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| 1 | Functional brain imaging in irritable bowel syndrome with rectal balloon-distention by using fMRI显示文摘AIM: Irritable bowel syndrome (IBS) is characterized by abdominal pain and changes in stool habits. Visceral hypersensitivity is a key factor in the pathophysiology of IBS. The aim of this study was to examine the effect of rectal balloon-distention stimulus by blood oxygenation leveldependent functional magnetic resonance imaging (BOLDfMRI) in visceral pain center and to compare the distribution,extent, and intensity of activated areas between IBS patients and normal controls.
METHODS: Twenty-six patients with IBS and eleven normal controls were tested for rectal sensation, and the subjective pain intensity at 90 ml and 120 ml rectal balloon-distention was reported by using Visual Analogue Scale. Then, BOLDfMRI was performed at 30 ml, 60 ml, 90 ml, and 120 ml rectal balloon-distention in all subjects.
RESULTS: Rectal distention stimulation increased the activity of anterior cingulate cortex (35/37), insular cortex (37/37),prefrontal cortex (37/37), and thalamus (35/37) in most cases.At 120 ml of rectal balloon-distention, the activation area and percentage change in MR signal intensity of the regions of interest (ROI) at IC, PFC, and THAL were significantly greater in patients with IBS than that in controls. Score of pain sensation at 90 ml and 120 ml rectal balloon-distention was significantly higher in patients with IBS than that in controls.
CONCLUSION: Using fMRI, some patients with IBS can be detected having visceral hypersensitivity in response to painful rectal balloon-distention. fMRI is an objective brain imaging technique to measure the change in regional cerebral activation more precisely. In this study, IC and PFC of the IBS patients were the major loci of the CNS processing of visceral perception. | Yao-ZongYuan Ran-JunTao BinXu JingSun Ke-MinChen FeiMiao Zhong-WeiZhang Jia-YuXu | 2003 | World Journal of Gastroenterology2003，9，6： | 31 |
| 2 | Cloning and Overexpression of CYP6F1,a Cytochrome P450 Gene,from Deltamethrin-resistant Culex pipiens pallens显示文摘CYP6F1 (GenBank/EMBL accession No. AY662654), a novel gene with a complete encoding sequence in the cytochrome P450 family 6, was cloned and sequenced from deltamethrin-resistant 4th instar larvae of Culex pipiens pallens. The cDNA sequence of CYP6F1 has an open reading frame of 1527 bp, which encodes a putative protein of 508 amino acid residues. The deduced amino acid sequence of CYP6F1 indicated that the encoded P450 has conserved domains of a putative membrane-anchoring signal,putative reductase-binding sites, a typical heme-binding site, an ETLR motif and substrate recognition sites.Semi-quantitative RT-PCR analysis indicated that the CYP6F1 gene was expressed to a greater extent in the deltamethrin-resistant strain than in the susceptible strain of Cx. pipiens pallens. The expression levels of the CYP6F1 gene in the deltamethrin-resistant 1 st, 2nd, 3rd, 4th instar larvae and adult female mosquitoes differed, with highest expression levels in the 4th instar larvae. In addition, the CYP6F1 gene was stably expressed in mosquito C6/36 cells, and the expected 61.2 kDa band was identified by Western blotting. The cells transfected with CYP6F1 had an increased resistance to deltamethrin as compared with control cells.These results indicate that CYP6F1 is expressed at higher levels in the deltamethrin-resistant strain, and may confer some insecticide resistance in Cx. pipiens pallens. | Mao-QingGONG YanGU Xiao-BangHU YanSUN LeiMA Xiu-LanLI Li-XinSUN JingSUN | 2005 | Acta Biochimica et Biophysica Sinica2005，37，5： | 10 |
