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| 1 | Three-dimensional crustal velocity structure model of the middle-eastern north China Craton (HBCrust1.0)显示文摘Lithosphere thinning and destruction in the middle-eastern North China Craton(NCC), a region susceptible to strong earthquakes, is one of the research hotspots in solid earth science. All 42 seismic wide-angle reflection/refraction profiles have been completed in the middle-eastern NCC. We collect all the 2-D profiling results and perform gridding of the velocity and interface depth data, building a 3-D crustal velocity structure model for the middle-eastern NCC, named HBCrust1.0, by using the Kriging interpolation method. Our result shows that the first-arrival times calculated by HBCust1.0 fit well with the observations. The result demonstrates that the upper crust is the main seismogenic layer, and the brittle-ductile transition occurs at depths near interface C(the interface between upper and lower crust). The depth of interface Moho varies beneath the source area of the Tangshan earthquake, and a low-velocity structure is found to extend from the source area to the lower crust. Based on these observations, it can be inferred that stress accumulation responsible for the Tangshan earthquake may have been closely related to the migration and deformation of the mantle materials. Comparisons of the average velocities of the whole crust, the upper and the lower crust show that the average velocity of the lower crust under the central part of the North China Basin(NCB) in the east of the craton is obviously higher than the regional average. This high-velocity probably results from long-term underplating of the mantle magma. | DUAN YongHong WANG FuYun ZHANG XianKang LIN JiYan LIU Zhi LIU BaoFeng YANG ZhuoXin GUO WenBin WEI YunHao | 2016 | Science China Earth Sciences2016，59，7： | 24 |
| 2 | Influencing factors of seismic signals generated by un-tuned large volume airgun array in a land reservoir显示文摘Un-tuned large volume airgun array in a water reservoir is recently proposed as a new way to generate seismic waves on land. It can be used to explore the earth velocity structure and its temporal variations as well.However, the characteristics of seismic signals(especially far-field signals) from an airgun array in a reservoir and its affecting factors(firing pressure, airgun towing depth,water level of the reservoir, etc.) has not been adequately studied. We analyzed the seismic data collected from field experiments at Binchuan Transmitting Seismic Station in2011 and 2013 and found that(1) The similarity of seismic signals decrease with distance, which is most likely induced by the decay of signal amplitude and signal to noise ratio(SNR);(2) The amplitudes of far-field airgun signals are almost linearly proportional to the firing pressure;(3) The towing depth of airgun has less effects on the far-field signals;(4) The amplitudes of far-field airgun signals are proportional to the water level of the reservoir. | Meng Chen Wei Yang Weitao Wang Baoshan Wang Hongkui Ge Li Chen Yansheng Ding Jiyan Qiao Yong Chen | 2014 | Earthquake Science2014，27，4： | 19 |
| 3 | 2-D P-wave velocity structure of lithosphere in the North China tectonic zone: Constraints from the Yancheng-Baotou deep seismic profile显示文摘We obtained the 2-D P-wave velocity structure of the lithosphere in the eastern North China Craton, Shanxi fault subsidence zone, and Yinchuan-Hetao fault subsidence zone by ray tracking technology based on six groups of clearly identified crustal phases and one group of lithospheric interface reflection phases from seismic recording sections of 21 shots along the 1300-km-long Yancheng-Baotou deep seismic wide-angle reflection/refraction profile. The results indicate significant differences between the lithospheric structure east and west of the Taihang Mountains, which is a gravity-gradient zone as well as a zone of abrupt change in lithospheric thickness and a separation zone of different rock components. East of the Taihang Mountains, the Mesozoic and Cenozoic lithospheric structure of the North China Craton has undergone strong reformation and destruction, resulting in the lithosphere thickness decreasing to 70–80 km. The North China Basin has a very thick Cenozoic sedimentary cover and the deepest point of crystalline basement is about 7.0 km, with the crustal thickness decreasing to about 31.0 km. The crystalline basement of the Luxi uplift zone is relatively shallow with a depth of 1.0–2.0 km and crustal thickness of 33.0–35.0 km. The Subei Basin has a thicker Cenozoic sedimentary cover