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| 1 | Cetuximab plus FOLFOX6 or FOLFIRI in metastatic colorectal cancer: CECOG trial显示文摘AIM: To investigate efficacy and safety of cetuximab combined with two chemotherapy regimens in patients with unresectable metastatic colorectal cancer (mCRC). METHODS: Randomized patients received cetuximab with 5-fluorouracil (5-FU), folinic acid (FA) and oxaliplatin (FOLFOX) 6 (arm A, n = 74) or 5-FU, FA and irinotecan (FOLFIRI) (arm B, n = 77). KRAS mutation status was determined retrospectively in a subset of tumors (n = 117). RESULTS: No significant difference was found between treatment arms A and B in the progression-free survival (PFS) rate at 9 mo, 45% vs 34%; median PFS, 8.6 mo vs 8.3 mo [hazard ratio (HR) = 1.06]; overall response rate (ORR) 43% vs 45% [odds ratio (OR) = 0.93] and median overall survival (OS), 17.4 mo vs 18.9 mo (HR = 0.98). Patients with KRAS wild-type tumors demonstrated improved PFS (HR = 0.55, P = 0.0051), OS, (HR = 0.62, P = 0.0296) and ORR (53% vs 36%) and in arm A, improved PFS (HR = 0.49, P = 0.0196), OS (HR = 0.48, P = 0.0201) and ORR (56%vs 30%), compared with patients with KRAS mutated tumors. In arm B no significant differences were found in efficacy by KRAS mutation status. Treatment in arms A and B was generally well tolerated. CONCLUSION: This study confirms that combinations of cetuximab with FOLFOX6 or FOLFIRI are effective and significantly improve clinical outcome in KRAS wild-type compared with KRAS mutated mCRC. | Janja Ocvirk Thomas Brodowicz Fritz Wrba Tudor E Ciuleanu Galina Kurteva Semir Beslija Ivan Koza Zsuzsanna Pápai Diethelm Messinger Ugur Yilmaz Zsolt Faluhelyi Suayib Yalcin Demetris Papamichael Miklós Wenczl Zrinka Mrsic-Krmpotic Einat Shacham-Shmueli Damir Vrbanec Regina Esser Werner Scheithauer Christoph C Zie-linski | 2010 | World Journal of Gastroenterology2010，16，25： | 17 |
| 2 | Characteristics of Underground Water Flow at Different Water Levels in Tianshengan Karst Area, Yunnan, China显示文摘Three tracing tests from the same injection point executed at low, medium, and high water levels in the karst aquifer near Tianshengan village, Lunan Stone Forest, Yunnan Province, China, have revealed the basic properties of underground water flow. They showed the general directions of water flows; tracer concentrations were observed at six successive points allowing for the calculation of apparent dominant flow velocities at these sections towards the Dalongtan karst spring. For the high water level, the discharge between single sections was between two and 10 times greater than that at low water level. For the medium water level, the flow velocity at different sections was between 1.4 and 3.7 times faster than that at low water level; and for high water level, it was between 1.3 and 2.7 times faster than that at medium water level. The fastest water flow appeared at the first section (23 cm/s at medium water level); and the slowest (0.6 cm/s at low water level) appeared where water flow must cross the Tianshengan fault (north–south direction), and later, a layer of 20–30 m thickness of quartz sandstone and shale clay-stones. It was also possible to calculate the recovery of the tracer for point 4, Dakenyan, where discharge was measured. At the medium water level, 50% of the injected tracer was detected a half-day after its first appearance and at low water level after more than 3 days. The previously published research illustrates the transport velocities of possible contaminants and their solubilities in water at different hydrological conditions. | Janja KOGOVEK | 2010 | Acta Geologica Sinica(English Edition)2010，84，1： | 3 |
