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| 1 | Texture analysis on parametric maps derived from dynamic contrast-enhanced magnetic resonance imaging in head and neck cancer显示文摘AIM: To investigate the merits of texture analysis on parametric maps derived from pharmacokinetic modeling with dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI) as imaging biomarkers for the prediction of treatment response in patients with head and neck squamous cell carcinoma(HNSCC). METHODS: In this retrospective study,19 HNSCC patients underwent pre- and intra-treatment DCEMRI scans at a 1.5T MRI scanner. All patients had chemo-radiation treatment. Pharmacokinetic modeling was performed on the acquired DCE-MRI images,generating maps of volume transfer rate(Ktrans) and volume fraction of the extravascular extracellular space(ve). Image texture analysis was then employed on maps of Ktrans and ve,generating two texture measures: Energy(E) and homogeneity.RESULTS: No significant changes were found for the mean and standard deviation for Ktrans and ve between pre- and intra-treatment(P > 0.09). Texture analysis revealed that the imaging biomarker E of ve was significantly higher in intra-treatment scans,relative to pretreatment scans(P < 0.04). CONCLUSION: Chemo-radiation treatment in HNSCC significantly reduces the heterogeneity of tumors. | Jacobus FA Jansen Yonggang Lu Gaorav Gupta Nancy Y Lee Hilda E Stambuk Yousef Mazaheri Joseph O Deasy Amita Shukla-Dave | 2016 | World Journal of Radiology2016，8，1： | 5 |
| 2 | 二十碳五烯酸对三种肝癌细胞系作用的实验研究显示文摘目的 探讨二十碳五烯酸 (eicosapentaenoicacid ,EPA)对 3种肝癌细胞系作用。方法EPA作用于HepG2 (携带有野生型p5 3基因 )、Huh7(携带有突变型p5 3基因 )和Hep3B(p5 3基因缺失 )这 3种肝癌细胞系 ,通过细胞计数、DNA电泳、流式细胞技术和末端转移酶标记技术等来检测EPA对这 3种细胞系的作用和可能的机制。结果 EPA主要是通过诱导HepG2肝癌细胞系的细胞凋亡来抑制其生长 ,而且这种抑制作用呈现出时间和剂量依赖的关系 ,而且同时发现EPA对于Huh7和Hep3B这两种肝癌细胞系无明显抑制作用。结论 细胞凋亡的诱导可能是EPA抑制HepG2肝癌细胞系生长的主要机制 ,而且p5 3基因可能参与EPA诱导HepG2细胞系细胞凋亡的过程。 | 王蓬 陈孝平 PBS Lai CK leow Joseph W Y Lau | 2001 | 中华普通外科杂志2001，16，1： | 4 |
| 3 | Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial显示文摘 | Paul Y Kwo Eric J Lawitz Jonathan McCone Eugene R Schiff John M Vierling David Pound Mitchell N Davis Joseph S Galati Stuart C Gordon Natarajan Ravendhran Lorenzo Rossaro Frank H Anderson Ira M Jacobson Raymond Rubin Kenneth Koury Lisa D Pedicone Clifford | 2010 | The Lancet2010，，9742： | 3 |
| 4 | Laparoscopic resection of gastrointestinal stromal tumors:Does laparoscopic surgery provide an adequate oncologic resection?显示文摘Gastrointestinal stromal tumors (GISTs) are rare tumors of the GI tract.Surgical resection remains the mainstay of non-metastatic disease.However,the ability to provide an adequate oncologic resection using laparoscopic surgery is still an area of debate.This is a thorough review of the current literature,looking particularly at the use of laparoscopic surgery for larger GISTs and the long-term oncologic outcomes compared to the results of open surgery.Laparoscopic resections provide an adequate oncologic result for GISTs of all sizes,including those greater than 5 cm in size. | Joseph J Kim James Y Lim Scott Q Nguyen | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，9： | 3 |
| 5 | Two-dimensional electrode Sensor for glucose显示文摘 | Gough DA Joseph Y Lucisano | 1985 | Anal Chem1985，57，： | 2 |
| 6 | Effect of closure of live poultry markets on poultry-to-person transmission of avian influenza A H7N9 virus: an ecological study显示文摘 | Hongjie Yu Joseph T Wu Benjamin J Cowling Qiaohong Liao Vicky J Fang Sheng Zhou Peng Wu Hang Zhou Eric H Y Lau Danhuai Guo Michael Y Ni Zhibin Peng Luzhao Feng Hui Jiang Huiming Luo Qun Li Zijian Feng Yu Wang Weizhong Yang Gabriel M Leung | 2013 | The Lancet2013，，： | 2 |
