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| 1 | Influence of tacrolimus metabolism rate on renal function after solid organ transplantation显示文摘The calcineurin inhibitor(CNI) tacrolimus(TAC) is an integral part of the immunosuppressive regimen after solid organ transplantation. Although TAC is very effective in prevention of acute rejection episodes, its highly variable pharmacokinetic and narrow therapeutic window require frequent monitoring of drug levels and dose adjustments. TAC can cause CNI nephrotoxicity even at low blood trough levels(4-6 ng/m L). Thus, other factors besides the TAC trough level might contribute to CNI-related kidney injury. Unfortunately, TAC pharmacokinetic is determined by a whole bunch of parameters. However, for daily clinical routine a simple application strategy is needed. To address this problem, we and others have evaluated a simple calculation method in which the TAC blood trough concentration(C) is divided by the daily dose(D). Fast TAC metabolism(C/D ratio < 1.05) was identified as a potential risk factor for an inferior kidney function after transplantation. In this regard, we recently showed a strong association between fast TAC metabolism and CNI nephrotoxicity as well as BKV infection. Therefore, the TAC C/D ratio may assist transplant clinicians in a simple way to individualize the immunosuppressive regimen. | Gerold Th?lking Hans Ulrich Gerth Katharina Schuette-Nuetgen Stefan Reuter | 2017 | World Journal of Transplantation2017，7，1： | 6 |
| 2 | 采用椭圆形非骨水泥压配固定髋臼杯行全髋关节置换术治疗髋关节发育不良显示文摘对继发于髋关节发育不良的晚期骨性关节炎患者来说,全髋关节置换术是较好的治疗选择,但由于此类患者存在的解剖结构异常,手术变得较为复杂。在分型为HartofilakidisⅡ型的患者中,股骨头的半脱位造成髋臼顶部外上方的骨缺损,往往需要某种形式的支撑来使髋臼杯获得稳定的固定。处理这种类型的骨缺损可以采用多种不同的方法,孰优孰劣尚有争议。本文的目的是通过回顾性分析比较两种不同的骨缺损处理方法,来探讨椭圆形非骨水泥髋臼杯是否可以作为传统处理方法的替代方法。 | 王俏杰 张先龙 Boris M.Holzapfel Felix Greimel Peter M.Prodinger Hakan Pilge Ulrich Nth Hans Gollwitzer Maximilian Rudert | 2012 | 中国矫形外科杂志2012，20，17： | 3 |
| 3 | Relationship between diabetes mellitus and cataract in Hungary显示文摘AIM:To examine the coexistence of diabetes mellitus(DM)and cataract in Hungary.The effects of DM on the cataract surgical results were also in the focus of analysis.METHODS:Statistical data analysis of the results of the Rapid Assessment of Avoidable Blindness with Diabetic Retinopathy(RAAB+DR)module conducted in Hungary in 2015.This cross-sectional,population-based,national survey included 3523 people aged 50 years and over.Participants of the survey were examined on-site.Visual acuity,main cause for visual impairment(using direct and indirect ophthalmoscopes),in case of best corrected visual acuity(BCVA)≤0.5 and blood glucose level(random test with glucometer)were examined.RESULTS:The prevalence of cataract was 23.4%,and DM was 20.0%.The occurrence of cataract steadily increased with age.Among the examined participants with DM,the prevalence of cataract was significantly(P=0.012)higher(+35%)than that in non-diabetic subjects(29.5%vs 21.8%).Following aging(OR=15.2%,P<0.001),DM proved to be the most independent influencing risk factor(OR=49.9%,P<0.001).The presence of DM was neither an influencing factor for complications of cataract surgery,nor for postoperative visual acuity.CONCLUSION:DM appears to be one of the main risk factors for developing cataract.Other risk factors,such as age,sex and environment also play an influencing role.Diabetes does not seem to affect the occurrence of cataract surgical complications. | Anita Pék Dorottya Szabó Gábor LászlóSándor Gábor Tóth András Papp Zoltán Zsolt Nagy Hans Limburg János Németh | 2020 | International Journal of Ophthalmology(English edition)2020，13，5： | 2 |
