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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Thermal behaviour during the pyrolysis of low rank perhydrous coals显示文摘 | A Arenillas F Rubiera J.J Pis M.J Cuesta M.J Iglesias A Jiménez I Suárez-Ruiz | 2003 | Journal of Analytical and Applied Pyrolysis2003，，： | 1 |
| 3 | Iron-binding ability of melanoidins from food and model systems显示文摘 | MORALES F J FERN(A)NDEZ-FRAGUAS C JIM(E)NEZ-P(E)REZ S | | 0，，04： | 1 |
| 4 | Effect of grape antioxidant dietary fibre on the prevention of lipid oxidation in minced fish:Evaluation by different methodologies显示文摘 | Sánchez-Alonso I Jiménez-Escrig A Saura-Calixto F | 2007 | Food Chemistry2007，，101： | 1 |
| 5 | The banana(Musa acuminata)genome andthe evolution of monocotyledonous plants显示文摘 | HONT A D DENOEUD F AURY J M BAURENSF C CARREELF GARSMEUR O NOEL B BOCS S DROC G ROUARD M SILVA C D JABBARI K CARDI C POULAIN J SOUQUET M LABADIEK JOURDA C LENGELLE J MARGUERITE R G ALBERTI A BERNARD M CORREA M AYYAMPALAYAM S MCKAIN M R JIM L M | 2012 | Nature2012，488，： | 1 |
| 6 | Microbial transformation and degradation of polychlorinated biphenyles 显示文摘 | Jim A F Reyes S A | 2008 | Environmental Pollution2008，155，： | 1 |
| 7 | Indoor pedestrian navigation using an INS/EKF framework for yaw drift reduction and a foot-mounted IMU显示文摘 | Jiménez A R Seco F Prieto J C | 2010 | Institute of Electrical&Electronics Engineers2010，，： | 1 |
| 8 | New cements for the 21st century:The pursuit of an alternative to Portland cement显示文摘 | Shi C J Jiménez A F Palomo A A | 2011 | Cement and Concrete Research2011，41，7： | 1 |
| 9 | Feasibility of expended granular sludge bed reactors for the anaerobic treatment of lowstrength soluble wastewater显示文摘 | Kato M T Jim F A Versteeg P | 1994 | Biotechnology and Bioengineering1994，44，5： | 1 |
| 10 | Improving the accuracy of magnetostrictive linear position sensors显示文摘 | SECO F MART(I)N J M JIM(E)NEZ A R | | 0，，03： | 1 |
| 11 | Biaxial Stress-Strain Relationships for Concrete显示文摘 | TASU JIM E NILSON A H SLATE F O | 1979 | Magazine of Concrete Resarch1979，，： | 1 |
| 12 | A single WAP domain-containing protein from Litopenaeus vannamei hemocytes显示文摘 | JIM (E)NEZ-VEGA F YEPIZ-PLASCENCIA G S(O)DERH (A)LL K | | 0，，03： | 1 |
| 13 | Simultaneous determination of amitriptyline,imipramine and perphenazine in pharmaceutical preparations and blood serum by multi-wavelength spectrophotometry显示文摘 | García Fraga J M Jiménez Abizanda A I Jiménez Moreno F | 1991 | Analytica Chimica Acta1991，252，12： | 1 |
| 14 | Middle cerebral artery alterations in a rat chronic hypoperfusion model显示文摘 | Márquez-Martín A Jiménez-Altayó F Dantas AP | | 0，，： | 1 |
| 15 | Utility of the antigen-specific interferon-γ assay for the management of tuberculosis显示文摘 | Keertan Dheda Zarir F Udwadia Jim F Huggett Margaret A Johnson Graham A.W Rook | 2005 | Current Opinion in Pulmonary Medicine2005，，3： | 1 |
| 16 | Joint channel and frequency offset estimation in MIMO-OFDM systems with insuffi-cient cyclic prefix显示文摘 | AMO C P D JIMéNEZ V P G GARCíA M J F G | | 0，，22： | 1 |
| 17 | NMR evidence of a short linear peptide that folds into a β-hairpin in aqueous solution显示文摘 | Blanco F J Jiménez M A Herranz J | 1993 | J Am Chem Soc1993，115，： | 1 |
| 18 | Com- parison of film condensation models in presence of non-condensable gases implemented in a CFD code显示文摘 | MARTIN J M JIM M A MARTIN F | 2005 | Heat Mass Transfer2005，41，11： | 1 |
| 19 | Azo dye decolourisation byanaerobic granular sludge 显示文摘 | F RANK P GATZE L JIM A | 2001 | Chemosphere2001，44，： | 1 |
| 20 | Timedomain analysis simulation for advanced tracking显示文摘 | Riker Jim F Crockett Gregg A Brunson Richard L | | 0，，： | 1 |
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