| 17 | 瑞舒伐他汀治疗后c反应蛋白、LDL胆固醇及心血管事件率的降低:JUPITER试验的一项前瞻性研究显示文摘背景他汀类药物可降低高敏c反应蛋白(hsCRP)和胆固醇的浓度,而假设生成分析提示,若予以他汀类药物治疗后能使hsCRP浓度〈2mg/L同时LDL胆固醇浓度〈1.8mmol/L(〈7mg/L),则患者的临床结局可得到改善。然而,对他汀类药物治疗使LDL胆固醇和hsCRP同时降低的临床益处仍存有争议。该研究旨在前瞻性验证这一假设。方法在对JUPITER试验的15548例(占全部队列的87%)初始健康的个体进行的分析中,前瞻性评估瑞舒伐他汀20mg与安慰剂相对比的疗效。按治疗时LDL胆固醇浓度(〈1.8mmol/L、≥1.8mmol/L)和hsCRP浓度(〈2mg/L、〉/2mv2L)划分,以非致死性心肌梗死率、非致死性卒中率、因不稳定型心绞痛入院率、动脉血运重建率、心血管性死亡率(预设终点)为指标进行疗效评价。该研究最长随访时间为5年(M=1.9)。将随机分组后发生的所有事件均纳入。该试验在Clinical Trails.gov的注册编号为NCT00239681。结果与安慰剂组相比,瑞舒伐他汀治疗组中达到LDLJ胆固醇〈1.8mmol/L人群的血管事件减少了55%[事件发生率1.11/100(人·年)US0.51/100(人·年);HR0.45,95%C10.34~0.60,P〈0.0001],达到hsCRP〈2mg/L.h.群的血管事件减少了62%[事件发生率0.42/100(人·年);HR0.38,95%CI0.26~0.56,P〈0.0001]。虽然对于患者个体而言,LDL胆固醇与hsCRP的降低仅有微弱相关(r〈0.15),但研究发现,瑞舒伐他汀治疗组中同时达到LDL)胆固醇〈1.8mmol/L和hsCRP〈2mg/L人群的血管事件减少了65%[事件发生率0.38/100(人·年);校正HR0.35,95%CI0.23~0.54],而仅达到其中一项或两项均未达到的人群的血管事件仅减少了33%[事件发生率0.74/100(人·年);HR0.67,95%CI0.52~0.87](治疗组间P〈0.0001)。在达到LDL胆固醇〈1.8mmol/L和hsCRP〈1mg/L的人群中,血管事件减少了79%[事件发生率0.24/100(人·年);HR0.21,95%CI0.09~0.52]。无论选用何种脂质检测项目(包括载脂蛋白B/载脂蛋白AI比)作为终点,所达到的hsCRP浓度均为事件发生率的预测指标。结论对于选择开始进行药物预防的人群,LDL胆固醇和hsCRP浓度同时降低可作为瑞舒伐他汀治疗成功的指标。 | Paul M Ridker Eleanor Danielson Francisco A H Fonseca Jacques Genest Antonio M Gotto Jr John J P Kastelein Wolfgang Koenig Peter Libby Alberto J Lorenzatti Jean G MocFadyen Barge G Nordestgaard James Shepherd James T Willerson Robert J Glynn 徐斌(译) | 2009 | 世界临床医学2009，，10： | 0 |
| 18 | Fungal diversity notes 1036-1150:taxonomic and phylogenetic contributions on genera and species of fungal taxa显示文摘This article is the tenth series of the Fungal Diversity Notes,where 114 taxa distributed in three phyla,ten classes,30 orders and 53 families are described and illustrated.Taxa described in the present study include one new family(viz.Pseudoberkleasmiaceae in Dothideomycetes),five new genera(Caatingomyces,Cryptoschizotrema,Neoacladium,Paramassaria and Trochilispora)and 71 new species,(viz.Acrogenospora thailandica,Amniculicola aquatica,A.guttulata,Angustimassarina sylvatica,Blackwellomyces lateris,Boubovia gelatinosa,Buellia viridula,Caatingomyces brasiliensis,Calophoma humuli,Camarosporidiella mori,Canalisporium dehongense,Cantharellus brunneopallidus,C.griseotinctus,Castanediella meliponae,Coprinopsis psammophila,Cordyceps succavus,Cortinarius minusculus,C.subscotoides,Diaporthe italiana,D.rumicicola,Diatrypella delonicis,Dictyocheirospora aquadulcis,D.taiwanense,Digitodesmium chiangmaiense,Distoseptispora dehongensis,D.palmarum,Dothiorella styphnolobii,Ellisembia aurea,Falciformispora aquatic,Fomitiporia carpinea,F.lagerstroemiae,Grammothele aurantiaca,G.micropora,Hermatomyces bauhiniae,Jahnula queenslandica,Kamalomyces mangrovei,Lecidella yunnanensis,Micarea squamulosa,Muriphaeosphaeria angustifoliae,Neoacladium indicum,Neodidymelliopsis sambuci,Neosetophoma miscanthi,N.salicis,Nodulosphaeria aquilegiae,N.thalictri,Paramassaria samaneae,Penicillium circulare,P.geumsanense,P.mali-pumilae,P.psychrotrophicum,P.wandoense,Phaeoisaria siamensis,Phaeopoacea asparagicola,Phaeosphaeria penniseti,Plectocarpon galapagoense,Porina sorediata,Pseudoberkleasmium chiangmaiense,Pyrenochaetopsis sinensis,Rhizophydium koreanum,Russula prasina,Sporoschisma chiangraiense,Stigmatomyces chamaemyiae,S.cocksii,S.papei,S.tschirnhausii,S.vikhrevii,Thysanorea uniseptata,Torula