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| 1 | The Cooperative Activities of CSLD2, CSLD3, and CSLD5 Are Required for Normal Arabidopsis Development显示文摘Glycosyltransferases of the Cellulose Synthase Like D (CSLD) subfamily have been reported to be involved in tip growth and stem development in Arabidopsis. The csld2 and csld3 mutants are root hair defective and the csld5 mutant has reduced stem growth. In this study, we produced double and triple knockout mutants of CSLD2, CSLD3, and CSLD5. Unlike the single mutants and the csld2/csld3 double mutant, the csld2/csld5, csld3/csld5, and csld2/ csld3/csld5 mutants were dwarfed and showed severely reduced viability. This demonstrates that the cooperative activities of CSLD2, CSLD3, and CSLD5 are required for normal Arabidopsis development, and that they are involved in important processes besides the specialized role in tip growth. The mutant phenotypes indicate that CSLD2 and CSLD3 have overlapping functions with CSLD5 in early plant development, whereas the CSLD2 and CSLD3 proteins are non-redundant. To determine the biochemical function of CSLD proteins, we used transient expression in tobacco leaves. Microsomes containing heterologously expressed CSLD5 transferred mannose from GDP–mannose onto endogenous acceptors. The same activity was detected when CSLD2 and CSLD3 were co-expressed but not when they were expressed separately. With monosaccharides as exogenous acceptors, microsomal preparations from CSLD5-expressing plants mediated the transfer of mannose from GDP–mannose onto mannose. These results were supported by immunodetection studies that showed reduced levels of a mannan epitope in the cell walls of stem interfascicular fibers and xylem vessels of the csld2/csld3/csld5 mutant. | Lan Yin Yves Verhertbruggen Ai Oikawa Chithra Manisseri Bernhard Knierim Lina Prak Jacob Kriiger Jensen Paul Knox Manfred Auer William G.T. Willatsa and Henrik Vibe Scheller | 2011 | Molecular Plant2011，4，6： | 2 |
| 2 | Anaphylaxis and hy- potension after administration of peginesatide显示文摘 | Bennett CL Jacob S Hymes J et aI | 2014 | N Engl J Med2014，370，21： | 1 |
| 3 | Endotoxin and bacteria in portal blood显示文摘 | Jacob AI Goldberg PK Bloom N | 1977 | Gastroenterology1977，72，： | 1 |
| 4 | Comparison of thyrotropin-releasing hormone(TRH),naloxone,and dexamethasone treatments in experimental spinal cord injury显示文摘 | Jacobs TP Smith MT | 1983 | Neurology1983，33，3： | 1 |
| 5 | Oscillating fluid flow regulates gap junction communication in osteocytic MLO-Y4 cells by an ERK1/2 MAP kinase-dependent mechanism small star,filled显示文摘 | Alford AI Jacobs CR Donahue HJ | | 0，，01： | 1 |
| 6 | Siglec-7 specifically recognizes Campylobacter jejuni strains associated with oeulomotor weakness in Guillain-Barr syndrome and Miller Fisher syndrome显示文摘 | Heikema AP Jacobs BC Horst-Kreft D et aI | 2015 | Clin Microbiol Infect2015，19，2： | 1 |
| 7 | Characterization of a cDNA encoding a rice mit~hondrial vohage-dependent anion t:hannel and its gene expression studied upon plant development and osmotic stressl 显示文摘 | Roosens N AI Bitar F Jacobs M | 2000 | Biochimica et Biophysica Acta2000，，1463： | 1 |
| 8 | Dynorphin induces partially reversible paraplegia in the rat 显示文摘 | Faden AI Jacobs TP | 1983 | Eur J Pharmacol1983，91，23： | 1 |
| 9 | Dissociation of AMP-activated protein kinase activation and glucose transport in contracting slow-twitch muscle显示文摘 | WIM DERAVE HUA AI JACOB IHLEMANN etal | 2000 | Diabetes2000，49，8： | 1 |
| 10 | Sacral neu- romodulation as a treatment for chronic pelvic pain 显示文摘 | Marcelissen T Jacobs R van Kerrebroeck P et ai | 2011 | J Urol2011，186，： | 1 |
