem carbon sequestration and approaches for increasing carbon sink显示文摘The oceans are the largest carbon pools on Earth, and play the role of a 'buffer' in climate change. Blue carbon, the carbon(mainly organic carbon) captured by marine ecosystems, is one of the important mechanisms of marine carbon storage.Blue carbon was initially recognized only in the form of visible coastal plant carbon sequestration. In fact, microorganisms(phytoplankton, bacteria, archaea, viruses, and protozoa), which did not receive much attention in the past, account for more than 90% of the total marine biomass and are the main contributors to blue carbon. Chinese coastal seas, equivalent to 1/3 of China's total land area, have a huge carbon sink potential needing urgently research and development. In this paper, we focus on the processes and mechanisms of coastal ocean's carbon sequestration and the approaches for increasing that sequestration. We discuss the structures of coastal ecosystems, the processes of carbon cycle, and the mechanisms of carbon sequestration. Using the evolution of coastal ocean's carbon sinks in sedimentary records over geologic times, we also discuss the possible effects of natural processes and anthropogenic activities on marine carbon sinks. Finally, we discuss the prospect of using carbon sequestration engineering for increasing coastal ocean's carbon storage capacity. | ZHANG Yao ZHAO MeiXun CUI Qiu FAN Wei QI JiaGuo CHEN Ying ZHANG YongYu GAO KunShan FAN JingFeng WANG GuangYi YAN ChongLing LU HaoLiang LUO YaWei ZHANG ZiLian ZHENG Qiang XIAO Wei JIAO NianZhi | 2017 | Science China Earth Sciences2017，60，5： | 6 |
| 4 | Separation performance of fine low-rank coal by vibrated gas-solid fluidized bed for dry coal beneficiation显示文摘 | Jingfeng He Yuemin Zhao Jie Zhao Zhenfu Luo Chenlong Duan Yaqun He | 2015 | Particuology2015，13，6： | 4 |
| 5 | A CRISPR/Cas12a-empowered surface plasmon resonance platform for rapid and specific diagnosis of the Omicron variant of SARS-CoV-2显示文摘The outbreak of the COVID-19 pandemic was partially due to the challenge of identifying asymptomatic and presymptomatic carriers of the virus,and thus highlights a strong motivation for diagnostics with high sensitivity that can be rapidly deployed.On the other hand,several concerning SARS-CoV-2 variants,including Omicron,are required to be identified as soon as the samples are identified as‘positive’.Unfortunately,a traditional PCR test does not allow their specific identification.Herein,for the first time,we have developed MOPCS(Methodologies of Photonic CRISPR Sensing),which combines an optical sensing technology-surface plasmon resonance(SPR)with the‘gene scissors’clustered regularly interspaced short palindromic repeat(CRISPR)technique to achieve both high sensitivity and specificity when it comes to measurement of viral variants.MOPCS is a low-cost,CRISPR/Cas12a-systemempowered SPR gene-detecting platform that can analyze viral RNA,without the need for amplification,within 38 min from sample input to results output,and achieve a limit of detection of 15 fM.MOPCS achieves a highly sensitive analysis of SARS-CoV-2,and mutations appear in variants B.1.617.2(Delta),B.1.1.529(Omicron)and BA.1(a subtype of Omicron).This platform was also used to analyze some recently collected patient samples from a local outbreak in China,identified by the Centers for Disease Control and Prevention.This innovative CRISPR-empowered SPR platform will further contribute to the fast,sensitive and accurate detection of target nucleic acid sequences with single-base mutations. | Zhi Chen Jingfeng Li Tianzhong Li Taojian Fan Changle Meng Chaozhou Li Jianlong Kang Luxiao Chai Yabin Hao Yuxuan Tang Omar AAl-Hartomy Swelm Wageh Abdullah GAl-Sehemi Zhiguang Luo Jiangtian Yu Yonghong Shao Defa Li Shuai Feng William J.Liu Yaqing He Xiaopeng Ma Zhongjian Xie Han Zhang | 2022 | National Science Review2022，9，8： | 3 |