| 7 | Strategies to tackle the challenges of external beam radiotherapy for liver tumors显示文摘Primary and metastatic liver cancer is an increasingly common and difficult to control disease entity.Radiation offers a non-invasive treatment alternative for these patients who often have few options and a poor prognosis.However,the anatomy and aggressiveness of liver cancer poses significant challenges such as accurate localization at simulation and treatment,management of motion and appropriate selection of dose regimen.This article aims to review the options available and provide information for the practical implementation and/or improvement of liver cancer radiation programs within the context of stereotactic body radiotherapy and image-guided radiotherapy guidelines.Specific patient inclusion and exclusion criteria are presented given the significant toxicity found in certain sub-populations treated with radiation.Indeed,certain sub-populations,such as those with tumor thrombosis or those with larger lesions treated with transarterial chemoembolization,have been shown to have significant improvements in outcome with the addition of radiation and merit special consideration.Implementing a liver radiation programrequires three primary challenges to be addressed:(1) immobilization and motion management;(2) localization;and(3) dose regimen and constraint selection.Strategies to deal with motion include simple internal target volume(ITV) expansions,non-gated ITV reduction strategies,breath hold methods,and surrogate marker methods to enable gating or tracking.Localization of the tumor and organs-at-risk are addressed using contrast infusion techniques to take advantage of different normal liver and cancer vascular anatomy,imaging modalities,and margin management.Finally,a dose response has been demonstrated and dose regimens appear to be converging.A more uniform approach to treatment in terms of technique,dose selection and patient selection will allow us to study liver radiation in larger and,hopefully,multicenter randomized studies. | Michael I Lock Jonathan Klein Hans T Chung Joseph M Herman Edward Y Kim William Small Nina A Mayr Simon S Lo | 2017 | World Journal of Hepatology2017，9，14： | 2 |
| 8 | Effects of milk somatic cell count on cottage cheese yield and quality 显示文摘 | Londa K Joseph Y Aditya S | 1998 | Journal of Dairy Science1998，81，5： | 1 |
| 9 | Polyethylene glycol - polyamidoamine dendritic micelle as solubility enhancer and the effect of the length of polyethylene glycol arms on the solubility of pyrene in water 显示文摘 | Hu Y Joseph JM Stephanie TL | 2004 | J Colloid Interface Sci2004，273，： | 1 |
| 10 | Self-organizing map for cluster analysis of a breast cancer database显示文摘 | Mia K M Joseph Y L Georgia D T | 2003 | Artificial Intelligence in Medicine2003，27，： | 1 |
| 11 | Comparison of MODIS cloud microphysical properties with imsitu measurements over 'the Southeast Pacific 显示文摘 | Min Q Joseph E Lin Y | 2012 | Atmospheric Chemistry and Physics2012，12，11： | 1 |
| 12 | FDA's pediatric device consortia:National program fosters pediatric medical device development显示文摘 | Ulrich L C Joseph F D Lewis D Y | 2013 | Pediatrics2013，131，5： | 1 |
| 13 | UV-absorbing plastic sheets protect crops from insect pests and from virus diseases vectored by insects显示文摘 | ANTIGNUS Y MOR N BEN JOSEPH R | 1996 | Environ Entomol1996，25，： | 1 |
| 14 | Factors associated with the quality of life of Chinese HIV patients显示文摘 | Joseph Lau Tsui H Y Patrick Li | 2004 | Qual Life Res2004，14，9： | 1 |
| 15 | Stability of rigid motions and rollers in bicomponent flows of immiscible liquids显示文摘 | Joseph D D Renardy Y Renardy M | 1985 | J Fluid Mech1985，153，： | 1 |
| 16 | A comparison of time delay estimators for the detection of leak noise signals in plastic water distribution pipes显示文摘 | Gao Y Brennan M J Joseph P F | 2006 | Journal of Sound and Vibration2006，292，35： | 1 |
| 17 | Subpixel edge detection and estimation with a microprocessor-controlled line scan camera显示文摘 | Li Yu-shan Young Tzay Y Joseph A Magerl | 1988 | IEEE Trans Industrial electronics1988，35，1： | 1 |
| 18 | Enhancement of Decolorization Rate and COD Removal from Dyes Containing Wastewater by the Addition of Hydrogen Peroxide Under Solar Photocatalytic Oxida- tion 显示文摘 | Ghaly Montaser Y Farah Joseph Y Fathy Amany M | 2007 | Desalination2007，217，13： | 1 |
| 19 | A need-based measure of consumer well being(CWB)in relation to personal transportation:Nomological validation显示文摘 | SIRG Y JOSEPH M L | 2006 | Social Indicators Research2006，79，： | 1 |
| 20 | Neural network modeling of coastal algal blooms显示文摘 | JOSEPH H W LEE Y H MIKE D | 2003 | Ecological Modeling2003，159，23： | 1 |
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