breviconidiophora,T.polyseptata,Trochilispora schefflerae and Vaginatispora palmae).Further,twelve new combinations(viz.Cryptoschizotrema cryptotrema,Prolixandromyces australi,P.elongatus,P.falcatus,P.longispinae,P.microveliae,P.neoalardi,P.polhemorum,P.protuberans,P.pseudoveliae,P.tenuistipitis and P.umbonatus),an epitype is chosen for Cantharellus goossensiae,a reference specimen for Acrogenospora sphaerocephala and new synonym Prolixandromyces are designated.Twenty-four new records on new hosts and new geographical distributions are also reported(i.e.Acrostalagmus annulatus,Cantharellus goossensiae,Coprinopsis villosa,Dothiorella plurivora,Dothiorella rhamni,Dothiorella symphoricarposicola,Dictyocheirospora rotunda,Fasciatispora arengae,Grammothele brasiliensis,Lasiodiplodia iraniensis,Lembosia xyliae,Morenoina palmicola,Murispora cicognanii,Neodidymelliopsis farokhinejadii,Neolinocarpon rachidis,Nothophoma quercina,Peroneutypa scoparia,Pestalotiopsis aggestorum,Pilidium concavum,Plagiostoma salicellum,Protofenestella ulmi,Sarocladium kiliense,Tetraploa nagasakiensis and Vaginatispora armatispora). | Kevin D.Hyde Danushka S.Tennakoon Rajesh Jeewon DJayarama Bhat Sajeewa S.N.Maharachchikumbura Walter Rossi Marco Leonardi Hyang Burm Lee Hye Yeon Mun Jos Houbraken Thuong T.T.Nguyen Sun Jeong Jeon Jens Christian Frisvad Dhanushka N.Wanasinghe Robert Lucking Andre Aptroot Marcela E.S.Caceres Samantha C.Karunarathna Sinang Hongsanan Rungtiwa Phookamsak Nimali Ide Silva Kasun M.Thambugala Ruvishika S.Jayawardena Indunil C.Senanayake Saranyaphat Boonmee Jie Chen Zong-Long Luo Chayanard Phukhamsakda Olinto L.Pereira Vanessa P.Abreu Andre Wilson Campos Rosado Buyck Bart Emile Randrianjohany Vale rie Hofstetter Tatiana B.Gibertoni Adriene Mayrada Silva Soares Helio Longoni Plautz Jr Helen Maria Pontes Sotao William Kalhy Silva Xavier Jadson Diogo Pereira Bezerra Thays Gabrielle Linsde Oliveira Cristina Mariade Souza-Motta Oliane Maria Correia Magalhaes Digvijayini Bundhun Dulanjalee Harishchandra Ishara S.Manawasinghe Wei Dong Sheng-Nan Zhang Dan-Feng Bao Milan C.Samarakoon Dhandevi Pem Anuruddha Karunarathna Chuan-Gen Lin Jing Yang Rekhani H.Perera Vinit Kumar Shi-Ke Huang Monika C.Dayarathne Anusha H.Ekanayaka Subashini C.Jayasiri Yuanpin Xiao Sirinapa Konta Tuula Niskanen Kare Liimatainen Yu-Cheng Dai Xiao-Hong Ji Xue-Mei Tian Armin Mesic Sanjay K.Singh Kunthida Phutthacharoen Lei Cai Touny Sorvongxay Vinodhini Thiyagaraja Chada Norphanphoun Napalai Chaiwan Yong-Zhong Lu Hong-Bo Jiang Jin-Feng Zhang Pranami D.Abeywickrama Janith V.S.Aluthmuhandiram Rashika S.Brahmanage Ming Zeng Thilini Chethana Deping Wei Martina Reblova Jacques Fournier Jana Nekvindova Renan do Nascimento Barbosa Jose Ewerton Felintodos Santos Neiva Tintide Oliveira Guo-Jie Li Damien Ertz Qiu-Ju Shang Alan J.L.Phillips Chang-Hsin Kuo Erio Camporesi Timur S.Bulgakov Saisamorn Lumyong E.B.Gareth Jones Putarak Chomnunti Eleni Gentekaki Frank Bungartz Xiang-Yu Zeng Sally Fryar Zdenko Tkalcec Junmin Liang Guangshuo Li Ting-Chi Wen Paras Nath Singh Yusufjon Gafforov Itthayakorn Promputtha Erandi Yasanthika Ishani D.Goonasekara Rui-Lin Zhao Qi Zhao Paul M.Kirk Jian-KuiLiu JiYe Yan Peter E.Mortimer Jianchu Xu Mingkwan Doilom | 2019 | Fungal Diversity2019，，3： | 0 |
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