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| 1 | CYP2E1 mediated isoniazid-induced hepatotoxicity in rats显示文摘AIM: To investigate the role of CYP2E1 in isoniazid (INH)-induced hepatotoxicity and the influence of rifampicin(RFP) on INH-induced liver injury. METHODS: Rats were treated with INH alone (100 mg/kg, ip) or co-administeredwith RFP (100 mg/kg, ig) for 10 d and 21 d. Hepatotoxicity was assayed by plasma enzymes (sALT, sAST) andhistopathological examinations. Hepatic CYP2E1 activity was measured by aniline hydroxylase (ANH), and CYP2E1mRNA expression was determined by RT-PCR. Plasma hydrazine concentration was determined by RP-HPLC.RESULTS: For a 10 d INH-treatment, hepatic CYP2E1 level was increased to 3.7-fold over the control; liverimpairment appeared after 21 d treatment, while CYP2E1 and plasma hydrazine were, respectively, increased to 4.6-fold and 1.7-fold. However, in INH-RFP group for 10 d, CYP2E1 and plasma hydrazine were, respectively,decreased by 13 % and 18 % over INH group; similarly, hepatic injury is equal to INH group appeared after 21 d,and CYP2E1 was further decreased by 26 %. Correlation analysis showed that sALT had a positive correlation withplasma hydrazine and with CYP2E1 activity; CYP2E1 activity was also markedly correlated with plasma hydrazine.And compared with control, there is no difference in changes of CYP2E1 mRNA expression in INH and INH-RFPtreatment for 21 d. CONCLUSION: The metabolite of INH, hydrazine, plays an important role in INH-inducedhepatotoxicity in rats. The induction of CYP2E1 by hydrazine is involved in the hepatotoxicity of INH. RFP doesnot exacerbate INH-induced hepatotoxicity in short term, which relates to down-regulation of CYP2E1. | JiangYUE Ren-xiuPENG JingYANG RmKONG JuanLIU | 2004 | Acta Pharmacologica Sinica2004，25，5： | 17 |
| 2 | Establishment of intestinal organoid cultures modeling injury-associated epithelial regeneration显示文摘The capacity of 3D organoids to mimic physiological tissue organization and functionality has provided an invaluable tool to model development and disease in vitro.However,conventional organoid cultures primarily represent the homeostasis of self-organizing stem cells and their derivatives.Here,we established a novel intestinal organoid culture system composed of 8 components,mainly including VPA,EPZ6438,LDN193189,and R-Spondin 1 conditioned medium,which mimics the gut epithelium regeneration that produces hyperplastic crypts following injury;therefore,these organoids were designated hyperplastic intestinal organoids(Hyper-organoids).Single-cell RNA sequencing identified different regenerative stem cell populations in our Hyper-organoids that shared molecular features with in vivo injury-responsive Lgr5+stem cells or Clu+revival stem cells.Further analysis revealed that VPA and EPZ6438 were indispensable for epigenome reprogramming and regeneration in Hyper-organoids,which functioned through epigenetically regulating YAP signaling.Furthermore,VPA and EPZ6438 synergistically promoted regenerative response in gut upon damage in vivo.In summary,our results demonstrated a new in vitro organoid model to study epithelial regeneration,highlighting the importance of epigenetic reprogramming that pioneers tissue repair. | Molong Qu Liang Xiong Yulin Lyu Xiannian Zhang Jie Shen Jingyang Guan Peiyuan Chai Zhongqing Lin Boyao Nie Cheng Li Jun Xu Hongkui Deng | 2021 | Cell Research2021，31，3： | 9 |