| 6 | CRISPR-Cas12a-Empowered Electrochemical Biosensor for Rapid and Ultrasensitive Detection of SARS-CoV-2 Delta Variant显示文摘Coronavirus disease 2019(COVID-19)is a highly contagious disease caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).The gold standard method for the diagnosis of SARS-CoV-2 depends on quantitative reverse transcription-polymerase chain reaction till now,which is time-consuming and requires expensive instrumentation,and the confirmation of variants relies on further sequencing techniques.Herein,we first proposed a robust technique-methodology of electrochemical CRISPR sensing with the advantages of rapid,highly sensitivity and specificity for the detection of SARS-CoV-2 variant.To enhance the sensing capability,gold electrodes are uniformly decorated with electro-deposited gold nanoparticles.Using DNA template identical to SARS-CoV-2 Delta spike gene sequence as model,our biosensor exhibits excellent analytical detection limit(50 fM)and high linearity(R2=0.987)over six orders of magnitude dynamic range from 100 fM to 10 nM without any nucleic-acid-amplification assays.The detection can be completed within 1 h with high stability and specificity which benefits from the CRISPR-Cas system.Furthermore,based on the wireless micro-electrochemical platform,the proposed biosensor reveals promising application ability in point-of-care testing. | Chenshuo Wu Zhi Chen Chaozhou Li Yabin Hao Yuxuan Tang Yuxuan Yuan Luxiao Chai Taojian Fan Jiangtian Yu Xiaopeng Ma Omar AAl-Hartomy SWageh Abdullah GAl-Sehemi Zhiguang Luo Yaqing He Jingfeng Li Zhongjian Xie Han Zhang | 2022 | Nano-Micro Letters2022，14，10： | 2 |
| 7 | Tumor Microenvironment Cascade‑Responsive Nanodrug with Self‑Targeting Activation and ROS Regeneration for Synergistic Oxidation‑Chemotherapy显示文摘Carrier-free nanodrug with exceptionally high drug payload has attracted increasing attentions.Herein,we construct a pH/ROS cascade-responsive nanodrug which could achieve tumor acidity-triggered targeting activation followed by circularly amplified ROS-triggered drug release via positive-feedback loop.The di-selenide-bridged prodrug synthesized from vitamin E succinate and methotrexate(MTX)self-assembles into nanoparticles(VSeM);decorating acidity-cleavable PEG onto VSeM surface temporarily shields the targeting ability of MTX to evade immune clearance and consequently elongate circulation time.Upon reaching tumor sites,acidity-triggered detachment of PEG results in targeting recovery to enhance tumor cell uptake.Afterward,the VSeM could be dissociated in response to intracellular ROS to trigger VES/MTX release;then the released VES could produce extra ROS to accelerate the collapse of VSeM.Finally,the excessive ROS produced from VES could synergize with the released MTX to efficiently suppress tumor growth via orchestrated oxidation-chemotherapy.Our study provides a novel strategy to engineer cascade-responsive nanodrug for synergistic cancer treatment. | Yang Li Jinyan Lin Peiyuan Wang Qiang Luo Fukai Zhu Yun Zhang Zhenqing Hou Xiaolong Liu Jingfeng Liu | 2020 | Nano-Micro Letters2020，12，12： | 2 |
| 8 | Short-term intensive atorvastatin therapy improves endothelial function partly via attenuating perivascular adipose tissue inflammation through 5-lipoxygenase pathway in hyperlipidemic rabbits显示文摘 | Wang Xiaoqiao Lin Yongqin Luo Niansang Chen Zhongqing Gu Miaoning Wang Jingfeng Chen Yangxin | 2014 | Chinese Medical Journal2014，，16： | 2 |
| 9 | Generation and characterisation of rabbit monoclonal antibodies against the native cell surface antigens of embryonic stem cells显示文摘Embryonic stem (ES) cells are potent resources for cell therapy,and monoclonal antibodies (mAbs) against native cell surface markers of ES cells could be useful tools for therapeutic applications.Here,we report the development of a feasible approach,which could be used in mass production,for experimentally producing rabbit mAbs against native cell surface antigens on the cell surface.Two of the 14 mAbs,which were selected at random,could be bound to the cell surface antigens of mES cells.The immunocytochemistry (ICC) and Western blot results showed that mAb 39 recognises conformational epitopes.The target antigen of mAb 39 was then successfully purified using an improved immunoprecipitation approach in which mAb was bounded to intact mES cells before the cells were lysed.The LC-LTQ mass spectrum analysis showed that the target antigen of mAb 39 was Glut3.This result was further confirmed by Western blot using commercially available antibodies against Glut3.Further experiments showed that mAb 39 exhibited an antiproliferative effect on mES cells.We also found that Glut3 was differentially expressed among the mES cell population as detected by flow cytometry. | Yongliang Lu Zhongyuan Su Ying Li Jingfeng Luo Zhou Tan Huijiao Ji Weimin Zhu Guoliang Yu Liangbiao Chen Ming Zhang | 2010 | Journal of Genetics and Genomics2010，37，7： | 1 |