| 3 | 关于群体性事件发生规律的10个判断——基于参与者行为特征的分析显示文摘群体性事件已成为现代中国社会发展过程中不可回避的一个社会问题。从现有研究看,关于群体性事件的描述及其发生的原因分析较多,但对于事件参与者的行为特点分析较少。本文以国内外社会学、心理学相关领域的理论为依据,结合国内群体性事件的一些特点,对群体性事件参与者的行为特征进行分析,尝试提出群体性事件参与者的行为特征描述模型,并据此对群体性事件发生规律给予尽可能的判断。 | 王新超 林泽炎 JingSun | 2011 | 国家行政学院学报2011，，1： | 8 |
| 4 | Antigenic and immunogenic changes due to mutation of sgene of HBV显示文摘AIM: To investigate the change of immunological characteristics of HBsAg caused by the mutation at codon 145 of HBsAg using DNA-based immunization.METHODS: Plasmids expressing mutant and wild type envelope antigens were transfected into human hepatocellular carcinoma cells via electrotransformation. The antigenicity of HBsAg was studied with EIA and immunocytochemical staining. Then plasmids were used to immunize 5 C57BL/6 mice. Sera of mice were detected for anti-HBs and anti-preS2with ELISA. RESULTS: The mutant HBsAg could be detected by native antibody in EIA and immunocytochemical study. But the A(450nm) value of the mutant HBsAg in the supernatant was apparently lower than that of the wild-type. Both mutant and native HBsAg expression plasmid could stimulate a strong humoral immune response to HBsAg and preS2 antigen in mice. Protective antibodies against HBsAg elicited by the native HBsAg occurred earlier than that elicited by the mutant HBsAg about one to two weeks. The occurrence of protective antibodies against preS2 antigen was one to two weeks earlier than that of anti-HBs.CONCLUSION: The amino acid substitution causes changes of the antigenicity and immunogenicity of HBsAg, but mutant HBsAg can still induce a protective humoral immune responsein mice. | Jun-HuiGe Hui-MinLiu JingSun Le-ZhiZhang ]inHe Yu-LiLi HongLiu YiXu Hong-YuYu Yi-PingHu | 2004 | World Journal of Gastroenterology2004，10，21： | 6 |
| 5 | THE SINGULARLY PERTURBED BOUNDARY VALUE PROBLEMS FOR SEMILINEAR ELLIPTIC EQUATION显示文摘The singularly perturbed boundary value problems for the semilinear elliptic equation are considered. Under suitable conditions and by using the fixed point theorem, the existence, uniqueness and asymptotic behavior of solution for the boundary value problems are studied. | Mo Jiaqi Yao Jingsun | 2001 | Analysis in Theory and Applications2001，17，4： | 5 |
| 6 | GENERALIZED SOLUTION OF SINGULARLY PERTURBED PROBLEMS FOR REACTION DIFFUSION EQUATIONS显示文摘The singularly perturbed initial boundary value problem for reaction diffusion equation is considered. Under suitable conditions the existence, uniqueness and asymptotic behavior of the generalized solution for the problems are studied. | Yao Jingsun Mo Jiaqi | 2006 | Annals of Differential Equations2006，22，1： | 4 |
| 7 | THE NONLINEAR NONLOCAL SINGULARLY PERTURBED PROBLEMS FOR REACTION DIFFUSION EQUATIONS WITH A BOUNDARY PERTURBATION显示文摘The nonlinear nonlocal singularly perturbed initial boundary value problems for reaction diffusion equations with a boundary perturbation is considered. Under suitable conditions, the outer solution of the original problem is obtained. Using the stretched variable, the composing expansion method and the expanding theory of power series the initial layer is constructed. And then using the theory of differential inequalities the asymptotic behavior of solution for the initial boundary value problems is studied. Finally the existence and uniqueness of solution for the original problem and the uniformly valid asymptotic estimation are discussed. | Jingsun Yao Jiaqi Mo | 2005 | Analysis in Theory and Applications2005，21，3： | 4 |
