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| 1 | 耐多药结核病——预防和控制的关键步骤显示文摘耐多药结核病(multidrug-resistant tuberculosis,MDR-TB)被定义为,由至少对异烟肼(isoniazid)和利福平(rifampicirn)治疗耐药的结核分枝杆菌(Mycobacterium tuberculosis)引起的疾病。广泛耐药结核病(extensively drug-resistant,tuberculosis,XDR-TB)是指导疾病的多重耐药菌株还对使用任何氟喹诺酮治疗, | Eva Nathanson Paul Nunn Mukund Uplekar Katherine Floyd Ernesto Jaramillo Knut Lnnroth Diana Weil Mario Raviglione 王细文 | 2010 | 中华肺部疾病杂志(电子版)2010，3，6： | 10 |
| 2 | Helicobacter pylori CagA protein polymorphisms and their lack of association with pathogenesis显示文摘AIM: To investigate Helicobacter pylori (H. pylori) CagA diversity and to evaluate the association between protein polymorphisms and the occurrence of gastric pathologies. METHODS: One hundred and twenty-two clinical isolates of H. pylori cultured from gastric biopsies obtained from Colombian patients with dyspepsia were included as study material. DNA extracted from isolates was used to determine cagA status, amplifying the C-terminal cagA gene region by polymerase chain reaction. One hundred and six strains with a single amplicon were sequenced and results were used to characterize the 3' variable region of the cagA gene. To establish the number and type of tyrosine phosphorylation motifs Glutamine acid-Proline-Isoleucine-Tyrosine-Alanine (EPI-YA) bioinformatic analysis using Amino Acid Sequence Analyzer-Amino Acid Sequence Analyzer software was conducted. Analysis of the association between the number of EPIYA motifs and the gastric pathology was performed using χ2 test and analysis of the presence of EPIYA-C motifs in relation to the pathology was made by logistic regression odds ratios. Comparisons among EPIYA types found and those reported in GenBank were performed using a proportion test in Statistix Analytical Software version 8.0. RESULTS: After amplification of the 3' of the cagA gene, 106 from 122 isolates presented a single amplicon and 16 showed multiple amplicons. As expected, diversity in the size of the cagA unique fragments among isolates was observed. The 106 strains that presented a single amplicon after 3' cagA amplification came from patients with gastritis (19 patients), atrophic gastritis (21), intestinal metaplasia (26), duodenal ulcer (22) and gastric cancer. DNA sequence analysis showed that the differences in size of 3' cagA unique fragments was attributable to the number of EPIYA motifs: 1.9% had two EPIYA motifs, 62.3% had three, 33.0% had four and 2.8% had five motifs. The majority of tested clinical strains (62.3%) were found to harbor the ABC combination of EPIYA motifs and a significant statistical difference was observed between the frequencies of ABCC tyrosine phosphorylation motifs and Western strains sequences deposited in GenBank. CONCLUSION: The present report describes a lack of association between H. pylori CagA-protein polymorphisms and pathogenesis. ABCC high frequency variations compared with Western-strains sequences deposited in GenBank require more investigation. | Nicole Acosta Andrés Quiroga Pilar Delgado María Mercedes Bravo Carlos Jaramillo | 2010 | World Journal of Gastroenterology2010，16，31： | 5 |
| 3 | High-performance oxygen reduction and evolution carbon catalysis: From mechanistic studies to device integration显示文摘能容易集成于存在的高效、便宜的氧减小和进化催化剂的发展设备为利用 O 2-H2 O 化学,例如再生燃料房间和金属空气电池。此处,我们报导 NH 3-activated 做 N 的层次碳(NHC ) 催化剂经由一条可伸缩的线路综合了,并且表明它的设备集成。NHC 催化剂为氧减小反应(ORR ) 和氧进化反应(OER ) 展出了好性能,当综合时,借助于电气化学的研究和评估示威了进一个再生燃料房间的氧电极。为 ORR 和 OER 观察的活动比得上最先进的磅和红外催化剂在碱的环境完成的那些。我们进一步通过密度为电气化学的活动作为活跃地点识别了碳缺点的关键角色功能的理论计算和高分辨率的 TEM 可视化。这个工作加亮 NHC 的潜力在再生燃料房间并且可能代替商业宝贵金属为断断续续的可更新的精力的划算的存储的金属空气电池。 | John W. F. To Jia Wei Desmond Ng Samira Siahrostami Ai Leen Koh Yangjin Lee Zhihua Chen Kara D. Fong Shucheng Chen Jiajun He Won-Gyu Bae Jennifer Wilcox Hu Young Jeong Kwanpyo Kim Felix Studt Jens K. Nфrskov Thomas F. Jaramillo Zhenan Bao | 2017 | Nano Research2017，10，4： | 4 |
