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| 1 | Blood platelet and monocyte activations and relation to stages of liver cirrhosis显示文摘AIM: Blood platelets (plt) and monocytes are the cells that play a crucial role in the pathogenesis of liver damage and liver cirrhosis (LC). In this paper, the analysis of mutual relationship between platelets and monocytes activation in LC was conducted.METHODS: Immunofluorescent flow cytometry was usedto measure the percentage of activated platelet populations(CD62P, CD63), the percentage of plt-monocyte aggregates (pma) (CD41/CD45), and activated monocytes (CD11b, CD14, CD16) in the blood of 20 volunteers and 40 patientswith LC. Platelet activation markers: sP-selectin, platelet factor 4 (PF4), beta-thromboglobulin (βTG) and monocyte chemotactic peptide-1 (MCP-1) were measured and compared in different stages of LC.RESULTS: Platelet activation with the increase in bothβTG serum concentration and elevation of plt population(CD62P and CD63 as well as MIF CD62P and CD63) is elevated as LC develops and thrombocytopenia rises. There is a positive correlation between medial intensityof fluorescence (MIF) CD62P and MIF CD63 in LC. We did not show any relationship between monocyte activation and pma level. SP-selectin concentration correlates positively with plt count and pma, and negatively with stage of plt activation and MIF CD62P and MIF CD63. There was no correlation between MCP-1 concentration andpit, monocyte activation as well as pma level in LC. CD16 monocytes and MIF CD16 populations are significantlyhigher in the end stage of LC. A positive correlation occurs between the value of CD11b monocyte population andMIF CD14 and MIF CD16 on monocytes in LC.CONCLUSION: Platelet and monocyte activation plays an important role in LC. Platelet activation stage does not influence monocyte activation and production of plt aggregates with monocytes in LC. With LC development, thrombocytopenia may be the result of plt consumption in platelet-monocyte aggregates. | Anatol Panasiuk Janusz Zak Edwina Kasprzycka Katarzyna Janicka Danuta Prokopowicz | 2005 | World Journal of Gastroenterology2005，11，18： | 11 |
| 2 | Timing of peak bonemass:discrepancies between CT and DXA显示文摘 | Wren T A Kim P S Janicka A | 2007 | J Clin EndocrinolMetab2007，92，3： | 1 |
| 3 | Large-Eddy Simulation of a Turbulent Hydrogen Diffusion Flame显示文摘 | Hendrik Forkel Johannes Janicka | 2000 | Flow Turbulence and Combustion2000，，2： | 1 |
| 4 | Resistance of Klebsiella pneumoniae strains producing and not producing ESBLs (extended-spectrum beta-lactamases) type enzymes to selected non-beta-lactam antibiotics显示文摘 | Sekowska A Janicka G Klyszejko C | 2002 | Med Sci Monit2002，8，3： | 1 |
| 5 | Flow Field Measurements of Stable and Locally Extinguish- ing Hydrocarbon-Fuelled Jet Flames 显示文摘 | Schneider Ch Dreizler A Janicka J | 2003 | Combustion and Flame2003，135，12： | 1 |
| 6 | Flow field measurements of stable and locally extinguishing hydrocarbon-fuelled jet flames显示文摘 | Schneider C Dreizler A Janicka J | 2003 | Combustion and Flame2003，135，12： | 1 |
| 7 | Fat mass isnot beneficial to bone in adolescents and young adults 显示文摘 | Janicka A Wren TA Sanchez MM | 2007 | J Clin Endocrinol Metab2007，92，1： | 1 |
| 8 | Large eddy simulation based analysis of the effects of cycle-to-cycle variations on air-fuel mixing in realistic DISI IC-engines 显示文摘 | GORYNTSEV D SADIKI A KLEIN M JANICKA J | 2009 | Proceedings of the Combustion Institute2009，32，2： | 1 |
| 9 | Difficulties and limitations in minimally invasiverepair of pectus excavatum-6 years experiences with Nuss technique显示文摘 | Dzielicki J Korlacki W Janicka I | 2006 | Eur J Cardiothorac Surg2006，30，5： | 1 |
| 10 | Aortic stiffness and valvular calcifications in patients with end-stage renal disease 显示文摘 | Zapolski T Wysokin ski A Janicka L | 2008 | PolArch Med Wewn2008，118，3： | 1 |
| 11 | Large Eddy Simulation of Turbulent Combustion Systems 显示文摘 | Janicka J Sadiki A | 2005 | Proceedings of the Combustion Institute2005，30，： | 1 |
| 12 | Large Eddy Simulation of a Bluff-Body Stabilized Nonpremixed Flame 显示文摘 | Kempf A Lindstedt R P Janicka J | 2006 | Combustion and Flame2006，144，： | 1 |
| 13 | Hyoid bone position and tongue size and patency of upper airway structures显示文摘 | Janicka A Halczy-Kowalik L | 2006 | Ann Acad Med Stetin2006，52，3： | 1 |
| 14 | Difficulties and limitations in minimally invasive repair of peetus exacvatum-6 years ex periences with Nuss technique显示文摘 | Dzielicki J Korlacki W Janicka L | 2006 | Eur J Cardiothorac Surg2006，30，5： | 1 |
| 15 | Difficulties andlimitations in minimally invasive repair of pectus excava-tum-6 years experiences with Nuss technique显示文摘 | Dzielicki J Korlacki W Janicka I | 2006 | Eur JCardiothorac Surg2006，30，5： | 1 |
| 16 | Fat mass is not beneficial to bone in adolescents and young adults显示文摘 | JANICKA A WREN T A L SANCHEZ M M | 2007 | Journal of Clinical Endocrinology and Metabolism2007，92，1： | 1 |
| 17 | Large-Eddy Simulation of a Turbulent Hydrogen Diffusion Flame显示文摘 | Hendrik Forkel Johannes Janicka | 2000 | Flow Turbulence and Combustion2000，，2： | 1 |
| 18 | Assisted reproductivemedicine in Poland, 2011-SPiN PTG report 显示文摘 | Janicka A Spaczynski RZ Kurzawa R | 2014 | Ginekol Pol2014，85，7： | 1 |
| 19 | Temperature - in- duced changes of HtrA2 (Omi) protease activity and structure 显示文摘 | Zurawa - Janicka D Jarzab M Polit A | 2013 | Cell Stress Chaperones2013，18，1： | 1 |
| 20 | Analytical procedures for determination of cocaine and its metabolites in biological samples显示文摘 | Janicka M Kot-Wasik A Namie~nik J | 2010 | Trac-Trend Anal Chem2010，29，3： | 1 |
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