3篇
您的检索式：作者名="Jean CLAIRAMBAULT"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Circadian Timing in Cancer Treatments显示文摘 | Francis Lévi Alper Okyar Sandrine Dulong Pasquale F. Innominato Jean Clairambault | 2010 | Annual Review of Pharmacology and Toxicology2010，，： | 1 |
| 2 | An Evolutionary Perspective on Cancer,with Applications to Anticancer Drug Resistance Modelling and Perspectives in Therapeutic Control显示文摘The question of a mathematical representation and theoretical overcoming by optimised therapeutic strategies of drug-induced drug resistance in cancer cell populations is tackled here from the point of view of adaptive dynamics and optimal population growth control,using integro-differential equations.Combined impacts of external continuous-time functions,standing for drug actions,on targets in a plastic(i.e.,able to quickly change its phenotype in deadly environmental conditions)cell population model,represent a therapeutical control to be optimised.A justification for the introduction of the adaptive dynamics setting,retaining such plasticity for cancer cell populations,is firstly presented in light of the evolution of multicellular species and disruptions in multicellularity coherence that are characteristics of cancer and of its progression.Finally,open general questions on cancer and evolution in the Darwinian sense are listed,that may open innovative tracks in modelling and treating cancer by circumventing drug resistance.This study sums up results that were presented at the international NUMACH workshop,Mulhouse,France,in July 2018. | Jean Clairambault | 2019 | Journal of Mathematical Study2019，52，4： | 0 |
| 3 | Analysis of a System Describing Proliferative-Quiescent Cell Dynamics显示文摘Systems describing the dynamics of proliferative and quiescent cells are commonly used as computational models, for instance for tumor growth and hematopoiesis.Focusing on the very earliest stages of hematopoiesis, stem cells and early progenitors, the authors introduce a new method, based on an energy/Lyapunov functional to analyze the long time behavior of solutions. Compared to existing works, the method in this paper has the advantage that it can be extended to more complex situations. The authors treat a system with space variable and diffusion, and then adapt the energy functional to models with three equations. | Jean CLAIRAMBAULT Benoit PERTHAME Andrada Quillas MARAN | 2018 | Chinese Annals of Mathematics,Series B2018，39，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员