| 3 | Genesis and Uranium Sources of Leucogranite-hosted Uranium Deposits in the Gaudeanmus Area, Central Damara Belt, Namibia: Study of Element and Nd Isotope Geochemistry显示文摘This paper presents a systematic study of major and trace elements and Sm-Nd isotopes in leucogranites closely related to uranium mineralization in the Gaudeanmus area, Namibia. The results illustrate that the uraniferous leucogranites possess high Si_O_2(68.8 wt%–76.0 wt%, average 73.1 wt%) and K(4.05 wt%–7.78 wt%, average 5.94 wt%) contents, and are sub-alkaline and metaluminous to weakly peraluminous, as reflected by A/CNK values of 0.96–1.07 with an average of 1.01. The leucogranites are rich in light rare earth elements(LREE/HREE = 2.53–7.71;(La/Yb)N = 2.14–10.40), have moderate Eu depletion and high Rb/Sr ratios(2.03–5.50 with an average of 4.36); meanwhile, they are enriched in Rb, K, Th, U and Pb, and depleted in Ba, Nb, Ta, and Sr. The ε_(Nd)(t) values of uraninites range from -14.8 to -16.5, and the two-stage Nd model ages are 2.43–2.56 Ga. Detailed elemental and Sm-Nd isotopic geochemical characteristics suggest that the leucogranites were formed in a postorogenic extensional environment. The U-rich pre-Damara basement was the main source of uranium during the primary mineralization event, which is disseminated in leucogranites, whereas the uranium mineralization in veins possibly resulted from remobilization of the primary uranium minerals. | FAN Honghai CHEN Jinyong WANG Shengyun ZHAO Jingyang GU Dazhao MENG Yanning | 2017 | Acta Geologica Sinica(English Edition)2017，91，6： | 7 |
| 4 | Experiment research on grain drying process in the heat pump assisted fluidized beds显示文摘A heat pump assisted fluidized bed grain drying experimental system was developed. Based on this system, a serial of ex- periments was performed under four kinds of air cycle conditions. According to the experimental analysis, an appropriate drying medium-air cycle for the heat pump assisted fluidized bed drying equipment was decided, which is different from the commonly used heat pump assisted drying system. The experimental results concerning the drying operation performance of the new system show that the averaged coefficient of performance (COP) can reach more than 2.5. The economical evaluation was performed and the power consumption for removing a kilogram water from grains was about 0.485 kW.h/kg (H2O), which shows its reasonable commercial efficiency and great application potentiality in future market. | JingYang LiWang FiXiang LigeTong HuaSu | 2004 | Journal of University of Science and Technology Beijing2004，11，4： | 7 |
| 5 | New technology to examine and improve the purity of hybrid rice with herbicide resistant gene显示文摘The herbicide resistant bar gene has been widely used as selectable marker genes in the study on plant genetic transformation. Owing to the integration of the gene into rice genome, transgenic rice was resistant to the herbicide Basta. Therefore, selection of transgenic plant and genetic analysis became easier. In the studies, bar gene was introduced as a genetic marker gene into rice restore line variety of two-line or three-line. Combined with conventional breeding method, the good herbicide resistant individual plant was derived as the new restore line for hybrid combination. After sprayed with Basta at seedling phase, the real hybrid rice that had herbicide resistance could grow normally, while the fake hybrid rice and weeds, having no bar gene, were killed by herbicide. The method described above helped rapidly to examine and improve the purity of hybrid rice. | Danian Huang Jingyang Li Shanqing Zhang Rui Xue Wei Yang Zhihua Hua Xiaobo Xie Xiaoling Wang | 1998 | Chinese Science Bulletin1998，43，9： | 7 |
