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| 1 | Engineering Non-transgenic Gynoecious Cucumber Using an Improved Transformation Protocol and Optimized CRISPR/Cas9 System显示文摘 | Bowen Hu Dawei Li Xin Liu Jingjing Qi Dongli Gao Shuqiao Zhao Sanwen Huang Jinjing Sun Li Yang | 2017 | Molecular Plant2017，10，12： | 25 |
| 2 | The bHLH Transcription Factors MYC2, MYC3, and MYC4 Are Required for Jasmonate-Mediated Inhibition of Flowering in Arabidopsis显示文摘 | Houping Wang Yang Li Jinjing Pan Dengji Lou Yanru Hu Diqiu Yu | 2017 | Molecular Plant2017，10，11： | 19 |
| 3 | DNA immunization with fusion genes encoding different regions of hepatitis C virus E2 fused to the gene for hepatitis B surface antigen elicits immune responses to both HCV and HBV显示文摘AIM: Both Hepatitis B virus (HBV) and Hepatitis C virus(HCV) are major causative agents of transfusion-associatedand community-acquired hepatitis worldwide. Developmentof a HCV vaccine as well as more effective HBV vaccines isan urgent task. DNA immunization provides a promisingapproach to elicit protective humoral and cellular immuneresponses against viral infection. The aim of this study is toachieve immune responses against both HCV and HBV by DNAimmunization with fusion constructs comprising various HCVE2 gene fragments fused to HBsAg gane of HBV.METHODS: C57BL/6 mice were immunized with plasmid DNAexpressing five fragments of HCV E2 fused to the gene forHBsAg respectively. After one primary and one boostingimmunizations, antibodies against HCV E2 and HBsAg weretested and subtyped in ELISA. Splenic cytokine expressionof IFN-γ and IL-10 was analyzed using an RT-PCR assay.Post-immune mouse antisera also were tested for theirability to capture HCV viruses in the serum of a hepatitis Cpatient in vitro.RESUTLTS: After immunization, antibodies against bothHBsAg and HCV E2 were detected in mouse sera, withIgG2a being the dominant immunoglobulin sub-class. High-level expression of INF-γ was deuetected in cultured splenic cells.Mouse antisera against three of the five fusion constructs wereable to capture HCV viruses in an in vitro assay.CONCLUSION: The results indicate that these fusionconstructs could efficiently elicit humoral and Th1 dominantcellular immune responses against both HBV S and HCV E2antigens in DNA-immunized mice. They thus could serve ascandidates for a bivalent vaccine against HBV and HCVinfection. In addition, the capacity of mouse antisera againstthree of the five fusion constnucts to capture HCV virusses invitro suggested that neutralizing epitopes may be present inother regions of E2 besides the hypervariable region 1. | JinJ YangJY 等 | 2002 | World Journal of Gastroenterology2002，8，3： | 18 |
| 4 | An ACC Oxidase Gene Essential for Cucumber Carpel Development显示文摘在植物的性决心产生便于 outcrossing 并且提高基因差异的单性的花。在黄瓜和甜瓜,乙烯支持心皮开发并且逮捕雄蕊开发。五性决心基因被识别了,包括四个编码在乙烯生合成催化限制率的步骤的 1-aminocyclopropane-1-carboxylate (ACC ) synthase,和抄写因素基因在甜瓜对应于孟德尔的地点 gynoecious 并且是女性的一个否定管理者的 CmWIP1。ACC oxidase (ACO ) 把 ACC 变换成乙烯;然而,它留下逃犯在黄瓜染色体的基因为性决心是它 ACO 并且怎么批评的 CmWIP1 镇压女花的开发。在这研究,我们在 ACO 基因发现了那个变化, CsACO2,在忍受仅仅男的花的黄瓜授与 androecy。变化破坏 CsACO2 的酶的活动,导致从射击尖端的 50% 更少的乙烯排放。CsACO2 在心皮 primordia 被表示,它的表示为性决心在关键阶段在女花与 CsACS11 的重叠了,大概提供为合适的 CsACS2 要求的足够的乙烯表示。CmACO3, CsACO2 的 ortholog,在心皮区域显示出一个类似的表示模式,建议 CsACO2/CmACO3 的保存功能。我们表明了那 CsWIP1, CmWIP1 的 ortholog,能直接绑 CsACO2 的倡导者并且镇压它的表示。一起拿,我们建议由 WIP1 抄写因素和 ACO 组成的一个大概保存的规章的模块在黄瓜和甜瓜控制单性的花开发。 | Huiming Chen Jinjing Sun Shuai Li Qingzhi Cui Huimin Zhang Fengjiao Xin Huaisong Wang Tao Lin Dongli Gao Shenhao Wang Xia Li Donghui Wang Zhonghua Zhang Zhihong Xu Sanwen Huang | 2016 | Molecular Plant2016，9，9： | 16 |
| 5 | Metaverse:Perspectives from graphics,interactions and visualization显示文摘The metaverse is a visual world that blends the physical world and digital world.At present,the development of the metaverse is still in the early stage,and there lacks a framework for the visual construction and exploration of the metaverse.In this paper,we propose a framework that summarizes how graphics,interaction,and visualization techniques support the visual construction of the metaverse and user-centric exploration.We introduce three kinds of visual elements that compose the metaverse and the two graphical construction methods in a pipeline.We propose a taxonomy of interaction technologies based on interaction tasks,user actions,feedback and various sensory channels,and a taxonomy of visualization techniques that assist user awareness.Current potential applications and future opportunities are discussed in the context of visual construction and exploration of the metaverse.We hope this paper can provide a stepping stone for further research in the area of graphics,interaction and visualization in the metaverse. | Yuheng Zhao Jinjing Jiang Yi Chen Richen Liu Yalong Yang Xiangyang Xue Siming Chen | 2022 | Visual Informatics2022，6，1： | 10 |
