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| 1 | Double-stranded DNA in exosomes: a novel biomarker in cancer detection显示文摘 | Basant Kumar Thakur Haiying Zhang Annette Becker Irina Matei Yujie Huang Bruno Costa-Silva Yan Zheng Ayuko Hoshino Helene Brazier Jenny Xiang Caitlin Williams Ruth Rodriguez-Barrueco Jose M Silva Weijia Zhang Stephen Hearn Olivier Elemento Navid Paknejad Katia Manova-Todorova Karl Welte Jacqueline Bromberg Hector Peinado David Lyden | 2014 | Cell Research2014，24，6： | 98 |
| 2 | Ferroptosis is an autophagic cell death process显示文摘Ferroptosis 是调整坏死的一种铁依赖者形式。它在各种各样的人的疾病被含有,包括 ischemic 机关损坏和癌症。这里,我们报导 autophagy 的关键角色,特别地细胞的铁存储蛋白质(作为 ferritinophagy 知道的一个过程) 的 autophagic 降级,在 ferroptosis。用 RNAi,屏蔽结合了随后的基因分析,我们作为 ferroptosis 的积极管理者识别了多重 autophagy 相关的基因。Ferroptosis 正式就职导致了 autophagy 激活和 ferritin 和 ferritinophagy 货物受体 NCOA4 的作为结果的降级。一致地,由 autophagy 的阻塞的 ferritinophagy 的抑制或废除的 NCOA4 击倒联系 ferroptosis 的细胞的易变的铁的累积和反应的氧种类,以及最终的 ferroptotic 细胞死亡。因此, ferroptosis 是一个 autophagic 房间死亡过程,并且调停 NCOA4 的 ferritinophagy 由控制细胞的铁动态平衡支持 ferroptosis。 | Minghui Gao Prashant Monian Qiuhui Pan Wei Zhang Jenny Xiang Xuejun Jiang | 2016 | Cell Research2016，26，9： | 138 |
| 3 | 地塞米松玻璃体腔植入剂治疗中国患者视网膜静脉阻塞继发黄斑水肿的安全性和有效性:随机、假注射对照、多中心研究显示文摘目的 评估地塞米松玻璃体腔植入物(DEX)治疗中国患者视网膜静脉阻塞继发黄斑水肿(RVO-ME)的安全性和有效性.方法 为期6个月的随机、双盲、假注射对照、多中心、3期临床研究,此后接续为期2个月的开放标签的延展研究.视网膜分支(BRVO)或中央静脉阻塞(CRVO)患眼于基线时接受DEX植入(n=129)或假注射(n=130)治疗;治疗后6个月时,两组中满足再治疗标准的全部患眼均再次接受DEX植入治疗.有效性变量包括最佳矫正视力(BCVA)和黄斑中心凹视网膜厚度(CRT).BCVA检查采用早期治疗糖尿病视网膜病变研究组视力表进行.光相干断层扫描(OCT)检查采用德国Heidelberg公司Spectralis OCT仪或德国Zeiss公司Cirrus OCT仪进行.结果 治疗后6个月中(主要终点),DEX治疗组BCVA较基线提高≥15个字母的时间早于假注射组(P<0.001).治疗后第2个月时(效应峰值),DEX治疗组、假注射组BCVA较基线提高≥15个字母患者百分比分别为34.9%,11.5%.DEX治疗组、假注射组平均BCVA较基线分别提高(10.6±10.4)、(1.7±12.3)个字母;平均CRT分别较基线下降(407±212)、(62±224) μm (P<0.001).DEX治疗组CRVO、BRVO患眼治疗效果均优于假注射组.主要常见治疗相关不良事件为眼压升高,均可通过局部降眼压药物控制;无患者需要接受抗青光眼手术.结论 DEX治疗中国患者RVO-ME具有良好的安全性和显著的临床疗效;单次植入DEX较假注射可获得持续3-4个月的视力和解剖结构改善. | 黎晓新 王宁利 梁小玲 徐格致 Xiao-yan Li Jenny Jiao Jean Lou Yehia Hashad | 2018 | 中华眼底病杂志2018，34，3： | 41 |
| 4 | Regression of cirrhosis during treatment with tenofovir disoproxil fumarate for chronic hepatitis B: a 5-year open-label follow-up study显示文摘 | Patrick Marcellin Edward Gane Maria Buti Nezam Afdhal William Sievert Ira M Jacobson Mary Kay Washington George Germanidis John F Flaherty Raul Aguilar Schall Jeffrey D Bornstein Kathryn M Kitrinos G Mani Subramanian John G McHutchison E Jenny Heathcote | 2012 | The Lancet2012，，： | 14 |