| 6 | Correlations Based on CFD and Their Applications in Optimization for Staggered and Parallel Plate Fin Heatsinks显示文摘Both parallel and staggered plate fin arrays have shown promise tbr use in high performance heatsinks regard of its individual manufacturing costs. The geometrical and operational parameters are very important to their cooling performance as heatsinks in prac- tical applications. Fluent 5.0 commercial CFD (computational tluid dynamic) code is used to simulate the flow and heat transfer of those heatsinks of different realistic parameters. Based on those simulations, two correlations, concerning Nusselt number and friction factor as the functions of geometrical and operational parameters, FB (tin-base area ratio), PR?(ratio of spanwise pitch to lengthwise pitch) and Re, were developed. From the both, the perfonnance comparisons for optimizing geometrical and operational parameters of a fixed di- mension heatsink are shown at constant pumping power and constant thermal resistance. Several optimized parameters were obtained with the discussion to various goals in real application. It demonstrates that in some particular situations, the parallel plate tin heatsinks can out perform the staggered ones. | JingYang DenpongSoodphakdee 等 | 2002 | Journal of University of Science and Technology Beijing2002，9，1： | 5 |
| 7 | Co3O4 nanocage derived from metal-organic frameworks: An excellent cathode catalyst for rechargeable Li-O2 battery显示文摘Rechargeable non-aqueous Li-O2 battery is regarded as one of the most promising energy-storage technologies on account of its high energy density.It is believed that the rational design of three-dimensional (3D) architecture for catalyst is a key factor for the remarkable performance.Metal-organic frameworks (MOFs) derived materials possess excellent architecture,which is beneficial for Li-O2 batteries.In this work,ZIF-67 is used as precursor template and calcinated under different temperature to produce Co3O4 crystals.When the anneal treatment is under 350℃,the derived Co3O4 nanocage holds the most complete skeleton,which provides better charge transfer ability as well as O2 and Li^+ diffusion.Meanwhile,the Co3O4 nanocage owns more oxygen vacancies,offering more active sites.With the synergistic effect of nanocage structure and active sites,the Co3O4 nanocage stably delivers a large specific capacity of 15,500 mAh·g^-1 as well as a long cycle-life of 132 cycles at limited discharge capacity of 1,000 mAh·g^-1 under discharge/charge current density of 0.5 A·g^-1. | Zhuoliang Jiang Hui Sun Wenke Shi Tianhang Zhou Jianyong Hu Jingyang Cheng Pengfei Hu Shigang Sun | 2019 | Nano Research2019，12，7： | 5 |
| 8 | Effects of Suction Side Squealer Tip on the Performance of a Low-Speed Axial Compressor显示文摘This paper presents the investigation of the effects of suction side squealer tip on the performance of an axial compressor.The experiment is carried out in a single-stage large-scale low-speed compressor.The investigated tip geometries include flat tip as the baseline and suction side squealer tip.The tip clearance of the baseline is 0.5% of the blade span.The static pressure rise characteristic curves of both the rotor and the stage are measured.The flow field at the exit of the rotor is measured by a 5-hole probe under design and off-design conditions.The static pressure on the endwall of the rotor passage is also obtained.The results show that the pressure rise characteristic curves obtained by measuring the pressure on the end wall are almost unchanged by using the suction side squealer tip.The measuring results of the 5-hole probe show the static pressure and the total pressure in tip region is slightly greater than that of the flat tip at the design condition at the exit of the rotor.It also leads to greater av-eraged static pressure rise and total pressure.At the near stall condition,the averaged static pressure and total pressure is lower than the baseline which is related to the redistribution of the blade load caused by the suction side squealer tip. | Jun Zhang Hongwei Ma Jingyang Li | 2012 | Journal of Thermal Science2012，21，3： | 5 |