| 6 | Preliminary evidence for the presence of multiple forms of cell death in diabetes cardiomyopathy显示文摘Diabetic mellitus(DM) is a common degenerative chronic metabolic disease often accompanied by severe cardiovascular complications(DCCs) as major causes of death in diabetic patients with diabetic cardiomyopathy(DCM) as the most common DCC. The metabolic disturbance in DCM generates the conditions/substrates and inducers/triggers and activates the signaling molecules and death executioners leading to cardiomyocyte death which accelerates the development of DCM and the degeneration of DCM to heart failure.Various forms of programmed active cell death including apoptosis, pyroptosis, autophagic cell death, autosis,necroptosis, ferroptosis and entosis have been identified and characterized in many types of cardiac disease.Evidence has also been obtained for the presence of multiple forms of cell death in DCM. Most importantly,published animal experiments have demonstrated that suppression of cardiomyocyte death of any forms yields tremendous protective effects on DCM. Herein, we provide the most updated data on the subject of cell death in DCM, critical analysis of published results focusing on the pathophysiological roles of cell death, and pertinent perspectives of future studies. | Jinjing Wei Yongting Zhao Haihai Liang Weijie Du Lihong Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 8 |
| 7 | Arabidopsis VQ10 interacts with WRKY8 to modulate basal defense against Botrytis cinerea显示文摘Recent studies in Arabidopsis have revealed that some VQ motif-containing proteins physically interact with WRKY transcription factors;however,their specific biological functions are still poorly understood.In this study,we confirmed the interaction between VQ10and WRKY8,and show that VQ10 and WRKY8 formed a complex in the plant cell nucleus.Yeast two-hybrid analysis showed that the middle region of WRKY8 and the VQ motif of VQ10 are critical for their interaction,and that this interaction promotes the DNA-binding activity of WRKY8.Further investigation revealed that the VQ10protein was exclusively localized in the nucleus,and VQ10was predominantly expressed in siliques.VQ10 expression was strongly responsive to the necrotrophic fungal pathogen,Botrytis cinerea and defense-related hormones.Phenotypic analysis showed that disruption of VQ10 increased mutant plants susceptibility to the fungal pathogen B.cinerea,whereas constitutive-expression of VQ10 enhanced resistance to B.cinerea.Consistent with these findings,expression of the defenserelated PLANT DEFENSIN1.2(PDF1.2)gene was decreased in vq10 mutant plants,after B.cinerea infection,but increased in VQ10-overexpressing transgenic plants.Taken together,our findings provide evidence that VQ10 physically interacts with WRKY8 and positively regulates plant basal resistance against the necrotrophic fungal pathogen B.cinerea. | Junqiu Chen Houping Wang Yang Li Jinjing Pan Yanru Hu Diqiu Yu | 2018 | Journal of Integrative Plant Biology2018，60，10： | 8 |
| 8 | Batch proxy quantum blind signature scheme显示文摘Motivated by proxy signature and blind signature for the secure communications,the batch signature is proposed to create a novel quantum cryptosystem.It is based on three-dimensional two-particle-entangled quantum system which is used to distribute the quantum keys and create strings of quantum-trits(qutrits) for messages.All of the messages,which are expected to be signed,are encrypted by the private key of the message owner during communications.Different from the classical blind signature,an authenticity verification of signatures and an arbitrator's efficient batch proxy signature are simultaneously applied in the present scheme.Analysis of security and efficiency shows that it enables us to achieve a large number of quantum blind signatures for quantities of messages with a high efficiency with the arbitrator's secure batch proxy blind signature. | SHI JinJing SHI RongHua GUO Ying PENG XiaoQi TANG Ying | 2013 | Science China(Information Sciences)2013，56，5： | 7 |
