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| 1 | 国际胃袖状切除专家共识:基于>12000手术病例的最佳操作指南显示文摘腹腔镜胃袖状切除术(1aparoscopic sleeve gastrectomy,LSG)系相对较新的减重手术方式。因其操作相对简单、治疗肥胖合并疾病及减重效果明显,逐步得以广泛接受。目前美国代谢与减重手术协会将其推荐为肥胖症治疗的单独标准术式。2011年3月25~26日, | 苏远涛 徐安安 朱江帆 Diaz AA Arvidsson D Baker RS Basso N Bellanger D Boza C El Mourad H France M Gagner M Galvao-Neto M Higa KD Himpens J Hutchinson CM Jacobs M Jorgensen JO Jossart G Lakdawala M Nguyen NT Nocca D Prager G Pomp A Ramos AC Rosenthal RJ Shah S Vix M Wittgrove A Zundel N | 2013 | 中国微创外科杂志2013，13，9： | 12 |
| 2 | INT-767 improves histopathological features in a dietinduced ob/ob mouse model of biopsy-confirmed nonalcoholic steatohepatitis显示文摘AIM To characterize the efficacy of the dual FXR/TGR5 receptor agonist INT-767 upon histological endpoints in a rodent model of diet-induced and biopsy-confirmed non-alcoholic steatohepatitis(NASH).METHODS The effects of INT-767 on histological features of NASH were assessed in two studies using Lep^(ob/ob)(ob/ob) NASH mice fed the AMLN diet(high fat with transfat, cholesterol and fructose). In a proof-of-conceptstudy, Lep^(ob/ob)(ob/ob) NASH mice were first dosed with INT-767(3 or 10 mg/kg for 8 wk). A second ob/ob NASH study compared INT-767(3 and 10 mg/kg) to obeticholic acid(OCA)(10 or 30 mg/kg; 16 wk). Primary histological endpoints included qualitative and quantitative assessments of NASH. Other metabolic and plasma endpoints were also assessed. A comparative assessment of INT-767 and OCA effects on drug distribution and hepatic gene expression was performed in C57 Bl/6 mice on standard chow. C57 Bl/6 mice were orally dosed with INT-767 or OCA(1-30 mg/kg) for 2 wk, and expression levels of candidate genes were assessed by RNA sequencing and tissue drug levels were measured by liquid chromatography tandem-mass spectrometry.RESULTS INT-767 dose-dependently(3 and 10 mg/kg, PO, QD, 8 wk) improved qualitative morphometric scores on steatohepatitis severity, inflammatory infiltrates and fibrosis stage. Quantitative morphometric analyses revealed that INT-767 reduced parenchymal collagen area, collagen fiber density, inflammation(assessed by Galectin-3 immunohistochemistry) and hepatocyte lipid droplet area following INT-767 treatment. In a comparative study(16 wk), the FXR agonists OCA(10 and 30 mg/kg) and INT-767(3 and 10 mg/kg) both improved NASH histopathology, with INT-767 exerting greater therapeutic potency and efficacy than OCA. Mechanistic studies suggest that both drugs accumulate similarly within the liver and ileum, however, the effects of INT-767 may be driven by enhanced hepatic, but not ileal, FXR function. CONCLUSION These findings confirm the potential utility of FXR and dual FXR/TGR5 activation as disease intervention strategies in NASH. | Jonathan D Roth Michael Feigh Sanne S Veidal Louise KD Fensholdt Kristoffer T Rigbolt Henrik H Hansen Li C Chen Mathieu Petitjean Weslyn Friley Niels Vrang Jacob Jelsing Mark Young | 2018 | World Journal of Gastroenterology2018，24，2： | 7 |
| 3 | Australian tertiary care outcomes of entecavir monotherapy in treatment naive patients with chronic hepatitis B显示文摘AIM:To evaluate the long-term treatment outcomes of entecavir monotherapy in treatment naive patients in an Australian tertiary care setting. METHODS:A retrospective analysis of treatment naive patients receiving entecavir monotherapy through Westmead Hospital was performed.Patients were excluded if they had received previous treatment with another nucleoside or nucleotide analogue,were pregnant or less than 18 years old. RESULTS:Out of 336 patients,163 patients fulfilled the selection criteria.Range of follow up was 3-46 mo (mean 26 mo).134 patients(82.2%)had pre-treatment biopsies,with 26 patients(16.0%)demonstrating F3-4 fibrosis.In total,153 patients(93.9%)achieved at least Partial Virological Suppression(PVS),with 134 patients (82.2%)achieving complete virological suppression. The cumulative CVS and PVS rates at 36 mo were 82.1%and 96.4%,respectively.3 patients(1.8%)failed to achieve PVS,while 5 patients(3.0%)developed virological rebound.128 patients(78.5%)maintained CVS throughout follow up.Predictors of CVS included lower baseline DNA level(P=0.001),hepatitis B virus e antigen negative status(P=0.001)and increasing age at treatment(log rank 0.001).No significant adverse effects were reported necessitating cessation of entecavir. CONCLUSION:Entecavir monotherapy is efficacious and safe in an Australian tertiary care setting.Resistance and rebound rates are very low.This is similar to data from controlled and uncontrolled trials around the world. | Farzan Fahrtash-Bahin Viraj C Kariyawasam Timothy Gray Karen Byth Jacob George Mark W Douglas | 2013 | World Journal of Gastroenterology2013，19，5： | 5 |
