|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno-or squamous cell carcinoma显示文摘AIM:To determine whether-1195 A→G and/or-765 G→C polymorphisms in Cyclooxygenase-2(COX-2 ) may have a risk modifying effect on the development of esophageal carcinoma in a Dutch Caucasian population.METHODS:Two study groups were recruited, 252 patients with esophageal carcinoma and 240 healthy controls, matched for race, age, gender and recruiting area.DNA was isolated from whole blood and used for genotyping.PCR products were digested with restriction enzymes and products were analyzed by agarose gel electrophoresis.Odds ratios(OR) and 95% confldence intervals(CI) were estimated.RESULTS:The distribution of the-1195 A→G polymorphism was signif icantly different in esophageal cancer patients compared to controls.The-1195 GG genotype resulted in a higher risk of developing esophageal adenocarcinoma(OR = 3.85, 95% CI:1.45-10.3) compared with the-1195 AA genotype as a reference.The-765 G→C genotype distribution was not different between the two groups.The GG/ GG haplotype was present more often in esophageal adenocarcinoma patients than in controls(OR = 3.45, 95% CI:1.24-9.58;with AG/AG as a reference).The same trends were observed in patients with squamous cell carcinomas, however, the results did not reach statistical signif icance.CONCLUSION:Presence of the COX-2-1195 GG genotype and of the GG/GG haplotype may result in a higher risk of developing esophageal carcinoma. | Jón O Kristinsson Paul van Westerveld Rene HM te Morsche Hennie MJ Roelofs T Wobbes Ben JM Witteman Adriaan CITL Tan Martijn GH van Oijen Jan BMJ Jansen Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，28： | 11 |
| 2 | Assessment of oxidative stress in chronic pancreatitis patients显示文摘AIM: To assess the levels of antioxidant capacity and oxidative damage in blood of chronic pancreatitis (CP) patients in comparison with those in healthy control sub- jects, by using several different analytical techniques. METHODS: Thirty-five CP patients and 35 healthy con- trol subjects were investigated prospectively with re- spect to plasma levels of thiols, ferric reducing ability of plasma (FRAP, i.e. antioxidant capacity), levels of protein carbonyls and thiobarbituric acid reactive substances (TBARS). Additionally, we evaluated the production of reactive oxygen species (ROS) in whole blood. RESULTS: The antioxidative thiols including cysteine, cysteinylglycine and glutathione were significantly lower in CP patients. In addition, the non-enzymatic antioxi- dant capacity was significantly lower in CP patients, which correlated with the amount of oxidative protein (protein carbonyls) and the extent of lipid damage (TBARS), both were significantly higher in CP patients. The ROS production in whole blood after stimulation with phorbol 12-myritate 13-acetaat, demonstrated a strong tendency to produce more ROS in CP patients. CONCLUSION: Oxidative stress may contribute to the pathogenesis of chronic pancreatitis by decreasing anti- oxidant capacity and increasing oxidative damage in CP patients may be a rationale for intervention with antioxi- dant therapy. | Mariette Verlaan Hennie MJ Roelofs Annie van Schaik Geert JA Wanten Jan BMJ Jansen Wilbert HM Peters Joost PH Drenth | 2006 | World Journal of Gastroenterology2006，12，35： | 3 |
| 3 | Adding salmeterol to an inhaled corticosteroid reduces allergen-induced serum IL-5 and peripheral blood eosinophils 显示文摘 | Koopmans JG Lutter R Jansen HM | 2005 | J Allergy Clin Immunol2005，116，5： | 1 |
| 4 | Pediatric fron- tal lobe epilepsy: white matter abnormalities and cognitive impairment显示文摘 | Braakman HM Vaessen M J Jansen JF | 2014 | Acta Neurol Scand2014，129，4： | 1 |
| 5 | T-cell regulation in allergic reactions显示文摘 | Jansen HM Kapsenberg ML | | 0，，： | 1 |