| 9 | Thermal behavior analysis of nickel/metal hydride battery during overcharging显示文摘To analyze the thermal behavior of the cylinder Ni/MH battery during overcharging,a two-dimensional thermal model is provided in this work.More reliable data is provided to create the precise thermal model.The amount of heat of the battery during overcharging at different currents was measured using quartz frequency microcalorimeter.To obtain the heat transfer coefficient of the battery during overcharging,the heat dissipation rate was fitted into linear functions and three different exponential functions from the temperature value measured by the microcalorimeter.The heat dissipation process after the linear stage was regared to accord with some mathematical differential expressions,which facilities understanding of the variation rule of heat dissipation rate during the transition stage and overcharging process.Theoretical values were used as heat generation rates in the heat transport equation.Using the measured data,the internal temperature profiles at the end of each stage during charging at 1C,3C and 5C were simulated using FEM. | Yang, Kai An, JinJing Chen, Shi | 2010 | Science China Chemistry2010，53，5： | 5 |
| 10 | Control of Corner Separation by Optimized Slot Configuration in a Linear Compressor Cascade显示文摘为控制压气机叶片吸力面与端壁处所形成的三维角区分离,本文在叶根处引入了从压力面到吸力面的槽道来控制角区分离流动。基于利用优化算法对叶根处槽道几何的优化结果,本文通过数值模拟和实验来分析槽道在不同进口攻角下对角区分离的控制效果。本文通过对比原始和开槽叶栅中总压损失、静压升和三维角区分离特征表明叶根处引入的槽道对角区分离有明显的控制效果。 | Jinjing Sun Yangwei Liu Lipeng Lu Xavier OTTAVY | 2016 | 风机技术2016，58，6： | 4 |
| 11 | Oxidation behavior of ammonium in a 3-dimensional biofilm-electrode reactor显示文摘Excess nitrogenous compounds are detrimental to natural water systems and to human health. To completely realize autohy- drogenotrophic nitrogen removal, a novel 3-dimensional biofilm-electrode reactor was designed. Titanium was electroplated with ruthenium and used as the anode. Activated carbon fiber felt was used as the cathode. The reactor was separated into two chambers by a permeable membrane. The cathode chamber was filled with granular graphite and glass beads. The cathode and cathode chamber were inhabited with domesticated biofilm. In the absence of organic substances, a nitrogen removal efciency of up to 91% was achieved at DO levels of 3.42 ± 0.37 mg/L when the applied current density was only 0.02 mA/cm2. The oxidation of ammonium in biofilm- electrode reactors was also investigated. It was found that ammonium could be oxidized not only on the anode but also on particle electrodes in the cathode chamber of the biofilm-electrode reactor. Oxidation rates of ammonium and nitrogen removal efciency were found to be afected by the electric current loading on the biofilm-electrode reactor. The kinetic model of ammonium at diferent electric currents was analyzed by a first-order reaction kinetics equation. The regression analysis implied that when the current density was less than 0.02 mA/cm2, ammonium removal was positively correlated to the current density. However, when the current density was more than 0.02 mA/cm2, the electric current became a limiting factor for the oxidation rate of ammonium and nitrogen removal efciency. | Jinjing Tang Jinsong Guo Fang Fang Youpeng Chen Lijing Lei Lin Yang | 2013 | Journal of Environmental Sciences2013，25，12： | 3 |