| 4 | 月季对根结线虫病抗性遗传研究(英文)显示文摘针对月季栽培过程中出现的最严重的根结线虫病防治问题 ,开展了月季对根结线虫抗性遗传研究。研究结果如下 :①对常用的 4种月季砧木R .multifloraK1 ,K2 ,CE63及R .indica对 4种常见根结线虫即南方根结线虫 (Meloidogyneincognita)、爪哇根结线虫 (M .javanica)、花生根结线虫 (M .arenaria)及北方根结线虫 (M .hapla)的抗性进行了测定 ,得出只有北方根结线虫能侵染月季 ,其余 3种不能侵染。②根结指数与对数转化后的每克根中雌虫数、雄虫数、3~ 4龄幼虫数之和、2龄幼虫数、卵数、成虫及 3~ 4龄幼虫数之总和、2龄幼虫与卵数之总和均呈线性相关关系 ,因此根结指数是进行抗性评价的可靠、简单及实用的指标。抗性划分标准如下 :根结指数 0 .0~ 1 .0 ,抗病 ;1 .0~ 2 .0 ,中等抗病 ;2 .0~ 3.0 ,感病 ;3.0~4.0 ,比较感病 ;4.0~ 5 .0 ,高度感病。③以根结指数为指标 ,通过对杂交所得 74个子代的抗性评价试验表明 :在 2抗性亲本所得 1 2个子代中 ,各子代抗性水平存在抗性分化 ,说明抗病基因不是由单一显性基因控制 ;在所有的 62个抗性亲本与感病亲本的杂交子代中 ,5 9个子代均比抗病亲本感病 ,表明抗病基因由隐性基因控制。因此 ,提出了月季对根结线虫的抗性遗传可能由 | 王新荣 Jacob Y Mastrantuono S Bazzano J Minot J C Voisin R Esmenjaud D | 2001 | 华中农业大学学报2001，20，3： | 4 |
| 5 | Nonsteady radial flow in an infinite leaky aquifer显示文摘 | Hantush M S Jacob C E | 1955 | EOS Transaction American Geopysical Union1955，36，： | 2 |
| 6 | Which Time-to-Peak Threshold Best Identifies Penumbral Flow?: A Comparison of Perfusion-Weighted Magnetic Resonance Imaging and Positron Emission Tomography in Acute Ischemic Stroke显示文摘 | J Sobesky O Zaro Weber F -G. Lehnhardt V Hesselmann A Thiel C Dohmen A Jacobs M Neveling W -D. Heiss | 2004 | Stroke2004，，12： | 2 |
| 7 | Insulin resistance is associated with chronic hepatitis C and virus infection fibrosis progression显示文摘 | Jason M Hui Archana Sud Geoffrey C Farrell Priyanka Bandara Karen Byth James G Kench Geoffrey W McCaughan Jacob George | 2003 | Gastroenterology2003，，6： | 2 |
| 8 | Comparing the Schrdinger and spinless Salpeter equation for heavy-quark bound states 显示文摘 | Olsson M G and Suchyta C | 1986 | Phys Rev D1986，33，11： | 1 |
| 9 | Incidental Effects of Emotional Valence in Single Word Processing:An FMRI Study显示文摘 | KUCHINKE L JACOBS A M GRUBICH C | 2005 | NeuroImage2005，28，4： | 1 |
| 10 | Mesh Saliency显示文摘 | LEE C H VARSHNEY A JACOBS D W | 2005 | ACM Transaction on Graph2005，24，3： | 1 |
| 11 | Molecular pathways mediating mechanical signaling in bone 显示文摘 | Rubin J Rubin C Jacobs CR | 2006 | Gene2006，15，367： | 1 |
| 12 | Measuring Canopy Structure with an Airborne Laser Altimeter显示文摘 | Ritchie J C Evans D L Jacobs D | 1993 | Transactions of the ASAE1993，36，4： | 1 |
| 13 | Water transport and the distribution of aquaporin - 1 in pulmonary air spaces显示文摘 | Effros RM Darin C Jacobs ER | 1997 | J Appl Physiol1997，83，3： | 1 |
| 14 | An 8-year record of the seasonal variation of ^2H and ^18O in atmospheric water vapour and precipitation at Heidelberg Germany显示文摘 | Jacob H Sonntag C | 1991 | Tellus1991，43，： | 1 |
| 15 | System for eleavable Fc fusion proteins using tobacco etch virus (TEV) protease 显示文摘 | Haspel J Blanco C Jacob J Grumet M | 2001 | Biotechniques2001，30，1： | 1 |
| 16 | The Influence of Music on Tem- poral Perceptions in An On - hold Waiting Situation 显示文摘 | Gueguen N Jacob C | 2002 | Psychology of Music2002，30，2： | 1 |
| 17 | Circulating tumor cells:detection,molecular profiling and future prospects显示文摘 | Jacob K Sollier C Jabado N | 2007 | Expert Rev Proteomics2007，4，6： | 1 |
| 18 | Activation volumes for solid-solid transformations in nanocrystals显示文摘 | Jacobs K Zaziski D Scher E C | 2001 | Science2001，293，5536： | 1 |
| 19 | Mast cell try ptase controls paracellular pemreability of the intestine : role of protease activated receptor 2and-arrestins 显示文摘 | JACOB C YANG P C DARMOUL D | 2005 | J Biol Chem2005，280，31： | 1 |
| 20 | Apidaecins:antibacterial peptides from honeybees显示文摘 | Ampe C Jacobs F | 1989 | Eur MolBiol Organiz J1989，8，8： | 1 |
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