| 5 | The calcium sensing receptor: from calcium sensing to signaling显示文摘The Ca2+-sensing receptor(the Ca SR),a G-protein-coupled receptor,regulates Ca2+ homeostasis in the body by monitoring extracellular levels of Ca2+([Ca2+]o) and responding to a diverse array of stimuli.Mutations in the Ca2+-sensing receptor result in hypercalcemic or hypocalcemic disorders,such as familial hypocalciuric hypercalcemia,neonatal severe primary hyperparathyroidism,and autosomal dominant hypocalcemic hypercalciuria.Compelling evidence suggests that the Ca SR plays multiple roles extending well beyond not only regulating the level of extracellular Ca2+ in the human body,but also controlling a diverse range of biological processes.In this review,we focus on the structural biology of the Ca SR,the ligand interaction sites as well as their relevance to the disease associated mutations.This systematic summary will provide a comprehensive exploration of how the Ca SR integrates extracellular Ca2+ into intracellular Ca2+ signaling. | ZHANG Chen MILLER Cassandra Lynn BROWN Edward M YANG Jenny J. | 2015 | Science China(Life Sciences)2015，58，1： | 14 |
| 6 | 脐血间充质干细胞的生物学特征及其对造血干/祖细胞体外扩增的支持作用显示文摘目的探讨脐血间充质干细胞(MSC)的生物学特征及其对造血干/祖细胞体外扩增的支持作用。方法用液体培养法分离脐血贴壁细胞,采用ELISA方法检测贴壁细胞条件培养液中细胞因子的表达;用流式细胞术分析其免疫表型特征;在成软骨细胞诱导培养条件下诱导细胞分化,并用RTPCR方法检测分化后细胞原胶原Ⅱ型基因的表达。采用分阶段共培养方法观察脐血贴壁细胞对CD34+细胞体外扩增的支持作用。结果脐血单个核细胞纤维样细胞集落形成率为(3.5±0.7)/106。脐血MSC体外至少可以扩增15代。没有分化的脐血MSC表型为CD13、CD29、CD90、CD105、CD166、SH2、SH3和SH4阳性,CD45、CD34和CD14阴性;脐血MSC培养上清中干细胞因子、IL6和肿瘤坏死因子α检测阳性。在成软骨细胞诱导培养基培养条件下,脐血MSC原胶原Ⅱ型基因mRNA表达阳性。脐血MSC与CD34+细胞共掊养14d,CD34+细胞扩增率高于未共培养组4倍。结论脐血MSC具有类似于成体骨髓MSC的特征,对造血干细胞增殖有明显的支持作用。 | 王丽娟 张叶萍 王金福 吴亦凡 项盈 解纯刚 贾冰冰 Jenny Harrington IanK. McNiece | 2005 | 中华血液学杂志2005，26，2： | 14 |
| 7 | Idiopathic sclerosing encapsulating peritonitis:Abdominal cocoon显示文摘Abdominal cocoon,the idiopathic form of sclerosing encapsulating peritonitis,is a rare condition of unknown etiology that results in an intestinal obstruction due to total or partial encapsulation of the small bowel by a f ibrocollagenous membrane.Preoperative diagnosis requires a high index of clinical suspicion.The early clinical features are nonspecif ic,are often not recognized and it is diff icult to make a def inite pre-operative diagnosis.Clinical suspicion may be generated by the recurrent episodes of small intestinal obstruction combined with relevant imaging f indings and lack of other plausible etiologies.The radiological diagnosis of abdominal cocoon may now be conf idently made on computed tomography scan.Surgery is important in the management of this disease.Careful dissection and excision of the thick sac with the release of the small intestine leads to complete recovery in the vast majority of cases. | Jenny N Tannoury Bassam N Abboud | 2012 | World Journal of Gastroenterology2012，18，17： | 14 |
| 8 | 2-Year GLOBE Trial Results: Telbivudine Is Superior to Lamivudine in Patients With Chronic Hepatitis B显示文摘 | Yun–Fan Liaw Edward Gane Nancy Leung Stefan Zeuzem Yuming Wang Ching Lung Lai E. Jenny Heathcote Michael Manns Natalie Bzowej Junqi Niu Steven–Huy Han Seong Gyu Hwang Yilmaz Cakaloglu Myron J. Tong George Papatheodoridis Yagang Chen Nathaniel A. Brown Efs | 2009 | Gastroenterology2009，，2： | 13 |