| 12 | Effects of Integrated Soil-Crop System Management on Soil Organic Carbon Characteristics in a Primosol in Northeast China显示文摘A synchronous increase in crop productivity, nutrient use efficiency, and soil carbon(C) sequestration is important from the point of view of food security and environmental protection. In recent years, integrated soil-crop system management(ISSM), which uses crop models and advanced nutrient management to redesign cropping systems, has been successfully demonstrated to achieve both high crop productivity and high nutrient use efficiency in China, but the effects of ISSM on soil organic C(SOC) characteristics remain unknown. In this study, the effects of current farmers' practice(FP), high-yielding practice(HY), which maximizes yields without considering costs, and ISSM on the content and chemical composition of SOC were studied in a 4-year(2009–2013) field plot experiment with maize(Zea mays L.) monoculture in an Alluvic Primosol in Northeast China. The ISSM resulted in higher soil total organic C(TOC), water-soluble organic C, easily-oxidizable organic C, particulate organic C, and humic acid C compared with HY and FP in the region. The SOC contents in aggregate size fractions generally followed a similar pattern to TOC. Compared with FP,HY decreased the mean weight diameter, geometric mean diameter, percentage of > 0.25-mm water-stable aggregates, and the stability ratio of water-stable aggregates, and increased the structure-deterioration rate and index of unstable aggregates. The opposite trend was observed between ISSM and HY. Solid-state ^(13)C nuclear magnetic resonance spectra of bulk soil showed that ISSM had higher O-alkyl C and aliphatic C/aromatic C ratio, but lower aromatic C, carbonyl C, and alkyl C/O-alkyl C and hydrophobic C/hydrophilic C ratios than HY and FP. Our results suggest that ISSM improves the quantity and quality of SOC and has a positive effect on soil aggregation and aggregate stability. | ZHANG Jinjing CAO Zhiyuan FENG Guozhong LI Mengyao LI Cuilan GAO Qiang WANG Lichun | 2017 | Pedosphere2017，27，5： | 3 |
| 13 | An exon skipping in a SEPALLATA-Like gene is associated with perturbed floral and fruits development in cucumber显示文摘We isolated a mutant showing perturbations in the development of male and female floral organs and fruits. Analysis of the single nucleotide polymorphisms from bulked F_2 pools identified the causative variant occurring in Csa4G126690. Csa4G126690 shows high homology to Arabidopsis SEPALLATA2(SEP2) thus being designated Cs SEP2. The causative variant was located on the splicing site of Cs SEP2, resulting in the skipping of exon 6 and abolishment of the transcriptional activity. Our data suggest that Cs SEP2 is involved in the floral organ and fruits development by conferring transcriptional activity. | Xin Wang Dongli Gao Jinjing Sun Min Liu YaoYao Lun Jianshu Zheng Shenhao Wang Qingzhi Cui Xiaofeng Wang Sanwen Huang | 2016 | Journal of Integrative Plant Biology2016，58，9： | 2 |
| 14 | Strata movement and stress evolution when mining two overlapping panels affected by hard stratum显示文摘Mining causes stress redistribution and stratum movement.In this paper,a numerical model was built according to the geological conditions in the 12th coal mine in Pingdingshan city to study the strata movement and the evolution of stress when mining two overlapping longwall panels,named panels#14 and#15.The strata close to the mined panel move directly towards the gob,while the strata that are farther away swing back and forth during the mining process.The directed movement and swinging can break the transverse boreholes for gas extraction;a surface borehole should not be within the range of directional movement.The stress evolution suggested that the mining of the lower panel#15 after the upper panel#14 would further increase the de-stressed range,while the stress concentration around the mined panel would be increased.Hard strata usually carry a greater stress than adjacent rocks and soft coal seams.The stress in a hard stratum increases greatly,and the stress decreases greatly in the coal seams below the hard stratum.This study supplies a reference for similar coal mines and is useful for determining the de-stressed range and transverse borehole arrangement for gas extraction. | Jianguo Zhang Wei Yang Baiquan Lin Jinjing Zhang Man Wang | 2019 | International Journal of Mining Science and Technology2019，29，5： | 2 |
