|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno-or squamous cell carcinoma显示文摘AIM:To determine whether-1195 A→G and/or-765 G→C polymorphisms in Cyclooxygenase-2(COX-2 ) may have a risk modifying effect on the development of esophageal carcinoma in a Dutch Caucasian population.METHODS:Two study groups were recruited, 252 patients with esophageal carcinoma and 240 healthy controls, matched for race, age, gender and recruiting area.DNA was isolated from whole blood and used for genotyping.PCR products were digested with restriction enzymes and products were analyzed by agarose gel electrophoresis.Odds ratios(OR) and 95% confldence intervals(CI) were estimated.RESULTS:The distribution of the-1195 A→G polymorphism was signif icantly different in esophageal cancer patients compared to controls.The-1195 GG genotype resulted in a higher risk of developing esophageal adenocarcinoma(OR = 3.85, 95% CI:1.45-10.3) compared with the-1195 AA genotype as a reference.The-765 G→C genotype distribution was not different between the two groups.The GG/ GG haplotype was present more often in esophageal adenocarcinoma patients than in controls(OR = 3.45, 95% CI:1.24-9.58;with AG/AG as a reference).The same trends were observed in patients with squamous cell carcinomas, however, the results did not reach statistical signif icance.CONCLUSION:Presence of the COX-2-1195 GG genotype and of the GG/GG haplotype may result in a higher risk of developing esophageal carcinoma. | Jón O Kristinsson Paul van Westerveld Rene HM te Morsche Hennie MJ Roelofs T Wobbes Ben JM Witteman Adriaan CITL Tan Martijn GH van Oijen Jan BMJ Jansen Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，28： | 11 |
| 2 | Assessment of oxidative stress in chronic pancreatitis patients显示文摘AIM: To assess the levels of antioxidant capacity and oxidative damage in blood of chronic pancreatitis (CP) patients in comparison with those in healthy control sub- jects, by using several different analytical techniques. METHODS: Thirty-five CP patients and 35 healthy con- trol subjects were investigated prospectively with re- spect to plasma levels of thiols, ferric reducing ability of plasma (FRAP, i.e. antioxidant capacity), levels of protein carbonyls and thiobarbituric acid reactive substances (TBARS). Additionally, we evaluated the production of reactive oxygen species (ROS) in whole blood. RESULTS: The antioxidative thiols including cysteine, cysteinylglycine and glutathione were significantly lower in CP patients. In addition, the non-enzymatic antioxi- dant capacity was significantly lower in CP patients, which correlated with the amount of oxidative protein (protein carbonyls) and the extent of lipid damage (TBARS), both were significantly higher in CP patients. The ROS production in whole blood after stimulation with phorbol 12-myritate 13-acetaat, demonstrated a strong tendency to produce more ROS in CP patients. CONCLUSION: Oxidative stress may contribute to the pathogenesis of chronic pancreatitis by decreasing anti- oxidant capacity and increasing oxidative damage in CP patients may be a rationale for intervention with antioxi- dant therapy. | Mariette Verlaan Hennie MJ Roelofs Annie van Schaik Geert JA Wanten Jan BMJ Jansen Wilbert HM Peters Joost PH Drenth | 2006 | World Journal of Gastroenterology2006，12，35： | 3 |
| 3 | New symptomatic vertebral compression fractures within a year following vertebroplasty in osteoporotic women显示文摘 | Syed MJ Patel NA Jan S | 2005 | AJNR Am J Neuroradiol2005，26，： | 1 |
| 4 | Wavelet-based spectrum analysis of sacral skin blood flow response to alternating pressure显示文摘 | Jan YK Brienza DM Geyer MJ | | 0，，01： | 1 |
| 5 | The diagnosis and management of ductal carcinoma in situ of the breast显示文摘 | David PW Jan MJ Robert AG | 2000 | Ca- A Cancer journal to Clinicians2000，50，3： | 1 |
| 6 | A randomised controlled trial into the effects of food on ADHD显示文摘 | Lidy MJ Huub FJ Jan K | 2009 | Eur Child Adolesc Psychiatry2009，18，： | 1 |
| 7 | Thl7 but not Th22 cells display pathological be haviour in arthritis显示文摘 | Jan Piet van Hamburg Odilia BJ Corneth Sandra MJ Paulis sen | 2012 | Ann Rheum Dis2012，71，10： | 1 |
| 8 | Tuning software phase- Iocked loop for series-connected convers 显示文摘 | Hilmy Awad Jan Svensson Bollen MJ | 2005 | IEEE Transactions on Power Delivery2005，20，1： | 1 |
| 9 | Factors that influence the decision to be an organ donor:a systematic review of the qualitative literature显示文摘 | Irving MJ Tong A Jan S | 2012 | Nephrol Dial Transplant2012，27，6： | 1 |
| 10 | A case of renal osteodystrophy with unexpected serum intact parathyroid hormone concentrations显示文摘 | Meany DL Jan de Beur SM Bill MJ | 2009 | Clin Chem2009，55，9： | 1 |
| 11 | Tuning software phase-locked loop for series-connecters显示文摘 | Hilmy Award Jan Svensson MJ Bollen | | 0，，01： | 1 |
| 12 | The diagnosis and manage ment of ductal carcinoma in situ of the breasl 显示文摘 | David PW Jan MJ Robert AG | 2000 | Ca-A Cancer journal to clinicians2000，50，： | 1 |
| 13 | Functional genetic polymorphisms in cytokines and metabolic genes as additional genetic markers for susceptibility to develop type 1 diabetes显示文摘 | Eerligh P Koeleman BP Dudbridge F Jan Bruining G Roep BO Giphart MJ | 2004 | Genes Immun2004，5，1： | 1 |
| 14 | PFP -dependent nuclear entry of granzyme B precedes apoptosis, and is not a consequence of nuclear membrane dysfunction 显示文摘 | Trapani JA Jans P Smyth MJ | 1998 | Cell Death Differ1998，5，6： | 1 |
| 15 | The diagnosis and management of ductal carcinoma in situ of the breast显示文摘 | David PW Jan MJ Robert AG | 2000 | CaA Cancer Journal for Clinicians2000，50，3： | 1 |
| 16 | Elimination of head and neck cancer initiating ceils through targeting glucose reg- ulated protein78 signaling显示文摘 | Wu MJ Jan CI Tsay YG | 2010 | Mol Cancer2010，27，9： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员