| 9 | Connections Between Insomnia and Cognitive Aging显示文摘Insomnia is a common sleep disorder among older adults,and a risk factor for poor physical and mental health.However,the relationship between insomnia and cognitive health is not well understood.Here,we review observational studies that have investigated whether insomnia is associated with deficits in objective cognitive performance and an increased risk of dementia,magnetic resonance imaging studies that have assessed grey matter volumes and white matter microstructure,and interventional studies that have explored whether the treatment of insomnia can improve cognitive outcomes.There are inconsistent findings regarding impaired performance in objective cognitive tests and reduced grey matter volumes,and limited,emerging,evidence that suggests that insomnia is associated with an increased risk of dementia and reduced white matter integrity.Although the interventional literature is still in its infancy,there is some indication that treatment may have an impact on vigilance.Well-powered studies examining sources of heterogeneity are warranted. | Claire E.Sexton Konstantina Sykara Elissaios Karageorgiou Jenny Zitser Talita Rosa Kristine Yaffe Yue Leng | 2020 | Neuroscience Bulletin2020，36，1： | 13 |
| 10 | Nature:死亡的肿瘤细胞释放出胞内钾离子来阻断免疫系统显示文摘在一项新的研究中。来自美国国家癌症研究所和英国巴布拉汉研究所的研究人员发现当肿瘤组织死亡时从它当中泄露出来的一种无机离子起着阻止抗肿瘤免疫细胞发挥功能的作用。这一发现为开发调动免疫系统抵抗癌症的疗法提供一种新的方法。相关研究结果在线发表在Nature期刊上。 | Robert Eil, Suman K. Vodnala, David Clever, Christopher A. Klebanoff, Madhusudhanan Sukumar, Jenny H. Pan, Douglas C. Palmer, Alena Gros, Tori N. Yamamoto, Shashank J. Patel, Geoffrey C. Guittard, Zhiya Yu, David S. Schrump, W. Marston Linehan, Nicholas P. Restifo Christopher A. Klebanoff Valentina Carbonaro, Klaus Okkenhaug, Rahul Roychoudhuri | 2016 | 现代生物医学进展2016，16，31： | 12 |
| 11 | Saposhnikoviae divaricata:a phytochemical,pharmacological,and pharmacokinetic review显示文摘Saposhnikoviae divaricata(Turcz.) Schischk(SD) is a traditional Chinese herb commonly used to treat clinical conditions such as rheumatism and allergic rhinitis. This review article evaluates a collection of works on in vitro and biochemical studies of SD. The discourse on the diverse class of chromones and coumarins in SD offers an insight to the pharmacological effects of these bioactive constituents as anti-inflammatory, analgesic, immunoregulatory, antioxidative, and anti-proliferative agents. It is highlighted that there is a structural relationship between the constituents and bioactive activities, which in effect provides a valid reasoning and reaffirm the use of SD in the treatment of the pathologies in Chinese medicine. | Jenny Kreiner Edwin Pang George Binh Lenon Angela Wei Hong Yang | 2017 | Chinese Journal of Natural Medicines2017，15，4： | 12 |