and the bottom of its crystalline basement is at about 5.0–6.0 km with a crustal thickness of 31.0–32.0 km. The Tanlu fault is a deep fracture which cuts the lithosphere with a significant velocity structure difference on either side of the fault. The Tanlu fault plays an important role in the lithospheric destruction in the eastern part of the North China Craton. West of the Taihang Mountains, the crustal thickness increases significantly. The crust thickness beneath the Shanxi fault depression zone is about 46 km, and there is a low-velocity structure with a velocity of less than 6.1 km s?? in the upper part of the middle crust. Combined with other geophysical study results, our data shows that the lithospheric destruction at the Shaanxi-Shanxi fault depression zone and the Yinchuan-Hetao rift surrounding the Ordos block is non-uniform. The lithosphere thickness is about 80–90 km in the Datong-Baotou area, 75–137 km at the Dingxiang-Shenmu region, and about 80–120 km in the Anyang-Yichuan area. The non-uniform lithospheric destruction may be related to the ancient tectonic zone surrounding the Ordos block. This zone experienced multi-period tectonic events in the long-term process of its tectonic evolution and was repeatedly transformed and weakened. The weakening level is related to the interactions with the Ordos block. The continental collision between the Cenozoic India and Eurasia plates and N-E thrusting by the Qinghai Tibet Plateau block is causing further reformation and reduction of the lithosphere. | DUAN YongHong LIU BaoJin ZHAO JinRen LIU BaoFeng ZHANG ChengKe PAN SuZhen LIN JiYan GUO WenBin | 2015 | Science China Earth Sciences2015，58，9： | 14 |
| 4 | Effects of ZrO_2 on the Performance of CuO-ZnO-Al_2O_3/HZSM-5 Catalyst for Dimethyl Ether Synthesis from CO_2 Hydrogenation显示文摘一系列合成催化剂被湿混合方法,和 CuO-ZnO-Al2O3-ZrO2 部件的集体比率准备到 HZSM-5 沸石(到 Al2O3 being 的 SiO2 的臼齿的比率 25 ) 是 2:1。CuO-ZnO-Al2O3-ZrO2 (由重量的 CuO/ZnO/Al2O3=3/6/1 ) 部件被一个修改‘ t wo-step' 一起沉淀方法准备。为从 CO2 加氢的暗淡乙醇醚合成的 CuO-ZnO-Al2O3/HZSM-5 催化剂的表演上的 ZrO2 的效果被调查。ZrO2 作为一个结构的倡导者改进了 CuO-ZnO-Al2O3/HZSM-5 的性质,这被发现。 | Yanqiao Zhao Jixiang Chen Jiyan Zhang | 2007 | Journal of Natural Gas Chemistry2007，16，4： | 13 |
| 5 | Grain-size characteristics of linear dunes on the northern margin of Qarhan Salt Lake, northwestern China显示文摘In order to clarify the formation mechanism of linear dunes on the northern margin of Qarhan Salt Lake, northwestern China, we analyzed the grain-size and sorting parameters of the dune and interdune sands. The surface sands(0–30 mm) from the dune base to the crest of both flanks and interdune corridors were sampled along transects from upwind to downwind through the dune field. The results indicated that the grain-size distribution differed at different positions between and within the dunes. The frequency curve for dune sands mainly showed a bimodal distribution, while the interdune sediments showed a trimodal distribution. The grain size distribution of the linear dunes showed a finer crest pattern, i.e. the crests were composed of sands that were generally finer, better sorted than those of base sands. In addition, at the dune field scale, the dune crest sands were tending to become much finer but sorting became worse along the downwind transects. However, the grain-size parameters of sediments in the interdune corridors showed no clear pattern. The results demonstrated that the grain size and sorting parameters exhibited a systematic change not only at the individual scale but also at the dune field scale. Our results quantitatively estimate the limited role of cohesive sediments on the formation of linear dune under unidirectional wind regime. More attention should be paid to a long-term wind regime observation, internal sedimentary structures and their formation ages. | LI Jiyan DONG Zhibao ZHANG Zhengcai QIAN Guangqiang LUO Wanyin LU Junfeng | 2015 | Journal of Arid Land2015，7，4： | 13 |
