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| 1 | Regulation of DNA double-strand break repair pathway choice显示文摘脱氧核糖核酸双海滨裂缝(DSB ) 是能包括大规模或小规模的删除,杂合现象的损失, translocations,和染色体损失导致房间死亡或许多基因改变的批评损害。DSB 被修理由非相应加入结束(NHEJ ) 并且相应再结合(HR ) ,和在这些小径的缺点引起染色体不稳定性并且支持 tumorigenesis。DSB 包括直接或间接地损坏脱氧核糖核酸并且通常在癌症治疗被使用的离子辐射和化学药品包括在细胞的新陈代谢,折叠复制叉,和核酸酶期间产生的反应的氧种类从内长的来源,并且从外长的来源产生。DSB 修理小径看起来竞争因为在他们之间的 DSB,而是平衡在种之中广泛地不同,在单个种的不同细胞类型之间,并且在一个单身者的不同细胞周期阶段期间,细胞打字。这里,我们考察在酵母和更高的优核质由 NHEJ 和 HR 调整 DSB 修理的规章的因素。这些因素包括修理蛋白质,修理因素可接近性的染色质调整,和相应修理模板的可获得性的调整表示和磷酸化。当大多数 DSB 修理蛋白质看起来专门在 NHEJ 或 HR 工作时,很多蛋白质影响两条小径,包括 MRE11/RAD50/NBS1 (XRS2 ) 建筑群, BRCA1,嘘一 H2AX, PARP-1, RAD18, DNA 依赖的蛋白激酶催化子单元(DNA-PKcs ) ,和 ATM。DNA-PKcs 在哺乳动物的 NHEJ 起一个作用,但是它也通过可以与涉及是由 DNA-PKcs 的 phosphorylated 的 HR 的至少 12 蛋白质的 ATM 或 ATM 包含串音的一个复杂规章的网络影响 HR。 | Meena Shrivastav Leyma P De Haro Jac A Nickoloff | 2008 | Cell Research2008，18，1： | 67 |
| 2 | Angiogenic markers endoglin and vascular endothelial growth factor in gastroenteropancreatic neuroendocrine tumors显示文摘AIM:To investigate the expression and potential prognostic role of vascular endothelial growth factor(VEGF) and endoglin in gastroenteropancreatic neuroendocrine tumors(GEP-NETs) . METHODS:Microvessel density(MVD) in GEP-NETs was evaluated using endoglin and CD31 immunohistochemistry.In addition,tissue levels of endoglin and VEGF were determined in homogenates by ELISA. RESULTS:Endoglin was highly expressed on tumor endothelial cells.CD31 MVD in GEP-NETs was significantly higher compared to endoglin MVD(P<0.01) .Two-tofour-fold higher tissue levels of endoglin and VEGF were seen in tumors compared to associated normal tissue. This increased endoglin tissue expression in tumors was significantly related to tumor size(P<0.01) ,presence of metastases(P=0.04) ,and a more advanced tumor stage(P=0.02) ,whereas expression of VEGF was not. CONCLUSION:We suggest that endoglin is a potential marker to indicate and predict metastases,which might be useful in the post-resection therapeutic approach of patients with GEP-NETs. | Patricia Kuiper Lukas JAC Hawinkels Eveline SM de Jonge-Muller Izk Biemond Cornelis BHW Lamers Hein W Verspaget | 2011 | World Journal of Gastroenterology2011，17，2： | 4 |
| 3 | Exploiting DNA repair pathways for tumor sensitization,mitigation of resistance,and normal tissue protection in radiotherapy显示文摘More than half of cancer patients are treated with radiotherapy,which kills tumor cells by directly and indirectly inducing DNA damage,including cytotoxic DNA double-strand breaks(DSBs).Tumor cells respond to these threats by activating a complex signaling network termed the DNA damage response(DDR).The DDR arrests the cell cycle,upregulates DNA repair,and triggers apoptosis when damage is excessive.The DDR signaling and DNA repair pathways are fertile terrain for therapeutic intervention.This review highlights strategies to improve therapeutic gain by targeting DDR and DNA repair pathways to radiosensitize tumor cells,overcome intrinsic and acquired tumor radioresistance,and protect normal tissue.Many biological and environmental factors determine tumor and normal cell responses to ionizing radiation and genotoxic chemotherapeutics.These include cell type and cell cycle phase distribution;tissue/tumor microenvironment and oxygen levels;DNA damage load and quality;DNA repair capacity;and susceptibility to apoptosis or other active or passive cell death pathways.We provide an overview of radiobiological parameters associated with X-ray,proton,and carbon ion radiotherapy;DNA repair and DNA damage signaling pathways;and other factors that regulate tumor and normal cell responses to radiation.We then focus on recent studies exploiting DSB repair pathways to enhance radiotherapy therapeutic gain. | Jac A.Nickoloff Lynn Taylor Neelam Sharma Takamitsu A.Kato | 2021 | Cancer Drug Resistance2021，4，2： | 4 |
| 4 | 形态分析:分析科学的新动向显示文摘形态分析:分析科学的新动向JACBroekaert德国多特蒙德大学化学系,D44221多特蒙德,德国在生态毒理学、药物剂量学和生物剂量学的研究中,首先感兴趣的不是无机元素的含量,而是含无机元素的化合物。这就要求我们能准确可靠地分析测定含无机元素的不同... | Bro.,JAC 刘克玲 | 1995 | 光谱学与光谱分析1995，15，5： | 3 |
| 5 | 早发性高血压患者中年时即出现高血压终末靶器官损害显示文摘早发高血压会增加社区心血管死亡的风险。早发高血压是否在中年时就可促发终末靶器官损害(target end-organ damage,TOD)的进展,目前仍不清楚。研究者纳入中青年人冠状动脉危险因素研究(coronary artery risk development in young adults,CARDIA)参与者2680例[平均年龄(50±4)岁,57%为女性],他们在1985-2011年间接受了多达8次系列血压测量(基线年龄范围18-30岁),并且在2010-2011年进行了左心室肥厚、冠状动脉钙化、白蛋白尿和舒张功能障碍的评估。 | 刘青(译) 叶鹏(审校) Suvila K McCabe EL Lehtonen A Ebinger JE Lima JAC Cheng S Niiranen TJ | 2019 | 中华高血压杂志2019，27，10： | 2 |