| 10 | Abundance and diversity based on amoA genes of ammonia-oxidizing archaea and bacteria in ten wastewater treatment systems显示文摘 | Jingfeng Gao Xin Luo Guixia Wu Ting Li Yongzhen Peng | 2014 | Applied Microbiology and Biotechnology2014，，7： | 1 |
| 11 | Extra-Large Seed Germplasms of Brassica Napus Created through Microspore Culture显示文摘 | Chen Wei Zhao Kaiqin Zhang Guojian Zhou Picai Zhao Desheng Qu Guan Luo Yangqing Zu Feng Li Jingfeng Dong Yunsong Wang Jingqiao | 2016 | Journal of Environmental Science and Engineering(A)2016，5，2： | 1 |
| 12 | Quantitative analyses of the composition and abundance of ammonia-oxidizing archaea and ammonia-oxidizing bacteria in eight full-scale biological wastewater treatment plants 显示文摘 | GAO Jingfeng LUO Xin WU Guixia | 2013 | Bioresource Technology2013，138，6： | 1 |
| 13 | Abundance and diversity based on amoA genes of ammonia-oxidizing archaea and bacteria in ten wastewater treatment systems 显示文摘 | GAO Jingfeng LUO Xin WU Guixia | 2014 | Applied Microbiology and Biotechnology2014，98，7： | 1 |
| 14 | Effect of Cu-Ti-C Reaction Composition on Reinforcing Particles Size of TiC_x/Cu Composites显示文摘TiC_x/Cu composites were fabricated by combustion synthesis and hot press technology. Using XRD, SEM, EDS, FESEM analysis methods, the effects of various carbon sources and different Cu contents on the microstructures of TiC_x/Cu composites and the size of TiC_x particles were investigated. Results showed that TiC_x reinforcing particles size increases with decreasing Cu content in Cu-Ti-C reaction system. With carbon nanotubes(carbon black) serving as carbon source, the generated TiC_x particles size transits from nanometer to submicron when Cu content corresponding to the reaction system is reduced to 60 vol%(70 vol%); while graphite serves as carbon source, there is no clear limiting concentration. C particles with smaller size, larger specific surface area and better distribution result in finer TiC_x particles, which is more beneficial to generating nano-sized TiC_x/Cu composites. | 张冬冬 GULI Hao LUO Jingfeng WU Chao 王金国 | 2018 | Journal of Wuhan University of Technology(Materials Science)2018，33，1： | 0 |
| 15 | B-lymphoid tyrosine kinase-mediated FAM83A phosphorylation elevates pancreatic tumorigenesis through interacting with β-catenin显示文摘Abnormal activation of Wnt/β-catenin-mediated transcription is closely associated with the malignancy of pancreatic cancer.Family with sequence similarity 83 member A(FAM83A)was shown recently to have oncogenic effects in a variety of cancer types,but the biological roles and molecular mechanisms of FAM83A in pancreatic cancer need further investigation.Here,we newly discovered that FAM83A binds directly toβ-catenin and inhibits the assembly of the cytoplasmic destruction complex thus inhibiting the subsequent phosphorylation and degradation.FAM83A is mainly phosphorylated by the SRC non-receptor kinase family member BLK(B-lymphoid tyrosine kinase)at tyrosine 138 residue within the DUF1669 domain that mediates the FAM83A-β-catenin interaction.Moreover,FAM83A tyrosine 138 phosphorylation enhances oncogenic Wnt/β-catenin-mediated transcription through promotingβ-catenin-TCF4 interaction and showed an elevated nucleus translocation,which inhibits the recruitment of histone deacetylases by TCF4.We also showed that FAM83A is a direct downstream target of Wnt/β-catenin signaling and correlates with the levels of Wnt target genes in human clinical pancreatic cancer tissues.Notably,the inhibitory peptides that target the FAM83A-β-catenin interaction significantly suppressed pancreatic cancer growth and metastasis in vitro and in vivo.Our results revealed that blocking the FAM83A cascade signaling defines a therapeutic target in human pancreatic cancer. | Cefan Zhou Xiaoting Zhu Nanxi Liu Xueying Dong Xuewen Zhang Huili Huang Yu Tang Shicheng Liu Mengyu Hu Ming Wang Xiaoling Deng Shi Li Rui Zhang Yuan Huang Hao Lyu Shuai Xiao Sang Luo Declan William Ali Marek Michalak Xing-Zhen Chen Zhentian Wang Jingfeng Tang | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 0 |