| 15 | Motor relearning program and Bobath method improve motor function of the upper extremities in patients with stroke显示文摘BACKGROUND: In the natural evolution of cerebrovascular disease, unconscious use of affected extremity during drug treatment and daily life can improve the function of affected upper extremity partially, but it is very slow and also accompanied by the formation of abnormal mode. Therefore, functional training should be emphasized in recovering the motor function of extremity. OBJECTIVE: To observe the effects of combination of motor relearning program and Bobath method on motor function of upper extremity of patients with stroke. DESIGN: Comparison of therapeutic effects taking stroke patients as observation subjects. SETTING: Department of Neurology, General Hospital of Beijing Jingmei Group. PARTICIPANTS: Totally 120 stroke patients, including 60 males and 60 females, averaged (59±3) years, who hospitalized in the Department of Neurology, General Hospital of Beijing Jingmei Group between January 2005 and June 2006 were recruited. The involved patients met the following criteria: Stroke attack within 2 weeks; diagnosis criteria of cerebral hemorrhage or infarction made in the 4th National Cerebrovascular Disease Conference; confirmed by skull CT or MRI; Informed consents of therapeutic regimen were obtained. The patients were assigned into 2 groups according to their wills: rehabilitation group and control group, with 30 males and 30 females in each group. Patients in rehabilitation group averaged (59±2)years old, and those in the control group averaged (58±2)years old. METHODS: ① Patients in two groups received routine treatment in the Department of Neurology. When the vital signs of patients in the rehabilitation group were stable, individualized treatment was conducted by combined application of motor relearning program and Bobath method. Meanwhile, training of activity of daily living was performed according to the disease condition changes of patients at different phases, including the nursing and instruction of body posture, the maintenance of good extremity position, bed exercise, bedside sit up and sitting position balance, sit up exercise, dynamic and static balance exercise, walking exercise, active training and passive training. The strength, time and speed of training were increased gradually according to their physical abilities. Patients were trained 45 to 60 minutes once, 5 times a week, within 2 weeks. ② Evaluation criteria of therapeutic effect: The motor function of upper extremity was evaluated by Fugl-Meyer method on the day of beginning and end of treatment. Higher points indicated better function of upper extremity. ③ t test and paired t test were used for comparing the difference of intergroup and intragroup measurement data, respectively. MAIN OUTCOME MEASURES: Changes in Fugl-Meyer scoring of two groups before and after treatment. RESULTS: Totally 120 stroke patients participated in the final analysis. Before treatment, Fugl-Meyer scoring was close between rehabilitation group and control group [(14.47±2.38),(14.16±2.39) points, P > 0.05]; Fugl-Meyer scoring of rehabilitation group after treatment was significantly higher than that before treatment and that of control group[(37.93±2.67),(18.36±2.43) points, t =11.053, 5.408, P < 0.01]; There were no significant differences in Fugl-Meyer scoring between before treatment in the control group and control group (P > 0.05). CONCLUSION: Combined application of motor relearning program and Bobath method can significantly improve the motor function of upper extremity of patients with stroke. | Jinjing Liu Fengsheng Li Guihua Liu | 2006 | Neural Regeneration Research2006，1，9： | 2 |
| 16 | Comparison of in-vial exhaust method versus conventional exhaust method in the injection of COVID-19 vaccine显示文摘Objective:The objective of the study was to compare the application effects of in-vial exhaust method and conventional exhaust method in the process of coronavirus disease 2019 vaccine injection.Materials and Methods:Using convenient sampling method,102 vaccines were selected as experiment group during the process of vaccine injection,and the in-vial exhaust method was used.One hundred and five vaccines were selected as the control group and the conventional exhaust method was adopted.The incidence of vaccine solution spillage and exhausting time in the two groups during exhaust were observed.Results:The incidence of solution spillage in the experiment group was lower than that in the control group(0 vs.6.67%,P<0.05).The exhausting time of the experiment group was shorter than that of the control group([15.12±4.43]s vs.[22.74±6.53]s,P<0.05).Conclusion:Implementing the in-vial exhaust method in the vaccine injection can effectively reduce the incidence of solution spillage,reduce nucleic acid contamination,and ensure that the vaccine is injected at the prescribed dose.Moreover,the operation is simple and easy,which improves the nurse’s vaccination efficiency,and has a higher promotion and application value. | Jingjin XU Hui ZHI Ye LI Jinjing LIU Wen ZHENG Ling TANG | 2021 | Journal of Integrative Nursing2021，3，3： | 2 |