| 4 | CagA EPIYA polymorphisms in Colombian Helicobacter pylori strains and their influence on disease-associated cellular responses显示文摘AIM: To investigate the influence of the CagA diversity in Helicobacter pylori (H. pylori ) strains from Colombia on the host cell biology. METHODS: Eighty-four H. pylori-cagA positive strains with different Glu-Pro-Ile-Tyr-Ala (EPIYA) motifs patterns, isolated from patients with gastritis (n=17), atrophic gastritis (n=17), duodenal ulcer (n=16), intestinal metaplasia (n=16) and gastric cancer (n=18), were included. To determine the integrity of the cag pathogenicity island (cag PAI) we evaluated the presence of cagA, cagT, cagE, and cag10 genes by polymerase chain reaction. AGS gastric epithelial cellswere infected with each strain and assayed for translo-cation and tyrosine phosphorylation of CagA by western blot, secretion of interleukin-8 (IL-8) by enzyme-linked immuno sorbent assay after taking supernatants from cocultures and cell elongation induction. For cell elongation quantification, coculture photographs were taken and the proportion of 'hummingbird' cells (>15 μm) was determined. RESULTS: Overall 72% (60/84) of the strains were found to harbor a functional cag PAI. Levels of phos-phorylated CagA were significantly higher for isolates from duodenal ulcer than the ones in strains from gas-tritis, atrophic gastritis, intestinal metaplasia and gastric cancer (49.1% ± 23.1% vs 21.1% ± 19.5%, P < 0.02; 49.1% ± 23.1% vs 26.2%±14.8%, P<0.045; 49.1% ± 23.1% vs 21.5% ± 19.5%, P<0.043 and 49.1% ± 23.1% vs 29.5% ± 27.1%, P < 0.047 respectively). We observed variable IL-8 expression levels ranging from 0 to 810 pg/mL and from 8.8 to 1442 pg/mL at 6 h and 30 h post-infection, respectively. cagPAI-defective strains did not induce detectable levels of IL-8 at 6 h post-infection. At 30 h post-infection all strains induced IL-8 expression in AGS cells, although cagPAI-defective strains induced significantly lower levels of IL-8 than strains with a functional cagPAI (57.1 ± 56.6 pg/mL vs 513.6 ± 338.6 pg/mL,P < 0.0001). We did not observe differences in the extent of cell elongation induction between strains with a functional or a defective cagPAI in 6 h cocultures. At 24 h post infection strains with functionalcagPAI showed high diversity in the extent of hummingbird phenotype induction ranging from 7% to 34%. cag PAI defective strains induced significantly lower levels of elongation than strains with functional cag-PAI with one or more than one EPIYA-C motif (15.1% ± 5.2%vs 18.9% ± 4.7%,P < 0.03; and 15.1% ± 5.2% vs 20.0% ± 5.1%, P < 0.003 respectively). No differences were observed in cellular elongation inductionor IL-8 expression among H. pylori strains bearing one and more than one EPIYA-C motifs, neither at 6 h nor at 24 h of coculture. There were no associations between the levels of induction of cell elongation or IL-8 expression and number of EPIYA motifs or pathology. CONCLUSION: The present work describes a lack of association between H. pylori CagA protein EPIYA motifs variations from Colombian isolates and disease-associated cellular responses. | Carlos Alberto Fajardo Andrés Javier Quiroga Andrea Coronado Karen Labrador Nicole Acosta Pilar Delgado Carlos Jaramillo María Mercedes Bravo | 2013 | World Journal of Gastrointestinal Oncology2013，5，3： | 3 |