| 16 | A combined Cox and logistic model provides accurate predictive performance in estimation of time-dependent probabilities for recurrence of intrahepatic cholangiocarcinoma after resection显示文摘HepatoBiliary Surg Nutr 2021;10(4):464-475|http://gffzz4205af39ffde493ehxbcncq0o9pop6v0x.ffgz.tsg.suse.edu.cn/10.21037/hbsn.2020.01.07 Original Article A combined Cox and logistic model provides accurate predictive performance in estimation of time-dependent probabilities for recurrence of intrahepatic cholangiocarcinoma after resection Seogsong Jeong1,2#,Guijuan Luo2,3#,Qiang Gao4#,Jing Chen2,3#,Xiaolong Liu5,Liangqing Dong4,Yongjie Zhang6,Feng Shen7,Qingbao Cheng8,Chengjun Sui9,Jingfeng Liu5,Hongyang Wang2,3,Qiang Xia1,Lei Chen2,101Department of Liver Surgery,Renji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai,China;2International Cooperation Laboratory on Signal Transduction,Eastern Hepatobiliary Surgery Institute,Second Military Medical University,Shanghai,China;3National Center for Liver Cancer,Shanghai,China;4Department of Liver Surgery and Transplantation,Liver Cancer Institute,Zhongshan Hospital,and Key Laboratory of Carcinogenesis and Cancer Invasion(Ministry of Education),Fudan University,Shanghai,China;5Mengchao Hepatobiliary Hospital,Fujian Medical University,Fuzhou,China;6Biliary Tract Department II,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai,China;7Department of Hepatobiliary Surgery,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai,China;8Biliary Tract Department I,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai,China;9Department of Special Medical Care&Liver Transplantation,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai,China;10Shanghai Cancer Center,Shanghai Medical College,Fudan University;Shanghai,China Contributions:(I)Conception and design:S Jeong,G Luo,Q Gao,J Chen,J Liu,H Wang,Q Xia,L Chen;(II)Administrative support:All authors;(III)Provision of study materials or patients:S Jeong,G Luo,Q Gao,J Chen,J Liu,H Wang,Q Xia,L Chen;(IV)Collection and assembly of data:All authors;(V)Data analysis and interpretation:S Jeong,G Luo,Q Gao,J Chen,J Liu,H Wang,Q Xia,L Chen;(VI)Manuscript writing:All authors;(VII)Final approval of manuscript:All authors.#These authors contributed equally to this work.Correspondence to:Lei Chen;Hongyang Wang.International Cooperation Laboratory on Signal Transduction,Eastern Hepatobiliary Surgery Institute,Second Military Medical University,225 Changhai Road,Shanghai 200438,China.Email:chenlei@smmu.edu.cn;hywangk@vip.sina.com;Qiang Xia.Department of Liver Surgery,Renji Hospital,School of Medicine,Shanghai Jiao Tong University,160 Pujian Road,Shanghai 200127,China.Email:xiaqiang@shsmu.edu.cn. | Seogsong Jeong Guijuan Luo Qiang Gao Jing Chen Xiaolong Liu Liangqing Dong Yongjie Zhang Feng Shen Qingbao Cheng Chengjun Sui Jingfeng Liu Hongyang Wang Qiang Xia Lei Chen | 2021 | Hepatobiliary Surgery and Nutrition2021，10，4： | 0 |
| 17 | Magnesium-based energy materials: Progress, challenges, and perspectives显示文摘Magnesium-based energy materials, which combine promising energy-related functional properties with low cost, environmental compatibility and high availability, have been regarded as fascinating candidates for sustainable energy conversion and storage. In this review,we provide a timely summary on the recent progress in three types of important Mg-based energy materials, based on the fundamental strategies of composition and structure engineering. With regard to Mg-based materials for batteries, we systematically review and analyze different material systems, structure regulation strategies as well as the relevant performance in Mg-ion batteries(MIBs) and Mg-air batteries(MABs), covering cathodes, electrolytes, anodes for MIBs, and anodes for MABs;as to Mg-based hydrogen storage materials, we discuss how catalyst adding, composite, alloying and nanostructuring improve the kinetic and thermodynamic properties of de/hydrogenation reactions, and in particular, the impacts of composition and structure modification on hydrogen absorption/dissociation processes and free energy modification mechanism are focused;regarding Mg-based thermoelectric materials, the relations between composition/structure and electrical/thermal transport properties of Mg_(3)X_(2)(X = Sb, Bi), Mg_(2)X(X = Si, Ge, Sn) and Mg Ag Sb-based materials, together with the representative research progress of each material system, are summarized and discussed. Finally, by pointing out remaining challenges and providing possible solutions, this review aims to shed light on the directions and perspectives for practical applications of magnesium-based energy materials in the future. | Guang Han Yangfan Lu Hongxing Jia Zhao Ding Liang Wu Yue Shi Guoyu Wang Qun Luo Yu'an Chen Jingfeng Wang Guangsheng Huang Xiaoyuan Zhou Qian Li Fusheng Pan | 2023 | Journal of Magnesium and Alloys2023，11，11： | 0 |
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