| 12 | The Isogene 1-Deoxy-D-Xylulose 5-Phosphate Synthase 2 Controls Isoprenoid Profiles, Precursor Pathway Allocation, and Density of Tomato Trichomes显示文摘植物 isoprenoids 从先锋被形成由 mevalonate (MVA ) 综合了在 cytosol 或由 methyl-D-erythritol 4 磷酸盐(MEP ) 的小径在质体的小径。尽管先锋的一些交换发生, cytosolic sesquiterpenes 被假定主要源于 MVA,当 plastidial monoterpenes 从 MEP 先锋优先地被生产时。另外的复杂性在 MEP 小径的第一步产生,它被二分叉的 1-deoxy-D-xylulose 5 磷酸盐 synthase isoforms 典型地催化(DXS1, DXS2 ) 。在西红柿(茄属 lycopersicum ) , SlDXS1 基因无所不在地在而 SlDXS2 抄本充满仅仅很少纸巾,成熟的水果期间与高水平被表示,包括年轻叶子,花瓣,和孤立的毛状体。SlDXS2 表示的特定的下面规定被 RNA 干扰在转基因的植物执行调查反馈机制。SlDXS2 下面规定在在二 sesquiterpenes 的 monoterpene -phellandrene 和毛状体的增加导致了减少。而且,进剩余 monoterpenes 并且进 sesquiterpenes 的导出 MVA 的先锋的加入是由 13C 的比较决定了到 12C 天赋同位素比率被提高。SlDXS1 的一条补偿起来规定没被观察。也展出的下面调整的线增加了毛状体密度并且由喂叶的 Spodoptera littoralis 毛虫显示出更少的损坏。结果在 isoprenoid 先锋分配在 modulating isoprenoid 新陈代谢和显著粘性揭示 DXS2 的新奇、非冗余的角色。 | Heike Paetzold Stefan Garms Stefan Bartram Jenny Wieczorek Eva-Maria Uros-Gracia Manuel Rodriguez-Concepcion Wilhelm Boland Dieter Strack Bettina Hause Michael H. Walter | 2010 | Molecular Plant2010，3，5： | 11 |
| 13 | 一种改进的近似动态规划方法及其在SVC的应用显示文摘近似动态规划的基本思想是通过近似计算代价函数,从而避免动态规划中的'维数灾'问题。随机选取初值使得近似动态规划方法需要多次的学习才能最终收敛,极大地限制了在实际系统中的应用。针对上述问题,提出一种基于改进PID神经网络的直接启发式动态规划算法,将初始执行网络与PID控制器之间建立起一种等价关系,因此可以利用已经设计好的PID控制器来指导其初值选取,从而使算法收敛性大大提高。改进的神经网络与常规PID神经网络相比,结构简单且具有更好的扩展性,性能上具有更强的鲁棒性。对4机2区系统的静止无功补偿器附加阻尼控制进行仿真测试,仿真结果表明基于改进PID神经网络的直接启发式动态规划算法和初值选取方法的有效性,并且在部分状态反馈和延时两种情况下有着很好的控制效果。 | 孙健 刘锋 SI Jennie 郭文涛 梅生伟 | 2011 | 电机与控制学报2011，15，5： | 11 |
| 14 | Inferring the biogeographic origins of inter-continental disjunct endemics using a Bayes-DIVA approach显示文摘arcto 第三级的 relictual 植物群由在东方亚洲,欧洲,东方北美洲,和西方的北美洲的适度的地区非接触地发生的许多类组成。在每个分布区域以内,种类典型地是地方性的并且可以广泛地因此在另外的区域以内与密切相关的种类被分开。分发的这个普通模式源于一个从前更多连续的 arcto 第三级的森林的破碎,这广泛地被接受。导致今日的分离的历史的 biogeographic 事件经常用一条种系发生的途径被调查了。限制到这些以前的研究在祖先的范围重建包括了种系发生的无常和无常。然而,最近描述的 Bayes 歌剧女主角方法处理无常的两种类型。因此,我们使用了 Bayes 歌剧女主角分析重建为从代表 17 个脉管的植物家庭的 23 个分离的类的 185 个地方性的系的茎系分布。特别地,我们问在每四个分布区域以内的地方性的系是否更经常演变从(1 ) 普遍祖先,(2 ) 祖先从另外的区域分散了,或(3 ) 地方性的祖先。我们也考虑了三 biogeographic 机制可以最好在 neotropics 向其这解释 arcto 第三级的分离 endemics 的起源。我们的结果证明东方亚洲 endemics 更经常在欧洲和东方、西方的北美洲与 endemics 相比从地方性的祖先演变。在后者区域的今日的地方性的系更经常从普遍祖先产生了。我们的结果也在在 neotropics 地方性的 arcto 第三级的种类的 biogeographic 起源为疏开的重要性提供轶事证据。 | AJ HARRIS Jun WEN Qiu-Yun (Jenny) XIANG | 2013 | Journal of Systematics and Evolution2013，51，2： | 10 |
| 15 | 新西兰医院-社区-家庭老年健康管理见闻与启示显示文摘介绍新西兰怀卡托省医院-社区-家庭老年健康管理相关情况。多学科团队通过服务对象的健康管理系统对医院术后患者进行早日康复,恢复其回归社会的能力;针对居家有康复需求的居民,政府把相应的服务人员与物品转移至家庭进行高效康复;为了维持及促进居民的健康,社区诊所成立相应的多学科服务团队,科学、规范地管理服务对象的健康。可参照其完善我国老年健康管理体系,以满足社区老年人健康护理服务需求。 | 马国珍 姜鹏君 薛晶 金娅芳 Song Jenny Lin Helen | 2020 | 护理学杂志2020，35，11： | 10 |
| 16 | Phylogenomic approaches to deciphering the tree of life显示文摘 | Jun Wen Jianquan Liu Song Ge Qiu-Yun (Jenny) Xiang Elizabeth A. Zimmer | 2015 | Journal of Systematics and Evolution2015，53，5： | 9 |
