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| 1 | Journal of Hepatology|血浆氨水平能够预测临床稳定的肝硬化门诊患者的肝脏相关并发症和病死率显示文摘高氨血症虽是肝性脑病发病机制的核心,但对其他器官系统也有多向毒害作用,影响免疫功能、能量代谢、门静脉高压及导致肌少症。该研究旨在验证临床稳定的门诊肝硬化患者中,高氨血症的严重程度是肝相关并发症的风险因素这一假设。研究收集了来自3个独立单位的754例临床稳定的肝硬化门诊患者的数据。将基准氨水平校正至参考实验室的正常值上限(AMM-ULN)。 | 董美丽 温晓玉 TRANAH TH BALLESTER MP CARBONELL-ASINS JA | 2022 | 临床肝胆病杂志2022，38，9： | 6 |
| 2 | 术中应用荧光素钠有利于胶质母细胞瘤浸润边缘的手术切除(英文)显示文摘Objective Extent of resection is an important prognostic factor in patients undergoing surgery for glioblastoma( GBM).Recent evidence suggests that intravenously administered fluorescein sodium associates with tumor tissue,facilitating safe maximal resection of GBM. In this study,the authors evaluate the safety and utility of intraoperative fluorescein guidance for the prediction of histopathological alteration both in the contrast-enhancing( CE) regions,where this relationship has been established,and into the nonCE( NCE),diffusely infiltrated margins. Methods Thirty-two patients received fluorescein sodium( 3 mg/kg) intravenously prior to resection. Fluorescence was intraoperatively visualized using a Zeiss Pentero surgical microscope equipped with a YELLOW 560 filter.Stereotactically localized biopsy specimens were acquired from CE and NCE regions based on preoperative MRI in conjunction with neuronavigation. The fluorescence intensity of these specimens was subjectively classified in real time with subsequent quantitative image analysis,histopathological evaluation of localized biopsy specimens,and radiological volumetric assessment of the extent of resection.Results Bright fluorescence was observed in all GBMs and localized to the CE regions and portions of the NCE margins of the tumors,thus serving as a visual guide during resection. Gross-total resection( GTR) was achieved in 84% of the patients with an average resected volume of 95%,and this rate was higher among patients for whom GTR was the surgical goal( GTR achieved in 93. 1% of patients,average resected volume of 99. 7%). Intraoperative fluorescein staining correlated with histopathological alteration in both CE and NCE regions,with positive predictive values by subjective fluorescence evaluation greater than 96% in NCE regions. Conclusions Intraoperative administration of fluorescein provides an easily visualized marker for glioma pathology in both CE and NCE regions of GBM. These findingssupport the use of fluorescein as a microsurgical adjunct for guiding GBM resection to facilitate safe maximal removal. | Neira JA Ung TH Sims J Malone HR Chow DS Samanamud JL Zanazzi GJ Guo X Bowden SG Zhao B Sheth SA McKhann GM 2nd Sisti MB Canoll P D'Amico RS Bruce JN | 2016 | 中华神经外科疾病研究杂志2016，15，5： | 2 |
| 3 | Guideline for the management of ingested foreign bodies显示文摘 | Eisen GM Baron TH Dominitz JA | 2002 | Gastrointest Endosc2002，35，： | 1 |
| 4 | AntimicrobAntimicrobial treat-ment and clinical outcomes of carbapenem-resistant Acinetobacterbaumannii ventilator-associated pneumonia显示文摘 | Chan JD Graves JA Dellit TH | 2010 | J Intensive CareMed2010，25，6： | 1 |
| 5 | Least cost poultry rations with nutrient variability: A comparison of linear programming with a margin of safety and stochastic programming models显示文摘 | D' ALFONSO TH ROUSH WB VENTURA JA | 1992 | Poultry Science1992，71，： | 1 |
| 6 | Xestospongins:potent membrane permeable blockers of the inositol 1,4,5-trisphosphate receptor显示文摘 | Gafni J Munsch JA Lam TH Catlin MC Costa LG Molinski TF | 1997 | Neuron1997，19，3： | 1 |
| 7 | Use of intraoperative ultrasonography to localize islet cell tumors显示文摘 | Zeiger MA Shawker TH Norton JA | 1993 | World J Surg1993，17，4： | 1 |
| 8 | Hemophagocytic syndrome:a review of 18 pediatric cases显示文摘 | Chen CJ Huang YC Jaing TH | 2004 | Chen CJ-J Microbiol Immunol Infect2004，37，3： | 1 |
| 9 | Inhibition of casein kinase II by heparin显示文摘 | Hathaway GM Lubben TH Traugh JA | 1980 | Biol Chem1980，255，17： | 1 |
| 10 | Localization and surgical treatment of occult insulinomas显示文摘 | Norton JA Shawker TH Doppman JL | 1990 | Ann Surg1990，212，5： | 1 |
| 11 | 显示文摘 | Schroeder JA Qui TH | 1995 | Cancer Res1995，55，17： | 1 |
| 12 | Neuronal death and bloodbrain barrier breakdown after excitotoxic injury are independent processes显示文摘 | Indyk JA Bugge TH | 1999 | JNeurosci1999，19，： | 1 |
| 13 | Parenteral structured triglyceride emulsion improves nitrogen balance and is cleared faster from the blood in moderately catabolic patients显示文摘 | Kruimel JW Naber TH van der Vliet JA | 2001 | JPEN J Parenter Enteral Nutr2001，25，5： | 1 |
| 14 | Total mismatch:negative diffusion-weighted imaging but extensive perfusion defect in acute stroke显示文摘 | Cho TH Hermier M Alawneh JA | 2009 | Stroke2009，40，： | 1 |
| 15 | Onset and effectiveness of rocuronium for rapid onset of paralysis in patients with major burns: priming or largebolus显示文摘 | Han TH Martyn JA | 2009 | Br J Anaesth2009，102，1： | 1 |
| 16 | Malignant triton tumor of cervical spine:report of one case and review of the literature显示文摘 | Jaing TH Chuang CC Jung SM | | 0，，： | 1 |
| 17 | Protective role of Toll-like receptor 4 during the initiation stage of cutaneous chemical carci nogenesis显示文摘 | Yusuf N Nasti TH Long JA | 2008 | Cancer Res2008，68，2： | 1 |
| 18 | Constitutive stabilization of B-catenin in the dental mesenchyme leads to excessive dentin and cementum formation显示文摘 | Kim TH Lee JY Baek JA | 2011 | Biochem Biophys Res Commun2011，412，4： | 1 |
| 19 | Phase study of oral eapecitabine in patients with advanced of metastatic pancreatic cancer 显示文摘 | Cartwright TH Cohn A Varkey JA | 2003 | J Clin Onco12003，20，： | 1 |
| 20 | Guideline for the management of ingested foreign bodies显示文摘 | Eisen GM Baron TH Dominitz JA | 2002 | Gastrointest Endosc2002，55，7： | 1 |
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