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| 1 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 2 | Small corona cage for wideband hvac radio noise studies: rati onale and critical design显示文摘 | Rodney G Urban Howard C Reader Jacobus P Holtzhausen | 2008 | IEEE Transactions on Power Delivery2008，23，11： | 1 |
| 3 | Use of medetomidine and ketamine for immobilization of free-ranging giraffes显示文摘 | Mitchell Bush Douw G Groblor Jacobus P Raath | 2001 | JAVMA2001，218，2： | 1 |
| 4 | Cyclic and static laboratory tests on Drammen clay 显示文摘 | Andersen K H Jacobus H P Stephen F B and Wim F R | 1980 | Journal of Geotechnical engineering Division1980，106，5： | 1 |
| 5 | Liberal Arts: Education and Employability 显示文摘 | Jacobus P H | 1973 | Allied Health Occupations1973，，43： | 1 |
| 6 | In vitro and in vivo antibacterial activities of a novel glycylcycline, the 9-t-butylglycylamido derivative of minocycline(GAR-936)显示文摘 | Petersen P J Jacobus N V Weiss W J | 1999 | Antimicrob Agents Chemother1999，43，： | 1 |
| 7 | Kinet-ics of ilmenite dissolution in hydrochloric acid 显示文摘 | Jacobus P van Dyk Nanne M Vegter PC Pistorius | 2002 | Hydro-metallurgy2002，65，： | 1 |
| 8 | Kinetics and mechanism of the oxidation of sulfur(IV) by ozone in aqueous solutions显示文摘 | Cornelus F B Julius H Jacobus J P | 1994 | Atmospheric Environment1994，28，20： | 1 |
| 9 | In vitro activity of cefoperazone-sulbactam against bacteroides species 显示文摘 | Dias M B S Jacobus N V Tally F P | 1986 | J Antimicrob Chemother1986，18，4： | 1 |
| 10 | A phase 3 trial of bevacizumab in ovarian cancer显示文摘 | Timothy JP Ann MS Jacobus P | 2011 | N Engl J Med2011，365，26： | 1 |
| 11 | Small corona cage for wideband HVAC radio noise studies:rationale and critical design显示文摘 | Rodney G Howard C Jacobus P | 2008 | IEEE Transactions on Power Delivery2008，23，2： | 1 |
| 12 | Kinetics of ilmenite dissolution in hydrochloric acid 显示文摘 | Jacobus P van Dyk Nanne M Vegter P Chris Pistorius | 2002 | Hydrometallurgy2002，65，： | 1 |
| 13 | In vitro activity of thienamycin显示文摘 | Tally F P Jacobus N V Gorbach S L | 1978 | Antimicrob Agents Chemother1978，14，3： | 1 |
| 14 | Comparative in vitro and in vivo activities of piperacillin combined with the β-lactamase inhibitors tazobactam,clavulanic acid,and sulbactam显示文摘 | Jacobus N V Petersen P J | 1989 | Antimicrob Agents Chemother1989，33，4： | 1 |
| 15 | Cellulose hydrolysis and cellulose adsorption after pretreatment d cellulose materials显示文摘 | JACOBUS P H VAN WYK | 1997 | Biotechnology Techniques1997，11，6： | 1 |
| 16 | 8-Aryl-and Alkyloxycaffeine Analogues as Inhibitors of Monoamine Oxidase显示文摘 | Belinda S Jacobus J B Jacobus P P | 2011 | European Journal of Medicinal Chemistry2011，46，8： | 1 |
| 17 | Monoamine Oxidase Inhibition by C4-Substituted Phthalonitriles显示文摘 | Clarina I M Jacobus J B Jacobus P P | 2012 | Bioorganic Chemistry2012，40，1： | 1 |
| 18 | Biotechnology and the Utilization of Biowaste as a Resource for Bioproduct Development显示文摘 | Jacobus P H van Wyk | | 0，，05： | 1 |
| 19 | Rapid signaling responses in Sertoli cell membranes induced by follicle stimulating hormone and testosterone:calcium inflow and electrophysiological changes显示文摘 | Loss E S Jacobus A P Wassermann G F | 2011 | Life Sci2011，89，1516： | 1 |
| 20 | Cellulose hydrolysis and cellulose adsorption after pretreatment of cellulose materials显示文摘 | Jacobus P H van Wyk | 1997 | Biotechnology Techniques1997，11，6： | 1 |
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