| 6 | 2018 update of expert consensus statement on antiplatelet therapy in East Asian patients with ACS or undergoing PCI显示文摘East Asians are the most populous race in the world and their health status is an important global issue.Compared with Caucasian populations, East Asian patients have a different benefit/risk ratio when using antithrombotic treatment. Despite this observation, treatment strategies in East Asian patients are mostly based on the American and European guidelines. Despite a lower platelet inhibitory response to clopidogrel, East Asian patients show a similar or even a lower rate of ischemic event occurrence and higher bleeding risk compared with Caucasian patients. For potent P2Y_(12) inhibitors(ticagrelor and prasugrel),East Asian patients have shown less favorable net clinical benefits compared with Caucasian patients,which may be related to differences in pharmacokinetic/pharmacodynamic profiles and therapeutic zone of antiplatelet effect. This updated consensus mainly focuses on state-of-the-art and current controversies in the East Asian population. In addition, when East Asian patients are administered potent P2Y_(12) receptor inhibitors, the strategies and ongoing trials to overcome the related hurdles are discussed. | Yong Huo Young-Hoon Jeong Yanjun Gong Daowen Wang Ben He Jiyan Chen Guosheng Fu Yundai Chen Jianping Li Yi Li Shinya Goto Udaya S.Tantry Paul A.Gurbel Jong-Hwa Ahn Hyo-Soo Kim Myung Ho Jeong Yaling Han Sidney C.Smith Jr. Junbo Ge | 2019 | Science Bulletin2019，64，3： | 12 |
| 7 | Preparation,characterization and photocatalytic properties of BiOBr/ZnO composites显示文摘BiOBr/ZnO composite photocatalysts were prepared by a simple hydrothermal method. The as-prepared samples were characterized by X-ray diffraction(XRD), scanning electron microscopy(SEM), transmission electron microscopy(TEM), high-resolution transmission electron microscopy(HRTEM), UV–Vis diffusion reflectance spectroscopy(DRS) and photoluminescence(PL) spectroscopy, respectively. The photocatalytic activities were evaluated by the degradation of methyl blue(MB) under the simulated sunlight irradiation. Among all the samples, the BiOBr/ZnO composite with a mole ratio of 3:1(Bi:Zn) exhibited the best photocatalytic activity. The improvement of photocatalytic activity was mainly attributed to the low recombination ratio of photo-induced electron-hole pairs. The possible photocatalytic mechanism was discussed on the basis of the band structures of BiOBr and ZnO. | Yanling Geng Na Li Jiyan Ma Zhenhai Sun | 2017 | Journal of Energy Chemistry2017，26，3： | 10 |
| 8 | New Evidence for Hydrothermal Sedimentary Genesis of the Ni-Mo Deposits in Black Rock Series of the Basal Cambrian, Guizhou Province: Discovery of Coarse-Grained Limestones and its Geochemical Characteristics显示文摘The molybdenum-nickel deposits in Shuidong District of Nayong County (Guizhou Province, Southwest China) are found mainly in black shale series of Lower Cambrian Niutitang Formation, which is another Mo-Ni-rich region besides Zunyi District (Guizhou province). Our systematic study on the Mo-Ni deposits in Tangjiaba of Nayong reveals that layered coarse-grained limestones, spherical beaded limestones concretions are hosted at the lower seam of the Mo-Ni deposits. Its strong negative carbon isotope anomaly (the carbon isotope value of the coarse-grained limestones varies from -2.148‰ to 8.223‰) is similar to that in the modern submarine black smoker chimney. The carbon in the coarse-grained limestones from black rock series of Nayong County might be deep source inorganic carbon. The seams, coarse-grained limestones, ore-bearing coarse-grained limestones and the roof and floor of the deposits are characterized by co-variation on the trace element spider diagram, showing good homology. The extraordinary enrichment of Ag, As and Sb resembles hydrothermal sedimentation. Pro-Earth's core elements Se is strongly enriched in Ni-Mo ore-bearing coarse-grained limestones. The ore-bearing rock series has an extremely low Th/U value (0.012-0.19); in the logU-logTh Cartesian Coordinates, the samples of the roof and floor of the deposits and ore-bearing coarse-grained limestones are found in the East Pacific tise; and the samples of coarse-grained limestones are found between the paleo-hydrothermal dedimentary area and the East Pacific tise. The chondrite-normalized rare earth element patterns of the Ni-Mo deposits show LREE enrichment, Ce negative anomaly, and Eu negative anomaly (which is supposed to be influenced by the deep magmatic processes in an extensional environment) resembles the rare earth element distribution patterns of the fluid and its sediments in modern submarine hydrothermal system. It proves that coarse-grained limestones is characterized by typical hydrothermal limestones, being closely related with the genesis of Mo-Ni deposits in Nayong County, which provides new evidence for hydrothermal sedimentary genesis of Mo-Ni deposit and negative carbon anomaly in the basal Cambrian on a global scale. | WEI Huairui YANG Ruidong GAO Junbo CHEN Jiyan LIU Kun CHENG Wei | 2012 | Acta Geologica Sinica(English Edition)2012，86，3： | 8 |