| 9 | Microelectronics-embedded channel bridging and signal regeneration of injured spinal cords显示文摘Due to the dificulty in spinal cord regeneration with biological methods,the microelectronic neural bridge,a new concept based on microelectronic technology,is presented.The microelectronic system has been realized in the forms of hybrid and integrated circuits.The integrated circuits forneural signal detection,stimulation,and regeneration are realized in a CMOS process.In animal experiments with 100 toads,48 rats,and 3 rabbits,nerve signals have been successfully detected from spinal cords and sciatic nerves,and functional electrical stimulation has been carried out for spinal cords and sciatic nerves.When the microelectronic system is bridged between the controlling and stimulated nerve,the relevant motion of legs and nerve signal waveforms,which are stimulated by the evoked or spontaneous nerve signal through such a system,have been observed.Therefore,the feasibility of the presented method was demonstrated. | Zhigong Wang Xiaosong Gu Xiaoying Lǔ Zhenglin Jiang Wenyuan Li Guangming Lǔ Yufeng Wang Xiaoyan Shen Xintai Zhao Huiling Wang Zhenyu Zhang Hongmei Shen Yang Wu Weixing Shen Jingyang Zhang Dong Chen Xiaoyi Mao Huaxiang Shen | 2009 | Progress in Natural Science:Materials International2009，19，10： | 5 |
| 10 | Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds显示文摘 | Pingping Hou Yanqin Li Xu Zhang Chun Liu Jingyang Guan Honggang Li Ting Zhao Junqing Ye Weifeng Yang Kang Liu Jian Ge Jun Xu Qiang Zhang Yang Zhao Hongkui Deng | 2013 | Science2013，，6146： | 4 |
| 11 | Mechanical and thermal properties of RE4Hf3O12(RE=Ho,Er, Tm) ceramics with defect fluorite structure显示文摘The thermal and environmental barrier coatings (T/EBC) are technologically important for advanced propulsion engine system. In this study, RE4Hf3Oi2 (RE=Ho, Er, Tm) with defect fluorite structure was investigated for potential use as top TBC layer. Dense pellets were fabricated via a hot pressing method and the mechanical and thermal properties were characterized. RE4Hf3Oi2 (RE=Ho, Er, Tm) possessed a high Vickers hardness of 11 GFa. The material retained high elastic modulus at elevated temperatures up to 1773 K, which made it attractive for high temperature application. The coefficient of thermal expansion (CTE) of RE4Hf3Oi2 (RE = Ho, Er, Tm) laid in the range between 7× 10^-6K^-1 to 10×10^16K^-1 from 473 K to 1673 K. In addition, the rare earth hafnates exhibited lower thermal conductivity which rendered it a good candidate material for thermal barrier applications. | Wanpeng Hu Yiming Lei Jie Zhang Jingyang Wang | 2019 | Journal of Materials Science & Technology2019，35，9： | 4 |
| 12 | Nonlinear Adaptive Slewing Motion Control of Spacecraft Truss Driven by Synchronous V-gimbaled CMG Precession显示文摘The slewing motion control of a truss arm driven by a V-gimbaled control-moment-gyro (CMG) is a nonlinear control problem. The V-gimbaled CMG consists of a pair of gyros that must precess synchronously. The moment of inertia of the system, the angular momentum of the gyros and the external disturbances are not exactly known. With the help of feedback linearization and recursive Lyapunov design method, an adaptive nonlinear controller is designed to deal with the unknown items. Performance of the proposed controller is verified by simulation. | Zhou Di Zhou Jingyang | 2007 | Chinese Journal of Aeronautics2007，20，4： | 4 |