| 8 | THE SOLVABILITY FOR NONLINEAR SINGULARLY PERTURBED DIFFERENTIAL SYSTEM显示文摘The solvability for the nonlinear singularly perturbed boundary value pro- blem of differential system is considered.Using the boundary layer corrective method the formal asymptotic solution is constructed.And using the theory of differential inequality proves the uniform validity of the asymptotic expansion for the solution. | Yao Jingsun Chen Lihua Mo Jiaqi | 2007 | Annals of Differential Equations2007，23，3： | 2 |
| 9 | Shock Solution for a Class of Nonlinear Elliptic Equation显示文摘The boundary value problem for the nonlinear elliptic equation is considered. The outer solution for the original problem is obtained. The boundary and interior layer correction terms are constructed by introducing stretched variables and setting local coordinate systems near the boundary and interior discontinuous point of outer solution. Under suitable conditions, using the differential inequalities and the mean value theorem, the existence of the shock solution for boundary value problem is proved and the asymptotic behavior of the solution is studied. | CHEN Lihua YAO Jingsun MO Jiaqi | 2011 | Wuhan University Journal of Natural Sciences2011，16，4： | 2 |
| 10 | A CLASS OF NONLINEAR PREDATOR-PREY SINGULARLY PERTURBED ROBIN PROBLEMS FOR REACTION DIFFUSION SYSTEM显示文摘A class of nonlinear predator-prey singularly perturbed Robin problems for reaction diffusion systems are considered. Under suitable conditions, using the theory of differential inequalities the existence and asymptotic behavior of solution for the initial boundary value problems are studied. | Mo Jiaqi Zhang Weijiang He Ming Yao Jingsun | 2006 | Annals of Differential Equations2006，22，2： | 1 |
| 11 | Human mesenchymal stem cells inhibit metastasis of a hepatocellular carcinoma model using the MHCC97‐H cell line显示文摘 | Guo‐CaiLi Qing‐HaiYe Yu‐HuaXue Hai‐JingSun Hai‐JunZhou NingRen Hu‐LiangJia JiongShi Jin‐CaiWu ChunDai Qiong‐ZhuDong | 2010 | Cancer Science2010，，12： | 1 |
| 12 | ASYMPTOTIC SOLUTION TO MODEL FOR A CLASS OF VIRUS TRANSMISSION显示文摘In this paper, a class of HIV virus transmission is considered. The transmissive dynamic model for the HIV virus is described. Using the functional-variational iteration theory, the rule for human group in the epidemic transmissive area is studied. | Jiaqi Mo 1,2 , Jingsun Yao 1 (1. Dept. of Math., Anhui Normal University, Wuhu 241003, Anhui 2. Division of Computational Science, E-Institutes of Shanghai Universities, at SJTU, Shanghai 200240) | 2010 | Annals of Differential Equations2010，26，4： | 1 |
| 13 | Anatase TiO2‐Coated Multi‐Wall Carbon Nanotubes with the Vapor Phase Method显示文摘 | WugangFan LianGao JingSun | 2005 | Journal of the American Ceramic Society2005，，： | 1 |
| 14 | Fuzzy mixture inventory model involving fuzzy random variable lead time and fuzzy total demand 显示文摘 | Chang H C Yao Jingsun Ouyang L Y | 2006 | European Journal of Operation Research2006，169，1： | 1 |
| 15 | SINGULARLY PERTURBED SOLUTION TO SEMILINEAR HIGHER ORDER REACTION DIFFUSION EQUATIONS WITH TWO PARAMETERS显示文摘A boundary value problem for semilinear higher order reaction diffusion equa-tions with two parameters is considered. Under suitable conditions, by the theory of differential inequalities, the existence and asymptotic behavior of solutions to initial boundary value problem are studied. | Yao Jingsun, Mo Jiaqi (Dept. of Math., Anhui Normal University, Wuhu 241000, Anhui Division of Computational Science, E-Institutes of Shanghai Universities, at SJTU, Shanghai 200240) | 2009 | Annals of Differential Equations2009，25，1： | 1 |