| 11 | Expression of molecular mediators of apoptosis and their role in the pathogenesis of lower- extremity varicose veins 显示文摘 | Ascher E Jacob T Hingorani A et ai | 2001 | J Vasc Surg2001，33，5： | 1 |
| 12 | No benefit from combining HE4 and CA125 as ovarian tumor markers in a clinical setting显示文摘 | Jacob F Meier M Caduff R et aI | 2011 | Gynecol Oncol2011，121，3： | 1 |
| 13 | Estimated prevalence and trends in smoking among adolescents in South Korea,2005-2021:a nationwide serial study显示文摘Background Although smoking is classified as a risk factor for severe COVID-19 outcomes,there is a scarcity of studies on prevalence of smoking during the COVID-19 pandemic.Thus,this study aims to analyze the trends of prevalence of smoking in adolescents over the COVID-19 pandemic period.Methods The present study used data from middle to high school adolescents between 2005 and 2021 who participated in the Korea Youth Risk Behavior Web-based Survey(KYRBS).We evaluated the smoking prevalence(ever or daily)by year groups and estimated the slope in smoking prevalence before and during the pandemic.Results A total of 1,137,823 adolescents participated in the study[mean age,15.04 years[95%confidence interval(CI)15.03-15.06];and male,52.4%(95%CI 51.7-53.1)].The prevalence of ever smokers was 27.7%(95%CI 27.3-28.1)between 2005 and 2008 but decreased to 9.8%(95%CI 9.3-10.3)in 2021.A consistent trend was found in daily smokers,as the estimates decreased from 5.4%(95%CI 5.2-5.6)between 2005 and 2008 to 2.3%(95%CI 2.1-2.5)in 2021.However,the downward slope in the overall prevalence of ever smokers and daily smokers became less pronounced in the COVID-19 pandemic period than in the pre-pandemic period.In the subgroup with substance use,the decreasing slope in daily smokers was significantly more pronounced during the pandemic than during the pre-pandemic period.Conclusions The proportion of ever smokers and daily smokers showed a less pronounced decreasing trend during the pandemic.The findings of our study provide an overall understanding of the pandemic's impact on smoking prevalence in adolescents. | Hyoin Shin Sangil Park Hyunju Yon Chae Yeon Ban Stephen Turner Seong Ho Cho Youn Ho Shin Jung U.Shin Ai Koyanagi Louis Jacob Lee Smith Chanyang Min Young Joo Lee So Young Kim Jinseok Lee Rosie Kwon Min Ji Koo Guillaume Fond Laurent Boyer Jong Woo Hahn Namwoo Kim Sang Youl Rhee Jae Il Shin Ho Geol Woo Hyeowon Park Hyeon Jin Kim Yoonsung Lee Man S.Kim Eléa Lefkir Vlasta Hadalin Jungwoo Choi Seung Won Lee Dong Keon Yon Sunyoung Kim | 2023 | World Journal of Pediatrics2023，19，4： | 1 |
| 14 | The safety of deep sedation without intubatfon for abortion in the out patient settfng显示文摘 | De an O Jacobs AE Goldstein EC et aI | 2011 | J Olin Anesth2011，25，6： | 1 |
| 15 | Megadose corticosteroid therapy following experimental traumatic spinal injury显示文摘 | Jacobs TP Patrick DH | 1984 | J Neunosurg1984，60，： | 1 |
| 16 | Dissociation of AMP-Activated Protein Kinase Activation and Glucose Transport in Contracting Slow-Twitch Muscle 显示文摘 | Wire Derave Hua Ai Jacob Ihlemann | 2000 | Diabetes2000，49，8： | 1 |
| 17 | MASCIS evaluation of open field locomotor scores:effects of experience and teamwork on reliability显示文摘 | Faden AI Jacobs TP Smith MT | 1996 | Neurotrauma1996，13，7： | 1 |
| 18 | Nuclear PTEN levels and G2 progression in melanoma cells 显示文摘 | Jacob AI Romigh T Waite KA | 2009 | Melanoma Res2009，19，： | 1 |
| 19 | Significance of a fragment- ed ORS complex versus a Q wave in patients with coro?nary artery disease显示文摘 | Das MK Khan B Jacob S et aI | 2006 | Circulation2006，113，21： | 1 |
| 20 | Defective photoproduction of cholecalciferol in normal and uremic humans显示文摘 | Jacob AI Sallman A Santiz Z Hollis BW | | 0，，： | 1 |
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