| 9 | Procalcitonin could be a reliable marker in differential diagnosis of post-implantation syndrome and infection after percutaneous endovascular aortic repair显示文摘 | Xue Ling Luo Songyuan Luo Jianfang Liu Zhen Gu Mengnan Kang Huiyuan Yang Fan Nie Bingrong Liu Yuan Huang Wenhui Xie Nianjin He Pengcheng Dong Haojian Ni Zhonghan Fan Ruixin Chen Jiyan | 2014 | Chinese Medical Journal2014，，14： | 8 |
| 10 | VNF-FG design and VNF placement for 5G mobile networks显示文摘Network function virtualization(NFV) is envisioned as one of the critical technologies in 5thGeneration(5G) mobile networks. This paper investigates the virtual network function forwarding graph(VNFFG) design and virtual network function(VNF) placement for 5G mobile networks. We first propose a two-step method composed of flow designing and flow combining for generating VNF-FGs according to network service requests. For mapping VNFs in the generated VNF-FG to physical resources, we then modify the hybrid NFV environment with introducing more types of physical nodes and mapping modes for the sake of completeness and practicality, and formulate the VNF placement optimization problem for achieving lower bandwidth consumption and lower maximum link utilization simultaneously. To resolve this problem, four genetic algorithms are proposed on the basis of the frameworks of two existing algorithms(multiple objective genetic algorithm and improved non-dominated sorting genetic algorithm). Simulation results show that Greedy-NSGA-II achieves the best performance among our four algorithms. Compared with three non-genetic algorithms(random, backtracking mapping and service chains deployment with affiliation-aware), Greedy-NSGA-II reduces 97.04%, 87.76% and88.42% of the average total bandwidth consumption, respectively, and achieves only 13.81%, 25.04% and 25.41%of the average maximum link utilization, respectively. Moreover, using our VNF-FG design method and GreedyNSGA-II together can also reduce the total bandwidth consumption remarkably. | Jiuyue CAO Yan ZHANG Wei AN Xin CHEN Jiyan SUN Yanni HAN | 2017 | Science China(Information Sciences)2017，60，4： | 8 |
| 11 | Analyses of nitrobenzene, benzene and aniline in environmental water samples by headspace solid phase micro-extraction coupled with gas chromatography-mass spectrometry显示文摘A headspace solid phase microextrac- tion coupled with gas chromatography mass spec- trometry (HS-SPME/GC-MS) method was estab- lished for analyzing nitrobenzene, benzene and ani- line in environmental water samples simultaneously. Factors affecting extraction efficiency (SPME fiber selection, acidity, temperature, salt addition, extrac- tion time, headspace, etc) were verified. Under opti- mal extraction conditions, the detection limits are 0.50, 0.11 and 1.00 μg/L for nitrobenzene, benzene and aniline, respectively. The results indicate that this method is capable of making sensitive and accuracy analyses on nitrobenzene, benzene and aniline in environmental water samples. | CHEN Ming YIN Yongguang TAI Chao ZHANG Qinghua LIU Jiyan HU Jingtian JIANG Guibin | 2006 | Chinese Science Bulletin2006，51，13： | 8 |
| 12 | Pattern analysis of a linear dune field on the northern margin of Qarhan Salt Lake,northwestern China显示文摘In terms of formation mechanisms of linear dunes,there are open arguments for their widespread distribution and multi-morphological diversities.In order to clarify the formation mechanism of linear dunes of Qarhan Salt Lake,we used pattern analysis method to analyze the statistical characteristics and spatial variation of their pattern parameters.Except at the west-northwest margin,the pattern parameters showed regular spatial variation from the up-middle part towards the downwind end of the dune field.Based on the cumulative probability plots for inter-crest spacing and crest length,we divided the linear dunes into three groups,which corresponding to the three evolution stages of these dunes.The first group comprises erosional relics,with shorter crests,smaller inter-crest spacing and more random dune orientation.The second group comprises dunes whose sand supply is just sufficient to maintain stability and these dunes are approaching the net erosion stage.The crest length and inter-crest spacing of these dunes are much larger than those of the first group,and dune orientation is closer to the resultant drift direction (RDD) .The last group comprises linear dunes that are still undergoing vertical accretion and longitudinal elongation,which follows the RDD of the modern wind regime.The presence of regular spatial variation of pattern parameters and a similar geometry with the vegetated linear dunes suggest that deposition and erosion coexist in the development and evolution of linear dunes of Qarhan Salt Lake,i.e.deposition predominates at the downwind end of linear dunes in the vertical accretion and longitudinal elongation stage,whereas erosion mainly occurs at the upwind end of linear dunes in the degradation stage.Therefore,the formation mechanism of linear dunes in Qarhan Salt Lake can be reasonably explained by the combination of depositional and erosional theories. | LI Jiyan DONG Zhibao QIAN Guangqiang ZHANG Zhengcai LUO Wanyin LU Junfeng WANG Meng | 2016 | Journal of Arid Land2016，8，5： | 6 |