| 4 | Transport of airborne particulate matters originating from Mentougou, Beijing, China显示文摘In this study, a coupled regional air quality modeling system is applied to investigate the time spatial variations in airborne particulate matters (PM10), originating from Mentougou to Beijing municipal area in the period of April 1-7, 2004, and the influences of complex terrain and meteorological conditions upon boundary layer structure and PM10 concentration distributions. An intercomparison of the performance with CALPUFF against the observed data is presented and an examination of scatter plots is provided. The statistics show that the correlation coefficient and STD between the modeled and observed data are 0.86 and 0.03, respectively. Analysis of model results illustrates that the pollutants emitted from Mentougou can be transported to Beijing municipal area along certain transport pathways, and PM10 concentration distributions show heterogeneity characteristics. Contributions of the Mentougou sources to the PM10 concentrations in Beijing municipal area are up to 0.1-15 g/m3. | Duoxing Yang Yongwei Han Jixi Gao Jesse Thé | 2007 | China Particuology2007，5，6： | 2 |
| 5 | The dose proportionality of telcagepant after administration of single oral and intravenous doses in healthy adult subjects显示文摘 | Han TH Blanchard RL Palcza J | | 0，，： | 1 |
| 6 | Increased levels of BAL cysteinyl leukotrienes in acute RSV bronchiolitis显示文摘 | Kim CK Koh JY Han TH | 2006 | Acta Paediatr2006，95，4： | 1 |
| 7 | Increased levels of BAL cysteinyl leukotrienesinacute RSV bronchiolitis显示文摘 | Kim CK Koh JY Han TH | 2006 | Acta Paediatr2006，95，4： | 1 |
| 8 | Increased Levels of BAL cysteinyl leukotrienes in Acute RSV bronchiolitis显示文摘 | KimCK Koh JY Han TH | | 0，，04： | 1 |
| 9 | Suppressive effects of Lithospermum erythrorhizon extracts on lipopolysaccharide-induced activation of AP-1 and NF- kappaB via mitogen-activated protein kinase pathways in mouse macrophage cells显示文摘 | Han KY Kwon TH Lee TH | 2008 | BMB Rep2008，41，4： | 1 |
| 10 | lncreased levels of BAL cys-teinyl leukotrienes in acute RSV bronchiolitis显示文摘 | Kim CK Koh JY Han TH | 2006 | Acta Paediatr2006，95，4： | 1 |
| 11 | Onset and effectiveness of rocuronium for rapid onset of paralysis in patients with major burns: priming or largebolus显示文摘 | Han TH Martyn JA | 2009 | Br J Anaesth2009，102，1： | 1 |
| 12 | Prevalenceof Diy eye disease in an elderly Korean population 显示文摘 | Han SB Hyon JY Woo SJ Lee JJ Kim TH Kim KW | 2011 | ArchOphialmol2011，129，5： | 1 |
| 13 | WU Polyomavirus in children with acute lower respiratory tract infections,South Korea显示文摘 | Han TH Chung JY Koo JW | 2007 | Emerg Infect Dis2007，13，11： | 1 |
| 14 | Correction of the nasal tip and columella in Koreans by a complete septal extension graft using an extensive harvesting technique显示文摘 | Kim JS Han KH Choi TH | 2007 | J Plast Reconstr Aesthet Surg2007，60，2： | 1 |
| 15 | Brentuximab vedotin does not cause clinically relevant QTc interval prolongation in patients with CD30-positive hematologic malignancies显示文摘 | Han TH Chen R Advani R | 2013 | Cancer Che- mother Pharmaeol2013，72，1： | 1 |
| 16 | WU polyomavirus in chil- dren with acute lower respiratory tract infections, South Korea 显示文摘 | Han TH Chung JY Koo JW | 2007 | EmergInfect Dis2007，13，11： | 1 |
| 17 | The favorable clinical and angiographic outcomes of a high-dose dexamethasane-eluting stent; randomized controlled prospective study显示文摘 | Han SH Ahn TH Kang WC | 2006 | Am Heart J2006，152，5： | 1 |
| 18 | Prevention of postoperativenausea and vomiting by continuous infusion of subhypnoticpropofol in female patients receiving intravenous patient-con-trolled analgesia显示文摘 | Kim SI Han TH Kil HY | 2000 | Br J Anaesth2000，85，6： | 1 |
| 19 | Antinociceptive mechanism of latycodin D administered intracere -bioventfic ularly in the mouse 显示文摘 | Choi SS Han EJ LEE TH | 2002 | Plant Med2002，68，9： | 1 |
| 20 | Bocavirus infection in hospitalized children,South Korea显示文摘 | Han TH Kim CK | 2006 | Emerg Infect Dis2006，12，8： | 1 |
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