| 13 | Weathering-pedogenesis of Carbonate Rocks and Its Environmental Effects in Subtropical Region显示文摘我们在中国的副热带的区域调查了碳酸盐岩石和它的环境效果的天气成土作用。调查证明碳酸盐岩石的天气成土作用在副热带的区域是腐蚀和淀积作用和交代作用的一个联合行动的过程。它被描绘由多级式,多路径和多风格。与碳酸盐岩石的天气成土作用的坚持的发展,交代矿床成土作用日益增多地成为了天气成土作用和矿物质的形成的主导的风格的主要过程。并且它通过碳酸盐岩石的天气成土作用的进化的整个过程继续。碳酸盐岩石的天气成土作用的阶段进化和最新生产的矿物质的分别进化被描绘由明显垂直地 zoning 结构和在捱过侧面的碳酸盐岩石中的元素 geochemical 特征的阶段的规则。碳酸盐岩石的天气成土作用的 geochemical 过程能被划分成三个 geochemical 进化阶段,即, Ca, Mg 弄空和 Si, Al 丰富舞台;Fe, Mn 丰富阶段和在副热带的区域的 Al 丰富舞台。与三个 geochemical 进化阶段一致,形成的顺序和矿物质的进化能被划分成泥土矿物质阶段;Fe, Mn 氧化物和 gibbsite 阶段。重元素的化学形式上的碳酸盐岩石的天气成土作用的影响主要在天气成土作用的过程经由最新生产的部件和矿物质被影响,例如,氧化铁矿物质和有机物。为 F 并且作为的动员,运输和污染的重要机制被影响 F 并且作为在在副热带的石灰岩地区常见的地形地区的氧化铁矿物质的表面上的选择吸附和解吸附作用,即,在天气成土作用的进程的最新生产的矿物质的矿物质表面上的选择吸附和解吸附作用在副热带的区域在地球的表面和环境质量上控制元素的 geochemical 行为。 | ZHU Lijun HE Shouyang LI Jingyang | 2008 | Acta Geologica Sinica(English Edition)2008，82，5： | 4 |
| 14 | Fluorescent silicon nanoparticle-based gene carriers featuring strong photostability and feeble cytotoxicity显示文摘安全荧光灯 gene-transfection 向量在对基本生物应用并且为基因治疗研究的大需求。这里,我们介绍基于的光硅 nanoparticle (SiNP ) 的一种新类型对以一种长期、即时的方式决定基因车辆的细胞内部的命运合适的基因搬运人。介绍基于 SiNP 的 nanocarriers 同时展示强壮、稳定的荧光,高装载 DNA 能力和 gene-transfection 效率,以及有利 biocompatibility。利用这些唯一的好处,我们能乐意地在实时房间观察基因搬运人的行为(例如细胞的举起,细胞内部的 trafficking,和 endosomal 逃跑) 以一种长期、即时的方式。结果表明这些的潜在的可用性荧光灯是的基于 SiNP 的基因向量基因治疗的领域里的强大的工具,并且为理解基因搬运人的细胞内部的行为提供无价的信息。 | Jingyang Pang Yuanyuan Su Yiling Zhong Fei Peng Bin Song Yao He | 2016 | Nano Research2016，9，10： | 4 |
| 15 | Summary of Laurasiatheria (Mammalia) Phylogeny显示文摘 | Jingyang HU Yaping ZHANG Li YU | 2012 | Zoological Research2012，33，6： | 4 |
| 16 | A review of cystic fibrosis:Basic and clinical aspects显示文摘Cystic fibrosis is an autosomal recessive disease caused by mutations of the gene encoding the cystic fibrosis transmembrane conductance regulator(CFTR).Here we summarize,at the basic descriptive level,clinical and genetic characteristics of cystic fibrosis gene mutations,while emphasizing differences between CF mutations found in Chinese pediatric CF patients compared to those found in Caucasian CF patients.In addition,we describe animal models used to study human cystic fibrosis disease and highlight unique features of each model that mimic specific human CF-associated signs and symptoms.At the clinical level,we summarize CF clinical manifestations and diagnostic,treatment,and prognostic methods to provide clinicians with infor-mation toward reducing CF misdiagnosis and missed diagnosis rates. | Qionghua Chen Yuelin Shen Jingyang Zheng | 2021 | Animal Models and Experimental Medicine2021，4，3： | 3 |
| 17 | Multi-modal anti-counterfeiting and encryption enabled through silicon-based materials featuring pH-responsive fluorescence and room-temperature phosphorescence显示文摘Nano Research volume 13,pages1614–1619(2020)Cite this article 236 Accesses Metrics details Abstract Optical silicon(Si)-based materials are highly attractive due to their widespread applications ranging from electronics to biomedicine.It is worth noting that while extensive efforts have been devoted to developing fluorescent Si-based structures,there currently exist no examples of Si-based materials featuring phosphorescence emission,severely limiting Si-based wide-ranging optical applications.To address this critical issue,we herein introduce a kind of Si-based material,in which metal-organic frameworks(MOFs)are in-situ growing on the surface of Si nanoparticles(SiNPs)assisted by microwave irradiation.Of particular significance,the resultant materials,i.e.,MOFs-encapsulated SiNPs(MOFs@SiNPs)could exhibit pH-responsive fluorescence,whose maximum emission wavelength is red-shifted from 442 to 592 nm when the pH increases from 2 to 13.More importantly,distinct room-temperature phosphorescence(maximum emission wavelength:505 nm)could be observed in this system,with long lifetime of 215 ms.Taking advantages of above-mentioned unique optical properties,the MOFs@SiNPs are further employed as high-quality anti-counterfeiting inks for advanced encryption.In comparison to conventional fluorescence anti-counterfeiting techniques(static fluorescence outputs are generally used,thus being easily duplicated and leading to counterfeiting risk),pH-responsive fluorescence and room-temperature phosphorescence of the resultant MOFs@SiNPs-based ink could offer advanced multi-modal security,which is therefore capable of realizing higher-level information security against counterfeiting. | Jinhua Wang Bin Song Jiali Tang Guyue Hu Jingyang Wang Mingyue Cui Yao He | 2020 | Nano Research2020，13，6： | 3 |