| 13 | Subaquatic volcanic eruptions in continental facies and their influence on high quality source rocks shown by the volcanic rocks of a faulted depression in Northeast China显示文摘This paper reports the analysis on cores and rock slices,data on seismic and logging activities,characteristics of core samples,and the paleogeographic background of the Yingcheng Formation of the Xujiaweizi faulted depression in the Songliao Basin.The results show that some of the volcanic rocks were formed during subaquatic eruptions.These subaqueous volcanic rocks are further characterized by the interbedded black mudstone and tuffite,the presence of double-layer perlite enclosing aphyric or sparsely phyric rhyolite,the presence of a bentonite layer,and the coefficient of oxidation(Fe2O3/FeO).The types of rocks are volcanic breccia,lava breccias,perlite,rhyolite,tuff and sedimentary tuff.The subaquatic eruptions are distributed mainly in Wangjiatun,Shengping,Xuxi,Xuzhong,and Xudong.The XS-1 area is the most typical.The organic abundance of overburden mud rocks within the volcanic rocks of the Yingcheng Formation indicates that these rocks represent high-quality source rocks.The analysis also shows that continental subaquatic volcanic eruptions provide a rich supply of minerals and energies for the lake basin and increase the organic matter content in the water.Moreover,the water differentiation provides a good reducing environment for the conservation of organic matter,and is beneficial for the formation of high-quality source rocks.Finally,we propose a hypothesis to describe the mode of subaquatic eruptions and the formation of high-quality source rocks. | SHAN XuanLong LI JiYan CHEN ShuMin RAN QingChang CHEN GuiBiao LIU Chao | 2013 | Science China Earth Sciences2013，56，11： | 6 |
| 14 | 基于IEC 61850-9-2的智能合并单元关键技术研究(英文)显示文摘A realization scheme of merging unit(MU) for electronic current transformers(ECT) and electronic voltage transformers(EVT) based on single field-programmable gate array(FPGA) and IEC 61850-9-2 protocol is given in this paper.The MU is divided into three modules: sampling pulse synchronization module,sampled values processing module and data frames transmission module.A two-stage synchronization scheme is proposed to compensate the data latency.In the first stage,the phase angle of the sampled signal is shifted forward in a large range by employing the digital phase-shifter.In the second stage,a fine adjustment for the signal phase angle is carried out in a small range by using the dynamic second-order Lagrange interpolation algorithm.This scheme can achieve SMV packet's highly accurate time synchronization in process bus.Tests about the basic bus data accuracy,performance of the temperature diversification and performance of the multi-channel signal in real-time communication show the testing is within the limits of the accuracy class 0.2 s in IEC 60044.The communication characteristics test proves the frame is fully comply with the format of IEC 61850-9-2.This series of tests demonstrate the utility and flexibility of the MU which can be applied in the digital substation based on IEC 61850. | DUAN Xiongying ZOU Jiyan LUO Yan | 2013 | 高电压技术2013，39，4： | 6 |
| 15 | Filtering detecting signal of rockbolt with harmonic wavelet显示文摘Harmonic wavelets not only possess the traditional advantages of a wavelet function,they also have other merits such as clear expressions,more flexible time-frequency divisions,a simple transformation algorithm,a finer box-like frequency spectrum and others.Given the frequency distribution characteristics of the nondestructive testing signals from a rockbolt support system and based on the discrete harmonic wavelet transformation theory,we have effectively abstracted signals from frequency ranges concerned by removing useless high and low frequency signals from the testing signals of the rockbolt support system and obtained filtered signals with a reconstruction algorithm of harmonic wavelets.Finally,we applied the harmonic wavelet transformation in filtering analog signals and measured response signals of rockbolts.The results indicate that harmonic wavelets also have excellent filtering characteristics. | WANG Jiyan ZHAO Yucheng YAO Banghua XU Jinhai | 2010 | Mining Science and Technology2010，20，3： | 5 |