| 17 | A STUDY OF STRUCTURE AND PROPERTY CHANGES OF BIODEGRADABLE POLYGLYCOLIDE AND POLY(GLYCOLIDE-co-LACTIDE)FIBERS DURING PROCESSING AND IN VITRO DEGRADATION显示文摘Structure and properties of bioabsorbable polyglycolide (PGA) and poly(glycolide-co-lactide) (PGA-co-PLA)fibers were investigated during several industrial processing stages and in vitro degradation by means of wide-angle X-ray diffraction (WAXD), dynamic mechanical analysis (DMA) and mechanical property tests. In the orientation stage, the PGA fibers were found to have higher degrees of crystallinity than corresponding PGA-co-PLA samples produced under similar conditions. In the hot-stretching and post-annealing stages, after fibers were braided, PGA samples were found to gain more crystallinity and higher Tg than PGA-co-PLA samples. The higher crystallinity in PGA fibers resulted in a slower rate of degradation. DMA results showed that a great deal of internal stress that was built during orientation and hot-stretching stages was released in the post-annealing stage for all PGA and PGA-co-PLA samples. During earlier stages ofin vitro degradation, both PGA and PGA-co-PLA samples exhibited the typical cleavage-induced crystallization mechanism. The heat shrinkage in the glass transition area was found to disappear after 6-8 days of degradation for all PGA and PGA-co-PLA samples, indicating the amorphous portions of the polymers lost orientation after a short period in the buffer solution, most likely due to relaxation of the cleaved chains. | Bruce X.Fu Benjamin S.Hsiao Gavin Chen Jack Zhou Susan Lin Jenny Yuan Ilya Koyfman Dennis D Jamiolkowski Edward Dormier | 2003 | Chinese Journal of Polymer Science2003，21，2： | 9 |
| 18 | Treatment options of inflammatory appendiceal masses in adults显示文摘At present, the treatment of choice for uncomplicated acute appendicitis in adults continues to be surgical. The inflammation in acute appendicitis may sometimes be enclosed by the patient's own defense mechanisms, by the formation of an inflammatory phlegmon or a circumscribed abscess. The management of these patients is controversial. Immediate appendectomy may be technically demanding. The exploration often ends up in an ileocecal resection or a right-sided hemicolectomy. Recently, the conditions for conservative management of these patients have changed due to the development of computed tomography and ultrasound, which has improved the diagnosis of enclosed inflammation and made drainage of intra-abdominal abscesses easier. New efficient antibiotics have also given new opportunities for nonsurgical treatment of complicated appendicitis. The traditional management of these patients is nonsurgical treatment followed by interval appendectomy to prevent recurrence. The need for interval appendectomy after successful nonsurgical treatment has recently been questioned because the risk of recurrence is relatively small. After successful nonsurgical treatment of an appendiceal