| 18 | Thermal Analysis of a Novel Oil Cooled Piston Using a Fluid-Solid Interaction Method显示文摘Thermal load has a vital influence on the normal operation and service life of diesel engines.In this study,the thermal load and oil-cooling effect on diesel engine pistons were investigated by means of computational fluid dynamics.In particular,the flow and heat transfer characteristics of the cooling gallery were determined during the oscillation of the piston.Moreover,the temperature field distribution of the piston with and without the cooling gallery were compared.The results revealed that the cooling gallery has a prominent effect on reducing the thermal load on the piston crown and piston lands.To fully understand the oscillating heat transfer effect related to the cooling gallery and verify the accuracy of the calculation,the numerical results were also compared with temperature values experimentally measured at key positions of the piston.The measurements were found to be consistent with the calculation results within an acceptable error range,which proves the rationality and accuracy of the mathematical and numerical models used. | Dehui Tong Shunshun Qin Jingguo Lin Jingyang Sun Yuping Hu | 2021 | Fluid Dynamics & Materials Processing2021，17，4： | 3 |
| 19 | Studies on the inheritance of transgenic rice with bar gene显示文摘Bar gene driven under the control of CaMV 35s promotor was delivered into the immature embroys of a japonica rice cultivar Jingying 119 through biolistic approach. Two putative transgenic plants were produced, which ex-pressed Basra-resistance. One of the Basra-re-sistance transgenic rices was completely sterile(JY 119-3), the other was self-fertile (JY119-4). | HUANG Danian, LI Jingyang, XIAO Han, ZHANG Shanqing, XUE Rui, WANG Xiaoling, YANG Wei, HUA Zhi-hua, and XIE Xiaobo, CNRRI, Hangzhou 310006, China | 1997 | Chinese Rice Research Newsletter1997，5，4： | 3 |
| 20 | 2D nanomaterials for tissue engineering application显示文摘Recently,tissue engineering has developed into a powerful tool for repairing and reconstructing damaged tissues and organs.Tissue engineering scaffolds play a vital role in tissue engineering,as they not only provide structural support for targeted cells but also serve as templates that guide tissue regeneration and control the tissue structure.Over the past few years,owing to unique physicochemical properties and excellent biocompatibility,various types of two-dimensional(2D)nanomaterials have been developed as candidates for the construction of tissue engineering scaffolds,enabling remarkable achievements in bone repair,wound healing,neural regeneration,and cardiac tissue engineering.These efforts have significantly advanced the development of tissue engineering.In this review,we summarize the latest advancements in the application of 2D nanomaterials in tissue engineering.First,each typical 2D nanomaterial is introduced briefly,followed by a detailed description of its applications in tissue engineering.Finally,the existing challenges and prospects for the future of the application of 2D nanomaterials in tissue engineering are discussed. | Jingyang Zhang Haolin Chen Meng Zhao Guiting Liu Jun Wu | 2020 | Nano Research2020，13，8： | 3 |
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