| 5 | Eosinophilic esophagitis: Current concepts in diagnosis and treatment显示文摘Eosinophilic esophagitis is an immune-allergic pathology of multifactorial etiology(genetic and environmental)that affects both pediatric and adult patients.Its symptoms,which include heartburn,regurgitation,and esophageal stenosis(with dysphagia being more frequent in eosinophilic esophagitis in young adults and children),are similar to those of gastroesophageal reflux disease,causing delays in diagnosis and treatment.Although endoscopic findings such as furrows,esophageal mucosa trachealization,and whitish exudates may suggest its presence,this diagnosis should be confirmed histologically based on the presence of more than 15 eosinophils per high-power field and the exclusion of other causes of eosinophilia(parasitic infections,hypereosinophilic syndrome,inflammatory bowel disease,among others)for which treatment could be initiated.Currently,the 3“D”s(“Drugs,Diet,and Dilation”)are considered the fundamental components of treatment.The first 2 components,which involve the use of proton pump inhibitors,corticosteroids,immunosuppressants and empirical diets or guided food elimination based on allergy tests,are more useful in the initial phases,whereas endoscopic dilation is reserved for esophageal strictures.Herein,the most important aspects of eosinophilic esophagitis pathophysiology will be reviewed,in addition to evidence for the various treatments. | Andrés Gómez-Aldana Mario Jaramillo-Santos Andrés Delgado Carlos Jaramillo Adán Lúquez-Mindiola | 2019 | World Journal of Gastroenterology2019，25，32： | 2 |
| 6 | Normal maturing distal tibia and fibula: changes with age at MR imaging显示文摘 | Chung T Jaramillo D | 1995 | Radiology1995，194，1： | 2 |
| 7 | Developing epiphysis: MR imaging characteristics and histologic correlation in the newborn lamb显示文摘 | Jaramillo D Connolly S Mulkern R | 1998 | Rodiology1998，207，2： | 2 |
| 8 | Comparison between fast spin-echo and conventional spin-echo imaging of normal and abnormal musculoskeletal structures in children and young adults显示文摘 | Jaramillo D Laor T Mulkern RV | 1994 | Invest Radiol1994，29，9： | 2 |
| 9 | Role of oregano and Citrus species-based essential oil preparation for the control of coccidiosis in broiler chickens显示文摘Background:Due to presence of drug-resistant Eimeria strains and raised public health safety concerns about drug residues in the meat,there is renewed interest in the search for natural alternatives to the coccidiosis control agents.This study was conducted to test the anticoccidial efficacy of oregano and Citrus spp.-based essential oils for broilers.Methods:A total of 2807-day-old broiler chicks were fed a control diet or diets with salinomycin or essential oils for up to 35 d of age.On d 14,half of the control groups and the treated groups were orally challenged with a coccidiosis vaccine at 25 times higher than the recommended vaccine dose.Control diet-fed chickens that were gavaged with phosphate-buffered saline were considered non-challenged control group.Results:Eimeria challenge or dietary additives failed to affect growth performance during the 7 to 20 d growth period although essential oil-fed chickens exhibited the lowest body wight gain(P=0.332)and the highest feed conversion ratio(P=0.062).Oocysts in the litter were detected in the challenged control diet group and the challenged/essential oil-fed groups at 21 and 35 d,respectively.Superoxide dismutase activity in the serum was elevated(P=0.059)in the salinomycin-fed chickens compared