| 16 | Inaccuracy of doppler echocardiographic estimates of pulmonary artery pressures in adult atrial septal defect patients with pulmonary arterial hypertension显示文摘 | Zhang Caojin Huang Tao Huang Xinsheng Huang Yigao Chen Jimei Chen Jiyan Wu Shulin Zhuang Jian | 2014 | Chinese Medical Journal2014，，19： | 5 |
| 17 | Neddylation is required for herpes simplex virus type I (HSV- 1)-induced early phase interferon-beta production显示文摘 | Xueying Zhang Zhenjie Ye Yujun Pei Guihua Qiu Qingyang Wang Yunlu Xu Beifen Shen Jiyan Zhang | 2016 | Cellular & Molecular Immunology2016，13，5： | 5 |
| 18 | Primary investigation of the pollution status of polycyclic aromatic hydrocarbons (PAHs) in water and soil of Xuanwei and Fuyuan,Yunnan Province,China显示文摘Lung cancer incidence in Xuanwei and Fuyuan is extremely high. The air pollution, especially indoor airborne PAHs generated by burning smoky coals, has been considered as the most probable reason. The air pollution may affect drinking water and soil through dry and wet deposition. In this study, the concentrations of PAHs in water and soil samples from Xuanwei and Fuyuan were monitored to investigate the influence of atmospheric PAHs pollution on water and soil. No obvious PAHs pollution in water was found in these two areas, indicating that airborne PAHs have no apparent effect on the drinking water (well water). The smoky coal combustion from household and industry, such as the activities related to power plants, coking plants and chemical industries, is responsible for the soil PAHs pollution in these two areas. The soil pollution might be the reemission source and would pose long-term threat to the local environment and health of residents. | LU JunGang XU RenJi ZHANG QingHua LIU JiYan LIAO ChunYang WEI FuSheng | 2009 | Chinese Science Bulletin2009，54，19： | 4 |
| 19 | Hybrid Phase-controlled Circuit Breaker with Switch System Used in the Railway Auto-passing Neutral Section with an Electric Load显示文摘Constrained by the characteristics of neutral sec- tions (NS) and traditional vacuum circuit breakers, previous phase-controlled strategies have a long power supply dead time, it is difficult to realize a continuous power supply to the auxiliary power system. The dead time can be reduced by using the ground automatic convert method, hybrid phase-controlled technologies can in theory completely eliminate inrush currents. In this paper, a new system based on hybrid phase-controlled switches is described and termed ground-switching passing neutral section system (GPNSS). The principle for restraining inrush currents is analyzed and strategies are carried out with the dead time limited to 5 ms. The characteristics of the vacuum circuit breaker are illustrated and the closing time window of the transformer is quantified. Through the use of mechanical switches and power electronics, the auxiliary power system may be continuously pow- ered. The prototype system is implemented and experimentally tested in the laboratory. | Shuo Wang Liyan Zhang Guanghui Yu Enyuan Dong Jiyan Zou Yu Cong Yu Tian | 2019 | CSEE Journal of Power and Energy Systems2019，5，4： | 4 |
| 20 | cAMP Modulates Macrophage Development by Suppressing M-CSF-Induced MAPKs Activation显示文摘M-CSF is a key cytokine in macrophage development by inducing MAPKs activation,and cAMP can inhibit MAPKs activation induced by inflammatory stimuli. To explore the effects of cAMP on M-CSF-induced MAPKs activation and on macrophage development,the model of bone marrow-derived murine macrophages (BMMs) was used. The effects of cAMP on M-CSF-induced MAPKs activation were analyzed by Western blotting assay,and the effects of cAMP on CD14 and F4/80 expression during macrophage development were examined by FACS analysis. Macrophage morphology showed the successful establishment of the model of macrophage development. Western blotting assay revealed that M-CSF activated ERK,JNK and p38 in both mature and immature macrophages,and cAMP inhibited M-CSF-induced ERK,JNK and p38 activation in a time-dependent manner. FACS analysis revealed that macrophage development was impaired with cAMP pretreatment. In conclusion,cAMP modulates macrophage development by suppressing M-CSF-induced MAPKs activation. | Ning Zhu Jian Cui Chunxia Qiao Yan Li Yuanfang Ma Jiyan Zhang Beifen Shen | 2008 | Cellular & Molecular Immunology2008，5，2： | 4 |
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