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| 1 | 难治性类风湿关节炎的临床特点:一项国际问卷调查研究显示文摘目的尽管按照目前欧洲抗风湿联盟(EULAR)的推荐对类风湿关节炎(rheumatoid arthritis,RA)患者进行治疗,难治性RA患者的临床症状却仍然没有得到完全控制,目前EULAR指南主要关注的是RA的早期治疗和药物治疗。本研究的目的在于分析难治性RA患者的临床特点,以及在患者管理中需要探索然而现有EULAR指南并未涉及的问题。方法对多个国家的风湿科医生进行问卷调查,分析难治性RA的临床特点。问卷包括多选题以及开放性问题,从开放性问题的回答中发现需要进一步阐明的问题以及现有EULAR指南需要增加的内容。结果410名受访者完成了调查问卷,关于难治性RA的特点:50%受访者认为基于28个关节评估的疾病活动评分(disease activity score assessing 28 joints,DAS28)>3.2或存在疾病活动的征象;42%受访者认为疲劳是其特点;48%认为至少两种传统合成改变病情抗风湿药(DMARDs)以及使用至少两种生物制剂或靶向合成DMARDs治疗失败;89%认为糖皮质激素不能减量到5 mg/天或泼尼松不能减量到10 mg/天或同等剂量的其他激素。另外,现有EULAR指南中应增加合并症和关节外表现的干预以及多种药物联合治疗等重要内容。结论目前风湿科医生对难治性RA的定义有很大争议。难治性RA患者的很多重要问题目前EULAR指南中均没有涉及。 | Nadia MT Roodenrijs Maria J H de Hair Marlies C van der Goes Johannes WG Jacobs Paco MJ Welsing Désirée van der Heijde Daniel Aletaha Maxime Dougados Kimme L Hyrich Iain B McInnes Ulf Mueller-Ladner Ladislav Senolt Zoltan Szekanecz Jacob Mvan Laar Nagy Gyorgy 黄艳荣(译) 张卓莉(审校) | 2019 | 英国医学杂志中文版2019，22，2： | 1 |
| 2 | Comparison of thyrotropin-releasing hormone(TRH),naloxone,and dexamethasone treatments in experimental spinal cord injury显示文摘 | Jacobs TP Smith MT | 1983 | Neurology1983，33，3： | 1 |
| 3 | Validation of the Stanford 7-day recall to assess habitual physical activi- ty显示文摘 | Richardson MT Ainsworth BE Jacobs DR | 2001 | Ann Epidemiol2001，11，2： | 1 |
| 4 | Giant lactating adenoma of the breast显示文摘 | Manipadam MT Jacob A Rajnikanth J | 2010 | J Surg Case Rep2010，9，： | 1 |
| 5 | Effects of car diopulmonary bypass and circulatory arrest on endothelium- de pendenl vasodilation in the lung 显示文摘 | Kirshbom PM Jacobs MT Tsui SS | 1999 | J Thorac Cardiovasc Surg1999，111，： | 1 |
| 6 | Characterization of growth factors derived from rat ventral prostate 显示文摘 | Jacobs SC Story MT Sasse J | 1998 | J Urol1998，139，5： | 1 |
| 7 | Locus ceruleus de- generation promotes Alzheimer pathogenesis in amyloid precursor protein 23 transgenic mice 显示文摘 | Heneka MT Ramanathan M Jacobs AH | 2006 | J Neurosci2006，26，： | 1 |
| 8 | Curcumin alleviates immune complex-mediated glomerulonephritis in factor-H- deficient mice 显示文摘 | Jacob A Chaves L Eadon MT | 2013 | Immunology2013，139，3： | 1 |
| 9 | Locus ceruleus degeneration promotes Alzheimer pathogenesis in amyloid precursor protein 23 transgenic mice显示文摘 | Heneka MT Ramanathan M Jacobs AH | 2006 | J Neurosci2006，26，： | 1 |
| 10 | Characterization of growth factors derived from the rat ventral prostate 显示文摘 | Story MT Sasse J | 1988 | J Urol1988，139，： | 1 |
| 11 | Evaluation of the calcium channel antagonist nimodipinein experimental spinal cord ischemia显示文摘 | Faden AL Jacobs TP Smich MT | 1984 | J Neurosurg1984，60，4： | 1 |
| 12 | MRI appearance of Wrisberg variant of discoid lateral meniscus显示文摘 | Singh K Helms CA Jacob MT | 2006 | AJR2006，187，2： | 1 |
| 13 | Effects of cardiopulmonary bypass and circulatory arrest on endothelium-dependent vasodilation in the lung显示文摘 | Jacobs MT Tsui SS | 1996 | J Thorac Cardiovasc Surg1996，111，6： | 1 |
| 14 | Transient bluebe~Ty muffin appearance of a newborn with congeni- tal monoblastic leukemia显示文摘 | Gottesfcld E Silverman RA Coccia PF Jacobs G Zaim MT | 1959 | J Am Acad Dermatol1959，21，2： | 1 |
| 15 | Intraindividual variation and estimates of usual physical activity显示文摘 | Levin S Jacobs Jr DR Ainsworth BE Richardson MT Leon AS | | 0，，： | 1 |
| 16 | MRI appearance of Wrisberg variant of discoid lateral meniscus显示文摘 | Singh K Helms CA Jacobs MT | 2006 | A JR Am J Roentgeno12006，187，2： | 1 |
| 17 | MASCIS evaluation of open field locomotor scores:effects of experience and teamwork on reliability显示文摘 | Faden AI Jacobs TP Smith MT | 1996 | Neurotrauma1996，13，7： | 1 |
| 18 | Effects of cardiopulmonary bypass and circulatory arrest on endothelium-dependent vasodilation in the lung显示文摘 | Kirshbom PM Jacobs MT Tsui SS a al | 1999 | J Thorac Cardiovasc Surg1999，111，： | 1 |
| 19 | AMPA glutamate receptor subunit 2 in normal and visually deprived macaque visual cortex显示文摘 | Wong-Riley MT Jacobs P | 2002 | Vis Neurosci2002，19，5： | 1 |
| 20 | Trisomy 9p and Prader-Willi syndromes in an infant resulting from a de-novo un- balanced t ( 9 ; 15 ) translocation 显示文摘 | Carter MT Jacob FD Sinclair-Bourque E | 2009 | Clin Dysmorphol2009，18，2： | 1 |
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