to the challenged controls.Alpha-1-acid glycoprotein was decreased by 28.7%in the salinomycin-fed chickens but increased by 38.1%in the essential oil group compared with the challenged control group.Challenged control group exhibited a significantly higher cooking loss of the thigh meat,compared to the non-challenged control diet group,which was marginally mitigated by dietary supplementation with essential oils.Chickens fed essential oil-added diet had the highest branched-chain fatty acids contents in the cecum.Conclusions:In conclusion,this study shows that oregano and Citrus-based essential oil preparation did not affect growth performance in broiler chickens challenged with the coccidiosis vaccine nor did Eimeria-specific duodenal lesion.However,dietary essential oil preparation lowered oocysts present in litter materials and altered branchedchain fatty acids in cecal digesta.Beneficial findings of the essential oil preparation on volatile fatty acids and oocysts output may warrant further research into assessing its effectiveness and its efficacy in pathogenic fieldisolate Eimeria spp.-induced coccidiosis disease model. | Francisco Xavier Gordillo Jaramillo Da-Hye Kim Sang Hyeok Lee Sun-Kwan Kwon Rajesh Jha Kyung-Woo Lee | 2021 | Journal of Animal Science and Biotechnology2021，12，3： | 2 |
| 10 | An integrated analysis of an orogen sedimentary basin pair: Latest Cretaceous-Cenozoic evolution of the linked Eastern Cordillera orogen and the Llanos foreland basin of Colombia显示文摘 | Bayona G Cortes M Jaramillo C | 2008 | GSA Bulletin2008，120，9： | 1 |
| 11 | Phylogeny and patterns of floral diversity in the genus Piper (Piperaceae) 显示文摘 | Jaramillo MA Manos PS | 2001 | American Journal of Botany2001，，4： | 1 |
| 12 | WHO guidelines for the programmatic management of drug-resistant tuberculosis: 2011 update 显示文摘 | Falzon D Jaramillo E Schunemann HI | 2011 | Eur Respir J2011，38，3： | 1 |
| 13 | Wind speed analysis in La Ventosa, Mexico : a bimodal probability distribution case显示文摘 | Jaramillo O A Borja M A | 2004 | Renewable Energy2004，29，10： | 1 |
| 14 | Nrf2 induces cisplatin resistance through activation of autophagy in ovarian carcinoma显示文摘 | Bao LJ Jaramillo MC Zhang ZB | 2014 | Int J Clin Exp Pathol2014，7，4： | 1 |
| 15 | The role of the Five Factor Model of personality in the perceptions of negative and positive forms of work–nonwork spillover: A meta-analytic review显示文摘 | Jesse S. Michel Malissa A. Clark David Jaramillo | 2011 | Journal of Vocational Behavior2011，，1： | 1 |
| 16 | Aggressiveness of a 20% bioethanol 80% gasoline mixture on autoparts: II behavior of polymeric materials显示文摘 | LABARI Baena FKLIPE Jaramillo JAM Adhescalder6n | 2012 | Fuel2012，95，1： | 1 |
| 17 | Post- closed reduction perfusion magnetic resonance imaging as a predictor of avascular necrosis in developmental hip dysplasia : a preliminary report显示文摘 | TIDERIUS C JARAMILLO D S GRIFFEY M et ol | 2009 | J Pediatr Orthop2009，29，1： | 1 |
| 18 | Signaling events involved in macrophnge chemokine expression in reponse to monosodium urate crystals显示文摘 | Jaramillo M Codbout M Naccache PH | 2004 | J Biol Chem2004，279，52： | 1 |
| 19 | Synthesis and Characterization of Pt-WO3 as Methanol Oxidation Catalysts for Fuel Ceils显示文摘 | Jayaraman S Jaramillo T F Baeck S H | 2005 | J Phys Chem B2005，109，22： | 1 |
| 20 | Cartilaginous path of physeal fracture-separations: evalution with MR imaging:an experimental study with histologic correlation in rabbits显示文摘 | Jaramillo D Kammen BF Shapiro F | 2000 | Radiology2000，215，2： | 1 |
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