| 6 | Short mucin 6 alleles are associated with H pylori infection显示文摘AIM: To investigate the relationship between mucin 6 (MUC6) VNTR length and H pylori infection. METHODS: Blood samples were collected from patients visiting the Can Tho General Hospital for upper gastrointestinal endoscopy. DNA was isolated from whole blood, the repeated section was cut out using a restriction enzyme (PvuⅡ) and the length of the allelefragments was determined by Southern blotting. H pylori infection was diagnosed by 14C urea breath test. For analysis, MUC6 allele fragment length was dichotomized as being either long (> 13.5 kbp) or short (≤ 13.5 kbp) and patients were classif ied according to genotype [long- long (LL), long-short (LS), short-short (SS)].RESULTS: 160 patients were studied (mean age 43 years, 36% were males, 58% H pylori positive). MUC6 PvuⅡ-restricted allele fragment lengths ranged from7 to 19 kbp. Of the patients with the LL, LS, SS MUC6 genotype, 43% (24/56), 57% (25/58) and 76% (11/46) were infected with H pylori, respectively (P = 0.003).CONCLUSION: Short MUC6 alleles are associated with H pylori infection. | Thai V Nguyen Marcel JR Janssen Paulien Gritters René HM te Morsche Joost PH Drenth Henri van Asten Robert JF Laheij Jan BMJ Jansen | 2006 | World Journal of Gastroenterology2006，12，37： | 1 |
| 7 | Meta analysis on the effect of off - pump coronary bypass surgery显示文摘 | van der Heilden GJ Nathoe HM Jansen EW | 2004 | Eur J Cardiothorac Surg2004，26，： | 1 |
| 8 | A comparison of onpump and off-pump coromary bypass surgery in low-risk patients 显示文摘 | Nathoe HM van Dijk D Jansen EW | 2003 | N Engl J Med2003，，5： | 1 |
| 9 | Intestinal Permeability,circulating endotoxin,and postoperative systemic responses in cardiac surgery patients显示文摘 | Jansen PG Hoek FJ | 1996 | J Cardiothorac Vasc Anesth1996，10，2： | 1 |
| 10 | ELISA of complement C3a in bronchoalveolar lavage fluid 显示文摘 | van de Graaf EA Jansen HM Bakker MM Alberts C Eeftinck Schattenkerk JK Out TA | 1992 | J Immunol Methods1992，147，2： | 1 |
| 11 | An unusual H antigen ( Z66 ) in strains of Salmonella typhi 显示文摘 | Guinee PA Jansen WH Mass HM | 1981 | Ann Microbiol1981，132，3： | 1 |
| 12 | Interleukir-4 and interferongamma synergistically increase secretory component gene expression, but are additive in stimulating secretory immunoglobulin A release by Calu-3 airway epithelial cells显示文摘 | Loman S Jansen HM Out TA | 1999 | Immunology1999，96，4： | 1 |
| 13 | Cognitive and behavioural findings in children with fronta lobe epilepsy 显示文摘 | Brlaakman HM Vaessen MJ Jansen JF | 2012 | Eur J Paediatr Neurol2012，16，6： | 1 |
| 14 | Virulence factors in thecolonization and persistence of bacteria in the airways显示文摘 | van Alphen L Jansen HM Dankert J | 1995 | AmJ Respir Crit Care Med1995，151，6： | 1 |
| 15 | A comparison of on-pump and off-pump coronary bypass surgery in low-risk patients显示文摘 | Nathoe HM van Dijk D Jansen EW | 2003 | N Engl J Med2003，348，5： | 1 |
| 16 | Similar lev- els of nitric oxide in exhaled air in non-asthmatic rhinitis and asthma after bronchial allergen challenge 显示文摘 | Lopuhaa CE Koopmans JG Jansen HM | 2003 | Allergy2003，58，4： | 1 |
| 17 | Surfactant protein A in bronchoalveolar lavage fluid显示文摘 | Jansen HM Lutter R | 1992 | J Lab Clin Med1992，120，2： | 1 |
| 18 | The influence of food temperature on postprandial blood pressure reduction and its relation to substance-P in healthy elderly subjects 显示文摘 | Kuipers HM Jansen RW Peeters TL | 1991 | J Am Geriatr Sac1991，39，2： | 1 |
| 19 | Multiplex PCR assay for immediate identification of the infecting species in patients with mycobacterial disease显示文摘 | Kox LFF Jansen HM Knijper SK | 1997 | J Clin Micrbiol1997，35，： | 1 |
| 20 | Idiopathic pulmonary fibrosis:molecular mechanisms and possible therapeutic strategies显示文摘 | Van DB Jansen HM Pepplenbosch MP | 2000 | Arch Immunol Ther Exp2000，48，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员