| 16 | Hematopoietic Stem Cell Transplantation for Patients with Chronic Myeloid Leukemia显示文摘OBJECTIVE To evaluate the effects of autologous and allogeneic hematopoietic stem cell transplantation (HSCT) for patients with chronic myeloid leukemia(CML).METHODS Fifty-seven patients with CML were treated by HSCT, including 8 cases treated with autologous transplantation purged in vivo and in vitro of minimal residual disease (MRD), 39 cases with related donor allogeneic HSCT (allo-HSCT) and 10 cases with unrelated donor alIo-HSCT. The conditioning regimen was a TBI (total-body irradiation) +CY (cyclophosphamide, CTX) protocol in 32 patients, a modified BuCY (hydroxyurea, busulfan, Ara-C, CTX) protocal in 24 patients, and a MACC ( Melphalan, Ara-C, CTX and chlorethyl cyclohexyl nitrosourea ) protocol in one patient. Cyclosporine (CsA) and methotrexate (MTX) were used in patients with related-donor allo-HSCT, and CsA and MTX were added to mycophenolate mofetil (MMF) and antithymocyte globulin (ATG) in unrelated donor allo-HSCT for graft versus host disease (GVHD) prophylaxis. Otherwise, CsA was only used for GVHD prophylaxis in patients with accelerated phase (AP) and blast crisis (BC). The Kaplan-Meier survival analysis model was used to estimate the overall survival (OS) and the disease-free survival (DSF) at 5 years after transplantation.RESULTS Eight patients with autologous transplantation, except for 1 case who died of transplantation-related complications, obtained cytogenetic part or complete remission (CR) within 3 months after transplantation. One patient, who was in BC and obtained CR in hematology before transplantation, had been in molecular CR for 92 months after autologous transplantation. Among the 49 patients treated with alIo-HSCT, all obtained CR, except for one patient who died of hepatic veno-occlusive disease (VOD) and one who had not obtained CR. The incidence of infection and VOD was 33.3% and 7.0%, respectively, during transplantation. After transplantation the incidence of hemorrhagic cystitis (HC) and cytomegalovirus (CMV) interstitial pneumonia (IP) was 22.8% and 8.8%, respectively. VOD, HC and CMV IP did not occur in patients with autologous transplantation. The incidence of acute GVHD and the frequency of chronic GVHD was 41.0% and 48.6%, respectively, in patients with related and unrelated transplantation. The rate of relapse in patients with autologous and allogeneic transplantation was 57.1% and 12.8%, respectively. The DFS at 5 years after transplantation was 25.0% and 61.7%, respectively, in patients with autologous and related donor transplantation. The DFS at 5 years was 70.7% and 34.1%, respectively, in patients with CP (chronic phase) or AP and BC before transplantation.CONCLUSION AIIo-HSCT may have a higher clinical cure rate for CML patients with CP. The CsA +MTX +MMF +ATG protocol is more effective for acute GVHD prophylaxis and can decrease the incidence and degree of GVHD in patients with unrelated donor transplantation, Autologous transplantation with purged bone marrow can prolong the survival time of CML patients and some may be cured with transplants of this type. | QifaLiu ZhipingFan JingSun YuZhang XiaoliLiu DanXu BingXu RuFeng FanyiMeng ShuyunZhou | 2004 | Chinese Journal of Clinical Oncology2004，1，6： | 0 |
| 17 | ASYMPTOTIC SOLUTION TO NONLINEAR REACTION DIFFUSION EQUATION WITH TWO SMALL PARAMETERS显示文摘In this paper, a class of nonlinear reaction diffusion singularly perturbed problem with two parameters is studied. Using the singular perturbation method, the structure of solution to the problem is discussed related two small parameters. The asymptotic solution to the problem is given. | Jingsun Yao, Jiaqi Mo (Dept. of Math., Anhui Normal University, Wuhu 241000, Anhui Division of Computational Science, E-Institutes of Shanghai Universities, at SJTU, Shanghai 200240) | 2010 | Annals of Differential Equations2010，26，1： | 0 |
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