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| 1 | Gastroesophageal reflux disease after diagnostic endoscopy in the clinical setting显示文摘AIM: To investigate the outcome of patients with symptoms of gastroesophageal reflux disease (GERD) referred for endoscopy at 2 and 6 mo post endoscopy. METHODS: Consecutive patients referred for upper endoscopy for assessment of GERD symptoms at two large metropolitan hospitals were invited to participate in a 6-mo non-interventional (observational) study.The two institutions are situated in geographically and socially disparate areas. Data collection was by selfcompletion of questionnaires including the patient assessment of upper gastrointestinal disorders symptoms severity and from hospital records. Endoscopic finding using the Los-Angeles classification, symptom severity and it's clinically relevant improvement as change of at least 25%, therapy and socio-demographic factors were assessed. RESULTS: Baseline data were available for 266 patients and 2-mo and 6-mo follow-up data for 128 and 108 patients respectively. At baseline, 128 patients had erosive and 138 non-erosive reflux disease. Allmost all patient had proton pump inhibitor (PPI) therapy in the past. Overall, patients with non-erosive GERD at the index endoscopy had significantly more severe symptoms as compared to patients with erosive or even complicated GERD while there was no difference with regard to medication. After 2 and 6 mo there was a small, but statistically significant improvement in symptom severity (7.02 ± 5.5 vs 5.9 ± 5.4 and 5.5 ± 5.4 respectively); however, the majority of patients continued to have symptoms (i.e. , after 6 mo 81% with GERD symptoms). Advantaged socioeconomic status as well as being unemployed was associated with greater improvement. CONCLUSION: The majority of GORD patients receive PPI therapy before being referred for endoscopy even though many have symptoms that do not sufficiently respond to PPI therapy. | Nora B Zschau Jane M Andrews Richard H Holloway Mark N Schoeman Kylie Lange William CE Tam Gerald J Holtmann | 2013 | World Journal of Gastroenterology2013，19，16： | 2 |
| 2 | Epidermal stem cells显示文摘 | Janes SM Lowell S Hutter CE | | 0，，02： | 1 |
| 3 | Epidemiology of left ventricular false tendons: clinical correlates in the Framingham Heart Study 显示文摘 | Satish K Emelia JB Jane CE | 2009 | Journal of the American Society of Echocardiography2009，22，6： | 1 |
| 4 | Clinical correlates and prognostic significance of exercise-induced ventricular premature beats in the community显示文摘 | Ali MM Jane CE Daniel L | 2004 | Circulation2004，109，20： | 1 |
| 5 | Epidermal stem显示文摘 | Janes SM Lowell S Hutter CE | 2002 | J Pathol2002，197，2： | 1 |
| 6 | Outcomes research in oncology: History, conceptual framework, and trends in the literature显示文摘 | Stephanie JL Craig CE Jane CW | 2000 | J National Cancer Institute2000，92，3： | 1 |
| 7 | Gamma - Glutamyl- transferase and metabolic syndrome, cardiovascular disease, and mortality risk ; the framing ham heart study 显示文摘 | Douglas SL Jane CE Sander JR | 2007 | Arterioscler Thromb VascBiol2007，27，1： | 1 |
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