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| 1 | Management of hilar cholangiocarcinoma in the North of England: Pathology, treatment, and outcome显示文摘AIM: To assess the management and outcome of hilar cholangiocarcinoma (Klatskin tumor) in a single tertiary referral center.METHODS: The notes of all patients with a diagnosis of hilar cholangiocarcinoma referred to our unit for over an 8-year period were identified and retrospectively reviewed. Presentation, management and outcome were assessed.RESULTS: Seventy-five patients were identified. The median age was 64 years (range 34-84 years). Male to female ratio was 1:1. Eighty-nine percent of patients presented with jaundice. Most patients referred were under Bismuth classification 3a, 3b or 4. Seventy patients required biliary drainage, 65 patients required 152percutaneous drainage procedures, and 25 had other complications. Forty-one patients had 51 endoscopic drainage procedures performed (15 failed). Of these,36 subsequently required percutaneous drainage. The median number of drainage procedures for all patients was three, 18 patients underwent resection (24%), nine had major complications and three died post-operatively.The 5-year survival rate was 4.2% for all patients, 21%for resected patients and 0% for those who did not undergo resection (P = 0.0021). The median number of admissions after diagnosis in resected patients was two and three in non-resected patients (P<0.05).Twelve patients had external-beam radiotherapy, seven brachytherapy, and eight chemotherapy. There was no significant benefit in terms of survival (P = 0.46) or hospital admissions.CONCLUSION: Resection increases survival but carries the risk of significant morbidity and mortality.Percutaneous biliary drainage is almost always necessary and endoscopic drainage should be avoided if possible. | SD Mansfield O Barakat RM Charnley BC Jaques CB O'Suilleabhain PJ Atherton D Manas | 2005 | World Journal of Gastroenterology2005，11，48： | 37 |
| 2 | Nd3+ ion based self frequency doubling solid state lasers显示文摘 | JAQUE D CAPMANY J GARCIA J | 1999 | Optical Materials1999，13，2： | 2 |
| 3 | Ischemic cholangiopathy after liver transplantation from controlled non-heart-beating donors-a single-center experience显示文摘 | KACZMAREK B MANAS M D JAQUES B C | 2007 | Transplant Proe2007，39，9： | 1 |
| 4 | Nickel sulphide deposits in Australia: characteristics, resources and potential显示文摘 | Hoatson D M Jaireth S Jaques A L | 2006 | Ore Geology Reviews2006，29，： | 1 |
| 5 | Generative feature-based design-by-constraints as a means of integration witnin the manufacture industry显示文摘 | Jaques M W S Billingsley J Harrison D | 1991 | Compuer-Aided Engineering Journal1991，8，6： | 1 |
| 6 | Salt effects in vapor-liquid:Testing the thermodynamic consistency of ethanol-water saturated with inorganic salts显示文摘 | Jaques D Furter W F | 1972 | AICHE J1972，18，2： | 1 |
| 7 | Isobaric LVE data for alcohol-water systems saturated with a salt which appear to contra- dict the Gibbs-Konovolov theorem显示文摘 | JAQUES D GALAN MA | 1980 | Chem Eng Sci1980，35，8： | 1 |
| 8 | Nickel sulfide deposit in Australia:Characteristics,resources,and potential显示文摘 | Hoatson D M Jaireth S and Jaques A L | 2006 | Ore Geolo- gy Review2006，29，34： | 1 |
| 9 | Cystic lesions of the pancreas:selection criteria for operative and nonoperative management in 209 patients显示文摘 | Allen P J Jaques D P D’Angelica M | 2003 | Gastrointest Surg2003，7，8： | 1 |
| 10 | Continuous wave laser radiation and self-frequency-doubling in ZnO doped LiNbO3:Nd^3+显示文摘 | Capmany J Jaque D Sanz García J A García Solé J | 1999 | Optics Communications1999，161，46： | 1 |
| 11 | Spectroscopic characterisation of the Tm^3+ -doped KLa ( WO4 )2 single crystals 显示文摘 | Macalik L Hanuza J Jaque D | 2006 | Optical Materials2006，28，89： | 1 |
| 12 | CW end-pumped Nd^3+:LaBGeO5 mini laser for self-frequency-doubling显示文摘 | Capmany J Bausá L E Jaque D García Solé J Kaminshii A A | 1997 | Journal of Luminescence1997，7274，： | 1 |
| 13 | Randomized clinical trials in soft tissue sarcoma显示文摘 | Mccarter M D Jaques D P Brennan M F | 2002 | Surg Oncol Clin N Am2002，11，1： | 1 |
| 14 | Lethal oxidative damage and mutagenesis are generated by iron in Fur mutants of Esherichla coli: Protective role of superoxied dismutase显示文摘 | Touati D Jaques M Tardat B | 1995 | J Bacteriol1995，177，： | 1 |
| 15 | Long-term survival following treatment of pseudomyxoma peritonei:an analysis of surgical therapy显示文摘 | Miner T J Shia J Jaques D P | 2005 | J Am Surg2005，242，5： | 1 |
| 16 | Anhydrous melting of peridotites at 0 - 15 kbar pressure and the genesis of tholeiitic basalts 显示文摘 | Jaques A L Green D H | 1980 | Contributions to Mineralogy and Petrology1980，73，3： | 1 |
| 17 | Indoor-outdoor air pollution relations: particulate matter less than 10 mm in aerodynamic diameter ( PM10 ) in the homes of asthmatics 显示文摘 | Colome S D Kado N Y Jaques P | 1992 | Atmospheric Environment1992，26，： | 1 |
| 18 | Long-term survival following treatment of pseudomyxoma peritonei : an analysis of surgical therapy显示文摘 | Miner T J Shia J Jaques D P | 2005 | Ann Surg2005，241，2： | 1 |
| 19 | Cystic lesions ofthe pancreas : selection criteria for operative and nonoperativemanagement in 209 patients显示文摘 | Allen PJ Jaques DP D’angelica M | 2003 | J Gastrointest Surg2003，7，8： | 1 |
| 20 | Outcome of patients with known metastatic gastric cancer undergoing resection with therapeutic intent 显示文摘 | Gold JS Jaques DP Bentrem D J | 2007 | Ann Surg Oncol2007，14，2： | 1 |
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