| 6 | More forks on the road to replication stress recovery显示文摘High-fidelity replication of DNA,and its accurate segregation to daughter cells,is critical for maintaining genome stability and suppressing cancer.DNA replication forks are stalled by many DNA lesions,activating checkpoint proteins that stabilize stalled forks.Stalled forks may eventually collapse,producing a broken DNA end.Fork restart is typically mediated by proteins initially identified by their roles in homologous recombination repair of DNA double-strand breaks(DSBs).In recent years,several proteins involved in DSB repair by non-homologous end joining(NHEJ)have been implicated in the replication stress response,including DNA-PKcs,Ku,DNA Ligase IV-XRCC4,Artemis,XLF and Metnase.It is currently unclear whether NHEJ proteins are involved in the replication stress response through indirect(signaling)roles,and/or direct roles involving DNA end joining.Additional complexity in the replication stress response centers around RPA,which undergoes significant post-translational modification after stress,and RAD52,a conserved HR protein whose role in DSB repair may have shifted to another protein in higher eukaryotes,such as BRCA2,but retained its role in fork restart.Most cancer therapeutic strategies create DNA replication stress.Thus,it is imperative to gain a better under-standing of replication stress response proteins and pathways to improve cancer therapy. | Chris Allen Amanda K.Ashley Robert Hromas Jac A.Nickoloff | 2011 | Journal of Molecular Cell Biology2011，3，1： | 2 |
| 7 | 由磁共振成像评估的主动脉弓脉搏波传导速度是心血管事件的预测因子:多种族动脉粥样硬化研究显示文摘通过磁共振成像评估的主动脉弓脉搏波传导速度(pulse wave velocity,PWV)对心血管病事件的预测价值尚未完全确定。为了评估多种族动脉粥样硬化研究(multi-ethnic study of atherosclerosis,MESA)受试者中主动脉弓PWV与心血管病的关系,Ohyama等纳入3527例MESA受试者[基线时平均年龄为(62±10)岁,47%为男性], | 刘莉 叶鹏 Ohyama Y Ambale-Venkatesh B Noda C Kim JY Tanami Y Teixido-Tura G Chugh AR Redheuil A Liu CY Wu CO Hundley WG Bluemke DA Guallar E Lima JAC | 2017 | 中华高血压杂志2017，25，8： | 2 |
| 8 | Effect of inoculated corn silage on rumen fermentation and lipid metabolism in an artificial rumen (rusitec)显示文摘 | Jac D Varadyova Z Laukova A | 2009 | Animal feed science and technology2009，152，3： | 1 |
| 9 | Neurohumoral features of myocardial stunning due to sudden emotional stress显示文摘 | Wittstein IS Thiemann DR Lima JAC | 2005 | N Engl J Med2005，352，6： | 1 |
| 10 | Techniques for and outcome of liver transplantation in neonates and infants weighing up to 5 kilograms显示文摘 | Noujaim HM Mayer DA Buckles JAC | 2002 | J Pediatr Surg2002，37，1： | 1 |
| 11 | Performance Analysis of Freauency-Domain Block LMS Adaptive Digital Fiters显示文摘 | Jac C L Chong K U | 1989 | Circuits and Systems IEEE Transaction on1989，36，2： | 1 |
| 12 | Left insular stroke is associated with adverse cardiac outcome 显示文摘 | Laowattana S Zeger SL Lima JAC | 2006 | Neurology2006，66，2： | 1 |
| 13 | DNA-PKcs and ATM co-regulate DNA double-strand break repair显示文摘 | Meena Shrivastav Cheryl A. Miller Leyma P. De Haro Stephen T. Durant Benjamin P.C. Chen David J. Chen Jac A. Nickoloff | 2009 | DNA Repair2009，，8： | 1 |
| 14 | Long-term results of laparoscopic repair of incisional hernias using an intraperitoneal composite mesh显示文摘 | Moreno-Egea A Bustos JAC Girela E | 2010 | Surg Endosc2010，24，2： | 1 |
| 15 | Left insularstroke is associated with adverse cardiac outcome显示文摘 | Laowattana S Zeger SL Lima JAC | 2006 | Neurology2006，66，2： | 1 |
| 16 | Use of gastric acid suppressive agents and the risk of community-acquired Clostridium difficile associated disease显示文摘 | Delaney JAC Barkun A N | 2005 | JAMA2005，294，： | 1 |
| 17 | Rheological behaviors of polypropylene/layered silicate nanocomposites prepared by melt compounding in shear and elongational flows显示文摘 | Seung H L Eunnari C Jac R Y | 2007 | Journal of Applied Polymer Science2007，103，6： | 1 |
| 18 | Neurohumoral features of myocardial stunning dueto sudden emotional stress显示文摘 | Wittstein IS Thiemann DR lima JAC | 2005 | N Engl J Med2005，352，： | 1 |
| 19 | Urban Agriculture and Biodiversity显示文摘 | Jac Smit | 2000 | Urban Agriculture Magazine2000，，1： | 1 |
| 20 | Multicarrier Modulation for Data Transmission: an idea who' s time has come 显示文摘 | BINGHAM JAC | 1990 | IEEE Communication Magazine1990，28，5： | 1 |
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