mass, the true diagnosis is uncertain in some cases and an underlying diagnosis of cancer or Crohn's disease may be delayed. This report aims at reviewing the treatment options of patients with enclosed appendiceal inflammation, with emphasis on the success rate of nonsurgical treatment, the need for drainage of abscesses, the risk of undetected serious disease, and the need for interval appendectomy to prevent recurrence. | Jenny Tannoury Bassam Abboud | 2013 | World Journal of Gastroenterology2013，19，25： | 9 |
| 19 | Phylogenomics of polyploid Fothergilla (Hamamelidaceae) by RAD-tag based GBS insights into species origin and effects of software pipelines显示文摘 | Zhe-Chen Qi Yi Yu Xiang LiuI Andrew Pais Thomas Ranney Ross Whetten Qiu-Yun (Jenny) Xiang | 2015 | Journal of Systematics and Evolution2015，53，5： | 7 |
| 20 | Prognosis of lymphotropic invasive micropapillary breast carcinoma analyzed by using data from the National Cancer Database显示文摘Background:Invasive micropapillary carcinoma(IMPC)is an uncommon subtype of breast cancer.Previous studies of this subtype demonstrated a higher propensity for lymph node metastases as compared with invasive ductal carci-noma(IDC).The purpose of the present study was to determine the clinical characteristics,outcomes,and propensity for lymph node metastasis of patients with IMPC of the breast recorded in the National Cancer Database(NCDB).Methods:Records of patients with IMPC diagnosed between 2004 and 2014 were retrieved from the NCDB.Log-rank test was performed to evaluate associations of clinical characteristics with overall survival(OS).Cox proportional hazards model was used to determine variables associated with OS.Results:Overall,2660 patients with IMPC met the selection criteria;the 5-year OS rate was 87.5%and 24.9%of patients had nodal involvement at presentation.Patients with≥4 positive lymph nodes had shorter OS than node-negative patients,whereas patients with 1-3 positive nodes had similar OS to node-negative patients.Age<65 years,receipt of radiotherapy,and estrogen receptor positivity were also associated with prolonged OS.The benefit of radiotherapy was limited to IMPC patients undergoing lumpectomy;there was no benefit for the patients undergoing mastectomy(regardless of nodal positivity/negativity).Conclusions:Favorable prognostic factors of IMPC patients included age<65 years,<4 positive lymph nodes,receipt of radiotherapy,and estrogen receptor positivity.The results presented herein suggest a survival benefit asso-ciated with radiotherapy in IMPC treatment,though this may be limited to the patients treated with lumpectomy. | Gary D.Lewis Yan Xing Waqar Haque Tejal Patel Mary Schwartz Albert Chen Andrew Farach Sandra S.Hatch E.Brian Butler Jenny Chang Bin S.Teh | 2019 | Cancer Communications2019，39，1： | 7 |
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