| 3 | New insights into adipose tissue dysfunction in insulin resistance显示文摘 | Barbara Mlinar Janja Marc | 2011 | Clinical Chemistry and Laboratory Medicine2011，，12： | 2 |
| 4 | Water tracing test in the Tianshenguan region, Yunnan-china at high water level 显示文摘 | Hong L | 2000 | Acta Carsologica2000，29，2： | 1 |
| 5 | Baiyun cave in Naigu Shilin, Yunnan Karst, China显示文摘 | Tadej S Janja K | 2001 | Acta Geologica Sinca (English Edition)2001，75，3： | 1 |
| 6 | Protective effects of xanthohumol against the genotoxicity of benzo(a)pyrene (BaP), 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and tert- butyl hydroperoxide ( t -BOOH) in HepG2 human hepatoma cells显示文摘 | Janja Plazar Bojana ?egura Tamara T. Lah Metka Filipi? | 2007 | MutRes-Genetic Toxicology and Environmental Mutagenesis2007，，1： | 1 |
| 7 | Determination of AKD sizing agents in papermaking systems by gas chromatography 显示文摘 | Janja Zule Jozica Dolenc | 2003 | Acta Chimica Slovenica2003，50，： | 1 |
| 8 | Estimating historicalanthropogenic global sulfur emission patterns for period1850-1990显示文摘 | Allen S L Janja D H Rudolf D H | 1999 | Atmospheric Environment1999，33，： | 1 |
| 9 | Expression of bone resorption genes in osteoarthritis and in osteoporosis显示文摘 | Darja Bitenc Logar Radko Komadina Janez Pre?elj Barbara Ostanek Zoran Tro?t Janja Marc | 2007 | Journal of Bone and Mineral Metabolism2007，，4： | 1 |
| 10 | Influence of Atorvastatin Treatment on l-Arginine Cerebrovascular Reactivity and Flow-Mediated Dilatation in Patients With Lacunar Infarctions显示文摘 | Janja Pretnar-Oblak Miso Sabovic Miran Sebestjen Tomaz Pogacnik Marjan Zaletel | 2006 | Stroke2006，，10： | 1 |
| 11 | Water tracing test in the Tianshengan region,China at low water level in November 1998显示文摘 | Janja Kogovsek Liu Hong | 1999 | Acta Carsologica1999，28，2： | 1 |
| 12 | Extractable antioxidants and non-extractable phenolics in the total antioxidant activity of selected plum cultivars ( Prunus domestica L . ): Evolution during on-tree ripening显示文摘 | Janja Kristl Metka Slekovec Stanislav Tojnko Tatjana Unuk | 2010 | Food Chemistry2010，，1： | 1 |
| 13 | Biodegradation of azo dye R016in different reactors by immobilized Irpex lacteus 显示文摘 | Mateja T Katerina S Janja K | 2006 | Acta ChimicaSlovenica2006，，53： | 1 |
| 14 | Influence of ionic strength on aqueous oxidation of SO2 catalyzed by manganese显示文摘 | Janja Tur(s)i(c) Irena Grgi(c) Bo(s)tjan Podkraj(s)ek | 2003 | Atmospheric Environment2003，37，19： | 1 |
| 15 | Molecular mechanism of insulin resistance and associated diseases显示文摘 | Barbara M Janja M Andrej J | | 0，，1： | 1 |
| 16 | Quick identification of acetic acid bacteria based on nucleotide sequences of the 1 6 S - 2 3 S rDNA internal transcribed spacer region and of the PQQ - dependent alcohol dehydrog enase gene 显示文摘 | Janja Trcek | 2005 | Systematic and Applied Microbiology2005，28，： | 1 |
| 17 | The highly tolerant acetic acid bacterium Gluconacetobacter europaeus adapts to the presence of acetic acid by changes in lipid composition,morphological properties and QQ-dependent ADH expression显示文摘 | Janja T Katarina J Kazunobu M | 2007 | Extremophiles2007，，11： | 1 |
| 18 | Indoor radon concentrations in relation to geology in Slovenia显示文摘 | Andreja Popit Janja Vaupotic | 2002 | Environmental Geology2002，，42： | 1 |
| 19 | Quick identification of acetic acid bacteria based on nucleotide sequences of the 16S-23S rDNA internal transcribed spacer region and of the PQQ-dependent alcohol dehydrogenaso gene显示文摘 | Janja T | 2005 | Systematic and Applied Microbiology2005，28，： | 1 |
| 20 | Molecular mechanism of insulin resistance and associated diseases 显示文摘 | Barbara M Janja M Andrej J | 2006 | Clin Chim Acta2006，375，12： | 1 |
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