| 17 | Delta-shocks and vacuums in zero-pressure gas dynamics by the flux approximation显示文摘In this paper,firstly,by solving the Riemann problem of the zero-pressure flow in gas dynamics with a flux approximation,we construct parameterized delta-shock and constant density solutions,then we show that,as the flux perturbation vanishes,they converge to the delta-shock and vacuum state solutions of the zero-pressure flow,respectively.Secondly,we solve the Riemann problem of the Euler equations of isentropic gas dynamics with a double parameter flux approximation including pressure.Furthermore,we rigorously prove that,as the two-parameter flux perturbation vanishes,any Riemann solution containing two shock waves tends to a delta-shock solution to the zero-pressure flow;any Riemann solution containing two rarefaction waves tends to a two-contact-discontinuity solution to the zero-pressure flow and the nonvacuum intermediate state in between tends to a vacuum state.Finally,numerical results are given to present the formation processes of delta shock waves and vacuum states. | YANG HanChun LIU JinJing | 2015 | Science China Mathematics2015，58，11： | 2 |
| 18 | Investigation of role of cartilage surface polymer brush border in lubrication of biological joints显示文摘Although experimental evidence has suggested that the polymer brush border(PBB)on the cartilage surface is important in regulating fluid permeability in the contact gap,the current theoretical understanding of joint lubrication is still limited.To address this research gap,a multiscale cartilage contact model that includes PBB,in particular its effect on the fluid permeability of the contact gap,is developed in this study.Microscale modeling is employed to estimate the permeability of the contact gap.This permeability is classified into two categories:For a gap size>1μm,the flow resistance is assumed to be dominated by the cartilage roughness;for gap size<1μm,flow resistance is assumed to be dominated by the surface polymers extending beyond the collagen network of the articular cartilage.For gap sizes of less than 1μm,the gap permeability decreases exponentially with increasing aggrecan concentration,whereas the aggrecan concentration varies inversely with the gap size.Subsequently,the gap permeability is employed in a macroscale cartilage contact model,in which both the contact gap space and articular cartilage are modeled as two interacting poroelastic systems.The fluid exchange between these two media is achieved by imposing pressure and normal flux continuity boundary conditions.The model results suggest that PBB can substantially enhance cartilage lubrication by increasing the gap fluid load support(e.g.,by 26 times after a 20-min indentation compared with the test model without a PBB).Additionally,the fluid flow resistance of PBB sustains the cartilage interstitial fluid pressure for a relatively long period,and hence reduces the vertical deformation of the tissue.Furthermore,it can be inferred that a reduction in the PBB thickness impairs cartilage lubrication ability. | JinJing LIAO David W.SMITH Saeed MIRAMINI Bruce S.GARDINER Lihai ZHANG | 2022 | Friction2022，10，1： | 2 |
| 19 | SAHA inhibits the growth of colon minors by decreasing histone deacetylase and the expression of cy- clin D1 and survivin显示文摘 | JinJS Tsao TY Sun PC | 2012 | Pathol Oncol Res2012，18，3： | 1 |
| 20 | Effect of MnO2 Addition on Sintering Properties of 18NiO-NiFe2O4 Composite Ceramics: Preliminary Results显示文摘 | Jinjing Du Yihan Liu Guangchun Yao Zhigang Zhang | 2012 | Journal of Materials Engineering and Performance2012，，9： | 1 |
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